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Conserved domains on  [gi|778729180|ref|XP_011659547|]
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uncharacterized protein LOC101203701 isoform X3 [Cucumis sativus]

Protein Classification

N-acetyltransferase( domain architecture ID 10529043)

N-acetyltransferase catalyzes the transfer of the acetyl group from acetyl coenzyme A donor to a substrate; contains Tudor-like Agenet domains, Jas domain(s) which in plant transcriptional repressors bind Groucho/Tup1-type co-repressor TOPLESS (TPL) and TPL-related proteins (TPRs), and plant homeodomain (PHD) finger(s) which bind zinc and may be involved in protein-protein interaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
 6-59 1.91e-12

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


:

Pssm-ID: 461700  Cd Length: 61  Bit Score: 61.56  E-value: 1.91e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 778729180    6 GDQVEVLNKKEVSSGSWSCAEILSG-NGRSYSVKFLSSDEA------VEKVPRKAIRPCPP 59
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVlKGDKYLVEYDDLLDEdgggplEEWVPASDIRPCPP 61
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
 66-121 1.98e-06

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


:

Pssm-ID: 214798  Cd Length: 59  Bit Score: 44.62  E-value: 1.98e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 778729180    66 DWDAGDLAEVFHNSLWKHAKIITIVGVNSYIVRILGS--PLDIMVGSSNLRMRQAWHD 121
Cdd:smart00743   2 DFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKGEsePLELTVDWSDLRPHPPWVD 59
ENT super family cl04239
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 308-366 1.16e-03

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


The actual alignment was detected with superfamily member pfam03735:

Pssm-ID: 461032  Cd Length: 71  Bit Score: 37.16  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 778729180  308 HRSELSVFRSFIRALYASGP-LSWEDEGQVSNIRASLHISNDEYLMELRNLMSANTRATI 366
Cdd:pfam03735   5 RKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTI 64
 
Name Accession Description Interval E-value
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
 6-59 1.91e-12

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 61.56  E-value: 1.91e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 778729180    6 GDQVEVLNKKEVSSGSWSCAEILSG-NGRSYSVKFLSSDEA------VEKVPRKAIRPCPP 59
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVlKGDKYLVEYDDLLDEdgggplEEWVPASDIRPCPP 61
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
 1-60 1.74e-08

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 50.40  E-value: 1.74e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 778729180     1 MRLRKGDQVEVLnkkevSSGSWSCAEILSGNGRS-YSVKFLSSDEAV-EKVPRKAIRPCPPP 60
Cdd:smart00743   1 SDFKEGDRVEVF-----SEDSWWEAVVTKVLGDGkYLVEYKGESEPLeLTVDWSDLRPHPPW 57
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
 3-59 4.41e-07

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 46.48  E-value: 4.41e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 778729180   3 LRKGDQVEVLNKKEVSSGSWSCAEILS--GNGRSYSVKF--LSSDEAVEK----VPRKAIRPCPP 59
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKepEGEKKFLVKYdeLLLDDGSEPleetVDLRRVRPVPP 65
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
 66-121 1.98e-06

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 44.62  E-value: 1.98e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 778729180    66 DWDAGDLAEVFHNSLWKHAKIITIVGVNSYIVRILGS--PLDIMVGSSNLRMRQAWHD 121
Cdd:smart00743   2 DFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKGEsePLELTVDWSDLRPHPPWVD 59
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
 70-114 1.00e-04

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 39.50  E-value: 1.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 778729180  70 GDLAEVFHNSLWKHAKIITIVGVNSYIVRILGSPLDIMVGSSNLR 114
Cdd:cd20406    2 GDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLR 46
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 308-366 1.16e-03

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 37.16  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 778729180  308 HRSELSVFRSFIRALYASGP-LSWEDEGQVSNIRASLHISNDEYLMELRNLMSANTRATI 366
Cdd:pfam03735   5 RKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTI 64
 
Name Accession Description Interval E-value
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
 6-59 1.91e-12

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 61.56  E-value: 1.91e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 778729180    6 GDQVEVLNKKEVSSGSWSCAEILSG-NGRSYSVKFLSSDEA------VEKVPRKAIRPCPP 59
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVlKGDKYLVEYDDLLDEdgggplEEWVPASDIRPCPP 61
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
 1-60 1.74e-08

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 50.40  E-value: 1.74e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 778729180     1 MRLRKGDQVEVLnkkevSSGSWSCAEILSGNGRS-YSVKFLSSDEAV-EKVPRKAIRPCPPP 60
Cdd:smart00743   1 SDFKEGDRVEVF-----SEDSWWEAVVTKVLGDGkYLVEYKGESEPLeLTVDWSDLRPHPPW 57
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
 3-59 4.41e-07

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 46.48  E-value: 4.41e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 778729180   3 LRKGDQVEVLNKKEVSSGSWSCAEILS--GNGRSYSVKF--LSSDEAVEK----VPRKAIRPCPP 59
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKepEGEKKFLVKYdeLLLDDGSEPleetVDLRRVRPVPP 65
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
 66-121 1.98e-06

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 44.62  E-value: 1.98e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 778729180    66 DWDAGDLAEVFHNSLWKHAKIITIVGVNSYIVRILGS--PLDIMVGSSNLRMRQAWHD 121
Cdd:smart00743   2 DFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKGEsePLELTVDWSDLRPHPPWVD 59
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
 70-114 1.00e-04

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 39.50  E-value: 1.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 778729180  70 GDLAEVFHNSLWKHAKIITIVGVNSYIVRILGSPLDIMVGSSNLR 114
Cdd:cd20406    2 GDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLR 46
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 308-366 1.16e-03

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 37.16  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 778729180  308 HRSELSVFRSFIRALYASGP-LSWEDEGQVSNIRASLHISNDEYLMELRNLMSANTRATI 366
Cdd:pfam03735   5 RKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTI 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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