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Conserved domains on  [gi|778682844|ref|XP_011651793|]
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uncharacterized protein LOC101210632 isoform X1 [Cucumis sativus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NEMP super family cl10912
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
 216-415 4.81e-42

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


The actual alignment was detected with superfamily member pfam10225:

Pssm-ID: 463008  Cd Length: 249  Bit Score: 151.21  E-value: 4.81e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  216 EVSTEEE-FFLYRIIFLILGVLLMSSASILSKSLVFYYGSGMAIGILLIVLMILFQGMKLLPtgRKSSLVIFLYASaVGL 294
Cdd:pfam10225   1 TVSLEEErFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLP--KKSTFYLLLYGG-WGV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  295 GSFFLRYISGLLYQILLEMGIsedmynplaaFLLAFIFLVGawlgfwvVHKFIL-DEDGSI-NTSTSLFVTWSIRILASL 372
Cdd:pfam10225  78 SLYLLQQLSENLRSILVEYRI----------YVLGYVLIVG-------LISFAVcYRHGPVtDERSINLLKWTLQLLGLV 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 778682844  373 LILQCSVDPLLATGVLICGIVASSMLRKIFKFRFLRRLFKNLF 415
Cdd:pfam10225 141 LIYQSSQDPEAAFAILIALLCSKNYPLSLLSYLRRKWKRRKWF 183
Thioredoxin_like super family cl00388
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; The thioredoxin ...
 17-48 7.01e-03

Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; The thioredoxin (TRX)-like superfamily is a large, diverse group of proteins containing a TRX fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of target proteins via the reversible oxidation of their active site dithiol. The PDO members of this superfamily include the families of TRX, protein disulfide isomerase (PDI), tlpA, glutaredoxin, NrdH redoxin, and bacterial Dsb proteins (DsbA, DsbC, DsbG, DsbE, DsbDgamma). Members of the superfamily that do not function as PDOs but contain a TRX-fold domain include phosducins, peroxiredoxins, glutathione (GSH) peroxidases, SCO proteins, GSH transferases (GST, N-terminal domain), arsenic reductases, TRX-like ferredoxins and calsequestrin, among others.


The actual alignment was detected with superfamily member cd02952:

Pssm-ID: 469754  Cd Length: 119  Bit Score: 36.55  E-value: 7.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 778682844  17 FDKFRSELPN--NKANFILFLADKDPsTSRSWCP 48
Cdd:cd02952    9 YEEFLKLLKSheGKPIFILFYGDKDP-DGQSWCP 41
 
Name Accession Description Interval E-value
NEMP pfam10225
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
 216-415 4.81e-42

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


Pssm-ID: 463008  Cd Length: 249  Bit Score: 151.21  E-value: 4.81e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  216 EVSTEEE-FFLYRIIFLILGVLLMSSASILSKSLVFYYGSGMAIGILLIVLMILFQGMKLLPtgRKSSLVIFLYASaVGL 294
Cdd:pfam10225   1 TVSLEEErFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLP--KKSTFYLLLYGG-WGV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  295 GSFFLRYISGLLYQILLEMGIsedmynplaaFLLAFIFLVGawlgfwvVHKFIL-DEDGSI-NTSTSLFVTWSIRILASL 372
Cdd:pfam10225  78 SLYLLQQLSENLRSILVEYRI----------YVLGYVLIVG-------LISFAVcYRHGPVtDERSINLLKWTLQLLGLV 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 778682844  373 LILQCSVDPLLATGVLICGIVASSMLRKIFKFRFLRRLFKNLF 415
Cdd:pfam10225 141 LIYQSSQDPEAAFAILIALLCSKNYPLSLLSYLRRKWKRRKWF 183
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 228-333 8.86e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 41.37  E-value: 8.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 228 IIFLILGVLLMSSASILSKSLVFYYGSG------MAIGILLIVLMILFQGMKLLPTGRKSSLVIFLYASAVGLGSFFLrY 301
Cdd:COG0697    5 ILLLLLAALLWGSSFVAIKLALAGLPPLqlaflrFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLL-F 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 778682844 302 ISGLLYQILLEMGISEDMYnPLAAFLLAFIFL 333
Cdd:COG0697   84 FLALQYTPAALAALLLALA-PLFVALLAALLL 114
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 228-341 6.65e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 228 IIFLILGVLLMSSASilskSLVFYYGSGMAIGILLIVLMILFQGM----------KLLPTGRKSSlVIFLYASAVGLGSF 297
Cdd:cd17370  263 RKKLLILGYLSLALA----YLGFALGSSLWLLLLGFILWGLYMGAqesieraavaDLVPAELRGT-AYGLFNTVVGIGWL 337

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 778682844 298 FLRYISGLLYqillemgiseDMYNPLAAFLLAFIFLVGAWLGFW 341
Cdd:cd17370  338 LASLIAGYLW----------DLISPSAAFLFSAVLALIALLLLL 371
TRP14_like cd02952
Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a ...
 17-48 7.01e-03

Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. TRP14 catalyzes the reduction of small disulfide-containing peptides but does not reduce disulfides of ribonucleotide reductase, peroxiredoxin and methionine sulfoxide reductase, which are TRX1 substrates. TRP14 also plays a role in tumor necrosis factor (TNF)-alpha signaling pathways, distinct from that of TRX1. Its depletion promoted TNF-alpha induced activation of c-Jun N-terminal kinase and mitogen-activated protein kinases.


Pssm-ID: 239250  Cd Length: 119  Bit Score: 36.55  E-value: 7.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 778682844  17 FDKFRSELPN--NKANFILFLADKDPsTSRSWCP 48
Cdd:cd02952    9 YEEFLKLLKSheGKPIFILFYGDKDP-DGQSWCP 41
 
Name Accession Description Interval E-value
NEMP pfam10225
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
 216-415 4.81e-42

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


Pssm-ID: 463008  Cd Length: 249  Bit Score: 151.21  E-value: 4.81e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  216 EVSTEEE-FFLYRIIFLILGVLLMSSASILSKSLVFYYGSGMAIGILLIVLMILFQGMKLLPtgRKSSLVIFLYASaVGL 294
Cdd:pfam10225   1 TVSLEEErFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLP--KKSTFYLLLYGG-WGV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844  295 GSFFLRYISGLLYQILLEMGIsedmynplaaFLLAFIFLVGawlgfwvVHKFIL-DEDGSI-NTSTSLFVTWSIRILASL 372
Cdd:pfam10225  78 SLYLLQQLSENLRSILVEYRI----------YVLGYVLIVG-------LISFAVcYRHGPVtDERSINLLKWTLQLLGLV 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 778682844  373 LILQCSVDPLLATGVLICGIVASSMLRKIFKFRFLRRLFKNLF 415
Cdd:pfam10225 141 LIYQSSQDPEAAFAILIALLCSKNYPLSLLSYLRRKWKRRKWF 183
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 228-333 8.86e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 41.37  E-value: 8.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 228 IIFLILGVLLMSSASILSKSLVFYYGSG------MAIGILLIVLMILFQGMKLLPTGRKSSLVIFLYASAVGLGSFFLrY 301
Cdd:COG0697    5 ILLLLLAALLWGSSFVAIKLALAGLPPLqlaflrFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLL-F 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 778682844 302 ISGLLYQILLEMGISEDMYnPLAAFLLAFIFL 333
Cdd:COG0697   84 FLALQYTPAALAALLLALA-PLFVALLAALLL 114
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 223-375 4.16e-03

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 40.02  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 223 FFLYRIIFLILGVLLMSSASILSKSLVFYYGSGMAIGILLIVLMILFqGMKLLPTGRKSSLVIFLY-------ASAVGLG 295
Cdd:COG1368    2 FLLFLLLLSLRLVFLLFNFDLSLGEILQAFLYGLRFILYLLLLLLLL-LLLLLPLLFRRPKLRWIYlllvlllLLLLLVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 296 SF-FLRYISGLLYQILLEMGISED------MYNPLAAFLLAFIFLVGAWLGFWVVHKFILDEdgsintstslfVTWSIRI 368
Cdd:COG1368   81 DIlYYRFFGDRLNFSDLDYLGDTGevlgslLSSYDLLLLLDLLLLLLLLLLLYRLLKKLRKS-----------LPWRKRL 149


                 ....*..
gi 778682844 369 LASLLIL 375
Cdd:COG1368  150 ALLLLLL 156
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 228-341 6.65e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778682844 228 IIFLILGVLLMSSASilskSLVFYYGSGMAIGILLIVLMILFQGM----------KLLPTGRKSSlVIFLYASAVGLGSF 297
Cdd:cd17370  263 RKKLLILGYLSLALA----YLGFALGSSLWLLLLGFILWGLYMGAqesieraavaDLVPAELRGT-AYGLFNTVVGIGWL 337

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 778682844 298 FLRYISGLLYqillemgiseDMYNPLAAFLLAFIFLVGAWLGFW 341
Cdd:cd17370  338 LASLIAGYLW----------DLISPSAAFLFSAVLALIALLLLL 371
TRP14_like cd02952
Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a ...
 17-48 7.01e-03

Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. TRP14 catalyzes the reduction of small disulfide-containing peptides but does not reduce disulfides of ribonucleotide reductase, peroxiredoxin and methionine sulfoxide reductase, which are TRX1 substrates. TRP14 also plays a role in tumor necrosis factor (TNF)-alpha signaling pathways, distinct from that of TRX1. Its depletion promoted TNF-alpha induced activation of c-Jun N-terminal kinase and mitogen-activated protein kinases.


Pssm-ID: 239250  Cd Length: 119  Bit Score: 36.55  E-value: 7.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 778682844  17 FDKFRSELPN--NKANFILFLADKDPsTSRSWCP 48
Cdd:cd02952    9 YEEFLKLLKSheGKPIFILFYGDKDP-DGQSWCP 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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