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Conserved domains on  [gi|768032120|ref|XP_011543778|]
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BCLAF1 and THRAP3 family member 3 isoform X1 [Homo sapiens]

Protein Classification

BCLAF1 and THRAP3 family protein( domain architecture ID 12173452)

BCLAF1 and THRAP3 family protein is an RNA processing factor that plays critical roles in maintaining DNA genomic stability, such as the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) and thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 697.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGhspDDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGR---YHG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LLDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  299 RTQKYCKEeDRKYSFQKGP-LNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYSNKNDVDLRSSNDKWKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  377 GDCRKESN-SSSNQLDKSQKLPDVKPSPINLR---KKSLTVKVDVKKTV-DTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDIHkADVNEIPLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeRDDQNSSFSKVKNVHTDGFQKPT 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 768032120  605 HFIKSNFRKciekpymnyTTQRKDIIThkpfeVEGNHRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 697.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGhspDDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGR---YHG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LLDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  299 RTQKYCKEeDRKYSFQKGP-LNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYSNKNDVDLRSSNDKWKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  377 GDCRKESN-SSSNQLDKSQKLPDVKPSPINLR---KKSLTVKVDVKKTV-DTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDIHkADVNEIPLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeRDDQNSSFSKVKNVHTDGFQKPT 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 768032120  605 HFIKSNFRKciekpymnyTTQRKDIIThkpfeVEGNHRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 697.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGhspDDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGR---YHG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LLDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  299 RTQKYCKEeDRKYSFQKGP-LNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYSNKNDVDLRSSNDKWKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  377 GDCRKESN-SSSNQLDKSQKLPDVKPSPINLR---KKSLTVKVDVKKTV-DTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDIHkADVNEIPLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032120  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeRDDQNSSFSKVKNVHTDGFQKPT 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 768032120  605 HFIKSNFRKciekpymnyTTQRKDIIThkpfeVEGNHRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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