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Conserved domains on  [gi|767904379|ref|XP_011539782|]
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protein zyg-11 homolog A isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
157-331 3.79e-05

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 157 NLQCLLLDS---TSIPQNsrllfFSQLTGLRILSVFNVCFhtEDLANVSQLPRLESLDISNTLVTDISALLTCKdRLKSL 233
Cdd:COG4886  206 NLEELDLSGnqlTDLPEP-----LANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 234 TMHY--LKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVELFIRLRP 311
Cdd:COG4886  278 DLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        170       180
                 ....*....|....*....|
gi 767904379 312 AMQFVGLLATDAGSSDFFTT 331
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
157-331 3.79e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 157 NLQCLLLDS---TSIPQNsrllfFSQLTGLRILSVFNVCFhtEDLANVSQLPRLESLDISNTLVTDISALLTCKdRLKSL 233
Cdd:COG4886  206 NLEELDLSGnqlTDLPEP-----LANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 234 TMHY--LKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVELFIRLRP 311
Cdd:COG4886  278 DLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        170       180
                 ....*....|....*....|
gi 767904379 312 AMQFVGLLATDAGSSDFFTT 331
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
157-331 3.79e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 157 NLQCLLLDS---TSIPQNsrllfFSQLTGLRILSVFNVCFhtEDLANVSQLPRLESLDISNTLVTDISALLTCKdRLKSL 233
Cdd:COG4886  206 NLEELDLSGnqlTDLPEP-----LANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 234 TMHY--LKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVELFIRLRP 311
Cdd:COG4886  278 DLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        170       180
                 ....*....|....*....|
gi 767904379 312 AMQFVGLLATDAGSSDFFTT 331
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
172-300 9.06e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 9.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904379 172 SRLLFFSQLTGLRILSVFNvcFHTEDL-ANVSQLPRLESLDISNTLVTDISALLTCKDRLKSLTmhylkcLAMTK-SQIL 249
Cdd:COG4886  104 SGNEELSNLTNLESLDLSG--NQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLD------LSNNQlTDLP 175

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767904379 250 AVIRELKCLLHLDISDHrQLkSDLAFHLLQqkdiLPNVVSLDISgGNCITD 300
Cdd:COG4886  176 EELGNLTNLKELDLSNN-QI-TDLPEPLGN----LTNLEELDLS-GNQLTD 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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