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Conserved domains on  [gi|767942482|ref|XP_011533984|]
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WD repeat-containing protein 27 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 1.25e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942482 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 3.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942482 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 1.25e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942482 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-842 1.57e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 703
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 704 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 782
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 783 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQV 842
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 3.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942482 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 1.98e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319  183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319  249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319  322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                 ..
gi 767942482 266 SL 267
Cdd:COG2319  400 DL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-613 3.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.92e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767942482   579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
579-613 4.22e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 4.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767942482  579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 7.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 7.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767942482   183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 1.25e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 697
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942482 777 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
545-837 2.99e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 2.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLS-TTGAVDMTSLSAvnD 697
Cdd:COG2319  160 GH---SGAVTSV------AFspdgkLLASGSDDGTVRLWDLAT-------------GKLLRTLTgHTGAVRSVAFSP--D 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 698 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQIcqnkgsSFTTQqpqayNLFLTTAIGDGM-RLWDLRTLRCE 776
Cdd:COG2319  216 --GKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSV------AFSPD-----GRLLASGSADGTvRLWDLATGELL 281

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942482 777 RHFEGHPtrGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319  282 RTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-842 1.57e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 623
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 624 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 703
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 704 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 782
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 783 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQV 842
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 579-838 3.91e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 3.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS-ARGAELALLLGKdmfSKPIQSAQFYYIDAFILLSSGpefqllry 657
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGH---TGPVRDVAASADGTYLASGSS-------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 658 hiDTCkdeIKRYKqKSKSKLICRLST-TGAVdmTSLSAVNDfySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQ 736
Cdd:cd00200   72 --DKT---IRLWD-LETGECVRTLTGhTSYV--SSVAFSPD--GRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 737 ICQNKGssfttqqpqayNLFLTTAIGDG-MRLWDLRTLRCERHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMG 815
Cdd:cd00200  141 VAFSPD-----------GTFVASSSQDGtIKLWDLRTGKCVATLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                        250       260
                 ....*....|....*....|...
gi 767942482 816 SSTFSHRLAGHTDTVTGVAFNPS 838
Cdd:cd00200  208 TGKCLGTLRGHENGVNSVAFSPD 230
WD40 COG2319
WD40 repeat [General function prediction only];
545-816 3.68e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG 624
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 625 KDmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVNDf 698
Cdd:COG2319  244 GH--SGSVRSV------AFspdgrLLASGSADGTVRLWDLAT-------------GELLRTLTGhSGGV--NSVAFSPD- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 699 ySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqpqAYNLFLTTAIGDGM-RLWDLRTLRCER 777
Cdd:COG2319  300 -GKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS-----PDGKTLASGSDDGTvRLWDLATGELLR 366

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767942482 778 HFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGS 816
Cdd:COG2319  367 TLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
551-837 3.15e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 3.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 551 YSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKdmFSK 630
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG--HTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 631 PIQSAQFyYIDAFILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVDMTSLSAvnDfySHIVLAAGRN 709
Cdd:COG2319  122 AVRSVAF-SPDGKTLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGAVTSVAFSP--D--GKLLASGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 710 RTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCERHFEGHptRGYP 788
Cdd:COG2319  184 GTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS---PD--GKLLASGSADGTvRLWDLATGKLLRTLTGH--SGSV 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767942482 789 CGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNP 837
Cdd:COG2319  250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 3.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942482 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 1.98e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319  183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319  249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319  322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                 ..
gi 767942482 266 SL 267
Cdd:COG2319  400 DL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 545-613 2.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 2.65e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767942482 545 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-270 6.68e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 6.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319  141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 123 lGKVLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVE 201
Cdd:COG2319  205 -GAVRSVAFSPDGKLLASGSADGtVRLWDL------------------------------ATGKLLRTLTGHSGSVRSVA 253

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767942482 202 FCPWRAgTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 270
Cdd:COG2319  254 FSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-270 9.32e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 9.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  48 DGTeLCIWNTKDPShQLLILRGHHQPIT---AMAFGNKvnpllICSASLDY-VIMWNLdecrekvlQGLVPRGTVMGSLl 123
Cdd:cd00200   30 DGT-IKVWDLETGE-LLRTLKGHTGPVRdvaASADGTY-----LASGSSDKtIRLWDL--------ETGECVRTLTGHT- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 124 GKVLCLQLSLDDHVVAVCAGNK-IFMLDIE---QRFSVTYIERPdVNNRHKVPPPTFLHTFSQTQAVR----------AE 189
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKtIKVWDVEtgkCLTTLRGHTDW-VNSVAFSPDGTFVASSSQDGTIKlwdlrtgkcvAT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 190 LQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYS-----SSVLSAypllsLFIDaeSRQLVTGCA-DGQLW 263
Cdd:cd00200  173 LTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTlrgheNGVNSV-----AFSP--DGYLLASGSeDGTIR 244


                 ....*..
gi 767942482 264 IFSLMDG 270
Cdd:cd00200  245 VWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-272 1.30e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECR-EKVLQGlvprgtvmgsLLGKVLCLQLSLDDHVVAVCAGN 144
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGElLRTLKG----------HTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 145 K-IFMLDIEQRFSVTYIE--RPDVNNRHKVPPPTFLHTFSQTQAVR----------AELQGHLGPVTAVEFCPwrAGTLI 211
Cdd:cd00200   73 KtIRLWDLETGECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKvwdvetgkclTTLRGHTDWVNSVAFSP--DGTFV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942482 212 -SASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFSLMDGHH 272
Cdd:cd00200  151 aSSSQDGTIKLWDLRTGKCVA---TLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-613 3.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.92e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767942482   579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
579-613 4.22e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 4.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767942482  579 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 613
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-271 5.39e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 187 RAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWD 79


                 ....*
gi 767942482 267 LMDGH 271
Cdd:cd00200   80 LETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
182-270 1.72e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942482 182 QTQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQ 261
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185


                 ....*....
gi 767942482 262 LWIFSLMDG 270
Cdd:COG2319  186 VRLWDLATG 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 7.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 7.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767942482   183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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