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Conserved domains on  [gi|767914659|ref|XP_011531200|]
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cysteine-rich motor neuron 1 protein isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 948-1077 1.36e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.36e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914659   948 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 1026
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767914659  1027 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1077
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 2.76e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 2.76e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767914659    39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 724-775 2.13e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.88  E-value: 2.13e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   724 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 775
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 860-914 7.86e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 44.34  E-value: 7.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   860 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 914
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
444-497 2.52e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.52e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    444 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 497
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
377-431 7.51e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 7.51e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    377 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 431
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 608-633 2.26e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 39.08  E-value: 2.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 767914659   608 CPELSCSKICPLGFQQDSHGCLICKC 633
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
799-849 2.97e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.97e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 767914659    799 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 849
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 653-703 1.19e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 38.17  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   653 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 703
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 948-1077 1.36e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.36e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914659   948 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 1026
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767914659  1027 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1077
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 2.76e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 2.76e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767914659    39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 724-775 2.13e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 2.13e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   724 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 775
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 860-914 7.86e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 7.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   860 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 914
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
444-497 2.52e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.52e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    444 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 497
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
724-775 6.61e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.73  E-value: 6.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767914659    724 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 775
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
377-431 7.51e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 7.51e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    377 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 431
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 377-431 1.92e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   377 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 431
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
860-914 2.13e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 2.13e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    860 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 914
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 608-633 2.26e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 39.08  E-value: 2.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 767914659   608 CPELSCSKICPLGFQQDSHGCLICKC 633
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
799-849 2.97e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.97e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 767914659    799 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 849
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 799-849 3.32e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 3.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767914659   799 GDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRK--GQCCPYC 849
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 5.48e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 39.76  E-value: 5.48e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914659     37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRCVIRPP 95
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 653-703 1.19e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.17  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   653 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 703
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 444-497 2.93e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   444 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 497
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 948-1077 1.36e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.36e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914659   948 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 1026
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767914659  1027 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1077
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 2.76e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.09  E-value: 2.76e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767914659    39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 724-775 2.13e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 2.13e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   724 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 775
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 860-914 7.86e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 7.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   860 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 914
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
444-497 2.52e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.52e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    444 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 497
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
724-775 6.61e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.73  E-value: 6.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767914659    724 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 775
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
377-431 7.51e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 7.51e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    377 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 431
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 377-431 1.92e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   377 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 431
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
860-914 2.13e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 2.13e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767914659    860 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 914
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 608-633 2.26e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 39.08  E-value: 2.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 767914659   608 CPELSCSKICPLGFQQDSHGCLICKC 633
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
799-849 2.97e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.97e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 767914659    799 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 849
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 799-849 3.32e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 3.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767914659   799 GDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRK--GQCCPYC 849
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 5.48e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 39.76  E-value: 5.48e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914659     37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRCVIRPP 95
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 653-703 1.19e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.17  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767914659   653 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 703
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 444-497 2.93e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767914659   444 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 497
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 868-914 2.95e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.22  E-value: 2.95e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767914659   868 ADEERWDLDSCTH---CYC---LQGQTLCSTVS--CPPLPCVEPINVEGSCCPMC 914
Cdd:pfam14828  181 AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 461-497 6.67e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 6.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914659   461 DCTFCQC---VNGERHC--VATVCGQ-TCTNPVKVPGECCPVC 497
Cdd:pfam14828  193 DPSGCGCgndENLERICanVLQRCPPpHCLSPLRPEGHCCDVC 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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