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Conserved domains on  [gi|768013906|ref|XP_011527565|]
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cardiolipin synthase (CMP-forming) isoform X2 [Homo sapiens]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein similar to enzymes that catalyze the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0005886|GO:0000287

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-193 4.31e-21

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 85.30  E-value: 4.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558    2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                         90
                 ....*....|....*
gi 768013906 179 ILYVSLTYADLIPGA 193
Cdd:COG0558   81 AALLGLVLLGLLPAW 95
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-193 4.31e-21

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 85.30  E-value: 4.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558    2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                         90
                 ....*....|....*
gi 768013906 179 ILYVSLTYADLIPGA 193
Cdd:COG0558   81 AALLGLVLLGLLPAW 95
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 107-191 8.57e-20

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 81.45  E-value: 8.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906  107 WTIPNMLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLT 185
Cdd:pfam01066   1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79


                  ....*.
gi 768013906  186 YADLIP 191
Cdd:pfam01066  80 ILGLLP 85
PLN02794 PLN02794
cardiolipin synthase
 101-192 2.20e-15

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 72.95  E-value: 2.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906 101 SLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISIL 180
Cdd:PLN02794 136 GIVKSFVNLPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCV 214

                         90
                 ....*....|...
gi 768013906 181 YVSLTYADLI-PG 192
Cdd:PLN02794 215 ALAMVEKDLLhPG 227
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 109-191 1.00e-13

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 66.22  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906  109 IPNMLSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81


                  ....*....
gi 768013906  183 SLTYADLIP 191
Cdd:TIGR00560  82 ILVYHGYVP 90
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-193 4.31e-21

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 85.30  E-value: 4.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558    2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                         90
                 ....*....|....*
gi 768013906 179 ILYVSLTYADLIPGA 193
Cdd:COG0558   81 AALLGLVLLGLLPAW 95
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 107-191 8.57e-20

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 81.45  E-value: 8.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906  107 WTIPNMLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLT 185
Cdd:pfam01066   1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79


                  ....*.
gi 768013906  186 YADLIP 191
Cdd:pfam01066  80 ILGLLP 85
PLN02794 PLN02794
cardiolipin synthase
 101-192 2.20e-15

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 72.95  E-value: 2.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906 101 SLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISIL 180
Cdd:PLN02794 136 GIVKSFVNLPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCV 214

                         90
                 ....*....|...
gi 768013906 181 YVSLTYADLI-PG 192
Cdd:PLN02794 215 ALAMVEKDLLhPG 227
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 109-191 1.00e-13

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 66.22  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013906  109 IPNMLSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81


                  ....*....
gi 768013906  183 SLTYADLIP 191
Cdd:TIGR00560  82 ILVYHGYVP 90
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
109-182 1.12e-07

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 49.46  E-value: 1.12e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768013906 109 IPNMLSMTRIGLAP--VLG-YLIIEEDFNIALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:PRK10832   5 IPTLLTLFRVILIPffVLVfYLPFTWAPFVCALIFCVAAVTDWFDGFLARRW-NQSTRFGAFLDPVADKVMVAIAMV 80
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 108-178 1.13e-04

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 41.17  E-value: 1.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768013906 108 TIPNMLSMTRIGLAPVLGYLIIEEDF---NIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILIS 178
Cdd:PLN02558  10 TLPTVLTLGRVAAVPLLVATFYVDSWwgrTATTSIFIAAAITDWLDGYLARK-MKLGTAFGAFLDPVADKLMVA 82
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
109-173 2.58e-03

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 37.49  E-value: 2.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768013906 109 IPNMLSMtrigLAPVLGYLII----EEDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLAD 173
Cdd:COG1183   12 LPNLFTL----LNLFCGFLAIvaaiEGDFELAALLILLAAVFDGLDGRVAR-LLNVQSEFGAELDSLAD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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