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Conserved domains on  [gi|768017963|ref|XP_011527280|]
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voltage-gated purine nucleotide uniporter SLC17A9 isoform X1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-302 1.69e-115

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17380:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 337.60  E-value: 1.69e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:cd17380   92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALV 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 VYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEETF-PDAKGWIFN 159
Cdd:cd17380  172 WLIYL---------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFN 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 160 VVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:cd17380  219 VVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVN 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017963 240 IQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17380  299 HQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-302 1.69e-115

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 337.60  E-value: 1.69e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:cd17380   92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALV 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 VYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEETF-PDAKGWIFN 159
Cdd:cd17380  172 WLIYL---------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFN 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 160 VVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:cd17380  219 VVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVN 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017963 240 IQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17380  299 HQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 3-315 4.87e-22

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 95.97  E-value: 4.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLE-WYGWQSIFYFSG--GLTLLWVW 79
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGivGCAWSLLW 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   80 YVYRY---------LLSEKDLILAlgVLAQSRPVSRHNrVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET- 149
Cdd:TIGR00894 216 FVFPAddpsihpciSKFEKKYINS--SLQGQKGSTRQS-LPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVl 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  150 -FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAIT-VRKLMQGMGLGLSSVFALCLGHTSS-FCESVVFASASI 226
Cdd:TIGR00894 293 rVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTaARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIILTLAN 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  227 GLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMET--TGSWTCLFNLVAIISNLGLCTFLVFGQA 304
Cdd:TIGR00894 373 AVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIFGSA 452

                         330
                  ....*....|.
gi 768017963  305 QRVDLSSTHED 315
Cdd:TIGR00894 453 ERQDWAKEEKD 463
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-289 1.39e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.70  E-value: 1.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:COG2271  101 LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdlilalgvlaqsrpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIF 158
Cdd:COG2271  181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLL 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 159 NVVPWLVAIPASLFSGFLSDHLINQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISV 238
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768017963 239 NIQDLAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAI 289
Cdd:COG2271  295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
MFS_1 pfam07690
Major Facilitator Superfamily;
1-266 3.02e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.01  E-value: 3.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:pfam07690  88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   81 VYRYLLSEKDlilalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSqLSAACSFFILLSWLPTFFEET-FPDAKGWIFN 159
Cdd:pfam07690 168 LLLPRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLgLSALLAGLLL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  160 VVPWLVAIPASLFSGFLSDHLinqgyrAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         250       260
                  ....*....|....*....|....*...
gi 768017963  240 IQDLAP-SCAGFLFGVANTAGALAGVVG 266
Cdd:pfam07690 316 VSDLAPkEERGTASGLYNTAGSLGGALG 343
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-226 3.92e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.87  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRY 84
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  85 LLSEKDLILALGVLAQSRPVsrhnrvpWRRLF---RKPAVWAAVVSQLSAACSFFILLSWLPTFFEE---TFPDAkGWI- 157
Cdd:PRK11551 190 LPESRAFAQAAGAGKQRAPV-------LRALFgegRATATLLLWISYFFTLIVLYFLLNWLPSLLVGqglSRSQA-GLVq 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 --FNVvpwlVAIPASLFSGFLSDHLinqgyRAITVRKLMQG------MGLGLSSVF------ALCLGHTSSFCESVVFAS 223
Cdd:PRK11551 262 iaFNI----GGALGSLLIGALMDRL-----RPRRVVLLIYAgilaslAALAAAPSFagmllaGFAAGLFVVGGQSVLYAL 332


                 ...
gi 768017963 224 ASI 226
Cdd:PRK11551 333 APL 335
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-302 1.69e-115

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 337.60  E-value: 1.69e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:cd17380   92 LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALV 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 VYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEETF-PDAKGWIFN 159
Cdd:cd17380  172 WLIYL---------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLvPLAKGWVFN 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 160 VVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:cd17380  219 VVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVN 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017963 240 IQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17380  299 HQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 1-302 8.16e-88

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 267.95  E-value: 8.16e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:cd17318  114 LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLL 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 VYRYLlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIF 158
Cdd:cd17318  194 WFFLV---------------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVlhFNIKSNGFL 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 159 NVVPWLVAIPASLFSGFLSDHLINQG-YRAITVRKLMQGMGLGLSSVFALCLGH-TSSFCESVVFASASIGLQTFNHSGI 236
Cdd:cd17318  241 SSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGF 320

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017963 237 SVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM---ETTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17318  321 LVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQTIGQWRIVFFISAAIYILGAIFYLIFG 389
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 5-302 1.43e-29

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 116.03  E-value: 1.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLW--VWYVy 82
Cdd:cd17381  127 RALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWffLWIW- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  83 ryllsekdLILALgvlaqsrpvsrhnrvpwrrlfrkpavWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIFNV 160
Cdd:cd17381  206 --------LVMPL--------------------------WAIVVAHFSYNWTFYTLLTLLPTYMKEIlrFDIQENGFLSA 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 161 VPWLVAIPASLFSGFLSDHLI-NQGYRAITVRKLMQGMGLGLSSVFALCLGHTS-SFCESVVFASASIGLQTFNHSGISV 238
Cdd:cd17381  252 LPYLGCWLFMILSGQIADNLReKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNI 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017963 239 NIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLME--TTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17381  332 NHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 2-302 3.32e-28

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 112.05  E-value: 3.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   2 TFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLlwVWYV 81
Cdd:cd17382  108 IFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGI--IWYM 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  82 YRYLLSEkdlilalgvlaqsrpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFN 159
Cdd:cd17382  186 FWMLVSM-------------------------------PVYAIIVANFCRSWTFYLLLISQPAYFKEVFgfDISKVGILS 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 160 VVPWLVAIPASLFSGFLSDHLINQGYRAIT-VRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISV 238
Cdd:cd17382  235 ALPHLVMTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNV 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017963 239 NIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM--ETTGSWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17382  315 NHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 5-300 1.58e-24

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 101.49  E-value: 1.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRY 84
Cdd:cd17319   98 RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  85 LlsekdlilalgvlaqsrpvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIFNVVP 162
Cdd:cd17319  178 L---------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQArgFSLKQVGLLAAIP 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 163 WLVAIPASLFSGFLSDHLINQgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQD 242
Cdd:cd17319  225 FLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPAD 298

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768017963 243 LAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLV 300
Cdd:cd17319  299 LLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 3-315 4.87e-22

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 95.97  E-value: 4.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLE-WYGWQSIFYFSG--GLTLLWVW 79
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGivGCAWSLLW 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   80 YVYRY---------LLSEKDLILAlgVLAQSRPVSRHNrVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET- 149
Cdd:TIGR00894 216 FVFPAddpsihpciSKFEKKYINS--SLQGQKGSTRQS-LPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVl 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  150 -FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAIT-VRKLMQGMGLGLSSVFALCLGHTSS-FCESVVFASASI 226
Cdd:TIGR00894 293 rVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTaARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIILTLAN 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  227 GLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMET--TGSWTCLFNLVAIISNLGLCTFLVFGQA 304
Cdd:TIGR00894 373 AVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKNVWLIVFLIMAFVNILCVIFYLIFGSA 452

                         330
                  ....*....|.
gi 768017963  305 QRVDLSSTHED 315
Cdd:TIGR00894 453 ERQDWAKEEKD 463
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-289 1.39e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.70  E-value: 1.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:COG2271  101 LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdlilalgvlaqsrpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWIF 158
Cdd:COG2271  181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLL 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 159 NVVPWLVAIPASLFSGFLSDHLINQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISV 238
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI-------GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768017963 239 NIQDLAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAI 289
Cdd:COG2271  295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
MFS_1 pfam07690
Major Facilitator Superfamily;
1-266 3.02e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.01  E-value: 3.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:pfam07690  88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   81 VYRYLLSEKDlilalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSqLSAACSFFILLSWLPTFFEET-FPDAKGWIFN 159
Cdd:pfam07690 168 LLLPRPPPES-----KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLgLSALLAGLLL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  160 VVPWLVAIPASLFSGFLSDHLinqgyrAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         250       260
                  ....*....|....*....|....*...
gi 768017963  240 IQDLAP-SCAGFLFGVANTAGALAGVVG 266
Cdd:pfam07690 316 VSDLAPkEERGTASGLYNTAGSLGGALG 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-300 1.19e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.46  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVY 82
Cdd:cd17325   89 LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLAL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  83 RYLLSEKdlilalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFN 159
Cdd:cd17325  169 LLLPEPR------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGglsPAQIGLLFG 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 160 VVPwLVAIPASLFSGFLSDHLinqgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVN 239
Cdd:cd17325  243 AQG-LASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017963 240 IQDLAPSCA-GFLFGVANTAGALAGVVGVCLGGYLMETTG-SWTCLFNLVAIISNLGLCTFLV 300
Cdd:cd17325  313 LADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGfATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-263 2.75e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.40  E-value: 2.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWvwy 80
Cdd:COG2814  101 LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA--- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdLILALGVLAQSRPVSRHN-RVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWI 157
Cdd:COG2814  178 ----------LLLLLRLLPESRPAARARlRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglSASAAGL 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 FNVVPWLVAIPASLFSGFLSDHLinqgyraitVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGIS 237
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        250       260
                 ....*....|....*....|....*..
gi 768017963 238 VNIQDLAP-SCAGFLFGVANTAGALAG 263
Cdd:COG2814  319 ALVAELAPpEARGRASGLYNSAFFLGG 345
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-284 1.29e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 73.35  E-value: 1.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWY 80
Cdd:cd17324   90 LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 VYRYLLSekdlilalgvLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWI 157
Cdd:cd17324  170 LWRLLPS----------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPgfsSSAIIGL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 FNVVpWLVAIPASLFSGFLSDHlinqgyraITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQtFNHSGIS 237
Cdd:cd17324  240 LLLF-GVAGVVGSPLAGRLADR--------GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF-AAHSALQ 309

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 768017963 238 VNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLF 284
Cdd:cd17324  310 TRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-306 4.25e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.22  E-value: 4.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVY 82
Cdd:COG2223   98 LLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAW 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  83 RYLLSEKdlilalgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPD--AKGWIFNV 160
Cdd:COG2223  178 LFLRDPP---------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLsaATAGLLAA 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 161 VPWLVAIPASLFSGFLSDHlinqgyraITVRKLMQGMGLGLSSVFALCLGHTSSFcesVVFASASIGLQTFNHSGISVNI 240
Cdd:COG2223  249 LFALLGALGRPLGGWLSDR--------IGGRRVLLIVFALMALGLLLLALALGSL---WLFLVLFLLLGLALGGGNGAVF 317

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 241 QDLA----PSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQR 306
Cdd:COG2223  318 ALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-299 2.14e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.98  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEW--YGWQSIFYFSGGLTLLWV 78
Cdd:cd06174   87 LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAA 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  79 WYVYRYLLSEKDLILAlgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGW 156
Cdd:cd06174  167 ILLLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLggLSVAVAG 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 157 IFNVVPWLVAIPASLFSGFLSDHLINqgyraitvRKLMQGMGLGLSSVFALCLGHTSSFCESVVFAS-ASIGLQTFNHSG 235
Cdd:cd06174  243 LLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLS 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017963 236 ISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 299
Cdd:cd06174  315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
3-305 1.38e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   3 FSRILMGLLQGVYFPALTSLLSQKVRESeRAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvy 82
Cdd:COG2807  111 AGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL------ 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  83 ryllsekdLILALGVLAQSRPVSRHN---RVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEET--FPDAKGWI 157
Cdd:COG2807  184 --------ALLLWLPLLRRRPAAAAAapaAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAglSAATAGLL 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 FNVVPwLVAIPASLFSGFLSDHLINQGYRAITVrklmqgMGLGLSSVFALCLGHTSSFCESVVFASASIGLqTFnhSGIS 237
Cdd:COG2807  256 LSLFQ-LAGIPGSLLVPLLADRLGDRRPLLLLL------GLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF--PLAL 325

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 238 VNIQDLAPSC--AGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQ 305
Cdd:COG2807  326 TLIGLRARTPaeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 5-178 9.11e-09

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 56.10  E-value: 9.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLE------WYGWQSIFYFSGGLTLLWV 78
Cdd:cd17327  101 RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvggLAGWRWLFIIEGLITIIIG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  79 WYVYRYL---------LSEKDLILALGVLAQSRPVSRHNRVPW---RRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFF 146
Cdd:cd17327  181 LVIFFWLpdnpskawfLTEEEKELAVERLRANQTGKGDQKFKWkqiKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLIL 260

                        170       180       190
                 ....*....|....*....|....*....|...
gi 768017963 147 EETFPD-AKGWIFNVVPWLVAIPASLFSGFLSD 178
Cdd:cd17327  261 KSLGFYsLQTNLLSVPIGALGAVSLLIAALLSD 293
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 5-274 2.37e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 54.67  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRY 84
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   85 L-LSEKDLIL--------------------ALGVLAQSRPVSRHNRVPWRRLFRK------PAVWAAVVSQLSaacSFFI 137
Cdd:TIGR00895 192 LpESIDFLVSkrpetvrrivnaiapqmqaeAQSALPEQKSTQGTKRSVFKALFQGktaritVLLWLLYFMLLV---GVYF 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  138 LLSWLPTFFEET-FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLinqGYRAITVrklmqgmGLGLSSVFALCLGhtSSFC 216
Cdd:TIGR00895 269 LTNWLPKLMVELgFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTAL-------LLLLGAVFAVLVG--STLF 336

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768017963  217 ESVVFASASIGLQTFNHSGISVNIQDLA----PSCAGFLFGVANTAGALAGVVGVCLGGYLM 274
Cdd:TIGR00895 337 SPTLLLLLGAIAGFFVNGGQSGLYALMAlfypTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 6-300 2.46e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 51.51  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL 85
Cdd:cd17312   99 GLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  86 LSekdlilalgvlaqsrpvsrhnrvpwrrlfRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAK---GWIFNVVP 162
Cdd:cd17312  179 RD-----------------------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLidaGWFSSLYE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 163 wLVAIPASLFSGFLSDHLInQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISvniQD 242
Cdd:cd17312  230 -VGGIAGTILAGLLSDKLF-GGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAA---QD 304

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768017963 243 LAPSCA-GFLFGVANTAGALAGVVGVCLGGYLMETTGSWTclFNLVAIISNLGLCTFLV 300
Cdd:cd17312  305 IGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWST--VFYFLISAALLSVLLLL 361
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 6-299 3.32e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 51.08  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL 85
Cdd:cd17475   92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  86 LSEKDLILAlgvlaqsRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFNVVP 162
Cdd:cd17475  172 REPPAASAA-------TESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVAAGALLAVAQ 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 163 WLvAIPASLFSGFLSDHLINQGYRAITVrkLMQGMGLGLSSVFALCLGHTSSFceSVVFASASIGLQTFNHSGISVN-IQ 241
Cdd:cd17475  245 LG-GALGRIGLGRVSDRVFGGRRRPVLV--ITAAIAAAALLVLSLLSPGTPLW--LLVLLLILLGLFAIGWNGLYLTlVA 319

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768017963 242 DLAP-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 299
Cdd:cd17475  320 ESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-176 1.92e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 48.65  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVY 82
Cdd:COG0477  107 AARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRL 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  83 RYLLSEKDLILALGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVP 162
Cdd:COG0477  187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266

                        170
                 ....*....|....
gi 768017963 163 WLVAIPASLFSGFL 176
Cdd:COG0477  267 LLLLLLALLLALLL 280
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 5-205 2.94e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.06  E-value: 2.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963    5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQF-GTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYR 83
Cdd:TIGR00881  90 WALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   84 yLLSEKDLILALGVLAQSR--------PVSRHNRVPWRRLFRK----PAVWAAVVSQLSAACSFFILLSWLPTFFEET-- 149
Cdd:TIGR00881 170 -LLRDSPQSCGLPPAEEMPneepdgdaEKKEEELTKKQIFLQYvllnKVLWYISLGYVFVYVVRTGILDWSPLYLTQEkg 248

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768017963  150 FPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINqGYRAITVRKLMQGMGLGLSSVF 205
Cdd:TIGR00881 249 FSKEKASWAFTLYELGGLVGTLLAGWLSDKLFN-GRRGPLAVFFMALIIVSLLVYW 303
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 6-293 6.95e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.18  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYL 85
Cdd:cd17355  100 LLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLL 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  86 LSEKDLIlalGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFNVVpW 163
Cdd:cd17355  180 RRRPADL---ALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGisPAAAAVALALI-G 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 164 LVAIPASLFSGFLSDhlinqgyRAITVRKLMQGMGLGLSSVFALCLGHTSSFceSVVFASASIGLQTFNHSGISVNI--Q 241
Cdd:cd17355  256 LFNIVGRLLSGWLGD-------RYSPRRLLAASYALRALGLALLLLLPFPPL--ALLLFAALFGLGWGATVPLTAALaaR 326

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768017963 242 DLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWT------CLFNLVAIISNL 293
Cdd:cd17355  327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTaawalaVALGLIAALLVL 384
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
6-278 1.21e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRES-ERAFTYSIVGAGSQFGTLLTGAVGSLLLEWY------GWQSIFYFSGGLTLLWV 78
Cdd:COG2211  118 LLLGLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAF 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  79 WYVYRYLlsekdlilalgvlaQSRPVSRHNRVP----WRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAK 154
Cdd:COG2211  198 LLTFFGT--------------KERPVPEEEKVSlkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 155 GW--IFNVVPWLVAIPASLFSGFLSDHLinqGYRAiTVRKLMQGMGLGLSSVFALCLGHTSSFCesVVFASASIGLQTFN 232
Cdd:COG2211  264 ALvgLLLALYFLAALLGAPLWPRLAKRF---GKKK-AFIIGLLLAALGLLLLFFLGPGNLWLLL--VLAALAGIGLGAIL 337

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768017963 233 hsGISVNIQ-DLAP--------SCAGFLFGVANTAGALAGVVGVCLGGYLMETTG 278
Cdd:COG2211  338 --VLPWAMLaDVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-226 3.92e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.87  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRY 84
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  85 LLSEKDLILALGVLAQSRPVsrhnrvpWRRLF---RKPAVWAAVVSQLSAACSFFILLSWLPTFFEE---TFPDAkGWI- 157
Cdd:PRK11551 190 LPESRAFAQAAGAGKQRAPV-------LRALFgegRATATLLLWISYFFTLIVLYFLLNWLPSLLVGqglSRSQA-GLVq 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 --FNVvpwlVAIPASLFSGFLSDHLinqgyRAITVRKLMQG------MGLGLSSVF------ALCLGHTSSFCESVVFAS 223
Cdd:PRK11551 262 iaFNI----GGALGSLLIGALMDRL-----RPRRVVLLIYAgilaslAALAAAPSFagmllaGFAAGLFVVGGQSVLYAL 332


                 ...
gi 768017963 224 ASI 226
Cdd:PRK11551 333 APL 335
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-274 4.01e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSggltllwvwy 80
Cdd:cd17321   87 LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---------- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdLILALGVLAQSRpvsrhnrvpwrrlfrkpAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWI 157
Cdd:cd17321  157 ----------VPIGLVALLLAR-----------------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLgysPLQAGLA 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 FnvVPWLVAIP-ASLFSGFLSDHLinqGYRAITVrklmQGMGLGLSSVFALCLGHTSSFCESVVFASA--SIGLQTFNHS 234
Cdd:cd17321  210 L--LPLALAMLvAAPLAGRLADRF---GPRLVLV----AGLLLTAVGLLLLALLGADSSVWLLLPGLVllGLGLGLFATP 280

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 768017963 235 GISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM 274
Cdd:cd17321  281 LTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 5-149 5.59e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.13  E-value: 5.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFG----TLLTGAVGSLLLEWYGWQSIFYFsGGLTLLWVWY 80
Cdd:cd17371   94 RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL-GALPALLVLF 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768017963  81 VYRYlLSEKDLILAlgvlAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFI---LLSWLPTFFEET 149
Cdd:cd17371  173 IRRF-VKEPPQWQA----ARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygITTWLPSYLTGE 239
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-300 6.06e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 6.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWvwy 80
Cdd:cd17365   90 LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLIL--- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdLILALGVLaqsrpvsrhnrvpwrrlfrkpAVWAA-VVSQLsaacSFFILLSWLPTFFEET-FPDAKGWIF 158
Cdd:cd17365  167 ----------LPLLRGTL---------------------LLWVTfFMGLL----LVYLLNSWLPKLMVEAgYSLSQALTI 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 159 NVVPWLVAIPASLFSGFLSDHlinqgYRAITVrkLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLqtfnhSGISV 238
Cdd:cd17365  212 TLLLNIGGVIGSLLLGWLADR-----FGPKRV--LALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV-----NGAQV 279

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017963 239 NIQDLAP-----SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLG-LCTFLV 300
Cdd:cd17365  280 GLYALAArfyptEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGaLAVLLL 347
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 36-299 1.26e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 40.25  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  36 YSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYF---SGGLTLLWVWYVYRYLLSEKDLILALGVLAQSrpvsrhnrvpW 112
Cdd:cd17320  125 FSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFlalLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRA----------Y 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 113 RRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF---PDAKGWIFnvvpwLVAIPASLFSGFLSDHLINQgyraIT 189
Cdd:cd17320  195 KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLglsPAQFGLLF-----ALNAIALILGSLLNGRLVRR----FG 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 190 VRKLMqGMGLGLSSVFALCL-GHTSSFCESVVFASASIGLQTFNHSGISVNIQDLA----PSCAGFLFGVANTAGALAGV 264
Cdd:cd17320  266 PRRLL-RLGLLLLLAAALVLlLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAlepfPHVAGTASALLGFLQFLIGA 344

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768017963 265 VGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFL 299
Cdd:cd17320  345 LAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-126 1.80e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   1 MTFSRILMGLLQGvYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVwy 80
Cdd:cd17391   92 LLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF-- 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 768017963  81 vyryllsekdLILALGVLAQSRPVSRHNRVP----WRRLFRKPAVWAAVV 126
Cdd:cd17391  169 ----------LLTLFFVKEDFKPVEKKKMVStkevWNSVPNPSLLISLFV 208
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 3-93 2.15e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   3 FSRILMGLLqGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVY 82
Cdd:cd17330   92 LARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVL 170

                         90
                 ....*....|.
gi 768017963  83 RYLLSEKDLIL 93
Cdd:cd17330  171 FFLPPLRRLLL 181
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 5-302 3.94e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.73  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   5 RILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLwvwyvyry 84
Cdd:cd17489   91 RLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-------- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  85 llsekDLILALGVLAQSRPVSRHNRVPWR--RLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVP 162
Cdd:cd17489  163 -----ALLLVFLVKDPPPVAAEEAEAGTRafRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 163 wLVAIPASLFSGFLSDHLinQGYRAITVrklmqgmGLGLSSVFALCLGHTSSFCESVVFAS-ASIGLQTFNHSGISVNIQ 241
Cdd:cd17489  238 -IALLLSRPFSGKLSDRK--GPKTVIIP-------GLLLLALGLLLLSFAGSPWMLLLAAVlYGLGFGLLFPALQALAVD 307

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768017963 242 DLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGsWTCLFNLVAIISNLGLCTFLVFG 302
Cdd:cd17489  308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 6-280 3.97e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEwYGWQSIFYFSGGLTLLWVWYVYRYL 85
Cdd:cd17329   96 VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  86 LSEKdlilalgvLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAkgwiFNVVPWLV 165
Cdd:cd17329  175 PETR--------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG----ESLLGLLL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 166 AIPASLFSGFLsdHLINQGYRAITVRKLMqGMGLGLSSVFALCLGHTSSFCESVVFAS-ASIGlQTFNHSGISVNIQDLA 244
Cdd:cd17329  243 ALNALLIVLLQ--FPVARLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLILAMIvLTLG-EMLVFPAVQTLVAALA 318

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 768017963 245 P-SCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSW 280
Cdd:cd17329  319 PpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 6-83 5.61e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 5.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYR 83
Cdd:cd17474  296 VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
2_A_01_02 TIGR00880
Multidrug resistance protein;
3-76 8.26e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 36.09  E-value: 8.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017963    3 FSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLL 76
Cdd:TIGR00880  56 IARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 6-278 9.12e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.59  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963   6 ILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWyvyryl 85
Cdd:cd06173  100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL------ 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963  86 lsekdLILALGVLAQSRPVSRHNRVP------WRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGW--I 157
Cdd:cd06173  174 -----LLLFIRRPPPAAPGESSSLLLrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGygL 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017963 158 FNVVPWLVAIPASLFSGFLSDHLINqgyraitvRKLMQGmGLGLSSVFALCLGHTSSFCESVV-FASASIGLQTFNHSGI 236
Cdd:cd06173  249 LLAAFGVGALLGALLLGRLSKRRRR--------GRLLLI-GALLLGLALLVLGLSPSLWLLLAaLFLLGLAGGLFNVPLN 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 768017963 237 SVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTG 278
Cdd:cd06173  320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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