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Conserved domains on  [gi|767991990|ref|XP_011522097|]
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Na(+)/citrate cotransporter isoform X1 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 31-479 3.96e-69

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 228.41  E-value: 3.96e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   31 MPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQ----VCVQYMKDTNMLFLGGLIVAVAVERWNLH 106
Cdd:pfam00939  26 LPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  107 KRIALRTLLWVGAKParLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSaateaglelvdkgkakelpGSQV 186
Cdd:pfam00939 106 RRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF-------------------GSDP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  187 ifegptlgqqEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELfpdSKDLVNFASWFAFAFPNMLVMLL 266
Cdd:pfam00939 165 ----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LGVTITWASWFLAAIPPGVILLL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  267 FAWLWLQFVYMRFNFKKSwgcgleskknekAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSrdpgfmpgwltvaw 346
Cdd:pfam00939 232 LAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIF-------------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  347 veGETKYVSDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWK-VTQEKVPWGIVLLLGGGFALAKGSE 425
Cdd:pfam00939 286 --GGSLNIDATTVAIIGLALMLL------------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLE 339

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990  426 ASGLSVWMGKQMEPL--HAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:pfam00939 340 RSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 31-479 3.96e-69

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 228.41  E-value: 3.96e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   31 MPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQ----VCVQYMKDTNMLFLGGLIVAVAVERWNLH 106
Cdd:pfam00939  26 LPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  107 KRIALRTLLWVGAKParLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSaateaglelvdkgkakelpGSQV 186
Cdd:pfam00939 106 RRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF-------------------GSDP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  187 ifegptlgqqEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELfpdSKDLVNFASWFAFAFPNMLVMLL 266
Cdd:pfam00939 165 ----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LGVTITWASWFLAAIPPGVILLL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  267 FAWLWLQFVYMRFNFKKSwgcgleskknekAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSrdpgfmpgwltvaw 346
Cdd:pfam00939 232 LAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIF-------------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  347 veGETKYVSDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWK-VTQEKVPWGIVLLLGGGFALAKGSE 425
Cdd:pfam00939 286 --GGSLNIDATTVAIIGLALMLL------------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLE 339

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990  426 ASGLSVWMGKQMEPL--HAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:pfam00939 340 RSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-485 2.27e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 207.70  E-value: 2.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  91 LGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEatsaateagl 170
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALG---------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 171 elvdkgkakelpgsqvifegptlgqqeDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNF 250
Cdd:COG0471   71 ---------------------------SEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP---ISF 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 251 ASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcgleSKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILW 330
Cdd:COG0471  121 FEWMLVGLPVALVGLLLLWLVLYRLLPP------------EIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLW 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 331 FSRDPGFMPgwltvawvegetkyvsDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWKVTQEKVPWGI 410
Cdd:COG0471  189 ITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSIPWGV 228

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990 411 VLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMCSVGGI 485
Cdd:COG0471  229 LLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-479 4.01e-52

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 181.24  E-value: 4.01e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  39 AYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVG 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 119 AKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATsaateaglelvdkgkakelpgsqvifegptlgqqed 198
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS------------------------------------ 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 199 qerkrlCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNFASWFAFAFPNMLVMLLFAWLWLQFvymr 278
Cdd:cd01115  125 ------PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFRL---- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 279 fnfkkswgcgleskknekaalkvlqeeyrklgplsfaeinvLICFFLLVILWFSRdpgFMPGWLtvawvegetkYVSDAT 358
Cdd:cd01115  192 -----------------------------------------AVLIITIVLLAALA---AITGLL----------PVSVAI 217

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 359 VAIFVATLLFIVpsqkpkfnfrsqteeerktpfyppplLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQME 438
Cdd:cd01115  218 AIGAIVLVFGGV--------------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALI 271

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 767991990 439 P-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:cd01115  272 SlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSI 313
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-485 9.65e-36

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 138.25  E-value: 9.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   41 VIILMAIYWCTEVIPLAVTSLMPVL----LFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLW 116
Cdd:TIGR00785  16 IFVAAIVGWILEPLPLPVTALLAIPiiavLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  117 VGAKPARL-MLGFMGVTALLSMWISNTA-TTAMMVPIVEAILqqmeatsaateaglelvdkgkakelpgsqvifegPTLG 194
Cdd:TIGR00785  96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLL----------------------------------PLLG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  195 QQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQF 274
Cdd:TIGR00785 142 SKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILS---KILGIQISWGDWFLAGLPLGIILLLLVPLLLYV 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  275 VYMRfnfkkswgcglESKKNEKAALkVLQEEYRKLGPLSFAEINVLICFFLLVILWFSrdpgfmpgwltvawveGETKYV 354
Cdd:TIGR00785 219 LFPP-----------ELKLKDEVDL-WAKEELEEMGPMSFREKALLGIFLLALLLWIF----------------GGSLGI 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  355 SDATVAIFVATLLFIvpsqkpkfnFRsqteeerktpfypppLLDWK-VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWM 433
Cdd:TIGR00785 271 NASVVALLAVVLMLF---------LG---------------IVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWF 326

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767991990  434 GKQMEP-LHAVPPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMCSVGGI 485
Cdd:TIGR00785 327 SEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGI 380
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 31-479 3.96e-69

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 228.41  E-value: 3.96e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   31 MPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQ----VCVQYMKDTNMLFLGGLIVAVAVERWNLH 106
Cdd:pfam00939  26 LPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSGFSSTTTWLVFGAFFISAAFEKTGLG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  107 KRIALRTLLWVGAKParLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSaateaglelvdkgkakelpGSQV 186
Cdd:pfam00939 106 RRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAF-------------------GSDP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  187 ifegptlgqqEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELfpdSKDLVNFASWFAFAFPNMLVMLL 266
Cdd:pfam00939 165 ----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI---LGVTITWASWFLAAIPPGVILLL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  267 FAWLWLQFVYMRFNFKKSwgcgleskknekAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSrdpgfmpgwltvaw 346
Cdd:pfam00939 232 LAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIF-------------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  347 veGETKYVSDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWK-VTQEKVPWGIVLLLGGGFALAKGSE 425
Cdd:pfam00939 286 --GGSLNIDATTVAIIGLALMLL------------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLE 339

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990  426 ASGLSVWMGKQMEPL--HAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:pfam00939 340 RSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-485 2.27e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 207.70  E-value: 2.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  91 LGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEatsaateagl 170
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALG---------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 171 elvdkgkakelpgsqvifegptlgqqeDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNF 250
Cdd:COG0471   71 ---------------------------SEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP---ISF 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 251 ASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcgleSKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILW 330
Cdd:COG0471  121 FEWMLVGLPVALVGLLLLWLVLYRLLPP------------EIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLW 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 331 FSRDPGFMPgwltvawvegetkyvsDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWKVTQEKVPWGI 410
Cdd:COG0471  189 ITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSIPWGV 228

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990 411 VLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMCSVGGI 485
Cdd:COG0471  229 LLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV 304
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 39-479 4.01e-52

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 181.24  E-value: 4.01e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  39 AYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVG 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 119 AKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATsaateaglelvdkgkakelpgsqvifegptlgqqed 198
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS------------------------------------ 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 199 qerkrlCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNFASWFAFAFPNMLVMLLFAWLWLQFvymr 278
Cdd:cd01115  125 ------PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIFRL---- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 279 fnfkkswgcgleskknekaalkvlqeeyrklgplsfaeinvLICFFLLVILWFSRdpgFMPGWLtvawvegetkYVSDAT 358
Cdd:cd01115  192 -----------------------------------------AVLIITIVLLAALA---AITGLL----------PVSVAI 217

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 359 VAIFVATLLFIVpsqkpkfnfrsqteeerktpfyppplLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQME 438
Cdd:cd01115  218 AIGAIVLVFGGV--------------------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALI 271

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 767991990 439 P-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:cd01115  272 SlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSI 313
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-485 9.65e-36

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 138.25  E-value: 9.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   41 VIILMAIYWCTEVIPLAVTSLMPVL----LFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLW 116
Cdd:TIGR00785  16 IFVAAIVGWILEPLPLPVTALLAIPiiavLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  117 VGAKPARL-MLGFMGVTALLSMWISNTA-TTAMMVPIVEAILqqmeatsaateaglelvdkgkakelpgsqvifegPTLG 194
Cdd:TIGR00785  96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLL----------------------------------PLLG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  195 QQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQF 274
Cdd:TIGR00785 142 SKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILS---KILGIQISWGDWFLAGLPLGIILLLLVPLLLYV 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  275 VYMRfnfkkswgcglESKKNEKAALkVLQEEYRKLGPLSFAEINVLICFFLLVILWFSrdpgfmpgwltvawveGETKYV 354
Cdd:TIGR00785 219 LFPP-----------ELKLKDEVDL-WAKEELEEMGPMSFREKALLGIFLLALLLWIF----------------GGSLGI 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  355 SDATVAIFVATLLFIvpsqkpkfnFRsqteeerktpfypppLLDWK-VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWM 433
Cdd:TIGR00785 271 NASVVALLAVVLMLF---------LG---------------IVTWKdIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWF 326

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767991990  434 GKQMEP-LHAVPPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMCSVGGI 485
Cdd:TIGR00785 327 SEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGI 380
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 46-479 1.68e-34

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 133.53  E-value: 1.68e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  46 AIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRtLLWVGAKPARLM 125
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAK-LARASKGSRRLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 126 LGFMGVTALLSMWISNTATTAMMVPIVEAILQqmeatsaateaglelvdkgKAKELPGSQVIfegptlgqqedqerkrlc 205
Cdd:cd00625   80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLR-------------------KLGLSPPVPLL------------------ 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 206 kamtLCICYAASIGGTATLTGTGPNVVLLGQMNelfpdskdlVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkksw 285
Cdd:cd00625  123 ----LALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRK------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 286 gcglESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPgwltvawvegetkyvsdATVAIFVAT 365
Cdd:cd00625  183 ----KLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLI-----------------ALLGALLLL 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 366 LLFIVpsqkpkfnfrsqteeerktpfypppLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPP 445
Cdd:cd00625  242 LLLVR-------------------------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPP 296

                        410       420       430
                 ....*....|....*....|....*....|....
gi 767991990 446 AAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:cd00625  297 LAALLLIGLLSALLSNFISNVPTVALLLPIAASL 330
CitMHS pfam03600
Citrate transporter;
46-485 4.76e-28

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 114.33  E-value: 4.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   46 AIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLM 125
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  126 LGFMGVTALLSMWISNTATTAMMVPIVeailqqmeatsaateagLELVDKGKAKELPgsqvifegptlgqqedqerkrlc 205
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIV-----------------LALARRLGLPPSP----------------------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  206 kaMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKdlvnFASWFAFAFPNMLVMLLFAWLWLqfvymrfnfkksw 285
Cdd:pfam03600 121 --LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFG----FFMFPPVGVALLLVGLLPLLLIF------------- 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  286 gcgleskKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKyvsdatvaifvat 365
Cdd:pfam03600 182 -------RKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTG------------- 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  366 llfivpsqkpkfnfrsqteeerktpfypppLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHavPP 445
Cdd:pfam03600 242 ------------------------------VLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GL 289

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 767991990  446 AAITLILSLLVAVFTECTSNVATTTLFLPIFASMCSVGGI 485
Cdd:pfam03600 290 LVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGL 329
CitMHS pfam03600
Citrate transporter;
11-164 4.13e-07

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 51.93  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990   11 FKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLF 90
Cdd:pfam03600 181 FRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFF 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767991990   91 LGGLIVAVAVERWNLHKRIAlrTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSA 164
Cdd:pfam03600 261 AGLFILVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDP 332
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
41-159 6.42e-07

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 51.31  E-value: 6.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  41 VIILMAIYWCTE---VIPLAVTSLMPVLLFPLFQILDSRQVcvqyMKDTN----MLFLGGLIVAVAVERWNLHKRIALRT 113
Cdd:COG0471  180 IFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDA----YKSIPwgvlLLFGGGLALGAALEKTGLAAWLADAL 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767991990 114 LLWVGAKPARLML-GFMGVTALLSMWISNTATTAMMVPIVEAILQQM 159
Cdd:COG0471  256 LPLLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
88-479 1.09e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 50.90  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  88 MLFLGGLIVAVAV-ERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVeailqqmeatsaat 166
Cdd:COG1055   56 ILFLLGMMIIVAIlDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVV-------------- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 167 eagLELVDKGKAKELPgsqvifegptlgqqedqerkrlckaMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfpdskd 246
Cdd:COG1055  122 ---LAIARRLGLNPVP-------------------------FLIAIVFAANIGGAATPIGNPTNIMIASAGG-------- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 247 lVNFASWFAFAFPNMLVMLLFAWLWLQFVymrfnFKKSWGCGLESKKNEKAALKvlqeeYRKLGPLSFAEINVLICFFLL 326
Cdd:COG1055  166 -LSFLDFLANLFPPSLVSLLVTLLVLYLL-----FRKELPAAPDLEDDPKEAIK-----DRRLLRISLLVLALLLVGFVL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990 327 VILWfsrdpGFMPGWltvawvegetkyvsdatVAIFVATLLFIVPSQKPKFNFRsqteeerktpfyppplldwkvtqeKV 406
Cdd:COG1055  235 HSFL-----GLPPAL-----------------IALLGAAVLLLLARVDVREVLK------------------------KV 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767991990 407 PWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASM 479
Cdd:COG1055  269 DWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDL 341
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 41-161 9.87e-05

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 44.50  E-value: 9.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  41 VIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWV-GA 119
Cdd:cd01115  198 IVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLgGL 277

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767991990 120 KPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEA 161
Cdd:cd01115  278 PPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGL 319
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 34-152 5.07e-04

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 42.24  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991990  34 KFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMK-DTNMLFLGGLIVAVAVERWNLHKRIALR 112
Cdd:cd00625  208 FLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDwGTLLFFAGLFVLVGALESTGLLEWLAEL 287

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767991990 113 TLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIV 152
Cdd:cd00625  288 LVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIA 327
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 85-160 5.01e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 39.16  E-value: 5.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767991990  85 DTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQME 160
Cdd:cd01116   48 ETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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