NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767989925|ref|XP_011521389|]
View 

diphosphomevalonate decarboxylase isoform X2 [Homo sapiens]

Protein Classification

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein( domain architecture ID 706585)

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein similar to diphosphomevalonate decarboxylase (DMD) that catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP), and mevalonate 3,5-bisphosphate decarboxylase (MBD) that catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate

EC:  4.1.1.-
Gene Ontology:  GO:0016831|GO:0008299
PubMed:  8382990|7947744|31268677

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MDD_C super family cl28577
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 4-350 2.02e-142

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


The actual alignment was detected with superfamily member PLN02407:

Pssm-ID: 475042  Cd Length: 343  Bit Score: 409.18  E-value: 2.02e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   4 GKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPS 83
Cdd:PLN02407  19 GKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRARATDVEDEEKGIKITK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  84 SL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQhtytlarvygvesdL 161
Cdd:PLN02407  99 KDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE--------------L 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 162 SEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFR 241
Cdd:PLN02407 149 SAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 242 AESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGP 321
Cdd:PLN02407 229 AKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGP 308

                        330       340       350
                 ....*....|....*....|....*....|
gi 767989925 322 NAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 350
Cdd:PLN02407 309 NAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 4-350 2.02e-142

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 409.18  E-value: 2.02e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   4 GKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPS 83
Cdd:PLN02407  19 GKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRARATDVEDEEKGIKITK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  84 SL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQhtytlarvygvesdL 161
Cdd:PLN02407  99 KDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE--------------L 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 162 SEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFR 241
Cdd:PLN02407 149 SAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 242 AESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGP 321
Cdd:PLN02407 229 AKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGP 308

                        330       340       350
                 ....*....|....*....|....*....|
gi 767989925 322 NAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 350
Cdd:PLN02407 309 NAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 210-395 5.80e-117

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 338.38  E-value: 5.80e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  210 VLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISY 289
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  290 LNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQA 369
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQFFKGLPVLPSELSEELKA 160

                         170       180
                  ....*....|....*....|....*.
gi 767989925  370 ALAMEPTPGGVKYIIVTQVGPGPQIL 395
Cdd:pfam18376 161 SLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 4-343 1.14e-73

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 232.53  E-value: 1.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925    4 GKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREE-DVGQPRLQACLREIRclarkrrnsrdgdpLP 82
Cdd:TIGR01240  16 GKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQhSIDNEKTSNCLDDFR--------------QL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   83 SSLSCKVHVASVNNFPTAaglassaagyACLVAAGVGLSPVIPVLKRLMgekhcrpgvqdQPGQHTytlarvygveSDLS 162
Cdd:TIGR01240  80 RKEQEKLHIVSQNNFPTA----------AGLASSASGLAALVSACAKLY-----------QLPLDT----------SELS 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  163 EVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRA 242
Cdd:TIGR01240 129 RIARKGSGSACRSLFGGYVAWEKGK--DDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWI 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  243 ESVVPaRMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNahHGDTKVAYTFDAGPN 322
Cdd:TIGR01240 207 EHVVP-DFEV*RKAIKTKDFATFGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLR--QGGTICYFTMDAGPN 283

                         330       340
                  ....*....|....*....|.
gi 767989925  323 AVIFTLDDTVAEFVAAVWHGF 343
Cdd:TIGR01240 284 VKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 4-394 4.15e-69

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 221.22  E-value: 4.15e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   4 GKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREED-VGQPRLQACLREIRCLARKRRnsrdgdplp 82
Cdd:COG3407   21 GKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKgKFLPKISKFLDRVRALAGKSY--------- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  83 sslscKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvlkrlmgekhcrpgvqdqpgqhtytLARVYGVESD-- 160
Cdd:COG3407   90 -----HARIESENNFPTAAGLASSASGFAALALA----------------------------------ANSAEGLDLDdr 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 161 -LSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPEsHWPeLRVLILVVSAEKKLTGSTVGMRaSVETSPLLR 239
Cdd:COG3407  131 kLSRLARLGSGSACRSIFGGFVEWGKGE--DDEDSYAVPIPAE-DWD-LADIILVVDKGEKKVSSREGMK-TAETSPFYP 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 240 FRAESvVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAhhGDTKVAYTFDA 319
Cdd:COG3407  206 AWVEQ-AEEDLEKLKEAIKAGDFEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVRELRE--EGLPVYFTLDA 282

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767989925 320 GPNAVIFTLDDTVAEFVAAvwhgfppgsngdtflkglqvrpapLSAELqaalameptpgGVKYIIVTQVGPGPQI 394
Cdd:COG3407  283 GPNVKVLCPEEDAEKVAAF------------------------LAAEL-----------VNGQVIVDKPGPGARL 322
 
Name Accession Description Interval E-value
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 4-350 2.02e-142

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 409.18  E-value: 2.02e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   4 GKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPS 83
Cdd:PLN02407  19 GKRDEKLILPINSSISVTLDPDHLCATTTVAVSPSFDQDRLWLNGKEISLSGGRYQNCLREIRARATDVEDEEKGIKITK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  84 SL--SCKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvLKRLMGEKhcrpgvQDQPGQhtytlarvygvesdL 161
Cdd:PLN02407  99 KDweKLHVHIASYNNFPTAAGLASSAAGFACLVFA----------LAKLMNVK------EDFPGE--------------L 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 162 SEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFR 241
Cdd:PLN02407 149 SAIARQGSGSACRSLYGGFVKWNMGKKEDGSDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 242 AESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGP 321
Cdd:PLN02407 229 AKEVVPKRILQMEEAIKNRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWNRSEGTPQVAYTFDAGP 308

                        330       340       350
                 ....*....|....*....|....*....|
gi 767989925 322 NAVIFTLDDTVAEFV-AAVWHGFPPGSNGD 350
Cdd:PLN02407 309 NAVLIALNRKVAAQLlQRLLYYFPPSSDTD 338
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 210-395 5.80e-117

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 338.38  E-value: 5.80e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  210 VLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISY 289
Cdd:pfam18376   1 VLILVVSDEKKEVSSTSGMQRSVETSPLLKHRAEHVVPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  290 LNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQA 369
Cdd:pfam18376  81 LNDTSRAIIQLVHAYNEFAGRIKVAYTFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQFFKGLPVLPSELSEELKA 160

                         170       180
                  ....*....|....*....|....*.
gi 767989925  370 ALAMEPTPGGVKYIIVTQVGPGPQIL 395
Cdd:pfam18376 161 SLAMKPIPGGVKYIIHTKVGDGPRVL 186
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 4-343 1.14e-73

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 232.53  E-value: 1.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925    4 GKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREE-DVGQPRLQACLREIRclarkrrnsrdgdpLP 82
Cdd:TIGR01240  16 GKRNTKLNLPTNSSISLTL--SQLRTLTSVAFADEFERDTFYLNGTLQhSIDNEKTSNCLDDFR--------------QL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   83 SSLSCKVHVASVNNFPTAaglassaagyACLVAAGVGLSPVIPVLKRLMgekhcrpgvqdQPGQHTytlarvygveSDLS 162
Cdd:TIGR01240  80 RKEQEKLHIVSQNNFPTA----------AGLASSASGLAALVSACAKLY-----------QLPLDT----------SELS 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  163 EVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRA 242
Cdd:TIGR01240 129 RIARKGSGSACRSLFGGYVAWEKGK--DDHSSAAVQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWI 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  243 ESVVPaRMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNahHGDTKVAYTFDAGPN 322
Cdd:TIGR01240 207 EHVVP-DFEV*RKAIKTKDFATFGKETEANSLSMHATTLDAFPPFFYLNDTSKRAMSAVHTLR--QGGTICYFTMDAGPN 283

                         330       340
                  ....*....|....*....|.
gi 767989925  323 AVIFTLDDTVAEFVAAVWHGF 343
Cdd:TIGR01240 284 VKVLYLAENLSKLFEFIYKLF 304
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 4-394 4.15e-69

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 221.22  E-value: 4.15e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925   4 GKRDEELVLPINSSLSVTLhqDQLKTTTTAVISKDFTEDRIWLNGREED-VGQPRLQACLREIRCLARKRRnsrdgdplp 82
Cdd:COG3407   21 GKRDEELNLPANPSLSLTL--DAFYTTTTVEFDKDLAEDEFILNGEPQKgKFLPKISKFLDRVRALAGKSY--------- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925  83 sslscKVHVASVNNFPTAAGLASSAAGYACLVAAgvglspvipvlkrlmgekhcrpgvqdqpgqhtytLARVYGVESD-- 160
Cdd:COG3407   90 -----HARIESENNFPTAAGLASSASGFAALALA----------------------------------ANSAEGLDLDdr 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 161 -LSEVARRGSGSACRSLYGGFVEWQMGEqaDGKDSIARQVAPEsHWPeLRVLILVVSAEKKLTGSTVGMRaSVETSPLLR 239
Cdd:COG3407  131 kLSRLARLGSGSACRSIFGGFVEWGKGE--DDEDSYAVPIPAE-DWD-LADIILVVDKGEKKVSSREGMK-TAETSPFYP 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989925 240 FRAESvVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAhhGDTKVAYTFDA 319
Cdd:COG3407  206 AWVEQ-AEEDLEKLKEAIKAGDFEALGEIAESNALRMHATMMTSNPPFIYWKPNTLEVINAVRELRE--EGLPVYFTLDA 282

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767989925 320 GPNAVIFTLDDTVAEFVAAvwhgfppgsngdtflkglqvrpapLSAELqaalameptpgGVKYIIVTQVGPGPQI 394
Cdd:COG3407  283 GPNVKVLCPEEDAEKVAAF------------------------LAAEL-----------VNGQVIVDKPGPGARL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH