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Conserved domains on  [gi|767983807|ref|XP_011519738|]
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WD repeat-containing protein 72 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190
                  ....*....|....*....|....*....|
gi 767983807  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 767983807  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190
                  ....*....|....*....|....*....|
gi 767983807  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIFTEEILHK 498
Cdd:COG2319   219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  499 FFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 578
Cdd:COG2319   284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                         170
                  ....*....|....*...
gi 767983807  579 EIETGTLERHETGERARI 596
Cdd:COG2319   358 DLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 767983807  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.62e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319   175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767983807  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 pfam00400
WD domain, G-beta repeat;
447-489 7.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767983807   447 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 489
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-589 1.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDS 483
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  484 CVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVE 563
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190
                  ....*....|....*....|....*....|
gi 767983807  564 NFLIVGCADDSVYIWEIETG----TLERHE 589
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-589 1.59e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  412 YIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIF 491
Cdd:cd00200    59 ASADGTYLASGSSDKTIRLWD---------LETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVE 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  492 TEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCA 571
Cdd:cd00200   124 TGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         170       180
                  ....*....|....*....|..
gi 767983807  572 DDSVYIWEIETG----TLERHE 589
Cdd:cd00200   198 DGTIKLWDLSTGkclgTLRGHE 219
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDIFTEEILHK 498
Cdd:COG2319   219 LASGSADGTVRL---WDLATGKLL------RTLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDLATGELLRT 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  499 FFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIW 578
Cdd:COG2319   284 LTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                         170
                  ....*....|....*...
gi 767983807  579 EIETGTLERHETGERARI 596
Cdd:COG2319   358 DLATGELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
419-596 8.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 8.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIFTEEILH 497
Cdd:COG2319   177 LASGSDDGTVRL---WDLATGKLL------RTLTGHTGAVRSVAFsPDG-------KLLASGSADGTVRLWDLATGKLLR 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  498 KFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYI 577
Cdd:COG2319   241 TLTGHSGSVRSVAFSPD-----GRLLASG-SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                         170
                  ....*....|....*....
gi 767983807  578 WEIETGTLERHETGERARI 596
Cdd:COG2319   315 WDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.00e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200   120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                         170       180
                  ....*....|....*....|.
gi 767983807  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.62e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319   175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767983807  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 385-591 3.82e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  385 DTMSQSIIDYFSGLKDGagtavVTSSEYIPSlDKLICGC-EDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLY 463
Cdd:cd00200    79 DLETGECVRTLTGHTSY-----VSSVAFSPD-GRILSSSsRDKTIKVWD---------VETGKCLTTLRGHTDWVNSVAF 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  464 PHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSC 543
Cdd:cd00200   144 SP------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-----GEKLLSS-SSDGTIKLWDLSTGKC 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767983807  544 LLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHETG 591
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
403-596 7.75e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 7.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  403 GTAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEDSPPHKVLKGHHQSVTSLLYphglSSklDQSWMLSGDLD 482
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWD---------LATGLLLRTLTGHTGAVRSVAF----SP--DGKTLASGSAD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  483 SCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPV 562
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-----GKLLAS-GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                         170       180       190
                  ....*....|....*....|....*....|....
gi 767983807  563 ENFLIVGCADDSVYIWEIETGTLERHETGERARI 596
Cdd:COG2319   216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
419-582 1.12e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  419 LICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIFTEEILH 497
Cdd:COG2319   261 LASGSADGTVRL---WDLATGELL------RTLTGHSGGVNSVAFsPDG-------KLLASGSDDGTVRLWDLATGKLLR 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  498 KFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYI 577
Cdd:COG2319   325 TLTGHTGAVRSVAFSPD-----GKTLASG-SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                  ....*
gi 767983807  578 WEIET 582
Cdd:COG2319   399 WDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
425-596 1.93e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  425 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPhglsskLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAG 504
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  505 PVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 584
Cdd:COG2319   122 AVRSVAFSPD-----GKTLAS-GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                         170
                  ....*....|..
gi 767983807  585 LERHETGERARI 596
Cdd:COG2319   196 LLRTLTGHTGAV 207
WD40 COG2319
WD40 repeat [General function prediction only];
14-191 1.39e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISakeLLFGHSASVTCLArardFSkqP---YIVSAAENGEMC 90
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGGVNSVA----FS--PdgkLLASGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   91 VWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRssQFPDWincmciVHSMRI 170
Cdd:COG2319   314 LWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLT--GHTGA------VTSVAF 380

                         170       180
                  ....*....|....*....|...
gi 767983807  171 QEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319   381 SPDGRTLASGSadGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-579 3.75e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 3.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  404 TAVVTSSEYIPSLDKLICGCEDGTIIItqaLNAAKARLLedspphKVLKGHHQSVTSL-LYPhglssklDQSWMLSGDLD 482
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKL---WDLRTGKCV------ATLTGHTGEVNSVaFSP-------DGEKLLSSSSD 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  483 SCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPV 562
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                         170
                  ....*....|....*..
gi 767983807  563 ENFLIVGCADDSVYIWE 579
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-191 3.18e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELkisAKELLFGHSASVTCLARARDfskQPYIVSAAENGEMCVWNVTNG 97
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   98 QCMekATLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVHSMRIQEDSLL 176
Cdd:COG2319   153 KLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKL 218

                         170
                  ....*....|....*..
gi 767983807  177 VVSVA--GELKVWDLSS 191
Cdd:COG2319   219 LASGSadGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 1.48e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   58 LFGHSASVTCLArardFS-KQPYIVSAAENGEMCVWNVTNGQCMEKATLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200     5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767983807  137 LIIDAKTLAVVHSFRssQFPDWINCMCIVHSMRIqedsLLVVSVAGELKVWDLSS 191
Cdd:cd00200    76 RLWDLETGECVRTLT--GHTSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
425-596 2.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  425 DGTIIITQALNAAKARLLEDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAG 504
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP------DGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  505 PVTSLLMSPekfklrGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGT 584
Cdd:COG2319    80 AVLSVAFSP------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                         170
                  ....*....|..
gi 767983807  585 LERHETGERARI 596
Cdd:COG2319   154 LLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-114 1.16e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   19 SITAIMITDDQRTIVTGSQEGQLCLWNLShelKISAKELLFGHSASVTCLArardFSKQPYIV-SAAENGEMCVWNVTNG 97
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVNSVA----FSPDGYLLaSGSEDGTIRVWDLRTG 251

                          90
                  ....*....|....*..
gi 767983807   98 QCMekATLPyRHTAICY 114
Cdd:cd00200   252 ECV--QTLS-GHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 8.16e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 8.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807   10 LWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENG 87
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLrtLTGHTGAVTSVAFSPD---GRTLASGSADG 394


                  ....*....
gi 767983807   88 EMCVWNVTN 96
Cdd:COG2319   395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 550-607 1.55e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983807  550 HLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI--ILNCCDDSQLV 607
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdVAASADGTYLA 67
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-93 3.69e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767983807   19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQ-PYIVSAAENGEMCVWN 93
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTNSVTSLA----WSPDgKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
447-489 7.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767983807   447 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 489
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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