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Conserved domains on  [gi|767958510|ref|XP_011517414|]
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netrin-G2 isoform X8 [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10441244)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 184-231 3.06e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 3.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767958510  184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 231
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 184-231 3.06e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 3.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767958510  184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 231
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 184-221 4.93e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.11  E-value: 4.93e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767958510 184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 221
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
184-221 1.03e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.91  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767958510   184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 221
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 184-231 3.06e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 3.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767958510  184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVC 231
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 184-221 4.93e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.11  E-value: 4.93e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767958510 184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 221
Cdd:cd00055    2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
184-221 1.03e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.91  E-value: 1.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767958510   184 CNCNQIGSVHDRCN-ETGFCECREGAAGPKCDDCLPTHY 221
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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