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Conserved domains on  [gi|1034671448|ref|XP_011517367|]
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microtubule organization protein AKNA isoform X3 [Homo sapiens]

Protein Classification

AKNA domain-containing protein( domain architecture ID 10575473)

AKNA domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKNA pfam12443
AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is ...
479-577 1.28e-35

AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.


:

Pssm-ID: 463585  Cd Length: 95  Bit Score: 130.66  E-value: 1.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  479 FQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDS 558
Cdd:pfam12443    1 FQQLKAAPAALEEEYLTGCRSETLALKLSSSKGQPGPFDPSRELEAEIYQLGQRLQELKDQTDQLKQKVEEFSKDIAQDS 80
                           90
                   ....*....|....*....
gi 1034671448  559 tpalPCLHQPTHLPAPSGQ 577
Cdd:pfam12443   81 ----PGPHQDAHLPLPSGQ 95
PHA03247 super family cl33720
large tegument protein UL36; Provisional
974-1264 5.46e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  974 DSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERL-----PGEPRGEEQIVPPGRQRARSSSVPREVL 1048
Cdd:PHA03247  2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpaPGRVSRPRRARRLGRAAQASSPPQRPRR 2685
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1049 RLSLSSESELPSLPLFSEKSKTTKDSPQAArdgkrgVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPI 1128
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHAL------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1129 RTQDAGGAVTGDPLGPP---------PADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSS 1199
Cdd:PHA03247  2760 PPTTAGPPAPAPPAAPAagpprrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034671448 1200 PRPPPglwylatappapappafayissvPIMPYPPAAVYYAPAGPTS----AQPAAKWPPTASPPPARR 1264
Cdd:PHA03247  2840 PPPPG-----------------------PPPPSLPLGGSVAPGGDVRrrppSRSPAAKPAAPARPPVRR 2885
 
Name Accession Description Interval E-value
AKNA pfam12443
AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is ...
479-577 1.28e-35

AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.


Pssm-ID: 463585  Cd Length: 95  Bit Score: 130.66  E-value: 1.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  479 FQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDS 558
Cdd:pfam12443    1 FQQLKAAPAALEEEYLTGCRSETLALKLSSSKGQPGPFDPSRELEAEIYQLGQRLQELKDQTDQLKQKVEEFSKDIAQDS 80
                           90
                   ....*....|....*....
gi 1034671448  559 tpalPCLHQPTHLPAPSGQ 577
Cdd:pfam12443   81 ----PGPHQDAHLPLPSGQ 95
PHA03247 PHA03247
large tegument protein UL36; Provisional
974-1264 5.46e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  974 DSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERL-----PGEPRGEEQIVPPGRQRARSSSVPREVL 1048
Cdd:PHA03247  2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpaPGRVSRPRRARRLGRAAQASSPPQRPRR 2685
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1049 RLSLSSESELPSLPLFSEKSKTTKDSPQAArdgkrgVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPI 1128
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHAL------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1129 RTQDAGGAVTGDPLGPP---------PADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSS 1199
Cdd:PHA03247  2760 PPTTAGPPAPAPPAAPAagpprrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034671448 1200 PRPPPglwylatappapappafayissvPIMPYPPAAVYYAPAGPTS----AQPAAKWPPTASPPPARR 1264
Cdd:PHA03247  2840 PPPPG-----------------------PPPPSLPLGGSVAPGGDVRrrppSRSPAAKPAAPARPPVRR 2885
 
Name Accession Description Interval E-value
AKNA pfam12443
AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is ...
479-577 1.28e-35

AT-hook-containing transcription factor; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.


Pssm-ID: 463585  Cd Length: 95  Bit Score: 130.66  E-value: 1.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  479 FQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDS 558
Cdd:pfam12443    1 FQQLKAAPAALEEEYLTGCRSETLALKLSSSKGQPGPFDPSRELEAEIYQLGQRLQELKDQTDQLKQKVEEFSKDIAQDS 80
                           90
                   ....*....|....*....
gi 1034671448  559 tpalPCLHQPTHLPAPSGQ 577
Cdd:pfam12443   81 ----PGPHQDAHLPLPSGQ 95
PHA03247 PHA03247
large tegument protein UL36; Provisional
974-1264 5.46e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448  974 DSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERL-----PGEPRGEEQIVPPGRQRARSSSVPREVL 1048
Cdd:PHA03247  2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpaPGRVSRPRRARRLGRAAQASSPPQRPRR 2685
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1049 RLSLSSESELPSLPLFSEKSKTTKDSPQAArdgkrgVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPI 1128
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHAL------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671448 1129 RTQDAGGAVTGDPLGPP---------PADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSS 1199
Cdd:PHA03247  2760 PPTTAGPPAPAPPAAPAagpprrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034671448 1200 PRPPPglwylatappapappafayissvPIMPYPPAAVYYAPAGPTS----AQPAAKWPPTASPPPARR 1264
Cdd:PHA03247  2840 PPPPG-----------------------PPPPSLPLGGSVAPGGDVRrrppSRSPAAKPAAPARPPVRR 2885
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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