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Conserved domains on  [gi|767926138|ref|XP_011510892|]
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plexin-D1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 49-547 0e+00

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 822.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   49 IQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKIL 128
Cdd:cd11247     1 VQRKFRSPTRTNNFALDGGRGRLYLAAVNRLYQLSGLVLALEAEAAVGPVLDSPLCHAPQLPQATCEHPRTLTDNYNKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  129 QLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAppaepVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLL 208
Cdd:cd11247    81 QPDPEQGVLVVCGSIYQGLCQLRRLYNISAVAVRFPVDG-----DTVFPSMLNVAANHPNASTVGLVLWPRGGGGGLRLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  209 VGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSD 288
Cdd:cd11247   156 VGATYTGYGSGFFPRNRSLEDHRFENTPEIAIRALNTRGDLAKLFTFDINPSDDNIFKIKQGAKARHKLSFVRAFLQHFL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  289 PPpgaqsYAYLALNSEARAGDKESQARSLLARICLPHGA---GGDAKKLTESYIQLGLQCAGgagrgdLYSRLVSVFPAR 365
Cdd:cd11247   236 QP-----YAYLAMNGEANAAGKESQPPSLLARICLPGRApppPGEAKKLTESYIQLGLRCEG------AYTRLVSVFPAR 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  366 ---ERLFAVFERPQGSPAARAApaalcaFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQ 442
Cdd:cd11247   305 veeEQLFAVFERAGGAPAALCA------FRFAEVEEPIRAARTACFVSPAAGVVTVLDSVVQGTGPACERKLNIQLQPEQ 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  443 LDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHV 522
Cdd:cd11247   379 LDCGAAHLQHPLAILQPLKATPVFRAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHV 458

                         490       500
                  ....*....|....*....|....*
gi 767926138  523 MQFDPADSGYLYLMTSHQMARVKVA 547
Cdd:cd11247   459 MQFDPSDSTYLYLMTSHQMTRVKVA 483
RasGAP super family cl02569
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1344-1439 7.40e-58

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


The actual alignment was detected with superfamily member cd12788:

Pssm-ID: 470620 [Multi-domain]  Cd Length: 419  Bit Score: 206.38  E-value: 7.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1344 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFL 1423
Cdd:cd12788     1 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQENNSQGPRQVPETHPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFL 80

                          90
                  ....*....|....*.
gi 767926138 1424 IVFVHALEQQKDFAVQ 1439
Cdd:cd12788    81 VTFVHALEQQKDFAVR 96
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 891-979 1.10e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 127.82  E-value: 1.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPL-SGVVTV---NA 966
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVfNGPVEVtvgHG 80

                          90
                  ....*....|...
gi 767926138  967 SKEGKSRDRFSYV 979
Cdd:cd01180    81 SFRTESSEGFSFV 93
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1069-1174 3.15e-34

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 126.76  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSN------ASAPVDFFIN 1142
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTSCKVRNSTLMTCPAPSLALLnrspepGERPVEFGLD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767926138 1143 GRAYAdevavaeelldpeEAQRGSRFRLDYLP 1174
Cdd:cd01181    81 GDNVQ-------------SLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 981-1067 4.25e-30

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 114.63  E-value: 4.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTdPCTELMRTDTSIACTMPEGALPAPVPVCVRFErRGCVHGN 1060
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQ-PCKILSVSSSQIVCLTPPSASPGEAPVKVLID-GARRLAP 78


                  ....*..
gi 767926138 1061 LTFWYMQ 1067
Cdd:cd01179    79 LVFTYTE 85
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 549-601 7.02e-12

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 61.57  E-value: 7.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767926138   549 CNVHSTCGDCVGAADAYCGWCALETRCTLQQDCT-NSSQQHFWTSASegpSRCP 601
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGaPEGNCEEWEQAS---SKCP 52
TIG_plexin super family cl39397
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 627-700 3.28e-08

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


The actual alignment was detected with superfamily member pfam17960:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 52.27  E-value: 3.28e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926138   627 LPSLSGmEMACDYGNNIRTVARVPGPAfghqiAYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRN--IVKANFTIY 700
Cdd:pfam17960   20 LPALSE-GYSCVFGDLTESPATVHDNG-----VKCATPPPSQLPPIPTGQDHVTVKLSLRSSETGvdFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
711-753 4.16e-07

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 47.92  E-value: 4.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767926138    711 HTACTSCLSAQWP-CFWCSQQHSCVSnQSRCEASPNPTSPQDCP 753
Cdd:smart00423    5 YTSCSECLLARDPyCAWCSSQGRCTS-GERCDSRRQNWLSGGCP 47
 
Name Accession Description Interval E-value
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 49-547 0e+00

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 822.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   49 IQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKIL 128
Cdd:cd11247     1 VQRKFRSPTRTNNFALDGGRGRLYLAAVNRLYQLSGLVLALEAEAAVGPVLDSPLCHAPQLPQATCEHPRTLTDNYNKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  129 QLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAppaepVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLL 208
Cdd:cd11247    81 QPDPEQGVLVVCGSIYQGLCQLRRLYNISAVAVRFPVDG-----DTVFPSMLNVAANHPNASTVGLVLWPRGGGGGLRLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  209 VGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSD 288
Cdd:cd11247   156 VGATYTGYGSGFFPRNRSLEDHRFENTPEIAIRALNTRGDLAKLFTFDINPSDDNIFKIKQGAKARHKLSFVRAFLQHFL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  289 PPpgaqsYAYLALNSEARAGDKESQARSLLARICLPHGA---GGDAKKLTESYIQLGLQCAGgagrgdLYSRLVSVFPAR 365
Cdd:cd11247   236 QP-----YAYLAMNGEANAAGKESQPPSLLARICLPGRApppPGEAKKLTESYIQLGLRCEG------AYTRLVSVFPAR 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  366 ---ERLFAVFERPQGSPAARAApaalcaFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQ 442
Cdd:cd11247   305 veeEQLFAVFERAGGAPAALCA------FRFAEVEEPIRAARTACFVSPAAGVVTVLDSVVQGTGPACERKLNIQLQPEQ 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  443 LDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHV 522
Cdd:cd11247   379 LDCGAAHLQHPLAILQPLKATPVFRAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHV 458

                         490       500
                  ....*....|....*....|....*
gi 767926138  523 MQFDPADSGYLYLMTSHQMARVKVA 547
Cdd:cd11247   459 MQFDPSDSTYLYLMTSHQMTRVKVA 483
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1344-1439 7.40e-58

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 206.38  E-value: 7.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1344 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFL 1423
Cdd:cd12788     1 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQENNSQGPRQVPETHPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFL 80

                          90
                  ....*....|....*.
gi 767926138 1424 IVFVHALEQQKDFAVQ 1439
Cdd:cd12788    81 VTFVHALEQQKDFAVR 96
Sema smart00630
semaphorin domain;
60-520 2.20e-43

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 163.31  E-value: 2.20e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138     60 NNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQLpqaSCEHPrrLTDNYNKI-LQLDPGQGLVV 138
Cdd:smart00630    2 QHLLLDEDNGTLYVGARNRLYQLSL-NLILEAELKTGPVLSSPDCEECVS---KGKDP--PTDCVNYIrLLLDYNEDRLL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    139 VCGS-IYQGFCQLRRRGNisavavrfppaappaepvtvfpsmlnvaanhpnastvglvlppaagaggsrLLVGATYTgyg 217
Cdd:smart00630   76 VCGTnAFQPVCRLRNLGE---------------------------------------------------LYVGTVAD--- 101

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    218 ssffprnrsledhrFENTPEIAIRSLDTRGDLAklftfDLNPSDDNILKIKQGAKEQHklgFVSAFLHpsdpppgaQSYA 297
Cdd:smart00630  102 --------------FSGSDPAIPRSLSVRRLKG-----TSGVSLRTVLYDSKWLNEPN---FVYAFES--------GDFV 151

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    298 YLALNSEARAGDKESQA-RSLLARICLPH-GAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVF------PARERLF 369
Cdd:smart00630  152 YFFFRETAVEDDNCGKAvHSRVARVCKNDvGGPRSLDKKWTSFLKARLECSVPGEDPFYFNELQAAFllppgsESDDVLY 231

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    370 AVFERPQGSPAARAAPAalcaFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERK-LNIQLQPEQLDCGAA 448
Cdd:smart00630  232 GVFSTSSNPIPGSAVCA----FSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRPGTCPNKpPSSKDLPDETLNFIK 307

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    449 HLQHPLSILQPLKATPVFR----APGLTSVAVASVN---NYTAVFLGTVNGRLLKINLNESMQVVSRRV---VTVA-YGE 517
Cdd:smart00630  308 SHPLMDEVVQPLTGRPLFVktdsNYLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSESVVleeISVFpDGS 387


                    ...
gi 767926138    518 PVH 520
Cdd:smart00630  388 PIS 390
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 891-979 1.10e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 127.82  E-value: 1.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPL-SGVVTV---NA 966
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVfNGPVEVtvgHG 80

                          90
                  ....*....|...
gi 767926138  967 SKEGKSRDRFSYV 979
Cdd:cd01180    81 SFRTESSEGFSFV 93
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1069-1174 3.15e-34

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 126.76  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSN------ASAPVDFFIN 1142
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTSCKVRNSTLMTCPAPSLALLnrspepGERPVEFGLD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767926138 1143 GRAYAdevavaeelldpeEAQRGSRFRLDYLP 1174
Cdd:cd01181    81 GDNVQ-------------SLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 981-1067 4.25e-30

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 114.63  E-value: 4.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTdPCTELMRTDTSIACTMPEGALPAPVPVCVRFErRGCVHGN 1060
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQ-PCKILSVSSSQIVCLTPPSASPGEAPVKVLID-GARRLAP 78


                  ....*..
gi 767926138 1061 LTFWYMQ 1067
Cdd:cd01179    79 LVFTYTE 85
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1345-1439 1.54e-21

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 100.35  E-value: 1.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgssqAQETHPLLGEWKIP---ESCRPNMEEGISLFSSLLNNKH 1421
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFP------------------------GVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKL 56

                           90
                   ....*....|....*...
gi 767926138  1422 FLIVFVHALEQQKDFAVQ 1439
Cdd:pfam08337   57 FLLTFIRTLESQRSFSIR 74
IPT smart00429
ig-like, plexins, transcription factors;
980-1066 3.30e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.15  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    980 LPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDT-DPCTELMRTDTSIACTMPEGA-LPAPVPVCVRFERRGCV 1057
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGeAPCTFSPSSSTAIVCKTPPYHnIPGSVPVRTVGLRNGGV 80

                            90
                    ....*....|
gi 767926138   1058 HGN-LTFWYM 1066
Cdd:smart00429   81 PSSpQPFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
891-979 8.87e-15

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 70.91  E-value: 8.87e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    891 PEIHAIEPLSGPLDGGTLLTIRGRNLGrRLSDVAHGVWIGGVACEPLPDRytvSEEIVCVTGPAP-GPLSGVVTVNASKE 969
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHnIPGSVPVRTVGLRN 77

                            90
                    ....*....|...
gi 767926138    970 GK---SRDRFSYV 979
Cdd:smart00429   78 GGvpsSPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 891-978 3.92e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 3.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAhgVWIGGVACEPLpdrYTVSEEIVCVTGP-APGPLSGVVTVNASKE 969
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTVI---SVSSTTIVCTTPPgTSGLVNVSVTVGGGGI 75


                   ....*....
gi 767926138   970 GKSRDRFSY 978
Cdd:pfam01833   76 SSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 549-601 7.02e-12

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 61.57  E-value: 7.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767926138   549 CNVHSTCGDCVGAADAYCGWCALETRCTLQQDCT-NSSQQHFWTSASegpSRCP 601
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGaPEGNCEEWEQAS---SKCP 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 981-1065 9.80e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.08  E-value: 9.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSE-LQVLVNDTdPCTELMRTDTSIACTMPEGAlPAPVPVCVRFERRGCVHG 1059
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGT-PCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 767926138  1060 NLTFWY 1065
Cdd:pfam01833   79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1068-1148 1.18e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 1.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   1068 NPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREptlCKVLN--STLITCPSPGAL-SNASAPVD--FFIN 1142
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP---CTFSPssSTAIVCKTPPYHnIPGSVPVRtvGLRN 77


                    ....*.
gi 767926138   1143 GRAYAD 1148
Cdd:smart00429   78 GGVPSS 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
549-601 3.82e-10

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 56.40  E-value: 3.82e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767926138    549 CNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQhfWTSASegpsrCP 601
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN--WLSGG-----CP 47
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1069-1143 2.96e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 2.96e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926138  1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAvhHIGREPTLCKVLNSTLITCPSPgALSNASAPVDFFING 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKV--TIGGTPCTVISVSSTTIVCTTP-PGTSGLVNVSVTVGG 72
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 627-700 3.28e-08

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 52.27  E-value: 3.28e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926138   627 LPSLSGmEMACDYGNNIRTVARVPGPAfghqiAYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRN--IVKANFTIY 700
Cdd:pfam17960   20 LPALSE-GYSCVFGDLTESPATVHDNG-----VKCATPPPSQLPPIPTGQDHVTVKLSLRSSETGvdFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
711-753 4.16e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 47.92  E-value: 4.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767926138    711 HTACTSCLSAQWP-CFWCSQQHSCVSnQSRCEASPNPTSPQDCP 753
Cdd:smart00423    5 YTSCSECLLARDPyCAWCSSQGRCTS-GERCDSRRQNWLSGGCP 47
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 452-497 1.91e-05

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 46.88  E-value: 1.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767926138   452 HPL--SILQPLKATPVF--RAPGLTSVAVASV----NNYTAVFLGTVNGRLLKI 497
Cdd:pfam01403   97 HPLmdEAVQPVGGRPLLvrTGVRLTSIAVDRVqaldGNYTVLFLGTDDGRLHKV 150
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 701-753 2.01e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 43.47  E-value: 2.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926138   701 DCSRtaqvypHTACTSCLSAQWP-CFWCSQQHSCVSNQSRCEASPNP----TSPQDCP 753
Cdd:pfam01437    1 RCSQ------YTSCSSCLAARDPyCGWCSSEGRCVRRSACGAPEGNCeeweQASSKCP 52
 
Name Accession Description Interval E-value
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 49-547 0e+00

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 822.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   49 IQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKIL 128
Cdd:cd11247     1 VQRKFRSPTRTNNFALDGGRGRLYLAAVNRLYQLSGLVLALEAEAAVGPVLDSPLCHAPQLPQATCEHPRTLTDNYNKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  129 QLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAppaepVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLL 208
Cdd:cd11247    81 QPDPEQGVLVVCGSIYQGLCQLRRLYNISAVAVRFPVDG-----DTVFPSMLNVAANHPNASTVGLVLWPRGGGGGLRLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  209 VGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSD 288
Cdd:cd11247   156 VGATYTGYGSGFFPRNRSLEDHRFENTPEIAIRALNTRGDLAKLFTFDINPSDDNIFKIKQGAKARHKLSFVRAFLQHFL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  289 PPpgaqsYAYLALNSEARAGDKESQARSLLARICLPHGA---GGDAKKLTESYIQLGLQCAGgagrgdLYSRLVSVFPAR 365
Cdd:cd11247   236 QP-----YAYLAMNGEANAAGKESQPPSLLARICLPGRApppPGEAKKLTESYIQLGLRCEG------AYTRLVSVFPAR 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  366 ---ERLFAVFERPQGSPAARAApaalcaFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQ 442
Cdd:cd11247   305 veeEQLFAVFERAGGAPAALCA------FRFAEVEEPIRAARTACFVSPAAGVVTVLDSVVQGTGPACERKLNIQLQPEQ 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  443 LDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHV 522
Cdd:cd11247   379 LDCGAAHLQHPLAILQPLKATPVFRAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHV 458

                         490       500
                  ....*....|....*....|....*
gi 767926138  523 MQFDPADSGYLYLMTSHQMARVKVA 547
Cdd:cd11247   459 MQFDPSDSTYLYLMTSHQMTRVKVA 483
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 58-547 1.14e-96

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 316.97  E-value: 1.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   58 PTNNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQlpQASCEHPRRLTDNYNKILQLDPGQGLV 137
Cdd:cd11236     1 PFNHLAVDNSTGRVYVGAVNRLYQLDS-SLLLEAEVSTGPVLDSPLCLPPG--CCSCDHPRSPTDNYNKILLIDYSSGRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  138 VVCGSIYQGFCQLRRRGNISAVAVRfppaappaepvtvfpSMLNVAANHPNASTVGLVLPPAAgAGGSRLLVGATYTGYG 217
Cdd:cd11236    78 ITCGSLYQGVCQLRNLSNISVVVER---------------SSTPVAANDPNASTVGFVGPGPY-NNENVLYVGATYTNNG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  218 ssffprnrsledhRFENTPEIAIRSLDTRGDLAklFTFDLNPSddnILKIKQGAKEQHKLGFVSAFLHpsdpppgaQSYA 297
Cdd:cd11236   142 -------------YRDYRPAVSSRSLPPDDDFN--AGSLTGGS---AISIDDEYRDRYSIKYVYGFSS--------GGFS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  298 YLALNSEARAgDKESQARSLLARICLPHgaggdakKLTESYIQLGLQCAGgaGRGDLYSRLVSVFPAR------------ 365
Cdd:cd11236   196 YFVTVQRKSV-DDESPYISRLVRVCQSD-------SNYYSYTEVPLQCTG--GDGTNYNLLQAAYVGKagsdlarslgis 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  366 ---ERLFAVFERPQGSPAARAAPAALCAFRFAdvraairaartacfvepapDVvavldsvvqgtgpacERKLNIqlqpeq 442
Cdd:cd11236   266 tddDVLFGVFSKSKGPSAEPSSKSALCVFSMK-------------------DI---------------EAAFND------ 305

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  443 ldcgaahlQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHV 522
Cdd:cd11236   306 --------NCPLGGGVPITTSAVLSDSLLTSVAVTTTRNHTVAFLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPD 377

                         490       500
                  ....*....|....*....|....*
gi 767926138  523 MQFDPaDSGYLYLMTSHQMARVKVA 547
Cdd:cd11236   378 MVFDP-DGEHLYVMTPKKVTKVPVE 401
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1344-1439 7.40e-58

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 206.38  E-value: 7.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1344 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFL 1423
Cdd:cd12788     1 QGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQENNSQGPRQVPETHPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFL 80

                          90
                  ....*....|....*.
gi 767926138 1424 IVFVHALEQQKDFAVQ 1439
Cdd:cd12788    81 VTFVHALEQQKDFAVR 96
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 60-547 6.87e-46

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 172.04  E-value: 6.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   60 NNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLCHAP----QLPQAscehprRLTDNYNKILQLDPGQG 135
Cdd:cd11245     3 NHLAQDPQTGRLYLGAVNGLFQLS-PNLQLESRADTGPKKDSPQCLPPitaaECPQA------KETDNFNKLLLVNSANG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  136 LVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEpvtvfpsmlnVAANHPNASTVGLVlpPAAGAGGSRLLVGATYTG 215
Cdd:cd11245    76 TLVVCGSLFQGVCELRNLNSVNKPLYRPETPGDKQY----------VAANEPSVSTVGLI--SYFKDGLSLLFVGRGYTS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  216 YGSsffprnrsledhrfENTPEIAIRSLDTRGDLAKLftfdlnpSDDNILKIKQGAKEQHKLGFVSAFlhpsdpppGAQS 295
Cdd:cd11245   144 SLS--------------GGIPPITTRLLQEHGEMDAF-------SNEVEAKLVVGSASRYHHDFVYAF--------ADNG 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  296 YAYLALNSeaRAGDKESQARSLLARICLphgaggdAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPARER-----LFA 370
Cdd:cd11245   195 YIYFLFSR--RPGTADSTKRTYISRLCE-------NDHHYYSYVELPLNCTVNQENTYNLVQAAYLAKPGKVlngkvLFG 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  371 VFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFV-----EPAPDVVAvldsVVQGTGPACErklniQLQPEQLD- 444
Cdd:cd11245   266 VFSADEASTAAPDGRSALCMYPLSSVDARFERTRESCYTgegleDDKPETAY----IEYNVKSICK-----TLPDKNVKa 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  445 --CGAAHLQHPLSILQPLKATPVF-RAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNES-MQVVSRrvVTVAYGEPVH 520
Cdd:cd11245   337 ypCGAEHTPSPLASRYPLAAKPILtRNDMLTAVAVAVENGHTIAFLGDSGGQLHKVYLDPNhTDFYST--IPGDQDSAVN 414

                         490       500
                  ....*....|....*....|....*..
gi 767926138  521 HVMQFDpADSGYLYLMTSHQMARVKVA 547
Cdd:cd11245   415 KDLLFD-STLNHLYVMTGKKISKVPVQ 440
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 53-547 1.94e-45

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 170.76  E-value: 1.94e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   53 FPSPTPT-NNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLCHAPQLPqASCEHPRrLTDNYNKILQLD 131
Cdd:cd11277     1 FSAPNATfNHLALDPGSGTLYVGAVNRLYQLS-PDLQLLGEAVTGPVLDSPDCLPFRDP-ADCPQAR-LTDNANKLLLVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  132 PGQGLVVVCGSIYQGFCQLRRRGNISAVAVRfppaaPPAEPVTVFpsmlnVAANHPNASTVGLVLPPaagAGGSRLLVGA 211
Cdd:cd11277    78 ERAGELVACGQVRQGVCEKRRLGNVAQVLYQ-----AEDPGDGQF-----VAANDPGVATVGLVVEA---PGRDLLLVGR 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  212 TYTGYGSSffprnrsledhrfeNTPEIAIRSLDTrgdlAKLFtfdlnpSDDNILKIKQGAKEQHKLGFVSAFLHpsdppp 291
Cdd:cd11277   145 GLTGKLSA--------------GIPPLTIRQLAG----AQAF------SSEGLGKLVVGDFSDYNNSYVGAFAH------ 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  292 gaQSYAYLALnseARAGDKeSQA--RSLLARICLphgagGDAKklTESYIQLGLQCAGGAGrgdlYSRLVSVFPARERLF 369
Cdd:cd11277   195 --NGYVYFLF---RRRGAR-AQAeyRTYVARVCL-----GDTN--LYSYVEVPLVCQGGYN----LAQAAYLAPGQGTLF 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  370 AVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQ-GTGPACerkLNI-QLQPEQLDCGA 447
Cdd:cd11277   258 VVFAAGQGSTPTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEyGVTSRC---VNLpKDSPESYPCGD 334

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  448 AHLQHPLSILQPLKATPVFR-APGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFD 526
Cdd:cd11277   335 EHTPSPIASRQPLEAEPLLTlTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPVGPPGSAVNPDLLLD 414

                         490       500
                  ....*....|....*....|.
gi 767926138  527 PADSgYLYLMTSHQMARVKVA 547
Cdd:cd11277   415 ATGS-HLYVLTARQVTKVPVA 434
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 53-546 1.30e-43

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 165.72  E-value: 1.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   53 FPSPTPTNNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLChAPQLPQASCeHPRRLTDNYNKILQLDP 132
Cdd:cd11276     2 FQSATELNHLVVDPQTGRVYLGAVNALYQLD-ADLQLESRVETGPKKDNKKC-TPPIEENQC-TEAKMTDNYNKLLLLDS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  133 GQGLVVVCGSIYQGFCQLRRRGNISAVavrfppaappaepvtVFPSMLN-----VAANHPNASTVGLV--LPPaagAGGS 205
Cdd:cd11276    79 ANKTLVVCGSLFKGICSLRNLSNISEV---------------IYYSDTSgeksfVASNDEGVSTVGLIssLKP---GNDR 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  206 RLLVGatyTGYGSSffprnrsledhrfENTPEIAIRSLDTRGDLAklfTFDLnpsddnilkIKQGAKEQHklGFVSAFLH 285
Cdd:cd11276   141 VFFVG---KGNGSN-------------DNGKIISTRLLQNYDDRE---VFEN---------YIDAATVKS--AYVSRYTQ 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  286 PSDPPPGAQSYAYLALNSEARAGDKEsqaRSLLARICL--PHgaggdakklTESYIQLGLQCAGGAGR------------ 351
Cdd:cd11276   191 QFRYAFEDNNYVYFLFNQQLGHPDKN---RTLIARLCEndHH---------YYSYTEMDLNCRDGANAynkcqaayvstp 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  352 GDLYSRLVSVFPARER-LFAVFERPQGSpaarAAPAALCAFRFADVRAAIRAARTACF--VEPAPDVVAVLDSvVQGTGP 428
Cdd:cd11276   259 GKELAQNYGNSILSDKvLFAVFSRDEKD----SGESALCMFPLKSINAKMEANREACYtgTIDDRDVFYKPFH-SQKDII 333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  429 -ACERKLNIQLQPeqldCGAAHLQHPLSILQPLK-ATPVFRAPG--LTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQ 504
Cdd:cd11276   334 cGSHQQKNSKSFP----CGSEHLPYPLGSRDELAlTAPVLQRGGlnLTAVTVAVENGHTVAFLGTSDGRILKVHLSPDPE 409

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 767926138  505 VVSRrvVTVAYGEPVHHVMQFDPaDSGYLYLMTSHQMARVKV 546
Cdd:cd11276   410 EYNS--ILIEKNKPVNKDLVLDK-TLEHLYIMTEDKVFRLPV 448
Sema smart00630
semaphorin domain;
60-520 2.20e-43

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 163.31  E-value: 2.20e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138     60 NNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQLpqaSCEHPrrLTDNYNKI-LQLDPGQGLVV 138
Cdd:smart00630    2 QHLLLDEDNGTLYVGARNRLYQLSL-NLILEAELKTGPVLSSPDCEECVS---KGKDP--PTDCVNYIrLLLDYNEDRLL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    139 VCGS-IYQGFCQLRRRGNisavavrfppaappaepvtvfpsmlnvaanhpnastvglvlppaagaggsrLLVGATYTgyg 217
Cdd:smart00630   76 VCGTnAFQPVCRLRNLGE---------------------------------------------------LYVGTVAD--- 101

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    218 ssffprnrsledhrFENTPEIAIRSLDTRGDLAklftfDLNPSDDNILKIKQGAKEQHklgFVSAFLHpsdpppgaQSYA 297
Cdd:smart00630  102 --------------FSGSDPAIPRSLSVRRLKG-----TSGVSLRTVLYDSKWLNEPN---FVYAFES--------GDFV 151

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    298 YLALNSEARAGDKESQA-RSLLARICLPH-GAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVF------PARERLF 369
Cdd:smart00630  152 YFFFRETAVEDDNCGKAvHSRVARVCKNDvGGPRSLDKKWTSFLKARLECSVPGEDPFYFNELQAAFllppgsESDDVLY 231

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    370 AVFERPQGSPAARAAPAalcaFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERK-LNIQLQPEQLDCGAA 448
Cdd:smart00630  232 GVFSTSSNPIPGSAVCA----FSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRPGTCPNKpPSSKDLPDETLNFIK 307

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    449 HLQHPLSILQPLKATPVFR----APGLTSVAVASVN---NYTAVFLGTVNGRLLKINLNESMQVVSRRV---VTVA-YGE 517
Cdd:smart00630  308 SHPLMDEVVQPLTGRPLFVktdsNYLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSESVVleeISVFpDGS 387


                    ...
gi 767926138    518 PVH 520
Cdd:smart00630  388 PIS 390
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 54-547 3.19e-39

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 153.19  E-value: 3.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   54 PSPTPTNNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLCHAP----QLPQAsceHPrrlTDNYNKILQ 129
Cdd:cd11275     3 PNGTKFLHLSMDPESGTLYLGATNFLFQLT-PDLLLENMVQTGPVLDSKDCLPPvsklECPQA---QH---TNNHNKLLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  130 LDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEpvtvfpsmlnVAANHPNASTVGLVlppAAGAGGSRLL- 208
Cdd:cd11275    76 VNPVQKELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQY----------VAANDPNVTTVGLV---AYSKDGVPLLf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  209 VGATYTGYGSSffprnrsledhrfENTPEIAIRSLDTRGDLA----KLFTFdlnpsdDNILKIKQGAKEQHKLGFVSAFL 284
Cdd:cd11275   143 VGRGYTSRGVG-------------GGIPPITTRNLRAHGDDAtdshSIFSY------EETAKLAVGRLSEYNHHFIKAFT 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  285 HpsdpppGAQSYaYLALNSEARAGDKEsqARSLLARICLphgagGDAKKLteSYIQLGLQCAGGAGRgdlYSRLVSVFPA 364
Cdd:cd11275   204 Y------GSSVY-FLFYRRDLKSQSRE--YKTYISRICL-----DDSHYY--SYVELPLLCQSKANT---YSLLQAAYVT 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  365 RER--------------LFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVE--PAPD--VVAVLDSVVQGT 426
Cdd:cd11275   265 QPGerlaqgqldtdgevLFAAFSAWQASSGKLSEESALCAYPMDEVDRLTNWTRDVCYTRdgKAEDgtEVAYIEYDVSSN 344

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  427 gpaCerklnIQLQPEQLD---CGAAHLQHPLSILQPLKATPVFRAPG--LTSVAVASVNNYTAVFLGTVNGRLLKINLNE 501
Cdd:cd11275   345 ---C-----VQLPADTLDaypCGSDHTPSPMASRVPLEATPLLEWTEirLTAVAVNVEDGHTIAFLGDSRGRLHKVYLGA 416

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 767926138  502 SMQVVSRRVVTVAYGEPVHHVMQFDPADSgYLYLMTSHQMARVKVA 547
Cdd:cd11275   417 GGDAHTYSSQSIQQNSAVSGDLLFDQLQE-HLYVMTQSTVLKVPIA 461
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 60-588 2.09e-36

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 145.84  E-value: 2.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   60 NNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQLPQAsCEHPRRLTDNYNKILQLDPGQGLVVV 139
Cdd:cd11272    14 NHLTVHQSTGAVYVGAINRVYKLSG-NLTILVAHKTGPEEDNKSCYPPLIVQP-CSEVLTLTNNVNKLLIIDYSENRLLA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  140 CGSIYQGFCQLRRRGNIsavavrfppaappaePVTVFPSMLN---VAANHPNASTVGLVLPPAAGAGgsRLLVGATYTGY 216
Cdd:cd11272    92 CGSLYQGVCKLLRLDDL---------------FILVEPSHKKehyLSSVNKTGTMYGVIVRSEGEDG--KLFIGTAVDGK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  217 GSSFfprnrsledhrfentPEIAIRSLDTRGDLAKLFTFDLNpSD--DNILKIKQGAkeqhkLGFVSAF--LHPSDPPPG 292
Cdd:cd11272   155 QDYF---------------PTLSSRKLPRDPESSAMLDYELH-SDfvSSLIKIPSDT-----LALVSHFdiFYIYGFASG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  293 AQSYaYLALNSEARAGDKESQARSL-----LARIClphgaGGDAKklTESYIQLGLQCAGG------------AGRGDLY 355
Cdd:cd11272   214 NFVY-FLTVQPETPEGVSINSAGDLfytsrIVRLC-----KDDPK--FHSYVSLPFGCVRGgveyrllqaaylSKPGEVL 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  356 SRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFV-EPAPDVVAVLDSVVQGTGPacerkl 434
Cdd:cd11272   286 ARSLNITAQEDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINAQIKERLQSCYQgEGNLELNWLLGKDVQCTKA------ 359

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  435 niqlqPEQLD---CGAaHLQHPLSILQPLKATPVFRAPG--LTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQV-VSR 508
Cdd:cd11272   360 -----PVPIDdnfCGL-DINQPLGGSTPVEGVTLYTSSRdrLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGgVQY 433

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  509 RVVTVAY-GEPVHHVMQFDpADSGYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQ 587
Cdd:cd11272   434 EMVSVFKdGSPILRDMAFS-IDHKYLYVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEP 512


                  .
gi 767926138  588 H 588
Cdd:cd11272   513 F 513
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 891-979 1.10e-34

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 127.82  E-value: 1.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPL-SGVVTV---NA 966
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPVfNGPVEVtvgHG 80

                          90
                  ....*....|...
gi 767926138  967 SKEGKSRDRFSYV 979
Cdd:cd01180    81 SFRTESSEGFSFV 93
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1069-1174 3.15e-34

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 126.76  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSN------ASAPVDFFIN 1142
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGVEKTSCKVRNSTLMTCPAPSLALLnrspepGERPVEFGLD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767926138 1143 GRAYAdevavaeelldpeEAQRGSRFRLDYLP 1174
Cdd:cd01181    81 GDNVQ-------------SLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 981-1067 4.25e-30

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 114.63  E-value: 4.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTdPCTELMRTDTSIACTMPEGALPAPVPVCVRFErRGCVHGN 1060
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQ-PCKILSVSSSQIVCLTPPSASPGEAPVKVLID-GARRLAP 78


                  ....*..
gi 767926138 1061 LTFWYMQ 1067
Cdd:cd01179    79 LVFTYTE 85
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 51-546 9.34e-28

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 118.77  E-value: 9.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   51 RRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQLPQaSCEHPRRLTDNYNKILQL 130
Cdd:cd11244     5 RGEPRDWSFNHLTVHRRTGEVYVGAINRVYKLSS-NLTVLVTHETGPVEDNPKCYPPPIVQ-TCNEPLTTTNNVNKLLLI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  131 DPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNastvglvlppaagaGGSRLLVG 210
Cdd:cd11244    83 DYSENRLIACGSLYQGVCKLLRLEDLFKLGEPHHKKEHYLSGVNESGTMFGVIVSYSN--------------GDDKLFIG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  211 ATYTGYGSSFfprnrsledhrfentPEIAIRSLDTRGDLAKLFTFDLNpsDDnilkikqgakeqhklgFVSAFLH-PSDP 289
Cdd:cd11244   149 TAVDGKSEYF---------------PTLSSRKLTADEESDGMFAYVYH--DE----------------FVSSQIKiPSDT 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  290 ----PPGAQSYAY------------LALNSEARAGD--KESQARSLLARIClphgaggdaKKLTE--SYIQLGLQC--AG 347
Cdd:cd11244   196 lsiiPDFDIYYVYgfssgnfvyfltLQPETQLTPGDstGEQFYTSKIVRLC---------KDDTKfySYVEFPIGCtrDG 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  348 GAGR----------GDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFV-EPAPDVV 416
Cdd:cd11244   267 VEYRllqaaylskpGKALAQALGISEDEDVLFTIFSKGQKNRMKPPDESALCLFTLKQINLRIKERLQSCYRgEGKLSLP 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  417 AVLDSVVQGTGpacerklniqlQPEQLD---CGAAhLQHPLSILQPLKATPVF--RAPGLTSVAVASVNNYTAVFLGTVN 491
Cdd:cd11244   347 WLLNKDLPCIN-----------APLQIDdnfCGLD-MNQPLGGSDMVEGIPLFtdDRDRMTSVAAYVYKGHSVVFVGTKS 414

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767926138  492 GRLLKINLN-ESMQVVSRRVVTVAYGEPVHHVMQFDPaDSGYLYLMTSHQMARVKV 546
Cdd:cd11244   415 GKLKKIRVDgPPHNALQYETVQVVEGSPILRDMAFSP-DHQYLYIMSERQVTRVPV 469
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 55-546 1.05e-25

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 112.72  E-value: 1.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   55 SPTPTNNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLCHAPQLPQAsCEHPRRLTDNYNKILQLDPGQ 134
Cdd:cd11273     9 TDTTLTHLAVHRVTGEVFVGAVNRVYKLS-ANLTELRAHVTGPVEDNARCYPPPSVRV-CAHRLAPVDNVNKLLLVDYAG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  135 GLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEpvtvfpsmlnvAANHPNAsTVGLVLppAAGAGGSRLLVGATYT 214
Cdd:cd11273    87 NRLVACGSIWQGVCQFLRLEDLFKLGEPHHRKEHYLS-----------GAQEPDS-MAGVIV--EQGKGPSKLFVGTAID 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  215 GyGSSFFPRNRSLEDHRFENTPEIairsldtrgdlaklftFDLNPSDDNI---LKIKQGAKEQH---KLGFVSAFLhpsd 288
Cdd:cd11273   153 G-KSEYFPTLSSRKLISDEDSADM----------------FSLVYQDEFVssqIKIPSDTLSLYpafDIYYVYGFV---- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  289 pppgAQSYAY---LALNSEARAGDK--ESQARSLLARIClphgaGGDakklTE--SYIQLGLQC------------AGGA 349
Cdd:cd11273   212 ----SASFVYfltLQLDTQQTLLDTagEKFFTSKIVRMC-----AND----TEfySYVEFPLGCskdgveyrlvqaAHLA 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  350 GRGDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFvepapdvvavldsvvQGTGP- 428
Cdd:cd11273   279 KPGLLLAQALGVPEDEDVLFTIFSQGQKNRASPPRETILCLFTLSNINAHIRERIQSCY---------------RGEGTl 343

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  429 ACERKLNIQL----QPEQLD---CGAAhLQHPLSILQPLKATPVF--RAPGLTSVAVASVNNYTAVFLGTVNGRLLKINL 499
Cdd:cd11273   344 SLPWLLNKELpcinTPMQINgnfCGLV-LNQPLGGLHVIEGLPLLadSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRV 422

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 767926138  500 NESMQVVSRRVVTVAYGEPVHHVMQFDPaDSGYLYLMTSHQMARVKV 546
Cdd:cd11273   423 DGFQDAHLYETVPVVDGSPILRDMVFSP-DHRYIYLLSEKQVSQLPV 468
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 60-549 8.61e-23

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 103.88  E-value: 8.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   60 NNFALDGAAGTVYLAAVNRLYQLSgANLSLEAEAAVGPVPDSPLCHAPQLPQaSCEHPRRLTDNYNKILQLDPGQGLVVV 139
Cdd:cd11274    14 NHLVVDERTGHIYLGAVNRIYKLS-SDLKVLVTHQTGPDEDNPKCYPPRIVQ-TCNEPLTLTNNINKMLLIDYKENRLIA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  140 CGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNAStvglvlppaagaggSRLLVGATYTGygss 219
Cdd:cd11274    92 CGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNLD--------------DKLFIATAVDG---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  220 ffprnrsledhRFENTPEIAIRSLDTRGDLAKLFTFDLN----------PSDdnILKIKQGAKEQHKLGFVSA------F 283
Cdd:cd11274   154 -----------KPEYFPTISSRKLTKNSEADGMFAYVFHdefvasmikiPSD--TFTIIPDFDIYYIYGFSSGnfvyflT 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  284 LHPS-DPPPGaqsyaylalnsearAGDKESQARSLLARICLPHGAggdakklTESYIQLGLQCAGG------------AG 350
Cdd:cd11274   221 LQPEmISPPG--------------STTKEQVYTSKLVRLCKEDTA-------FNSYVEVPIGCEKNgveyrllqaaylSK 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  351 RGDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFvepapdvvavldsvvQGTGpac 430
Cdd:cd11274   280 AGAILARSLGVGPDDDILFTVFSKGQKRKMKSLDESALCIFVLKEINDRIKDRLQSCY---------------RGEG--- 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  431 erKLNIQ-LQPEQLDCGAAHL-----------QHPLSILQPLKATPVFRAPG--LTSVAVASVNNYTAVFLGTVNGRLLK 496
Cdd:cd11274   342 --TLDLAwLKVKDIPCSSALLtiddnfcgldmNAPLGVSEMVRGLPVFTEDRdrMTSVIAYVYKNHSLAFVGTKSGKLKK 419

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767926138  497 INLN-ESMQVVSRRVVTVAYGEPVHHVMQFDpADSGYLYLMTSHQMARVKVAAC 549
Cdd:cd11274   420 IRVDgTTKNALQYETVQVVDTGPILRDMAFS-KDHEQLYIMSEKQLTRVPVESC 472
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 51-546 8.99e-22

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 100.81  E-value: 8.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   51 RRFPSPT-PTNNFALDGAAGTVYLAAVNRLYQLSGaNLSLEAEAAVGPVPDSPLCHAPQLPQaSCEHPRRLTDNYNKILQ 129
Cdd:cd11271     5 RTFTASDwSLTHLVVHNKTGEVYVGAVNRIYKLSN-NLTLLRTHVTGPVEDNEKCYPPPSVQ-SCPHGLGTTNNVNKLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  130 LDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNastvglvlppaagaGGSRLLV 209
Cdd:cd11271    83 VDYAANRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIEVGN--------------GQNKLFV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  210 GATYTGyGSSFFP--RNRSL----EDHR---FENTPEIAIRSLDTRGD-LAKLFTFDlnpsddnILKIKQGAKEQhklgF 279
Cdd:cd11271   149 GTPIDG-KSEYFPtlSSRKLmaneENAEmfgFVYQDEFVSSQLKIPSDtLSKFPTFD-------IYYVYSFSSEQ----F 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  280 VsaflhpsdpppgaqSYAYLALNSEARAGDKESQA--RSLLARICLphgaggDAKKLTeSYIQLGLQC--AGGAGR---- 351
Cdd:cd11271   217 V--------------YYLTLQLDTQLTSPDSTGEQffTSKIVRLCV------DDPKFY-SYVEFPIGCeqDGVEYRliqd 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  352 ------GDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFvepapdvvavldsvvQG 425
Cdd:cd11271   276 aylskpGKALAKQLGISEREDILFTVFSQGQKNRVKPPKESVLCLFTLKKIKDKIKERIQSCY---------------RG 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  426 TGP-ACERKLNIQL----QPEQLD---CGaAHLQHPLSILQPLKATPVF--RAPGLTSVAVASVNNYTAVFLGTVNGRLL 495
Cdd:cd11271   341 EGKlSLPWLLNKELgcinSPLQIDdnfCG-QDFNQPLGGTVTIEGTPLFvdKEDGMTSVAAYDYRGRTVVFAGTRSGRIK 419

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767926138  496 KINLN----ESMQVVSRRVVTVAYGEPVHHVMQFDPaDSGYLYLMTSHQMARVKV 546
Cdd:cd11271   420 KILVDlsapSSRPALQYENVVAHEGSPILRDLVLSP-DRQYIYAMTEKQVTRVPV 473
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1345-1439 1.54e-21

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 100.35  E-value: 1.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgssqAQETHPLLGEWKIP---ESCRPNMEEGISLFSSLLNNKH 1421
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFP------------------------GVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKL 56

                           90
                   ....*....|....*...
gi 767926138  1422 FLIVFVHALEQQKDFAVQ 1439
Cdd:pfam08337   57 FLLTFIRTLESQRSFSIR 74
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 891-979 1.40e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 84.81  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAhgVWIGGVACEPLPdryTVSEEIVCVTGPAPGPLSGVVTV-----N 965
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLN---VSSTEIVCRTPAAATPGEGPVEVtvdgaN 75

                          90
                  ....*....|....
gi 767926138  966 ASKEGKSRDRFSYV 979
Cdd:cd00603    76 VSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 981-1067 2.03e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 84.43  E-value: 2.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSE-LQVLVNDTdPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRG---C 1056
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGV-PCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANvsaR 79

                          90
                  ....*....|.
gi 767926138 1057 VHGNLTFWYMQ 1067
Cdd:cd00603    80 VLSNTTFTYVE 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 981-1067 2.84e-19

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 83.66  E-value: 2.84e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRG--CVH 1058
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNggITS 80


                  ....*....
gi 767926138 1059 GNLTFWYMQ 1067
Cdd:cd00102    81 SPLTFTYVP 89
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1345-1439 1.99e-18

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 89.20  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgssqAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12205     1 GIPFLDFREYIIRVLFP------------------------GVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLL 56

                          90
                  ....*....|....*
gi 767926138 1425 VFVHALEQQKDFAVQ 1439
Cdd:cd12205    57 TFIRTLESQPKFSSR 71
IPT smart00429
ig-like, plexins, transcription factors;
980-1066 3.30e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.15  E-value: 3.30e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    980 LPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDT-DPCTELMRTDTSIACTMPEGA-LPAPVPVCVRFERRGCV 1057
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGeAPCTFSPSSSTAIVCKTPPYHnIPGSVPVRTVGLRNGGV 80

                            90
                    ....*....|
gi 767926138   1058 HGN-LTFWYM 1066
Cdd:smart00429   81 PSSpQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 891-979 1.68e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 73.26  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  891 PEIHAIEPLSGPLDGGTLLTIRGRNLGrrlSDVAHGVWIGG-VACEPLPDRytvSEEIVCVTGPAPGPLSGVVTV----N 965
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFG---SGSNLRVTFGGgVPCSVLSVS---STAIVCTTPPYANPGPGPVEVtvdrG 74

                          90
                  ....*....|....
gi 767926138  966 ASKEGKSRDRFSYV 979
Cdd:cd00102    75 NGGITSSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
891-979 8.87e-15

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 70.91  E-value: 8.87e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138    891 PEIHAIEPLSGPLDGGTLLTIRGRNLGrRLSDVAHGVWIGGVACEPLPDRytvSEEIVCVTGPAP-GPLSGVVTVNASKE 969
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHnIPGSVPVRTVGLRN 77

                            90
                    ....*....|...
gi 767926138    970 GK---SRDRFSYV 979
Cdd:smart00429   78 GGvpsSPQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1069-1144 9.22e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 9.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQnVSMAVHHIGREptlCKVLN--STLITCPSPGALSNASAPVDFFINGR 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVP---CKVLNvsSTEIVCRTPAAATPGEGPVEVTVDGA 74
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1345-1436 2.23e-12

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 70.53  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgssqAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12790     1 GIPFLDYRTYAMRVLFP------------------------GIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLL 56

                          90
                  ....*....|..
gi 767926138 1425 VFVHALEQQKDF 1436
Cdd:cd12790    57 TFIRTLESQRSF 68
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 891-978 3.92e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.23  E-value: 3.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   891 PEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAhgVWIGGVACEPLpdrYTVSEEIVCVTGP-APGPLSGVVTVNASKE 969
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTVI---SVSSTTIVCTTPPgTSGLVNVSVTVGGGGI 75


                   ....*....
gi 767926138   970 GKSRDRFSY 978
Cdd:pfam01833   76 SSSPLTFTY 84
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 549-601 7.02e-12

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 61.57  E-value: 7.02e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767926138   549 CNVHSTCGDCVGAADAYCGWCALETRCTLQQDCT-NSSQQHFWTSASegpSRCP 601
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGaPEGNCEEWEQAS---SKCP 52
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1345-1436 9.69e-12

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 68.88  E-value: 9.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFpkcsslyeeryvLPSQtlnsQGSSQAQEThpllGEWKIPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12792     1 RIPFLDYKTYTDRVFF------------LPSK----DGANDVMIT----GKLDIPEARRATVEQALNQFSNLLNSKTFLI 60

                          90
                  ....*....|..
gi 767926138 1425 VFVHALEQQKDF 1436
Cdd:cd12792    61 NFIHTLENQRDF 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 981-1065 9.80e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.08  E-value: 9.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   981 PLVHSLEPTMGPKAGGTRITIHGNDLHVGSE-LQVLVNDTdPCTELMRTDTSIACTMPEGAlPAPVPVCVRFERRGCVHG 1059
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSdLKVTIGGT-PCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGISSS 78


                   ....*.
gi 767926138  1060 NLTFWY 1065
Cdd:pfam01833   79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1068-1148 1.18e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 1.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   1068 NPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREptlCKVLN--STLITCPSPGAL-SNASAPVD--FFIN 1142
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAP---CTFSPssSTAIVCKTPPYHnIPGSVPVRtvGLRN 77


                    ....*.
gi 767926138   1143 GRAYAD 1148
Cdd:smart00429   78 GGVPSS 83
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1345-1437 9.64e-11

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 65.72  E-value: 9.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgSSQAQETHPLLgEWKIPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12787     1 GIPFLDYKTYAERVFFP---------------------GHKDGPLDVMI-KLDIPEPRRPTVEQGLYQLSNLLNSKLFLI 58

                          90
                  ....*....|...
gi 767926138 1425 VFVHALEQQKDFA 1437
Cdd:cd12787    59 NFIHTLENQREFS 71
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1069-1144 1.20e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 1.20e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSmaVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGR 1144
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLR--VTFGGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRG 74
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1345-1437 2.63e-10

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 64.28  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnsqgssqAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12793     1 GIPFLDYRMYAERIFFP------------------------GHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLT 56

                          90
                  ....*....|...
gi 767926138 1425 VFVHALEQQKDFA 1437
Cdd:cd12793    57 KFIHTLESQRTFS 69
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1346-1439 2.86e-10

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 64.11  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1346 IPFLEYKHFVTRTFFPKcsslyeeryvlpsqtlnsQGSSQAQETHPllgewkIPESCRPNME-EGISLFSSLLNNKHFLI 1424
Cdd:cd12789     4 VPFLDYKHFALRTFFPE------------------SGGFTHIFTRD------DPHDRDQTDKdESLTALDKLICNKSFLV 59

                          90
                  ....*....|....*
gi 767926138 1425 VFVHALEQQKDFAVQ 1439
Cdd:cd12789    60 TLIHTLEKQKNFSVK 74
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
549-601 3.82e-10

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 56.40  E-value: 3.82e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767926138    549 CNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQhfWTSASegpsrCP 601
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN--WLSGG-----CP 47
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1069-1143 2.96e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 2.96e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926138  1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAvhHIGREPTLCKVLNSTLITCPSPgALSNASAPVDFFING 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKV--TIGGTPCTVISVSSTTIVCTTP-PGTSGLVNVSVTVGG 72
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1345-1437 5.33e-09

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 60.24  E-value: 5.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138 1345 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqtlnSQGSSQAQETHPLLGewkiPESCRPNMEEGISLFSSLLNNKHFLI 1424
Cdd:cd12791     1 GIPFLDYRTYAERVFFP------------------GHGGCPLQPSLEGDG----EEGRRATVEQGLTQLSNLLNSKLFLL 58

                          90
                  ....*....|...
gi 767926138 1425 VFVHALEQQKDFA 1437
Cdd:cd12791    59 TLIHTLEEQPSFS 71
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 53-544 1.40e-08

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 58.97  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   53 FPSPTPTNNFALDGAAGTVYLAAVNRLYQLsGANLSLEAEAAVGPVpDSPLCHAPQLPQASCEHPRRLtDNYNKILQLDP 132
Cdd:cd11248     4 FTADTPIQNIVLNEGSTEVYVAAQNVIYAL-NPDLQKVWEYKTGPV-GSPDCQTCQDCSSGADPGVPK-DTDNMVLVLET 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  133 GQGL-VVVCGSIYQGFCQ---LRRRGNI-SAVAVrfppaappaepvtvfpsMLNVAANHPNASTVGLvlppaAGAGGSRL 207
Cdd:cd11248    81 YYDDyLYSCGSTQNGVCYrhvLEDGADIqSEVHC-----------------LFSKKNNSPSYCPDCV-----ASPLGTKV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  208 LVgaTYTGYGSSFFPRNrSLEDHRFENTPEiaiRSLDTRGDLAKLFTFDlnpSDDNILKIKQGAKEQHKLGFVSAFlhps 287
Cdd:cd11248   139 TN--VESGRTIYFFVAN-SVNSSLAGSFPP---HSISVRRLKEDGFGFL---SDQSYLDVLPSLRDSYPIKYVYSF---- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  288 dpppGAQSYAYLaLNSEARAGDKESQA-RSLLARIC-LPHGAGgdakklteSYIQLGLQCAGGAGRGDLYSRLVSVFP-- 363
Cdd:cd11248   206 ----HSGPFVYF-LTVQRESLTKPSSAfHTRLVRLCsSDSEIW--------RYREMPLECIFTPKRRRRSTEEDVVYNvl 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  364 ------------ARER--------LFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEpapdvvavldSVV 423
Cdd:cd11248   273 qaahvskvgadlADELgasegddiLFGVFARSKPDSGEPMPNSALCAFPIKYVNDAIEKGVEKCCTS----------GLE 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  424 QGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPVF----RAPGLTSVAVASVNNYTAVFLGTVNGRLLKInl 499
Cdd:cd11248   343 HFSGSLCHFQPCPTCPGESSSCEATCKEYRTEVTKPYQRVDLFngqmSNVLLTSILVTTIGNHTVAHLGTSDGRVLQV-- 420

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926138  500 nesmqVVSR--RVVTVAY---GEPVHHVMQFdPADSGYLYLMTSHQMARV 544
Cdd:cd11248   421 -----VLSRsgPIPHVNFsldSQPVSREVAV-LSSNGSLLFVTGDKITKV 464
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
 459-547 1.72e-08

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200507  Cd Length: 401  Bit Score: 58.38  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138  459 PLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGE-PVHHVMQFDPADSGYLYLMT 537
Cdd:cd11246   312 PSNNLTTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEEtPVFYKLVPDPVNNIYIYLTS 391

                          90
                  ....*....|
gi 767926138  538 SHQMARVKVA 547
Cdd:cd11246   392 GNKVRRIPVA 401
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 627-700 3.28e-08

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 52.27  E-value: 3.28e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926138   627 LPSLSGmEMACDYGNNIRTVARVPGPAfghqiAYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRN--IVKANFTIY 700
Cdd:pfam17960   20 LPALSE-GYSCVFGDLTESPATVHDNG-----VKCATPPPSQLPPIPTGQDHVTVKLSLRSSETGvdFASTNFTFY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
711-753 4.16e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 47.92  E-value: 4.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767926138    711 HTACTSCLSAQWP-CFWCSQQHSCVSnQSRCEASPNPTSPQDCP 753
Cdd:smart00423    5 YTSCSECLLARDPyCAWCSSQGRCTS-GERCDSRRQNWLSGGCP 47
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 981-1050 2.20e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 47.31  E-value: 2.20e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926138  981 PLVHSLEPTMGPKAGGTRITIHGNDL--HV-GSELQVLVNDTdPCT---ELMRTDTSIACTM---PEGALPAPVPVCVR 1050
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLglRKnDVRHGVRVGGV-PCNpepPEYSSSEKIVCTTgpaGNPVFNGPVEVTVG 78
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 452-497 1.91e-05

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 46.88  E-value: 1.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767926138   452 HPL--SILQPLKATPVF--RAPGLTSVAVASV----NNYTAVFLGTVNGRLLKI 497
Cdd:pfam01403   97 HPLmdEAVQPVGGRPLLvrTGVRLTSIAVDRVqaldGNYTVLFLGTDDGRLHKV 150
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1069-1143 1.96e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.52  E-value: 1.96e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926138 1069 PVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVhhiGREPTLCKVLNSTLITCPSPGALSNASAPVDFFING 1143
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTV---GGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLIDG 72
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 701-753 2.01e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 43.47  E-value: 2.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926138   701 DCSRtaqvypHTACTSCLSAQWP-CFWCSQQHSCVSNQSRCEASPNP----TSPQDCP 753
Cdd:pfam01437    1 RCSQ------YTSCSSCLAARDPyCGWCSSEGRCVRRSACGAPEGNCeeweQASSKCP 52
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 53-160 7.15e-03

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 40.53  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926138   53 FPSPTPTNNFALDGAAGTVYLAAVNRLYQLsGANLSLEAEAAVGPVpDSPLCHAPQLPQAScEHPRRLTDNYNKILQLDP 132
Cdd:cd11279    23 FSAGSPIQNIVSYEDASAVFVATRNHLHVL-NPELKLLQNLVTGPT-GSPGCQICALCPPG-PPGPSPEDTDNKVLVLDP 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767926138  133 GQGLVVVCGSIYQGFC---QLRRRGNISAVA 160
Cdd:cd11279   100 EEPWLYSCGSSLHGRCflhELESRGSAVHIA 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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