NCBI Conserved Domain Search

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2834-2913

2.18e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 68.29 E-value: 2.18e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2834 PRDLQFSEIGETSAKVSWMPPP---SRVDSFKVSYQLAHGGEPQSVQVDGRARTQ-KLKGLIPGAHYEVTVVSVRGFEES 2909
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 759177740 2910 EPLT 2913
Cdd:cd00063    84 PPSE 87

fn3

Fibronectin type III domain;

1551-1626

3.67e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.67e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1551 GELTVTDVTPDSVSLSWTVPE---GEFDSFIIKYKDRDGQ--PQVVSVAADQLEVTVPGLEPNRKYKFMLFGIQDGRRHG 1625
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   .
gi 759177740  1626 P 1626
Cdd:pfam00041   84 P 84

fn3

Fibronectin type III domain;

1960-2033

3.81e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.81e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1960 PRLGELSVTDTTPDSLHLSWTVPE---GQFEHFLVQYKNGDGQ--PKVVRVPGHEDEVTISGLEPDHKYKMNLYGFHDG 2033
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2731-2813

6.45e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.97 E-value: 6.45e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2731 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRYGVPSSSTLEphprpllqRELTVPGTRHSAALRDLRPGTLYSFT 2807
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPW--------NEITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 759177740  2808 LYGLRG 2813
Cdd:pfam00041   73 VQAVNG 78

fn3

Fibronectin type III domain;

2632-2705

1.52e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 1.52e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  2632 PRLGELAVTDRTPDSLHLSWT---VAQGPFDSFVVQYWDTNGQ--PQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEG 2705
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2081-2151

2.10e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 2.10e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740  2081 GEVNVMDATPDSLHLSWTVPE---GQFDHFLVQYKNGDGQ--PKVVRVPGHEKEVTISGLEPDHKYKMNLYGFHDG 2151
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

812-888

2.55e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 2.55e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   812 PQDLRVVAVTPTTLELSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPAEADGTLLTDLMPGVEYVVTVTAEQGRAVS 886
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740   887 YP 888
Cdd:pfam00041   83 PP 84

fn3

Fibronectin type III domain;

2522-2597

4.00e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 4.00e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2522 PPSRLGelmVTDETPDSLHLSWT---VAQGPIDSFVIQYRDTNGQ--PQAMSMAADQREVTVEGLEPGRKYKFLLYGFIG 2596
Cdd:pfam00041    2 APSNLT---VTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 759177740  2597 G 2597
Cdd:pfam00041   79 G 79

fn3

Fibronectin type III domain;

1448-1528

1.18e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 1.18e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1448 PRLGDMTVTDVTPNSVGLTWTVPE---GQFDSFVVQYKDKDGQ--LQVVPVAADQREATIPGLEPAHKYKMNLYGLHGGQ 1522
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*.
gi 759177740  1523 rVGPLS 1528
Cdd:pfam00041   81 -EGPPS 85

fn3

Fibronectin type III domain;

1031-1109

2.02e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 2.02e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1031 PPRlgELTVTNVTSNSLLLHWTVPE---GEFDSFMIQYKDRNGPQM---VPVEGPQRSALITNLDMGRKYKFVLYGLVGK 1104
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 759177740  1105 KRHGP 1109
Cdd:pfam00041   80 GEGPP 84

fn3

Fibronectin type III domain;

731-800

6.39e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 6.39e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740   731 ETTVRTEWTRAP---GPVDAYEIQFIPTTEGEnTPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTTWGPP 800
Cdd:pfam00041   13 STSLTVSWTPPPdgnGPITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84

fn3

Fibronectin type III domain;

3011-3087

1.10e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.42 E-value: 1.10e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3011 PRDLEAKEVTPRTARLTWIEP---QVPPTGYLLTYDTPGGQT--QEIMLPGGVTSYQLLGLFPSTTYRAWLRAMWGESFT 3085
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740  3086 PP 3087
Cdd:pfam00041   83 PP 84

FN3 super family

cl27307

Fibronectin type 3 domain [General function prediction only];

2889-3079

2.92e-09

Fibronectin type 3 domain [General function prediction only];

The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 2.92e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2889 GLIPGAHYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGTALLHWKPPQAP-VDTYDVKVTAPGAPLLE 2963
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2964 ASAPGSAVDYPLHDLVLHTNYTATVHGLRGPNVTSPAS-----ITFITGLEGPRDLEAKEVTPRTARLTWIE-PQVPPTG 3037
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvvsvTTDLTPPAAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 759177740 3038 YLLTYDT-PGGQTQEIMLPGGVTSYQLLGLFPSTTYRAWLRAM 3079
Cdd:COG3401   358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400

fn3

Fibronectin type III domain;

1233-1302

8.75e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 8.75e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740  1233 GELTVTDVTPDSLHLSWT---VAQGNFDSFMVQYKDAQGQ--PQAVPVSGDKNEVTVRSLESDRKYKMNLYGLHG 1302
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

FN3 super family

cl27307

Fibronectin type 3 domain [General function prediction only];

1490-1912

6.19e-08

Fibronectin type 3 domain [General function prediction only];

The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 6.19e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1490 VVPVAADQREATIPGLEPAHKYKMNLYGLHGGQRVGPLSVIAMTAPllpapvTESPEKPhlGELTVTDVTPDSVSLSWT- 1568
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP------TTPPSAP--TGLTATADTPGSVTLSWDp 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1569 VPEGEFDSFIIKYKDRDGQPQVVSVAADQLEVTVPGLEPNRKYKFMLFGI-QDGRRHGP-VSVEAKTaiqgDTSPGAPPR 1646
Cdd:COG3401   256 VTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsNVVSVTT----DLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1647 lgELWVTDPTLDSLHLSWT-VPEGHFDSFVVQFKDRDGPRMVPV--EGHERSVTITPLDPARKYRFLLygflgkrrhgpl 1723
Cdd:COG3401   332 --GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKV------------ 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1724 tadgttetqSAVGNTGMKRPPKPRLGEELQVTSVTPDSVGLSWTVPEGQFDSFVVQYKDRNGQPQVVPVEGSFKEVSISG 1803
Cdd:COG3401   398 ---------TAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1804 LDPARRYKLLLYGLhEGKRVGPVSTIAVTAPREEIEAETMAPNPPESKPHLGELMVDGVTPYTlhLSWTVTEGEFDSFEI 1883
Cdd:COG3401   469 PFTTTSSTVTATTT-DTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNV--TGASPVTVGASTGDV 545

                         410       420
                  ....*....|....*....|....*....
gi 759177740 1884 QYTDQDGQLQVVSIGGDQNDITLSGLESD 1912
Cdd:COG3401   546 LITDLVSLTTSASSSVSGAGLGSGNLYLI 574

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

528-555

9.77e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 50.37 E-value: 9.77e-08

                           10        20
                   ....*....|....*....|....*...
gi 759177740   528 CPGGCRGRGQCLDGRCVCDDGYSGDDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

fn3

Fibronectin type III domain;

1135-1198

1.15e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 1.15e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1135 VTDPSPDSLLLSWTVPE---GHFDSFMVQYRDRDG--RPQVVPVEGPERSLIVSPLDPDHKYRFTLFGI 1198
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76

fn3

Fibronectin type III domain;

1360-1421

2.35e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 2.35e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740  1360 WTVP---QGHFDSFTIQYKDRDG--RPQVVRVGGEENEVTVQGLEPGRKYKVYLYGLHeGQRVGPMS 1421
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPPS 85

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

342-368

1.28e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 46.91 E-value: 1.28e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   342 CPRDCQGRGRCEDGECICDTGYSGDDC 368
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3 super family

cl27307

Fibronectin type 3 domain [General function prediction only];

2256-2745

1.43e-06

Fibronectin type 3 domain [General function prediction only];

The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 54.24 E-value: 1.43e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2256 RVGPVSTVGVTVPQEVVEETPSAKEPSTEAPESPtepLLGDLTVTGSSPDSLSLSWTVPQGHFDSFTIQ-YKDRSPSGVT 2334
Cdd:COG3401    63 SGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTT---LTGSGSVGGATNTGLTSSDEVPSPAVGTATTAtAVAGGAATAG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2335 PHVEELTVAAVTSNTAHLSWTVAQGPFDSVQCRDAQGqPQAVPVGGDSSYSSVSGMRK-----GMAHSLQMQSSSKEGQR 2409
Cdd:COG3401   140 TYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSA-TAAVATTSLTVTSTTLVDGGgdiepGTTYYYRVAATDTGGES 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2410 PPLPlePLTVFLPDTKLSPLLGeLTVTE*TQDSVGLLWT-VPQGTFNSFVVQYKDRAGQPQVVPEAADQREVTISGLEPN 2488
Cdd:COG3401   219 APSN--EVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNG 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2489 RKCKFLLYGLGGRKQLGPISAEGTMAPPEKEWQPPSrlgELMVTDETPDSLHLSWT-VAQGPIDSFVIqYRDTN--GQPQ 2565
Cdd:COG3401   296 TTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS---GLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTSggGTYT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2566 AMSMAADQREVTVEGLEPGRKYKFLlygfiggqrlgpVSALGVTVPEEDTPAPwhPATEAPEASEGPRLGELAVTDRTPD 2645
Cdd:COG3401   372 KIAETVTTTSYTDTGLTPGTTYYYK------------VTAVDAAGNESAPSEE--VSATTASAASGESLTASVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2646 SLHLSWTVAQGPFDSFVVQYWDTNGQPQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEGKRLGPVSAKGTTGSAPAGQT 2725
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490       500
                  ....*....|....*....|
gi 759177740 2726 PGEPGPRLSQLSVTDVTTSS 2745
Cdd:COG3401   518 AAVGGAPDGTPNVTGASPVT 537

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

280-306

4.24e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 45.75 E-value: 4.24e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   280 CPRGCSQKGRCEDGRCVCDPGYAGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

fn3

Fibronectin type III domain;

2200-2254

1.10e-05

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 1.10e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2200 WTIP---QGHFDSFTIQYKDRDG--RPQVVRAGGEESEVTVRGLEPGHKYKMHLYGLHGG 2254
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

C_rich_MXAN6577 super family

cl49352

MXAN_6577-like cysteine-rich domain;

283-404

2.39e-05

MXAN_6577-like cysteine-rich domain;

The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 46.67 E-value: 2.39e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  283 GCSQKG-RCEDGRCVC-----DPGYAGEDCGSrsCRWDCGEGGRCVDGHCVCWPGYA--GEDC-STRTCPRDCQGRG-RC 352
Cdd:NF041328   13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGaAC 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  353 EDGEcICDTGYSGDDC--GVRSCPGDC----NQRGRCedGSC--VCWPGYTgpdCSARAC 404
Cdd:NF041328   91 APGQ-VCEGGACREACseGLTRCGGACvdlaTDPLHC--GACgvACDPGES---CRGGAC 144

PTZ00214 super family

cl31756

high cysteine membrane protein Group 4; Provisional

266-638

5.18e-05

high cysteine membrane protein Group 4; Provisional

The actual alignment was detected with superfamily member PTZ00214:

Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 49.14 E-value: 5.18e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  266 CNPGYTGEDCgvRSCPRGCSQkgrceDGRCVCDPGYAGEDCGSRSCRwdcgeggrcvdghCVCWPGYAGEDCSTRTCPRD 345
Cdd:PTZ00214  379 CSAGYLGVDG--KSCSESCSG-----DTRGVCTKVAEGSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDS 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  346 CqgrGRCEDG------------------------ECI--CDTGYSGDDCGV-----RSCPgdcnqrgRCEDGSC-----V 389
Cdd:PTZ00214  439 C---AVCKDGtptgcqqcspgkilefsivssesaDCVdqCSVGSECAECGItidgsRYCT-------RCKDASTypfngV 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  390 CWPGyTGPD--CSARA---CPrNCRGRGRCENGVCVCNEGYSGED-CGVRScpedcrgRGRCESGRCVCWPGYTGR--DC 461
Cdd:PTZ00214  509 CIPN-TQRDayCTSTAngaCT-TCSGAAFLMNGGCYTTEHYPGSTiCDKQS-------NGKCTTTKKGYGISPDGKllEC 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  462 GKRACPGDCRGRGRCVdglcvcnpgftgedcgsrRCPGDC---RGRGrCEDGVC----ACDSGY--EGEDCSARSCPGgC 532
Cdd:PTZ00214  580 DPTCLACTAPGPGRCT------------------RCPSDKllkRASG-AATGSCvdpgACVDGYyaDGDACLPCATPG-C 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  533 RGRG------QCLDGRCVCDDGYSgddcsvrrCPHDCSQRGVCQD---GVCTCW--EGYA----GEDCGLRT-CPSNCHR 596
Cdd:PTZ00214  640 KTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWceRGFLpaldRSGCVLPTeCPPDMPS 711

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 759177740  597 RGRC-EDGRCV-CDSGYTGPSCATRTCPADCRGRGRCVQGVCVC 638
Cdd:PTZ00214  712 CAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

249-275

6.86e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 42.29 E-value: 6.86e-05

                           10        20
                   ....*....|....*....|....*..
gi 759177740   249 CPRGCSKKGRCENGRCVCNPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

218-245

6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 39.59 E-value: 6.00e-04

                           10        20
                   ....*....|....*....|....*...
gi 759177740   218 CPGDCHGRGRCVQGVCVCRAGFSGNDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

190-213

1.50e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.50e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

657-684

6.86e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 36.51 E-value: 6.86e-03

                           10        20
                   ....*....|....*....|....*...
gi 759177740   657 CPGGCGPRALCRTGQCVCVEGFRGPDCA 684
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_Tenascin super family

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

688-714

7.35e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934 Cd Length: 29 Bit Score: 36.51 E-value: 7.35e-03

                           10        20
                   ....*....|....*....|....*..
gi 759177740   688 CPGDCQGRGECREGSCVCQDGFAGEDC 714
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

Name

Accession

Description

Interval

E-value

Fibrinogen_C

pfam00147

Fibrinogen beta and gamma chains, C-terminal globular domain;

3101-3310

6.33e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;

Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 369.54 E-value: 6.33e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3101 FPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNIS-GEFWLGN 3179
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3180 EALHSLTKTGDYSMRVDLRAG-DEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3251
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 759177740  3252 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221

FBG

smart00186

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...

3101-3310

1.43e-111

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.

Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 353.89 E-value: 1.43e-111

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   3101 FPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNISGEFWLGNE 3180
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   3181 ALHSLTKTGDYSMRVDLR-AGDEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 3258
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 759177740   3259 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212

FReD

cd00087

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...

3100-3310

1.38e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.

Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 348.46 E-value: 1.38e-109

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3100 PFPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNISGEFWLGN 3179
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3180 EALHSLTKTGDYSMRVDLR-AGDEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 3258
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740 3259 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2834-2913

2.18e-13

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 68.29 E-value: 2.18e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2834 PRDLQFSEIGETSAKVSWMPPP---SRVDSFKVSYQLAHGGEPQSVQVDGRARTQ-KLKGLIPGAHYEVTVVSVRGFEES 2909
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 759177740 2910 EPLT 2913
Cdd:cd00063    84 PPSE 87

fn3

Fibronectin type III domain;

2833-2911

2.82e-13

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 67.83 E-value: 2.82e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2833 SPRDLQFSEIGETSAKVSWMPPPSR---VDSFKVSYQLA-HGGEPQSVQVDGRARTQKLKGLIPGAHYEVTVVSVRGFEE 2908
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 759177740  2909 SEP 2911
Cdd:pfam00041   82 GPP 84

fn3

Fibronectin type III domain;

1551-1626

3.67e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.67e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1551 GELTVTDVTPDSVSLSWTVPE---GEFDSFIIKYKDRDGQ--PQVVSVAADQLEVTVPGLEPNRKYKFMLFGIQDGRRHG 1625
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   .
gi 759177740  1626 P 1626
Cdd:pfam00041   84 P 84

fn3

Fibronectin type III domain;

1960-2033

3.81e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.81e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1960 PRLGELSVTDTTPDSLHLSWTVPE---GQFEHFLVQYKNGDGQ--PKVVRVPGHEDEVTISGLEPDHKYKMNLYGFHDG 2033
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2731-2813

6.45e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.97 E-value: 6.45e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2731 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRYGVPSSSTLEphprpllqRELTVPGTRHSAALRDLRPGTLYSFT 2807
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPW--------NEITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 759177740  2808 LYGLRG 2813
Cdd:pfam00041   73 VQAVNG 78

fn3

Fibronectin type III domain;

2632-2705

1.52e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 1.52e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  2632 PRLGELAVTDRTPDSLHLSWT---VAQGPFDSFVVQYWDTNGQ--PQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEG 2705
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2081-2151

2.10e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 2.10e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740  2081 GEVNVMDATPDSLHLSWTVPE---GQFDHFLVQYKNGDGQ--PKVVRVPGHEKEVTISGLEPDHKYKMNLYGFHDG 2151
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

812-888

2.55e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 2.55e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   812 PQDLRVVAVTPTTLELSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPAEADGTLLTDLMPGVEYVVTVTAEQGRAVS 886
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740   887 YP 888
Cdd:pfam00041   83 PP 84

fn3

Fibronectin type III domain;

2522-2597

4.00e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 4.00e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2522 PPSRLGelmVTDETPDSLHLSWT---VAQGPIDSFVIQYRDTNGQ--PQAMSMAADQREVTVEGLEPGRKYKFLLYGFIG 2596
Cdd:pfam00041    2 APSNLT---VTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 759177740  2597 G 2597
Cdd:pfam00041   79 G 79

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1545-1613

6.33e-11

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 6.33e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740 1545 PEKPhlGELTVTDVTPDSVSLSWTVPE---GEFDSFIIKYKDRDGQP--QVVSVAADQLEVTVPGLEPNRKYKF 1613
Cdd:cd00063     1 PSPP--TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72

fn3

Fibronectin type III domain;

1448-1528

1.18e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 1.18e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1448 PRLGDMTVTDVTPNSVGLTWTVPE---GQFDSFVVQYKDKDGQ--LQVVPVAADQREATIPGLEPAHKYKMNLYGLHGGQ 1522
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*.
gi 759177740  1523 rVGPLS 1528
Cdd:pfam00041   81 -EGPPS 85

fn3

Fibronectin type III domain;

1031-1109

2.02e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 2.02e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1031 PPRlgELTVTNVTSNSLLLHWTVPE---GEFDSFMIQYKDRNGPQM---VPVEGPQRSALITNLDMGRKYKFVLYGLVGK 1104
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 759177740  1105 KRHGP 1109
Cdd:pfam00041   80 GEGPP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1545-1613

4.21e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.78 E-value: 4.21e-10

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740   1545 PEKPhlGELTVTDVTPDSVSLSWTVPE-----GEFDSFIIKYKDRDGQPQVVSVAADQLEVTVPGLEPNRKYKF 1613
Cdd:smart00060    1 PSPP--SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

fn3

Fibronectin type III domain;

731-800

6.39e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 6.39e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740   731 ETTVRTEWTRAP---GPVDAYEIQFIPTTEGEnTPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTTWGPP 800
Cdd:pfam00041   13 STSLTVSWTPPPdgnGPITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84

fn3

Fibronectin type III domain;

3011-3087

1.10e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.42 E-value: 1.10e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3011 PRDLEAKEVTPRTARLTWIEP---QVPPTGYLLTYDTPGGQT--QEIMLPGGVTSYQLLGLFPSTTYRAWLRAMWGESFT 3085
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740  3086 PP 3087
Cdd:pfam00041   83 PP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2833-2909

1.62e-09

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.85 E-value: 1.62e-09

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   2833 SPRDLQFSEIGETSAKVSWMPPPS-RVDSFKVSYQLAHGGEP---QSVQVDGRARTQKLKGLIPGAHYEVTVVSVRGFEE 2908
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 759177740   2909 S 2909
Cdd:smart00060   83 G 83

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

810-890

1.74e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 1.74e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  810 DGPQDLRVVAVTPTTLELSWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPAEADGT--LLTDLMPGVEYVVTVTAEQGRA 884
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 759177740  885 VSYPAS 890
Cdd:cd00063    82 ESPPSE 87

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1965-2045

1.90e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 1.90e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1965 LSVTDTTPDSLHLSWTVPE---GQFEHFLVQYKNGDGQP--KVVRVPGHEDEVTISGLEPDHKYKMNLYGFHDGQRQGPV 2039
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 759177740 2040 SAIGVT 2045
Cdd:cd00063    87 ESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2523-2604

2.10e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 2.10e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2523 PSRLGELMVTDETPDSLHLSWTVAQ---GPIDSFVIQYRDTNGQP--QAMSMAADQREVTVEGLEPGRKYKFLLYGFIGG 2597
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ....*..
gi 759177740 2598 QRlGPVS 2604
Cdd:cd00063    81 GE-SPPS 86

FN3

Fibronectin type 3 domain [General function prediction only];

2889-3079

2.92e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 2.92e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2889 GLIPGAHYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGTALLHWKPPQAP-VDTYDVKVTAPGAPLLE 2963
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2964 ASAPGSAVDYPLHDLVLHTNYTATVHGLRGPNVTSPAS-----ITFITGLEGPRDLEAKEVTPRTARLTWIE-PQVPPTG 3037
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvvsvTTDLTPPAAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 759177740 3038 YLLTYDT-PGGQTQEIMLPGGVTSYQLLGLFPSTTYRAWLRAM 3079
Cdd:COG3401   358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1445-1528

3.48e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 3.48e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1445 PLKPRlgDMTVTDVTPNSVGLTWTVPE---GQFDSFVVQYKDKDGQ--LQVVPVAADQREATIPGLEPAHKYKMNLYGLH 1519
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*....
gi 759177740 1520 GGQRvGPLS 1528
Cdd:cd00063    79 GGGE-SPPS 86

FN3

Fibronectin type 3 domain [General function prediction only];

732-925

3.49e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 3.49e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  732 TTVRTEWTRAPGP-VDAYEIQFIPTTEGentPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTTWGPPASKTITTM 808
Cdd:COG3401   247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  809 I---DGPQDLRVVAVTPTTLELSW-LRPQAEVDRFVVsYVSAGNQRVRLEVPAEADGTLLTD--LMPGVEYVVTVTA--E 880
Cdd:COG3401   324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 759177740  881 QGRAVSYPASVRANTGSSPLGllEATDEPPPSGPSTTQGAQAPGL 925
Cdd:COG3401   403 AGNESAPSEEVSATTASAASG--ESLTASVDAVPLTDVAGATAAA 445

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

810-880

4.21e-09

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 4.21e-09

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740    810 DGPQDLRVVAVTPTTLELSWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPAEADGTLLTDLMPGVEYVVTVTAE 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77

fn3

Fibronectin type III domain;

1233-1302

8.75e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 8.75e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740  1233 GELTVTDVTPDSLHLSWT---VAQGNFDSFMVQYKDAQGQ--PQAVPVSGDKNEVTVRSLESDRKYKMNLYGLHG 1302
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2083-2163

1.74e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.42 E-value: 1.74e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2083 VNVMDATPDSLHLSWTVPE---GQFDHFLVQYKNGDGQP--KVVRVPGHEKEVTISGLEPDHKYKMNLYGFHDGQRQGPV 2157
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 759177740 2158 SAIGVT 2163
Cdd:cd00063    87 ESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1031-1099

1.83e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.42 E-value: 1.83e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740 1031 PPRLGELTVTNVTSNSLLLHWTVPE---GEFDSFMIQYKDRNGPQMVPVE---GPQRSALITNLDMGRKYKFVLY 1099
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

3011-3078

2.24e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.77 E-value: 2.24e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740   3011 PRDLEAKEVTPRTARLTWIEPQVPP-----TGYLLTYDTPGGQTQEIMLPGGVTSYQLLGLFPSTTYRAWLRA 3078
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1445-1516

2.70e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 2.70e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740   1445 PLKPRlgDMTVTDVTPNSVGLTWTVPE-----GQFDSFVVQYKDKDGQLQVVPVAADQREATIPGLEPAHKYKMNLY 1516
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

3011-3094

3.15e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.65 E-value: 3.15e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3011 PRDLEAKEVTPRTARLTWIEPQ---VPPTGYLLTY-DTPGGQTQEIML-PGGVTSYQLLGLFPSTTYRAWLRAM--WGES 3083
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVngGGES 83

                          90
                  ....*....|.
gi 759177740 3084 fTPPMSTFFTT 3094
Cdd:cd00063    84 -PPSESVTVTT 93

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2523-2589

3.44e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 3.44e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 759177740   2523 PSRLGELMVTDETPDSLHLSWT-----VAQGPIDSFVIQYRDTNGQPQAMSMAADQREVTVEGLEPGRKYKF 2589
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2637-2700

4.94e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.88 E-value: 4.94e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740 2637 LAVTDRTPDSLHLSWTVAQ---GPFDSFVVQYWDTNGQP--QALLVGGDQNKVIVSGLEPSTLYKFSLY 2700
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2726-2809

5.09e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.62 E-value: 5.09e-08

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   2726 PGEPgprlSQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRYgvpsssTLEPHPRPLLQRELTVPGTRHSAALRDLRPGTLY 2804
Cdd:smart00060    1 PSPP----SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEY 70


                    ....*
gi 759177740   2805 SFTLY 2809
Cdd:smart00060   71 EFRVR 75

FN3

Fibronectin type 3 domain [General function prediction only];

1490-1912

6.19e-08

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 6.19e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1490 VVPVAADQREATIPGLEPAHKYKMNLYGLHGGQRVGPLSVIAMTAPllpapvTESPEKPhlGELTVTDVTPDSVSLSWT- 1568
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP------TTPPSAP--TGLTATADTPGSVTLSWDp 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1569 VPEGEFDSFIIKYKDRDGQPQVVSVAADQLEVTVPGLEPNRKYKFMLFGI-QDGRRHGP-VSVEAKTaiqgDTSPGAPPR 1646
Cdd:COG3401   256 VTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsNVVSVTT----DLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1647 lgELWVTDPTLDSLHLSWT-VPEGHFDSFVVQFKDRDGPRMVPV--EGHERSVTITPLDPARKYRFLLygflgkrrhgpl 1723
Cdd:COG3401   332 --GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKV------------ 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1724 tadgttetqSAVGNTGMKRPPKPRLGEELQVTSVTPDSVGLSWTVPEGQFDSFVVQYKDRNGQPQVVPVEGSFKEVSISG 1803
Cdd:COG3401   398 ---------TAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1804 LDPARRYKLLLYGLhEGKRVGPVSTIAVTAPREEIEAETMAPNPPESKPHLGELMVDGVTPYTlhLSWTVTEGEFDSFEI 1883
Cdd:COG3401   469 PFTTTSSTVTATTT-DTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNV--TGASPVTVGASTGDV 545

                         410       420
                  ....*....|....*....|....*....
gi 759177740 1884 QYTDQDGQLQVVSIGGDQNDITLSGLESD 1912
Cdd:COG3401   546 LITDLVSLTTSASSSVSGAGLGSGNLYLI 574

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1957-2028

8.88e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 8.88e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740   1957 PIKPRlgELSVTDTTPDSLHLSWTVPE-----GQFEHFLVQYKNGDGQPKVVRVPGHEDEVTISGLEPDHKYKMNLY 2028
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

528-555

9.77e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 50.37 E-value: 9.77e-08

                           10        20
                   ....*....|....*....|....*...
gi 759177740   528 CPGGCRGRGQCLDGRCVCDDGYSGDDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

719-807

1.03e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.11 E-value: 1.03e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  719 PAIESMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPTTEGENTPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 795
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 759177740  796 TWGPPA-SKTITT 807
Cdd:cd00063    81 GESPPSeSVTVTT 93

fn3

Fibronectin type III domain;

1135-1198

1.15e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 1.15e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1135 VTDPSPDSLLLSWTVPE---GHFDSFMVQYRDRDG--RPQVVPVEGPERSLIVSPLDPDHKYRFTLFGI 1198
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2637-2700

1.21e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.46 E-value: 1.21e-07

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   2637 LAVTDRTPDSLHLSWT-----VAQGPFDSFVVQYWDTNGQPQALLVGGDQNKVIVSGLEPSTLYKFSLY 2700
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

fn3

Fibronectin type III domain;

1642-1709

1.33e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 1.33e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740  1642 GAPPRLGelwVTDPTLDSLHLSWTVPE---GHFDSFVVQFKDRDGP---RMVPVEGHERSVTITPLDPARKYRF 1709
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepwNEITVPGTTTSVTLTGLKPGTEYEV 71

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1133-1206

1.97e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 1.97e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740 1133 LWVTDPSPDSLLLSWTVPE---GHFDSFMVQYRDRDGRP--QVVPVEGPERSLIVSPLDPDHKYRFTLFGIaNKKRHGP 1206
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1122-1195

2.00e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.08 E-value: 2.00e-07

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   1122 PSPATTPRlgmlwVTDPSPDSLLLSWTVPE-----GHFDSFMVQYRDRDGRPQVVPVEGPERSLIVSPLDPDHKYRFTL 1195
Cdd:smart00060    1 PSPPSNLR-----VTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

fn3

Fibronectin type III domain;

1360-1421

2.35e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 2.35e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740  1360 WTVP---QGHFDSFTIQYKDRDG--RPQVVRVGGEENEVTVQGLEPGRKYKVYLYGLHeGQRVGPMS 1421
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPPS 85

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1743-1832

2.75e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.96 E-value: 2.75e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1743 PPKPRlgeELQVTSVTPDSVGLSWTVPE---GQFDSFVVQYKDRNGQP--QVVPVEGSFKEVSISGLDPARRYKLLLYGL 1817
Cdd:cd00063     1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*
gi 759177740 1818 HEGKRVGPVSTIAVT 1832
Cdd:cd00063    78 NGGGESPPSESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1028-1096

6.09e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.54 E-value: 6.09e-07

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1028 PLAPPRLgelTVTNVTSNSLLLHWTVPEGE-FDSFMIQYKDRNGP-----QMVPVEGPQRSALITNLDMGRKYKF 1096
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2726-2809

8.61e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.42 E-value: 8.61e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2726 PGEPgprlSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRYGVPSSSTLEPHPrpllqrelTVPGTRHSAALRDLRPGT 2802
Cdd:cd00063     1 PSPP----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVE--------VTPGSETSYTLTGLKPGT 68


                  ....*..
gi 759177740 2803 LYSFTLY 2809
Cdd:cd00063    69 EYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1224-1315

1.14e-06

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.03 E-value: 1.14e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1224 PEPPEQpllgeLTVTDVTPDSLHLSWTVAQ---GNFDSFMVQYKDAQGQP--QAVPVSGDKNEVTVRSLESDRKYKMNLY 1298
Cdd:cd00063     1 PSPPTN-----LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*..
gi 759177740 1299 GLHGRQRVGPVSVVATT 1315
Cdd:cd00063    76 AVNGGGESPPSESVTVT 92

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

342-368

1.28e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 46.91 E-value: 1.28e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   342 CPRDCQGRGRCEDGECICDTGYSGDDC 368
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2083-2146

1.34e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.76 E-value: 1.34e-06

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   2083 VNVMDATPDSLHLSWTVPE-----GQFDHFLVQYKNGDGQPKVVRVPGHEKEVTISGLEPDHKYKMNLY 2146
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain [General function prediction only];

2256-2745

1.43e-06

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 54.24 E-value: 1.43e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2256 RVGPVSTVGVTVPQEVVEETPSAKEPSTEAPESPtepLLGDLTVTGSSPDSLSLSWTVPQGHFDSFTIQ-YKDRSPSGVT 2334
Cdd:COG3401    63 SGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTT---LTGSGSVGGATNTGLTSSDEVPSPAVGTATTAtAVAGGAATAG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2335 PHVEELTVAAVTSNTAHLSWTVAQGPFDSVQCRDAQGqPQAVPVGGDSSYSSVSGMRK-----GMAHSLQMQSSSKEGQR 2409
Cdd:COG3401   140 TYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSA-TAAVATTSLTVTSTTLVDGGgdiepGTTYYYRVAATDTGGES 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2410 PPLPlePLTVFLPDTKLSPLLGeLTVTE*TQDSVGLLWT-VPQGTFNSFVVQYKDRAGQPQVVPEAADQREVTISGLEPN 2488
Cdd:COG3401   219 APSN--EVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNG 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2489 RKCKFLLYGLGGRKQLGPISAEGTMAPPEKEWQPPSrlgELMVTDETPDSLHLSWT-VAQGPIDSFVIqYRDTN--GQPQ 2565
Cdd:COG3401   296 TTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS---GLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTSggGTYT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2566 AMSMAADQREVTVEGLEPGRKYKFLlygfiggqrlgpVSALGVTVPEEDTPAPwhPATEAPEASEGPRLGELAVTDRTPD 2645
Cdd:COG3401   372 KIAETVTTTSYTDTGLTPGTTYYYK------------VTAVDAAGNESAPSEE--VSATTASAASGESLTASVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2646 SLHLSWTVAQGPFDSFVVQYWDTNGQPQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEGKRLGPVSAKGTTGSAPAGQT 2725
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490       500
                  ....*....|....*....|
gi 759177740 2726 PGEPGPRLSQLSVTDVTTSS 2745
Cdd:COG3401   518 AAVGGAPDGTPNVTGASPVT 537

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1743-1812

2.88e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 2.88e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1743 PPKPRlgeELQVTSVTPDSVGLSWTVPE-----GQFDSFVVQYKDRNGQPQVVPVEGSFKEVSISGLDPARRYKL 1812
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1224-1298

3.47e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 3.47e-06

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   1224 PEPPEqpllgELTVTDVTPDSLHLSWTVAQGN-----FDSFMVQYKDAQGQPQAVPVSGDKNEVTVRSLESDRKYKMNLY 1298
Cdd:smart00060    1 PSPPS-----NLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

280-306

4.24e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 45.75 E-value: 4.24e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   280 CPRGCSQKGRCEDGRCVCDPGYAGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

fn3

Fibronectin type III domain;

2923-2993

9.01e-06

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 9.01e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740  2923 PTQLRALNLTEGTALLHWKPP---QAPVDTYDVKVTAPGA--PLLEASAPGSAVDYPLHDLVLHTNYTATVHGLRG 2993
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

fn3

Fibronectin type III domain;

2200-2254

1.10e-05

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 1.10e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2200 WTIP---QGHFDSFTIQYKDRDG--RPQVVRAGGEESEVTVRGLEPGHKYKMHLYGLHGG 2254
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

283-404

2.39e-05

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 46.67 E-value: 2.39e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  283 GCSQKG-RCEDGRCVC-----DPGYAGEDCGSrsCRWDCGEGGRCVDGHCVCWPGYA--GEDC-STRTCPRDCQGRG-RC 352
Cdd:NF041328   13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGaAC 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  353 EDGEcICDTGYSGDDC--GVRSCPGDC----NQRGRCedGSC--VCWPGYTgpdCSARAC 404
Cdd:NF041328   91 APGQ-VCEGGACREACseGLTRCGGACvdlaTDPLHC--GACgvACDPGES---CRGGAC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2920-3006

4.35e-05

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 4.35e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2920 PDGPTQLRALNLTEGTALLHWKPPQ---APVDTYDVKVTAPGAPLLE--ASAPGSAVDYPLHDLVLHTNYTATVHGLRGP 2994
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 759177740 2995 NVTSPA-SITFIT 3006
Cdd:cd00063    81 GESPPSeSVTVTT 93

PTZ00214

high cysteine membrane protein Group 4; Provisional

266-638

5.18e-05

high cysteine membrane protein Group 4; Provisional

Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 49.14 E-value: 5.18e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  266 CNPGYTGEDCgvRSCPRGCSQkgrceDGRCVCDPGYAGEDCGSRSCRwdcgeggrcvdghCVCWPGYAGEDCSTRTCPRD 345
Cdd:PTZ00214  379 CSAGYLGVDG--KSCSESCSG-----DTRGVCTKVAEGSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDS 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  346 CqgrGRCEDG------------------------ECI--CDTGYSGDDCGV-----RSCPgdcnqrgRCEDGSC-----V 389
Cdd:PTZ00214  439 C---AVCKDGtptgcqqcspgkilefsivssesaDCVdqCSVGSECAECGItidgsRYCT-------RCKDASTypfngV 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  390 CWPGyTGPD--CSARA---CPrNCRGRGRCENGVCVCNEGYSGED-CGVRScpedcrgRGRCESGRCVCWPGYTGR--DC 461
Cdd:PTZ00214  509 CIPN-TQRDayCTSTAngaCT-TCSGAAFLMNGGCYTTEHYPGSTiCDKQS-------NGKCTTTKKGYGISPDGKllEC 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  462 GKRACPGDCRGRGRCVdglcvcnpgftgedcgsrRCPGDC---RGRGrCEDGVC----ACDSGY--EGEDCSARSCPGgC 532
Cdd:PTZ00214  580 DPTCLACTAPGPGRCT------------------RCPSDKllkRASG-AATGSCvdpgACVDGYyaDGDACLPCATPG-C 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  533 RGRG------QCLDGRCVCDDGYSgddcsvrrCPHDCSQRGVCQD---GVCTCW--EGYA----GEDCGLRT-CPSNCHR 596
Cdd:PTZ00214  640 KTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWceRGFLpaldRSGCVLPTeCPPDMPS 711

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 759177740  597 RGRC-EDGRCV-CDSGYTGPSCATRTCPADCRGRGRCVQGVCVC 638
Cdd:PTZ00214  712 CAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

249-275

6.86e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 42.29 E-value: 6.86e-05

                           10        20
                   ....*....|....*....|....*..
gi 759177740   249 CPRGCSKKGRCENGRCVCNPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

497-524

8.68e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 41.90 E-value: 8.68e-05

                           10        20
                   ....*....|....*....|....*...
gi 759177740   497 CPGDCRGRGRCEDGVCACDSGYEGEDCS 524
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2920-2988

1.81e-04

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.60 E-value: 1.81e-04

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740   2920 PDGPTQLRALNLTEGTALLHWKPPQ-----APVDTYDVKVTAPGAPLLEASAPGSAVDYPLHDLVLHTNYTATV 2988
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

fn3

Fibronectin type III domain;

2431-2490

1.89e-04

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 42.79 E-value: 1.89e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740  2431 GELTVTE*TQDSVGLLWTVP---QGTFNSFVVQYK--DRAGQPQVVPEAADQREVTISGLEPNRK 2490
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTE 68

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

538-672

4.37e-04

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.21 E-value: 4.37e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  538 CLDGRCVCDDGYS--GDDCSVRR--------CPHDCSQRGVCQDGVCTCWEGyaGEDCG-----LRTCPSNCHRRG-RCE 601
Cdd:NF041328   14 CPEPGAVCPEGLSvcGGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGACGaACA 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759177740  602 DGRcVCDSGytgpSCAtRTCPAdcrGRGRCvQGVCVCHAgYSGEDCGqeeppasACPGGCGPRALCRTGQC 672
Cdd:NF041328   92 PGQ-VCEGG----ACR-EACSE---GLTRC-GGACVDLA-TDPLHCG-------ACGVACDPGESCRGGAC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2433-2493

5.96e-04

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 41.33 E-value: 5.96e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740 2433 LTVTE*TQDSVGLLWTVPQ---GTFNSFVVQYKDRAGQP--QVVPEAADQREVTISGLEPNRKCKF 2493
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

218-245

6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.59 E-value: 6.00e-04

                           10        20
                   ....*....|....*....|....*...
gi 759177740   218 CPGDCHGRGRCVQGVCVCRAGFSGNDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2433-2493

9.19e-04

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.68 E-value: 9.19e-04

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740   2433 LTVTE*TQDSVGLLWTVPQGTFN-----SFVVQYKDRAGQPQVVPEAADQREVTISGLEPNRKCKF 2493
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGItgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

719-798

1.05e-03

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 1.05e-03

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740    719 PAIESMRMHLLEETTVRTEWTRAPGP-VDAYEIQFIPTTEGENTPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTT 796
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 759177740    797 WG 798
Cdd:smart00060   82 EG 83

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

373-400

1.32e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.43 E-value: 1.32e-03

                           10        20
                   ....*....|....*....|....*...
gi 759177740   373 CPGDCNQRGRCEDGSCVCWPGYTGPDCS 400
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

190-213

1.50e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.50e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

GGGWT_bact

NF040941

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...

3130-3144

1.54e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.

Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 38.70 E-value: 1.54e-03

                          10
                  ....*....|....*
gi 759177740 3130 PLNVFCDMETDGGGW 3144
Cdd:NF040941   29 PFQVYCDMTTDGGGW 43

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

248-383

2.60e-03

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 2.60e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  248 SCPRGCSkkgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQKGRCEDGRCVCDPGyaGEDCgsrscrwdcgeGGRCVD---- 323
Cdd:NF041328   20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVAC-----------GGACVDtasd 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  324 -GHC-----VCWPGYAgedCSTRTCPRDC-QGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 383
Cdd:NF041328   80 pAHCgacgaACAPGQV---CEGGACREACsEGLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1360-1427

2.65e-03

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.79 E-value: 2.65e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740 1360 WTVPQ---GHFDSFTIQYKDRDGRP--QVVRVGGEENEVTVQGLEPGRKYKVYLYGLHEGQRvGPMSTVGPST 1427
Cdd:cd00063    21 WTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPPSESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1360-1409

3.41e-03

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.13 E-value: 3.41e-03

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1360 WTVPQ-----GHFDSFTIQYKDRDGRPQVVRVGGEENEVTVQGLEPGRKYKVYLY 1409
Cdd:smart00060   21 WEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

563-703

3.70e-03

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.70e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  563 CSQRG-VCQDGVCTCwegyaGEDC-GLRTCPSNChrrGRCEDgrcVCDSGytgpscatrtcpadcrgrGRCVQGVCVCHA 640
Cdd:NF041328   14 CPEPGaVCPEGLSVC-----GGACvDLRSDPSNC---GACGV---ACGAG------------------QTCVAGACGCGP 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  641 GysGEDCGQE-----EPPAS--ACPGGCGPRALCRTGQC--VCVEGFR--GPDCA-IRTCPGDCQ------GRGE-CREG 701
Cdd:NF041328   65 G--TVACGGAcvdtaSDPAHcgACGAACAPGQVCEGGACreACSEGLTrcGGACVdLATDPLHCGacgvacDPGEsCRGG 142


                  ..
gi 759177740  702 SC 703
Cdd:NF041328  143 AC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2200-2267

6.26e-03

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 38.63 E-value: 6.26e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740 2200 WTIPQ---GHFDSFTIQYKDRDGRP--QVVRAGGEESEVTVRGLEPGHKYKMHLYGLHGGRRVGPVSTVGVTV 2267
Cdd:cd00063    21 WTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

657-684

6.86e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.51 E-value: 6.86e-03

                           10        20
                   ....*....|....*....|....*...
gi 759177740   657 CPGGCGPRALCRTGQCVCVEGFRGPDCA 684
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

688-714

7.35e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.51 E-value: 7.35e-03

                           10        20
                   ....*....|....*....|....*..
gi 759177740   688 CPGDCQGRGECREGSCVCQDGFAGEDC 714
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

Name

Accession

Description

Interval

E-value

Fibrinogen_C

pfam00147

Fibrinogen beta and gamma chains, C-terminal globular domain;

3101-3310

6.33e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;

Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 369.54 E-value: 6.33e-117

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3101 FPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNIS-GEFWLGN 3179
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3180 EALHSLTKTGDYSMRVDLRAG-DEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3251
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 759177740  3252 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221

FBG

smart00186

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...

3101-3310

1.43e-111

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.

Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 353.89 E-value: 1.43e-111

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   3101 FPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNISGEFWLGNE 3180
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   3181 ALHSLTKTGDYSMRVDLR-AGDEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 3258
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 759177740   3259 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212

FReD

cd00087

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...

3100-3310

1.38e-109

Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 348.46 E-value: 1.38e-109

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3100 PFPRDCGEEMQNGAGHSRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGHTDFWRDWEDYAHGFGNISGEFWLGN 3179
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3180 EALHSLTKTGDYSMRVDLR-AGDEAVFAQYDSFRVDSAADYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 3258
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740 3259 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYHWKGFEFSVPFTEMKLRPR 3310
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2834-2913

2.18e-13

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 68.29 E-value: 2.18e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2834 PRDLQFSEIGETSAKVSWMPPP---SRVDSFKVSYQLAHGGEPQSVQVDGRARTQ-KLKGLIPGAHYEVTVVSVRGFEES 2909
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 759177740 2910 EPLT 2913
Cdd:cd00063    84 PPSE 87

fn3

Fibronectin type III domain;

2833-2911

2.82e-13

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 67.83 E-value: 2.82e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2833 SPRDLQFSEIGETSAKVSWMPPPSR---VDSFKVSYQLA-HGGEPQSVQVDGRARTQKLKGLIPGAHYEVTVVSVRGFEE 2908
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 759177740  2909 SEP 2911
Cdd:pfam00041   82 GPP 84

fn3

Fibronectin type III domain;

1551-1626

3.67e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.67e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1551 GELTVTDVTPDSVSLSWTVPE---GEFDSFIIKYKDRDGQ--PQVVSVAADQLEVTVPGLEPNRKYKFMLFGIQDGRRHG 1625
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   .
gi 759177740  1626 P 1626
Cdd:pfam00041   84 P 84

fn3

Fibronectin type III domain;

1960-2033

3.81e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 64.36 E-value: 3.81e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1960 PRLGELSVTDTTPDSLHLSWTVPE---GQFEHFLVQYKNGDGQ--PKVVRVPGHEDEVTISGLEPDHKYKMNLYGFHDG 2033
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2731-2813

6.45e-12

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.97 E-value: 6.45e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2731 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRYGVPSSSTLEphprpllqRELTVPGTRHSAALRDLRPGTLYSFT 2807
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPW--------NEITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 759177740  2808 LYGLRG 2813
Cdd:pfam00041   73 VQAVNG 78

fn3

Fibronectin type III domain;

2632-2705

1.52e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.82 E-value: 1.52e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  2632 PRLGELAVTDRTPDSLHLSWT---VAQGPFDSFVVQYWDTNGQ--PQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEG 2705
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

2081-2151

2.10e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 2.10e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740  2081 GEVNVMDATPDSLHLSWTVPE---GQFDHFLVQYKNGDGQ--PKVVRVPGHEKEVTISGLEPDHKYKMNLYGFHDG 2151
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

fn3

Fibronectin type III domain;

812-888

2.55e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.05 E-value: 2.55e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   812 PQDLRVVAVTPTTLELSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPAEADGTLLTDLMPGVEYVVTVTAEQGRAVS 886
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740   887 YP 888
Cdd:pfam00041   83 PP 84

fn3

Fibronectin type III domain;

2522-2597

4.00e-11

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 4.00e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2522 PPSRLGelmVTDETPDSLHLSWT---VAQGPIDSFVIQYRDTNGQ--PQAMSMAADQREVTVEGLEPGRKYKFLLYGFIG 2596
Cdd:pfam00041    2 APSNLT---VTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 759177740  2597 G 2597
Cdd:pfam00041   79 G 79

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1545-1613

6.33e-11

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 6.33e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740 1545 PEKPhlGELTVTDVTPDSVSLSWTVPE---GEFDSFIIKYKDRDGQP--QVVSVAADQLEVTVPGLEPNRKYKF 1613
Cdd:cd00063     1 PSPP--TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72

fn3

Fibronectin type III domain;

1448-1528

1.18e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.12 E-value: 1.18e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1448 PRLGDMTVTDVTPNSVGLTWTVPE---GQFDSFVVQYKDKDGQ--LQVVPVAADQREATIPGLEPAHKYKMNLYGLHGGQ 1522
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*.
gi 759177740  1523 rVGPLS 1528
Cdd:pfam00041   81 -EGPPS 85

fn3

Fibronectin type III domain;

1031-1109

2.02e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 2.02e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  1031 PPRlgELTVTNVTSNSLLLHWTVPE---GEFDSFMIQYKDRNGPQM---VPVEGPQRSALITNLDMGRKYKFVLYGLVGK 1104
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 759177740  1105 KRHGP 1109
Cdd:pfam00041   80 GEGPP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1545-1613

4.21e-10

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 58.78 E-value: 4.21e-10

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740   1545 PEKPhlGELTVTDVTPDSVSLSWTVPE-----GEFDSFIIKYKDRDGQPQVVSVAADQLEVTVPGLEPNRKYKF 1613
Cdd:smart00060    1 PSPP--SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

fn3

Fibronectin type III domain;

731-800

6.39e-10

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.20 E-value: 6.39e-10

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740   731 ETTVRTEWTRAP---GPVDAYEIQFIPTTEGEnTPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTTWGPP 800
Cdd:pfam00041   13 STSLTVSWTPPPdgnGPITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84

fn3

Fibronectin type III domain;

3011-3087

1.10e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.42 E-value: 1.10e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  3011 PRDLEAKEVTPRTARLTWIEP---QVPPTGYLLTYDTPGGQT--QEIMLPGGVTSYQLLGLFPSTTYRAWLRAMWGESFT 3085
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740  3086 PP 3087
Cdd:pfam00041   83 PP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2833-2909

1.62e-09

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.85 E-value: 1.62e-09

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   2833 SPRDLQFSEIGETSAKVSWMPPPS-RVDSFKVSYQLAHGGEP---QSVQVDGRARTQKLKGLIPGAHYEVTVVSVRGFEE 2908
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 759177740   2909 S 2909
Cdd:smart00060   83 G 83

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

810-890

1.74e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 1.74e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  810 DGPQDLRVVAVTPTTLELSWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPAEADGT--LLTDLMPGVEYVVTVTAEQGRA 884
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 759177740  885 VSYPAS 890
Cdd:cd00063    82 ESPPSE 87

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1965-2045

1.90e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 1.90e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1965 LSVTDTTPDSLHLSWTVPE---GQFEHFLVQYKNGDGQP--KVVRVPGHEDEVTISGLEPDHKYKMNLYGFHDGQRQGPV 2039
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 759177740 2040 SAIGVT 2045
Cdd:cd00063    87 ESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2523-2604

2.10e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 2.10e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2523 PSRLGELMVTDETPDSLHLSWTVAQ---GPIDSFVIQYRDTNGQP--QAMSMAADQREVTVEGLEPGRKYKFLLYGFIGG 2597
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ....*..
gi 759177740 2598 QRlGPVS 2604
Cdd:cd00063    81 GE-SPPS 86

FN3

Fibronectin type 3 domain [General function prediction only];

2889-3079

2.92e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 2.92e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2889 GLIPGAHYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGTALLHWKPPQAP-VDTYDVKVTAPGAPLLE 2963
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2964 ASAPGSAVDYPLHDLVLHTNYTATVHGLRGPNVTSPAS-----ITFITGLEGPRDLEAKEVTPRTARLTWIE-PQVPPTG 3037
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvvsvTTDLTPPAAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 759177740 3038 YLLTYDT-PGGQTQEIMLPGGVTSYQLLGLFPSTTYRAWLRAM 3079
Cdd:COG3401   358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400

FN3

Fibronectin type 3 domain [General function prediction only];

2677-3081

3.02e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 3.02e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2677 VGGDQNKVIVSGLEPSTLYKFSLYGLHEGKrlgpVSAKGTTGSAPAGQTPGEPgPrlSQLSVTDVTTSSLRLNWEAPPG- 2755
Cdd:COG3401   187 VTSTTLVDGGGDIEPGTTYYYRVAATDTGG----ESAPSNEVSVTTPTTPPSA-P--TGLTATADTPGSVTLSWDPVTEs 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2756 AFDSFLLRYGVPSSSTLEphprpllqrEL-TVPGTRHSAAlrDLRPGTLYSFTL--YGLRGPHKADSIQGTARTLSPVLE 2832
Cdd:COG3401   260 DATGYRVYRSNSGDGPFT---------KVaTVTTTSYTDT--GLTNGTTYYYRVtaVDAAGNESAPSNVVSVTTDLTPPA 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2833 SPRDLQFSEIGETSAKVSWMPPPS-RVDSFKVSYQLAHGGEPQSVQVDGRARTQKLKGLIPGA--HYEVTVVSVRGFEE- 2908
Cdd:COG3401   329 APSGLTATAVGSSSITLSWTASSDaDVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTtyYYKVTAVDAAGNESa 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2909 -SEPLTGFLTTVPDGPTQLRALNLTEGTALLHWKPPQAPVDTYDVK--VTAPGAPLLEASAPGSAVDYPLHDLVLHTNY- 2984
Cdd:COG3401   409 pSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSaaVLADGGDTGNAVPFTTTSSTVTATTTDTTTAn 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2985 ---TATVHGLRGPNVTSPASITFITGLEGPRDLEAKEVTPRTArLTWIEPQVPPTGYLLTYDTPGGQTQEIM------LP 3055
Cdd:COG3401   489 lsvTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVT-GASPVTVGASTGDVLITDLVSLTTSASSsvsgagLG 567

                         410       420
                  ....*....|....*....|....*.
gi 759177740 3056 GGVTSYQLLGLFPSTTYRAWLRAMWG 3081
Cdd:COG3401   568 SGNLYLITTLGGSLLTTTSTNTNDVA 593

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1445-1528

3.48e-09

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 3.48e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1445 PLKPRlgDMTVTDVTPNSVGLTWTVPE---GQFDSFVVQYKDKDGQ--LQVVPVAADQREATIPGLEPAHKYKMNLYGLH 1519
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*....
gi 759177740 1520 GGQRvGPLS 1528
Cdd:cd00063    79 GGGE-SPPS 86

FN3

Fibronectin type 3 domain [General function prediction only];

732-925

3.49e-09

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.71 E-value: 3.49e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  732 TTVRTEWTRAPGP-VDAYEIQFIPTTEGentPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTTWGPPASKTITTM 808
Cdd:COG3401   247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  809 I---DGPQDLRVVAVTPTTLELSW-LRPQAEVDRFVVsYVSAGNQRVRLEVPAEADGTLLTD--LMPGVEYVVTVTA--E 880
Cdd:COG3401   324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 759177740  881 QGRAVSYPASVRANTGSSPLGllEATDEPPPSGPSTTQGAQAPGL 925
Cdd:COG3401   403 AGNESAPSEEVSATTASAASG--ESLTASVDAVPLTDVAGATAAA 445

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

810-880

4.21e-09

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 4.21e-09

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740    810 DGPQDLRVVAVTPTTLELSWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPAEADGTLLTDLMPGVEYVVTVTAE 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77

fn3

Fibronectin type III domain;

1233-1302

8.75e-09

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 8.75e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740  1233 GELTVTDVTPDSLHLSWT---VAQGNFDSFMVQYKDAQGQ--PQAVPVSGDKNEVTVRSLESDRKYKMNLYGLHG 1302
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2083-2163

1.74e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.42 E-value: 1.74e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2083 VNVMDATPDSLHLSWTVPE---GQFDHFLVQYKNGDGQP--KVVRVPGHEKEVTISGLEPDHKYKMNLYGFHDGQRQGPV 2157
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 759177740 2158 SAIGVT 2163
Cdd:cd00063    87 ESVTVT 92

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1031-1099

1.83e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 54.42 E-value: 1.83e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740 1031 PPRLGELTVTNVTSNSLLLHWTVPE---GEFDSFMIQYKDRNGPQMVPVE---GPQRSALITNLDMGRKYKFVLY 1099
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

3011-3078

2.24e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.77 E-value: 2.24e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740   3011 PRDLEAKEVTPRTARLTWIEPQVPP-----TGYLLTYDTPGGQTQEIMLPGGVTSYQLLGLFPSTTYRAWLRA 3078
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1445-1516

2.70e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.39 E-value: 2.70e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740   1445 PLKPRlgDMTVTDVTPNSVGLTWTVPE-----GQFDSFVVQYKDKDGQLQVVPVAADQREATIPGLEPAHKYKMNLY 1516
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

3011-3094

3.15e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 53.65 E-value: 3.15e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 3011 PRDLEAKEVTPRTARLTWIEPQ---VPPTGYLLTY-DTPGGQTQEIML-PGGVTSYQLLGLFPSTTYRAWLRAM--WGES 3083
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVngGGES 83

                          90
                  ....*....|.
gi 759177740 3084 fTPPMSTFFTT 3094
Cdd:cd00063    84 -PPSESVTVTT 93

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2523-2589

3.44e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 3.44e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 759177740   2523 PSRLGELMVTDETPDSLHLSWT-----VAQGPIDSFVIQYRDTNGQPQAMSMAADQREVTVEGLEPGRKYKF 2589
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2637-2700

4.94e-08

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.88 E-value: 4.94e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740 2637 LAVTDRTPDSLHLSWTVAQ---GPFDSFVVQYWDTNGQP--QALLVGGDQNKVIVSGLEPSTLYKFSLY 2700
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2726-2809

5.09e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.62 E-value: 5.09e-08

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   2726 PGEPgprlSQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRYgvpsssTLEPHPRPLLQRELTVPGTRHSAALRDLRPGTLY 2804
Cdd:smart00060    1 PSPP----SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEY 70


                    ....*
gi 759177740   2805 SFTLY 2809
Cdd:smart00060   71 EFRVR 75

FN3

Fibronectin type 3 domain [General function prediction only];

1490-1912

6.19e-08

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 6.19e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1490 VVPVAADQREATIPGLEPAHKYKMNLYGLHGGQRVGPLSVIAMTAPllpapvTESPEKPhlGELTVTDVTPDSVSLSWT- 1568
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP------TTPPSAP--TGLTATADTPGSVTLSWDp 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1569 VPEGEFDSFIIKYKDRDGQPQVVSVAADQLEVTVPGLEPNRKYKFMLFGI-QDGRRHGP-VSVEAKTaiqgDTSPGAPPR 1646
Cdd:COG3401   256 VTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsNVVSVTT----DLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1647 lgELWVTDPTLDSLHLSWT-VPEGHFDSFVVQFKDRDGPRMVPV--EGHERSVTITPLDPARKYRFLLygflgkrrhgpl 1723
Cdd:COG3401   332 --GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKV------------ 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1724 tadgttetqSAVGNTGMKRPPKPRLGEELQVTSVTPDSVGLSWTVPEGQFDSFVVQYKDRNGQPQVVPVEGSFKEVSISG 1803
Cdd:COG3401   398 ---------TAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAV 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1804 LDPARRYKLLLYGLhEGKRVGPVSTIAVTAPREEIEAETMAPNPPESKPHLGELMVDGVTPYTlhLSWTVTEGEFDSFEI 1883
Cdd:COG3401   469 PFTTTSSTVTATTT-DTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNV--TGASPVTVGASTGDV 545

                         410       420
                  ....*....|....*....|....*....
gi 759177740 1884 QYTDQDGQLQVVSIGGDQNDITLSGLESD 1912
Cdd:COG3401   546 LITDLVSLTTSASSSVSGAGLGSGNLYLI 574

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1957-2028

8.88e-08

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 8.88e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740   1957 PIKPRlgELSVTDTTPDSLHLSWTVPE-----GQFEHFLVQYKNGDGQPKVVRVPGHEDEVTISGLEPDHKYKMNLY 2028
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

528-555

9.77e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 50.37 E-value: 9.77e-08

                           10        20
                   ....*....|....*....|....*...
gi 759177740   528 CPGGCRGRGQCLDGRCVCDDGYSGDDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

719-807

1.03e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.11 E-value: 1.03e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  719 PAIESMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPTTEGENTPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 795
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 759177740  796 TWGPPA-SKTITT 807
Cdd:cd00063    81 GESPPSeSVTVTT 93

fn3

Fibronectin type III domain;

1135-1198

1.15e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 1.15e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740  1135 VTDPSPDSLLLSWTVPE---GHFDSFMVQYRDRDG--RPQVVPVEGPERSLIVSPLDPDHKYRFTLFGI 1198
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2637-2700

1.21e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.46 E-value: 1.21e-07

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   2637 LAVTDRTPDSLHLSWT-----VAQGPFDSFVVQYWDTNGQPQALLVGGDQNKVIVSGLEPSTLYKFSLY 2700
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

fn3

Fibronectin type III domain;

1642-1709

1.33e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 51.65 E-value: 1.33e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740  1642 GAPPRLGelwVTDPTLDSLHLSWTVPE---GHFDSFVVQFKDRDGP---RMVPVEGHERSVTITPLDPARKYRF 1709
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepwNEITVPGTTTSVTLTGLKPGTEYEV 71

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1133-1206

1.97e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 1.97e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740 1133 LWVTDPSPDSLLLSWTVPE---GHFDSFMVQYRDRDGRP--QVVPVEGPERSLIVSPLDPDHKYRFTLFGIaNKKRHGP 1206
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESP 84

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1122-1195

2.00e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.08 E-value: 2.00e-07

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   1122 PSPATTPRlgmlwVTDPSPDSLLLSWTVPE-----GHFDSFMVQYRDRDGRPQVVPVEGPERSLIVSPLDPDHKYRFTL 1195
Cdd:smart00060    1 PSPPSNLR-----VTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

fn3

Fibronectin type III domain;

1360-1421

2.35e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 2.35e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740  1360 WTVP---QGHFDSFTIQYKDRDG--RPQVVRVGGEENEVTVQGLEPGRKYKVYLYGLHeGQRVGPMS 1421
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPPS 85

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1743-1832

2.75e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.96 E-value: 2.75e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1743 PPKPRlgeELQVTSVTPDSVGLSWTVPE---GQFDSFVVQYKDRNGQP--QVVPVEGSFKEVSISGLDPARRYKLLLYGL 1817
Cdd:cd00063     1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*
gi 759177740 1818 HEGKRVGPVSTIAVT 1832
Cdd:cd00063    78 NGGGESPPSESVTVT 92

FN3

Fibronectin type 3 domain [General function prediction only];

2522-2744

2.77e-07

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 56.55 E-value: 2.77e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2522 PPSRLGELMVTDETPDSLHLSWT-VAQGPIDSFVIqYRDTNGQPQAMSMAA-DQREVTVEGLEPGRKYKFLLYGFIG-GQ 2598
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDpVTESDATGYRV-YRSNSGDGPFTKVATvTTTSYTDTGLTNGTTYYYRVTAVDAaGN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2599 RLGPVSALGVTVpeeDTPAPwhpatEAPEAsegprlgeLAVTDRTPDSLHLSWT-VAQGPFDSFVVQYWDT-NGQPQALL 2676
Cdd:COG3401   311 ESAPSNVVSVTT---DLTPP-----AAPSG--------LTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIA 374

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2677 VGGDQNKVIVSGLEPSTLYKFSlyglhegkrlgpVSAKGTTG--SAPAGQTPGEPGPRLSQLSVTDVTTS 2744
Cdd:COG3401   375 ETVTTTSYTDTGLTPGTTYYYK------------VTAVDAAGneSAPSEEVSATTASAASGESLTASVDA 432

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1641-1731

5.71e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.19 E-value: 5.71e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1641 PGAPprlGELWVTDPTLDSLHLSWTVPE---GHFDSFVVQFKDRDGPRMVPVE---GHERSVTITPLDPARKYRFLLYGF 1714
Cdd:cd00063     1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*..
gi 759177740 1715 LGKRRhGPLTADGTTET 1731
Cdd:cd00063    78 NGGGE-SPPSESVTVTT 93

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1028-1096

6.09e-07

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.54 E-value: 6.09e-07

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1028 PLAPPRLgelTVTNVTSNSLLLHWTVPEGE-FDSFMIQYKDRNGP-----QMVPVEGPQRSALITNLDMGRKYKF 1096
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2726-2809

8.61e-07

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.42 E-value: 8.61e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2726 PGEPgprlSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRYGVPSSSTLEPHPrpllqrelTVPGTRHSAALRDLRPGT 2802
Cdd:cd00063     1 PSPP----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVE--------VTPGSETSYTLTGLKPGT 68


                  ....*..
gi 759177740 2803 LYSFTLY 2809
Cdd:cd00063    69 EYEFRVR 75

fn3

Fibronectin type III domain;

1744-1812

8.97e-07

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 49.34 E-value: 8.97e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740  1744 PKPRlgeELQVTSVTPDSVGLSWTVPE---GQFDSFVVQYKDRNGQ--PQVVPVEGSFKEVSISGLDPARRYKL 1812
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71

fn3

Fibronectin type III domain;

1859-1924

1.10e-06

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 48.95 E-value: 1.10e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759177740  1859 VDGVTPYTLHLSWT---VTEGEFDSFEIQYTDQDGQ--LQVVSIGGDQNDITLSGLESDHRYRVNLYGFHG 1924
Cdd:pfam00041    8 VTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1224-1315

1.14e-06

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.03 E-value: 1.14e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1224 PEPPEQpllgeLTVTDVTPDSLHLSWTVAQ---GNFDSFMVQYKDAQGQP--QAVPVSGDKNEVTVRSLESDRKYKMNLY 1298
Cdd:cd00063     1 PSPPTN-----LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*..
gi 759177740 1299 GLHGRQRVGPVSVVATT 1315
Cdd:cd00063    76 AVNGGGESPPSESVTVT 92

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

342-368

1.28e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 46.91 E-value: 1.28e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   342 CPRDCQGRGRCEDGECICDTGYSGDDC 368
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2083-2146

1.34e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.76 E-value: 1.34e-06

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740   2083 VNVMDATPDSLHLSWTVPE-----GQFDHFLVQYKNGDGQPKVVRVPGHEKEVTISGLEPDHKYKMNLY 2146
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

FN3

Fibronectin type 3 domain [General function prediction only];

2256-2745

1.43e-06

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 54.24 E-value: 1.43e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2256 RVGPVSTVGVTVPQEVVEETPSAKEPSTEAPESPtepLLGDLTVTGSSPDSLSLSWTVPQGHFDSFTIQ-YKDRSPSGVT 2334
Cdd:COG3401    63 SGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTT---LTGSGSVGGATNTGLTSSDEVPSPAVGTATTAtAVAGGAATAG 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2335 PHVEELTVAAVTSNTAHLSWTVAQGPFDSVQCRDAQGqPQAVPVGGDSSYSSVSGMRK-----GMAHSLQMQSSSKEGQR 2409
Cdd:COG3401   140 TYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSA-TAAVATTSLTVTSTTLVDGGgdiepGTTYYYRVAATDTGGES 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2410 PPLPlePLTVFLPDTKLSPLLGeLTVTE*TQDSVGLLWT-VPQGTFNSFVVQYKDRAGQPQVVPEAADQREVTISGLEPN 2488
Cdd:COG3401   219 APSN--EVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNG 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2489 RKCKFLLYGLGGRKQLGPISAEGTMAPPEKEWQPPSrlgELMVTDETPDSLHLSWT-VAQGPIDSFVIqYRDTN--GQPQ 2565
Cdd:COG3401   296 TTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS---GLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTSggGTYT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2566 AMSMAADQREVTVEGLEPGRKYKFLlygfiggqrlgpVSALGVTVPEEDTPAPwhPATEAPEASEGPRLGELAVTDRTPD 2645
Cdd:COG3401   372 KIAETVTTTSYTDTGLTPGTTYYYK------------VTAVDAAGNESAPSEE--VSATTASAASGESLTASVDAVPLTD 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2646 SLHLSWTVAQGPFDSFVVQYWDTNGQPQALLVGGDQNKVIVSGLEPSTLYKFSLYGLHEGKRLGPVSAKGTTGSAPAGQT 2725
Cdd:COG3401   438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                         490       500
                  ....*....|....*....|
gi 759177740 2726 PGEPGPRLSQLSVTDVTTSS 2745
Cdd:COG3401   518 AAVGGAPDGTPNVTGASPVT 537

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1743-1812

2.88e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 2.88e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1743 PPKPRlgeELQVTSVTPDSVGLSWTVPE-----GQFDSFVVQYKDRNGQPQVVPVEGSFKEVSISGLDPARRYKL 1812
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1224-1298

3.47e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.61 E-value: 3.47e-06

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   1224 PEPPEqpllgELTVTDVTPDSLHLSWTVAQGN-----FDSFMVQYKDAQGQPQAVPVSGDKNEVTVRSLESDRKYKMNLY 1298
Cdd:smart00060    1 PSPPS-----NLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

280-306

4.24e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 45.75 E-value: 4.24e-06

                           10        20
                   ....*....|....*....|....*..
gi 759177740   280 CPRGCSQKGRCEDGRCVCDPGYAGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1641-1709

7.67e-06

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.45 E-value: 7.67e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1641 PGAPPRLgelWVTDPTLDSLHLSWTVPE-GHFDSFVVQFKDRDGP-----RMVPVEGHERSVTITPLDPARKYRF 1709
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72

fn3

Fibronectin type III domain;

2923-2993

9.01e-06

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 9.01e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740  2923 PTQLRALNLTEGTALLHWKPP---QAPVDTYDVKVTAPGA--PLLEASAPGSAVDYPLHDLVLHTNYTATVHGLRG 2993
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

fn3

Fibronectin type III domain;

2200-2254

1.10e-05

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 46.25 E-value: 1.10e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2200 WTIP---QGHFDSFTIQYKDRDG--RPQVVRAGGEESEVTVRGLEPGHKYKMHLYGLHGG 2254
Cdd:pfam00041   20 WTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

283-404

2.39e-05

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 46.67 E-value: 2.39e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  283 GCSQKG-RCEDGRCVC-----DPGYAGEDCGSrsCRWDCGEGGRCVDGHCVCWPGYA--GEDC-STRTCPRDCQGRG-RC 352
Cdd:NF041328   13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGaAC 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  353 EDGEcICDTGYSGDDC--GVRSCPGDC----NQRGRCedGSC--VCWPGYTgpdCSARAC 404
Cdd:NF041328   91 APGQ-VCEGGACREACseGLTRCGGACvdlaTDPLHC--GACgvACDPGES---CRGGAC 144

FN3

Fibronectin type 3 domain [General function prediction only];

991-1194

3.43e-05

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.62 E-value: 3.43e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  991 PGTPYELSLRGVPPEGEPSAPLIYQGIMDRDLekpgkPLAPprlGELTVTNVTSNSLLLHWT-VPEGEFDSFMIQYKDRN 1069
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTP-----PSAP---TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1070 GPQMVPVEGPQRSALI-TNLDMGRKYKFVLYGLVGKKRHGPLVTEAKILPqsDPSPATTPRlgMLWVTDPSPDSLLLSWT 1148
Cdd:COG3401   273 DGPFTKVATVTTTSYTdTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTT--DLTPPAAPS--GLTATAVGSSSITLSWT 348

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 759177740 1149 -VPEGHFDSFMVqYRD--RDGRPQVVPVEGPERSLIVSPLDPDHKYRFT 1194
Cdd:COG3401   349 aSSDADVTGYNV-YRStsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYK 396

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2920-3006

4.35e-05

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 4.35e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2920 PDGPTQLRALNLTEGTALLHWKPPQ---APVDTYDVKVTAPGAPLLE--ASAPGSAVDYPLHDLVLHTNYTATVHGLRGP 2994
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 759177740 2995 NVTSPA-SITFIT 3006
Cdd:cd00063    81 GESPPSeSVTVTT 93

FN3

Fibronectin type 3 domain [General function prediction only];

1225-1473

4.99e-05

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.23 E-value: 4.99e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1225 EPPEQPllGELTVTDVTPDSLHLSWT-VAQGNFDSFMVQYKDAQGQPQAVPVSGDKNEVTVRSLESDRKYKmnlYglhgr 1303
Cdd:COG3401   231 TPPSAP--TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---Y----- 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1304 qrvgpvSVVA------TTAPQEAVEETTSPTEPSteAPEFpkeailgeLTVTGSSSDSLSLSWT-VPQGHFDSFTIQYKD 1376
Cdd:COG3401   301 ------RVTAvdaagnESAPSNVVSVTTDLTPPA--APSG--------LTATAVGSSSITLSWTaSSDADVTGYNVYRST 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1377 R-DGRPQVVRVGGEENEVTVQGLEPGRKYKVYLYGLHEGQRVGPMSTVGpSTISVSVPQPEEILAATehplkprlGDMTV 1455
Cdd:COG3401   365 SgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEV-SATTASAASGESLTASV--------DAVPL 435

                         250
                  ....*....|....*...
gi 759177740 1456 TDVTPNSVGLTWTVPEGQ 1473
Cdd:COG3401   436 TDVAGATAAASAASNPGV 453

PTZ00214

high cysteine membrane protein Group 4; Provisional

266-638

5.18e-05

high cysteine membrane protein Group 4; Provisional

Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 49.14 E-value: 5.18e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  266 CNPGYTGEDCgvRSCPRGCSQkgrceDGRCVCDPGYAGEDCGSRSCRwdcgeggrcvdghCVCWPGYAGEDCSTRTCPRD 345
Cdd:PTZ00214  379 CSAGYLGVDG--KSCSESCSG-----DTRGVCTKVAEGSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDS 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  346 CqgrGRCEDG------------------------ECI--CDTGYSGDDCGV-----RSCPgdcnqrgRCEDGSC-----V 389
Cdd:PTZ00214  439 C---AVCKDGtptgcqqcspgkilefsivssesaDCVdqCSVGSECAECGItidgsRYCT-------RCKDASTypfngV 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  390 CWPGyTGPD--CSARA---CPrNCRGRGRCENGVCVCNEGYSGED-CGVRScpedcrgRGRCESGRCVCWPGYTGR--DC 461
Cdd:PTZ00214  509 CIPN-TQRDayCTSTAngaCT-TCSGAAFLMNGGCYTTEHYPGSTiCDKQS-------NGKCTTTKKGYGISPDGKllEC 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  462 GKRACPGDCRGRGRCVdglcvcnpgftgedcgsrRCPGDC---RGRGrCEDGVC----ACDSGY--EGEDCSARSCPGgC 532
Cdd:PTZ00214  580 DPTCLACTAPGPGRCT------------------RCPSDKllkRASG-AATGSCvdpgACVDGYyaDGDACLPCATPG-C 639

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  533 RGRG------QCLDGRCVCDDGYSgddcsvrrCPHDCSQRGVCQD---GVCTCW--EGYA----GEDCGLRT-CPSNCHR 596
Cdd:PTZ00214  640 KTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWceRGFLpaldRSGCVLPTeCPPDMPS 711

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 759177740  597 RGRC-EDGRCV-CDSGYTGPSCATRTCPADCRGRGRCVQGVCVC 638
Cdd:PTZ00214  712 CAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

249-275

6.86e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 42.29 E-value: 6.86e-05

                           10        20
                   ....*....|....*....|....*..
gi 759177740   249 CPRGCSKKGRCENGRCVCNPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

497-524

8.68e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 41.90 E-value: 8.68e-05

                           10        20
                   ....*....|....*....|....*...
gi 759177740   497 CPGDCRGRGRCEDGVCACDSGYEGEDCS 524
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

590-617

1.50e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 41.13 E-value: 1.50e-04

                           10        20
                   ....*....|....*....|....*...
gi 759177740   590 CPSNCHRRGRCEDGRCVCDSGYTGPSCA 617
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1845-1920

1.78e-04

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.87 E-value: 1.78e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1845 PNPPESkphlgeLMVDGVTPYTLHLSWTV---TEGEFDSFEIQYTDQDGQ--LQVVSIGGDQNDITLSGLESDHRYRVNL 1919
Cdd:cd00063     1 PSPPTN------LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRV 74


                  .
gi 759177740 1920 Y 1920
Cdd:cd00063    75 R 75

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2920-2988

1.81e-04

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.60 E-value: 1.81e-04

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 759177740   2920 PDGPTQLRALNLTEGTALLHWKPPQ-----APVDTYDVKVTAPGAPLLEASAPGSAVDYPLHDLVLHTNYTATV 2988
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

fn3

Fibronectin type III domain;

2431-2490

1.89e-04

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 42.79 E-value: 1.89e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759177740  2431 GELTVTE*TQDSVGLLWTVP---QGTFNSFVVQYK--DRAGQPQVVPEAADQREVTISGLEPNRK 2490
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTE 68

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

621-647

2.50e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 40.74 E-value: 2.50e-04

                           10        20
                   ....*....|....*....|....*..
gi 759177740   621 CPADCRGRGRCVQGVCVCHAGYSGEDC 647
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

532-554

2.61e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.41 E-value: 2.61e-04

                           10        20
                   ....*....|....*....|....*
gi 759177740   532 CRGRGQCLD--GRCVCDDGYSGDDC 554
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

FN3

Fibronectin type 3 domain [General function prediction only];

2134-2349

2.62e-04

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.92 E-value: 2.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2134 GLEPDHKYKMNLYGFHDGQRQGPVSAIGVTgewtetpspkePSTEAPESPTEPLLG*SSPDSLSLSWT-IPQGHFDSFTI 2212
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVT-----------TPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2213 QYKDRDGRPQVVRAGGEESEVTVRGLEPGHKYKmhlYglhggrRVGPVSTVGVT-VPQEVVEETPSakepsTEAPESPTe 2291
Cdd:COG3401   267 YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---Y------RVTAVDAAGNEsAPSNVVSVTTD-----LTPPAAPS- 331

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 759177740 2292 pllgDLTVTGSSPDSLSLSWT-VPQGHFDSFTIQYKDRSPSGVTphveelTVAAVTSNT 2349
Cdd:COG3401   332 ----GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYT------KIAETVTTT 380

FN3

Fibronectin type 3 domain [General function prediction only];

1932-2362

2.88e-04

Fibronectin type 3 domain [General function prediction only];

Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 46.53 E-value: 2.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 1932 QVEAMTAPKEEEDKPSEAPTTTPELPIKPrlGELSVTDTTPDSLHLSWT-VPEGQFEHFLVQYKNGDGQP--KVVRVPgh 2008
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTTPTTPPSAP--TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPftKVATVT-- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2009 EDEVTISGLEPDHKYKmnlYGfhdgqrqgpVSAIGVTDEETPFPTEVEETPSPKEPIpeeeppaspslKPhlGEVNVMDA 2088
Cdd:COG3401   284 TTSYTDTGLTNGTTYY---YR---------VTAVDAAGNESAPSNVVSVTTDLTPPA-----------AP--SGLTATAV 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2089 TPDSLHLSWT-VPEGQFDHFLVQYKNGDGQP--KVVRVPGhEKEVTISGLEPDHKYKmnlYGfhdgqrqgpVSAIGVTGE 2165
Cdd:COG3401   339 GSSSITLSWTaSSDADVTGYNVYRSTSGGGTytKIAETVT-TTSYTDTGLTPGTTYY---YK---------VTAVDAAGN 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2166 WTetpspkEPSTEAPESPTEPLLG*SSPDSLSLSWTIPQGHFDSFTIQYKDRDGRPQVVRAGGEESEVTVRGLEPGHKYK 2245
Cdd:COG3401   406 ES------APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740 2246 MHLYGLHGGRRVGPVSTVG----VTVPQEVVEETPSAKEPSTEAPESPTEPLLGDLTVTGSSPDSLSLSWTVPQGHfdSF 2321
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVGgsgaSSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTT--SA 557

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 759177740 2322 TIQYKDRSPSGVTPHVEELTVAAVTSNTAHLSWTVAQGPFD 2362
Cdd:COG3401   558 SSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGG 598

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

559-585

2.96e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 40.36 E-value: 2.96e-04

                           10        20
                   ....*....|....*....|....*..
gi 759177740   559 CPHDCSQRGVCQDGVCTCWEGYAGEDC 585
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1845-1920

3.45e-04

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.83 E-value: 3.45e-04

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740   1845 PNPPESkphlgeLMVDGVTPYTLHLSWT-----VTEGEFDSFEIQYTDQDGQLQVVSIGGDQNDITLSGLESDHRYRVNL 1919
Cdd:smart00060    1 PSPPSN------LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 759177740   1920 Y 1920
Cdd:smart00060   75 R 75

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

466-492

4.34e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.97 E-value: 4.34e-04

                           10        20
                   ....*....|....*....|....*..
gi 759177740   466 CPGDCRGRGRCVDGLCVCNPGFTGEDC 492
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

538-672

4.37e-04

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.21 E-value: 4.37e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  538 CLDGRCVCDDGYS--GDDCSVRR--------CPHDCSQRGVCQDGVCTCWEGyaGEDCG-----LRTCPSNCHRRG-RCE 601
Cdd:NF041328   14 CPEPGAVCPEGLSvcGGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGACGaACA 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759177740  602 DGRcVCDSGytgpSCAtRTCPAdcrGRGRCvQGVCVCHAgYSGEDCGqeeppasACPGGCGPRALCRTGQC 672
Cdd:NF041328   92 PGQ-VCEGG----ACR-EACSE---GLTRC-GGACVDLA-TDPLHCG-------ACGVACDPGESCRGGAC 144

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

345-368

5.03e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 5.03e-04

                           10        20
                   ....*....|....*....|....*.
gi 759177740   345 DCQGRGRCED--GECICDTGYSGDDC 368
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

438-461

5.24e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 5.24e-04

                           10        20
                   ....*....|....*....|....*.
gi 759177740   438 DCRGRGRCES--GRCVCWPGYTGRDC 461
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2433-2493

5.96e-04

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 41.33 E-value: 5.96e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740 2433 LTVTE*TQDSVGLLWTVPQ---GTFNSFVVQYKDRAGQP--QVVPEAADQREVTISGLEPNRKCKF 2493
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

218-245

6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.59 E-value: 6.00e-04

                           10        20
                   ....*....|....*....|....*...
gi 759177740   218 CPGDCHGRGRCVQGVCVCRAGFSGNDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

404-430

7.09e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 39.20 E-value: 7.09e-04

                           10        20
                   ....*....|....*....|....*..
gi 759177740   404 CPRNCRGRGRCENGVCVCNEGYSGEDC 430
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

2433-2493

9.19e-04

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.68 E-value: 9.19e-04

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 759177740   2433 LTVTE*TQDSVGLLWTVPQGTFN-----SFVVQYKDRAGQPQVVPEAADQREVTISGLEPNRKCKF 2493
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGItgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

719-798

1.05e-03

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 1.05e-03

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740    719 PAIESMRMHLLEETTVRTEWTRAPGP-VDAYEIQFIPTTEGENTPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTT 796
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 759177740    797 WG 798
Cdd:smart00060   82 EG 83

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

469-492

1.09e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 1.09e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   469 DCRGRGRCVD--GLCVCNPGFTGEDC 492
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

221-244

1.22e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.22e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   221 DCHGRGRCVQ--GVCVCRAGFSGNDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

373-400

1.32e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.43 E-value: 1.32e-03

                           10        20
                   ....*....|....*....|....*...
gi 759177740   373 CPGDCNQRGRCEDGSCVCWPGYTGPDCS 400
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

190-213

1.50e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.50e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

fn3

Fibronectin type III domain;

2295-2349

1.50e-03

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.09 E-value: 1.50e-03

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759177740  2295 GDLTVTGSSPDSLSLSWTVP---QGHFDSFTIQYK-------------DRSPSGVT-----PHVE-ELTVAAVTSNT 2349
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRpknsgepwneitvPGTTTSVTltglkPGTEyEVRVQAVNGGG 80

GGGWT_bact

NF040941

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...

3130-3144

1.54e-03

Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 38.70 E-value: 1.54e-03

                          10
                  ....*....|....*
gi 759177740 3130 PLNVFCDMETDGGGW 3144
Cdd:NF040941   29 PFQVYCDMTTDGGGW 43

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

376-399

1.65e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.65e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   376 DCNQRGRCED--GSCVCWPGYTGPDC 399
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

408-430

1.95e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.95e-03

                           10        20
                   ....*....|....*....|....*
gi 759177740   408 CRGRGRCEN--GVCVCNEGYSGEDC 430
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

500-523

2.13e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 2.13e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   500 DCRGRGRCED--GVCACDSGYEGEDC 523
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

594-616

2.54e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 2.54e-03

                           10        20
                   ....*....|....*....|....*
gi 759177740   594 CHRRGRCED--GRCVCDSGYTGPSC 616
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

248-383

2.60e-03

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 2.60e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  248 SCPRGCSkkgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQKGRCEDGRCVCDPGyaGEDCgsrscrwdcgeGGRCVD---- 323
Cdd:NF041328   20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVAC-----------GGACVDtasd 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  324 -GHC-----VCWPGYAgedCSTRTCPRDC-QGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 383
Cdd:NF041328   80 pAHCgacgaACAPGQV---CEGGACREACsEGLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

1360-1427

2.65e-03

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.79 E-value: 2.65e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740 1360 WTVPQ---GHFDSFTIQYKDRDGRP--QVVRVGGEENEVTVQGLEPGRKYKVYLYGLHEGQRvGPMSTVGPST 1427
Cdd:cd00063    21 WTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPPSESVTVT 92

EGF_2

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

624-647

2.67e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 2.67e-03

                           10        20
                   ....*....|....*....|....*.
gi 759177740   624 DCRGRGRCVQ--GVCVCHAGYSGEDC 647
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

FN3

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...

1360-1409

3.41e-03

Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.13 E-value: 3.41e-03

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 759177740   1360 WTVPQ-----GHFDSFTIQYKDRDGRPQVVRVGGEENEVTVQGLEPGRKYKVYLY 1409
Cdd:smart00060   21 WEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75

C_rich_MXAN6577

MXAN_6577-like cysteine-rich domain;

563-703

3.70e-03

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.70e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  563 CSQRG-VCQDGVCTCwegyaGEDC-GLRTCPSNChrrGRCEDgrcVCDSGytgpscatrtcpadcrgrGRCVQGVCVCHA 640
Cdd:NF041328   14 CPEPGaVCPEGLSVC-----GGACvDLRSDPSNC---GACGV---ACGAG------------------QTCVAGACGCGP 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  641 GysGEDCGQE-----EPPAS--ACPGGCGPRALCRTGQC--VCVEGFR--GPDCA-IRTCPGDCQ------GRGE-CREG 701
Cdd:NF041328   65 G--TVACGGAcvdtaSDPAHcgACGAACAPGQVCEGGACreACSEGLTrcGGACVdLATDPLHCGacgvacDPGEsCRGG 142


                  ..
gi 759177740  702 SC 703
Cdd:NF041328  143 AC 144

FN3

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...

2200-2267

6.26e-03

Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 38.63 E-value: 6.26e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759177740 2200 WTIPQ---GHFDSFTIQYKDRDGRP--QVVRAGGEESEVTVRGLEPGHKYKMHLYGLHGGRRVGPVSTVGVTV 2267
Cdd:cd00063    21 WTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

657-684

6.86e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.51 E-value: 6.86e-03

                           10        20
                   ....*....|....*....|....*...
gi 759177740   657 CPGGCGPRALCRTGQCVCVEGFRGPDCA 684
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29

EGF_Tenascin

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

688-714

7.35e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 36.51 E-value: 7.35e-03

                           10        20
                   ....*....|....*....|....*..
gi 759177740   688 CPGDCQGRGECREGSCVCQDGFAGEDC 714
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

fn3

Fibronectin type III domain;

2337-2411

7.55e-03

Fibronectin type III domain;

Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 38.16 E-value: 7.55e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759177740  2337 VEELTVAAVTSNTAHLSWT---VAQGPFDS--VQCRDAQGQ--PQAVPVGGDSSYSSVSGMRKGMAHSLQMQSSSKEGQR 2409
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTpppDGNGPITGyeVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 759177740  2410 PP 2411
Cdd:pfam00041   83 PP 84

EGF_2