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Conserved domains on  [gi|755560385|ref|XP_011245109|]
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gamma-soluble NSF attachment protein isoform X2 [Mus musculus]

Protein Classification

soluble NSF attachment family protein( domain architecture ID 581131)

soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) is involved in intracellular membrane trafficking; may contain TPR repeats

CATH:  1.25.40.10
Gene Ontology:  GO:0005483|GO:0000149
PubMed:  11536358|17634982
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNAP super family cl24038
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-246 1.82e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


The actual alignment was detected with superfamily member cd15832:

Pssm-ID: 451671 [Multi-domain]  Cd Length: 278  Bit Score: 143.87  E-value: 1.82e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYkvefwspaertgtgtkrtgtdpreeehlgkgnplcvwptqilavg 157
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAK--------------------------------------------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385 158 twdrpKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQLLEGYDQQDQDQVSEVCNSPLfKYMDNDYAK 236
Cdd:cd15832  194 -----DYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDLLEAVEEGDVEAFTDAVKEYD-SISKLDKWK 267

                        250
                 ....*....|
gi 755560385 237 LGLSLVVPGG 246
Cdd:cd15832  268 TTMLLKIKKS 277
 
Name Accession Description Interval E-value
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-246 1.82e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 143.87  E-value: 1.82e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYkvefwspaertgtgtkrtgtdpreeehlgkgnplcvwptqilavg 157
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAK--------------------------------------------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385 158 twdrpKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQLLEGYDQQDQDQVSEVCNSPLfKYMDNDYAK 236
Cdd:cd15832  194 -----DYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDLLEAVEEGDVEAFTDAVKEYD-SISKLDKWK 267

                        250
                 ....*....|
gi 755560385 237 LGLSLVVPGG 246
Cdd:cd15832  268 TTMLLKIKKS 277
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 11-222 4.37e-08

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 52.96  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   11 EAVQLIEKASMMYLENGTPDTAAMALERAGKLIEN--VDPEKAVQLYQQTANVFENEERLRQAVELLGKAsrllvrgrrf 88
Cdd:pfam14938  84 EAVRALEKAIEIYTEMGRFRRAAKHKKEIAELYEQelGDLEKAIEAYEQAADWYEGEGASALANKCYLKV---------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   89 deAALSIQKEkNIYKEIENYptcykvefwspaertgtgtkrtgtdpreeEHLGK---GNPLcvwpTQILAVGTWDRpkkt 165
Cdd:pfam14938 154 --ADLSAELE-DYPKAIEIY-----------------------------EKVAKnslENNL----LKYSVKEYFLK---- 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755560385  166 iaQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQLLEGYDQQDQDQVSEVC 222
Cdd:pfam14938 194 --AGLCHLAAGDLVAAQRALERYEELdPSFADTREYKLLNDLLEAVEEGDVEAFTDAV 249
 
Name Accession Description Interval E-value
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-246 1.82e-41

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 143.87  E-value: 1.82e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   1 MMLKEMQKlPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENV--DPEKAVQLYQQTANVFENEERLRQAVELLGKA 78
Cdd:cd15832   80 KCYKKVDP-QEAVNCLEKAIEIYTEMGRFRQAAKHLKEIAELYENElgDLDKAIEAYEQAADYYEGEGANSLANKCYLKV 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385  79 SRLLVRGRRFDEAALSIQKEKNIYKEIE-NYPTCYkvefwspaertgtgtkrtgtdpreeehlgkgnplcvwptqilavg 157
Cdd:cd15832  159 ADLAAQLEDYDKAIEIYEQVARSSLENNlLKYSAK--------------------------------------------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385 158 twdrpKKTIAQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQLLEGYDQQDQDQVSEVCNSPLfKYMDNDYAK 236
Cdd:cd15832  194 -----DYFLKAGLCHLAAGDVVAAQRALEKYAELdPSFAGSRECKLLEDLLEAVEEGDVEAFTDAVKEYD-SISKLDKWK 267

                        250
                 ....*....|
gi 755560385 237 LGLSLVVPGG 246
Cdd:cd15832  268 TTMLLKIKKS 277
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 11-222 4.37e-08

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 52.96  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   11 EAVQLIEKASMMYLENGTPDTAAMALERAGKLIEN--VDPEKAVQLYQQTANVFENEERLRQAVELLGKAsrllvrgrrf 88
Cdd:pfam14938  84 EAVRALEKAIEIYTEMGRFRRAAKHKKEIAELYEQelGDLEKAIEAYEQAADWYEGEGASALANKCYLKV---------- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755560385   89 deAALSIQKEkNIYKEIENYptcykvefwspaertgtgtkrtgtdpreeEHLGK---GNPLcvwpTQILAVGTWDRpkkt 165
Cdd:pfam14938 154 --ADLSAELE-DYPKAIEIY-----------------------------EKVAKnslENNL----LKYSVKEYFLK---- 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755560385  166 iaQVLVHLHRNDYVAAERCVRESYSI-PGFNGSEDCAALEQLLEGYDQQDQDQVSEVC 222
Cdd:pfam14938 194 --AGLCHLAAGDLVAAQRALERYEELdPSFADTREYKLLNDLLEAVEEGDVEAFTDAV 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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