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Conserved domains on  [gi|723575290|ref|XP_010307659|]
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PREDICTED: galactokinase, partial [Balearica regulorum gibbericeps]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
23-316 1.07e-147

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 420.33  E-value: 1.07e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  23 SPLSPG-QPRWANYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCpdDGDLAAKALA--CQ 97
Cdd:COG0153   78 DDLEPGeEDGWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVELAkiGQ 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  98 KAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLG 177
Cdd:COG0153  156 RAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 178 KASLRDATMAELEASRSRLG-EEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVA 256
Cdd:COG0153  236 VKSLRDVTLEDLEAARARLGdEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVE 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290 257 AALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYS----GTATFYLTKPSGGAKVL 316
Cdd:COG0153  316 LALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
23-316 1.07e-147

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 420.33  E-value: 1.07e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  23 SPLSPG-QPRWANYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCpdDGDLAAKALA--CQ 97
Cdd:COG0153   78 DDLEPGeEDGWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVELAkiGQ 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  98 KAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLG 177
Cdd:COG0153  156 RAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 178 KASLRDATMAELEASRSRLG-EEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVA 256
Cdd:COG0153  236 VKSLRDVTLEDLEAARARLGdEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVE 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290 257 AALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYS----GTATFYLTKPSGGAKVL 316
Cdd:COG0153  316 LALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 4-316 1.79e-119

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 348.45  E-value: 1.79e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   4 SSAEPVEPHRVQfpaprqgsplspgqpRWANYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQ 81
Cdd:PRK05101  79 SLDAPIVPHPEQ---------------QWANYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQ 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  82 LCPDDGDLAAKALACQKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDaNLAVLITNSNVRHTLTGSE 161
Cdd:PRK05101 144 LYHLPLSGAEIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSE 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 162 YPTRRRQCEEAAAVLGKASLRDATMAELEASRSRLGEEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLR 241
Cdd:PRK05101 223 YNTRRQQCETAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMR 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 242 DDYEVSCPELD---ELVAAALEVDGvyGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYSGT----ATFYLTKPSGGAK 314
Cdd:PRK05101 303 DDFEITVPQIDtlvEIVKAVIGDQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAG 380


                 ..
gi 723575290 315 VL 316
Cdd:PRK05101 381 QC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 16-316 3.05e-105

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 312.53  E-value: 3.05e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   16 FPAPRQGSPLSpgqpRWANYVKGVIQHY--RGGPVP-GFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAK 92
Cdd:TIGR00131  77 LDLPLDGSEVS----DWANYFKGVLHVAqeRFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   93 ALACQKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEA 172
Cdd:TIGR00131 153 LLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  173 AAVLGK---ASLRDATMAELEASRSRLGE---EVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEV 246
Cdd:TIGR00131 233 ANFLAAtdkGALRDFMNEYFARYIARLTKmlpLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290  247 SCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYSGT----ATFYLTKPSGGAKVL 316
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKtgleLTFYVIVSKPGAGSC 386
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 54-120 5.36e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 5.36e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723575290   54 VIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGdlaakALACQKAEHTFAGMPCGIMDQFISVMGK 120
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
23-316 1.07e-147

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 420.33  E-value: 1.07e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  23 SPLSPG-QPRWANYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCpdDGDLAAKALA--CQ 97
Cdd:COG0153   78 DDLEPGeEDGWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVELAkiGQ 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  98 KAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLG 177
Cdd:COG0153  156 RAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 178 KASLRDATMAELEASRSRLG-EEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVA 256
Cdd:COG0153  236 VKSLRDVTLEDLEAARARLGdEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVE 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290 257 AALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYS----GTATFYLTKPSGGAKVL 316
Cdd:COG0153  316 LALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 4-316 1.79e-119

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 348.45  E-value: 1.79e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   4 SSAEPVEPHRVQfpaprqgsplspgqpRWANYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQ 81
Cdd:PRK05101  79 SLDAPIVPHPEQ---------------QWANYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQ 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  82 LCPDDGDLAAKALACQKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDaNLAVLITNSNVRHTLTGSE 161
Cdd:PRK05101 144 LYHLPLSGAEIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSE 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 162 YPTRRRQCEEAAAVLGKASLRDATMAELEASRSRLGEEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLR 241
Cdd:PRK05101 223 YNTRRQQCETAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMR 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 242 DDYEVSCPELD---ELVAAALEVDGvyGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYSGT----ATFYLTKPSGGAK 314
Cdd:PRK05101 303 DDFEITVPQIDtlvEIVKAVIGDQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAG 380


                 ..
gi 723575290 315 VL 316
Cdd:PRK05101 381 QC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 16-316 3.05e-105

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 312.53  E-value: 3.05e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   16 FPAPRQGSPLSpgqpRWANYVKGVIQHY--RGGPVP-GFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAK 92
Cdd:TIGR00131  77 LDLPLDGSEVS----DWANYFKGVLHVAqeRFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   93 ALACQKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEA 172
Cdd:TIGR00131 153 LLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  173 AAVLGK---ASLRDATMAELEASRSRLGE---EVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEV 246
Cdd:TIGR00131 233 ANFLAAtdkGALRDFMNEYFARYIARLTKmlpLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290  247 SCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYSGT----ATFYLTKPSGGAKVL 316
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKtgleLTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 31-316 5.48e-99

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 296.77  E-value: 5.48e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  31 RWANYVKGVIQHY--RGGPVP-GFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAKALACQKAEHTFAGMP 107
Cdd:PRK05322  90 DWANYPKGVLKFLqeAGYKIDhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTENEFIGVN 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 108 CGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLGK----ASLRD 183
Cdd:PRK05322 170 SGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKkldiKSLGE 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 184 ATMAELEASRSRLGEEV-YQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVAAALEVD 262
Cdd:PRK05322 250 LTEEEFDEYSYLIKDETlLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQE 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 723575290 263 GVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKYSGT----ATFYLTKPSGGAKVL 316
Cdd:PRK05322 330 GVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKigyaASFYVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 31-316 2.10e-91

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 276.11  E-value: 2.10e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  31 RWANYVKGVI-----QHYRGGPVPGFsavIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAKALACQKAEHTFAG 105
Cdd:PRK03817  65 SWADYIKGVIwvlekRGYEVGGVKGK---VSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 106 MPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDaNLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLGKASLRDAT 185
Cdd:PRK03817 142 VPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFPE-DYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVT 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 186 MAELeasrSRLGEEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVAAALEVdGVY 265
Cdd:PRK03817 221 EEDL----SKLPPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAY 295

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 723575290 266 GSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKY----SGTATFYLTKPSGGAKVL 316
Cdd:PRK03817 296 GARLTGAGFGGSAIALVDKGKFESIGEELLEEYkkrfGIDPKYFVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 26-289 4.07e-67

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 214.34  E-value: 4.07e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  26 SPGQPR-WANYVKGVIQHYR--GGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAKALACQKAEHT 102
Cdd:PRK00555  64 TPGQVTgWAAYAAGVIWALRgaGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 103 FAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLT--DANLAVLITNSNVRHTLTGSEYPTRRRQCEEAAAVLGKAS 180
Cdd:PRK00555 144 YVGAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAFDpdAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 181 LRDATMAELEASRSRLGEEVYQRARHVIGEIARTVQAAQALQDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVAAALE 260
Cdd:PRK00555 224 LRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVR 303

                        250       260
                 ....*....|....*....|....*....
gi 723575290 261 VdGVYGSRMTGGGFGGCTVTLLEAGAAER 289
Cdd:PRK00555 304 A-GALGARMTGGGFGGCVIALVPADRAED 331
PLN02865 PLN02865
galactokinase
 14-298 3.62e-39

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 142.63  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  14 VQFPAPrQGSPLSPGQPRWANYVKGVIQHYRGGPV---PGFSAVIASDIPL-GGGLSSSAALEVAtytFLQQLcPDDGDL 89
Cdd:PLN02865  92 IQHPIA-NVSSDSKEESNWGDYARGAVYALQSRGHalsQGITGYISGSEGLdSSGLSSSAAVGVA---YLLAL-ENANNL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  90 AAKALAC----QKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDAN------LAVLITNSNVRHTLTG 159
Cdd:PLN02865 167 TVSPEDNieldRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALTN 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 160 SE-YPTRRRQCEEAAAVLGKAS--------LRDATMAELEASRSRLGEEVYQRARHVIGEIARTVQAAQALQDRDYKTFG 230
Cdd:PLN02865 247 KPgYNLRVSECQEAARFLLEASgndeleplLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFG 326

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 723575290 231 RLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKY 298
Cdd:PLN02865 327 KLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEY 394
PLN02521 PLN02521
galactokinase
 24-316 3.52e-33

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 127.52  E-value: 3.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  24 PLSPGQP------RWANYV----KGVIQHYR------GGPVpGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDG 87
Cdd:PLN02521 108 PADPDQEvdlanhKWGNYFicgyKGVFEFLKskgvdvGPPV-GLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNF 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  88 DLAAKA-LACQKAEHTfaGMPCGIMDQFISVMGKEGHALLIDCRSLETVLVPLTDANlAVLITNSnvrhtLTGSE----- 161
Cdd:PLN02521 187 TKKEVAqFTCKCERHI--GTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGG-TFVIANS-----LAESNkavta 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 162 ---YPTRRRQCEEAAAVLG--------KASLRDATMAELE-----------------ASRSRLGEEVY------------ 201
Cdd:PLN02521 259 atnYNNRVVECRLAAIVLAvklgmsaeEAISKVKTLSDVEglcvsfagshgssdpavAVKELLHEGPYtaeeieeilges 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 202 ------------------------QRARHVIGEIARTVQ----AAQALQDRDY-KTFGRLMVESHNSLRDDYEVSCPELD 252
Cdd:PLN02521 339 ltsifknsptslavlkaakhfklhQRAVHVYSEAKRVHAfrdtVSSSLSEEEKlKKLGDLMNESHYSCSVLYECSCPELE 418

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723575290 253 ELVAAALEvDGVYGSRMTGGGFGGCTVTLLEAGAAERAQHHIKEKY------SGT-------ATFYLTKPSGGAKVL 316
Cdd:PLN02521 419 ELVKVCRD-NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFyksrieKGVikeedlgLYVFASKPSSGAAIL 494
PTZ00290 PTZ00290
galactokinase; Provisional
 32-318 5.76e-33

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 126.48  E-value: 5.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  32 WANYVKGV--IQHYRGG------PVPGFSAVIASDIPLGGGLSSSAALEVA----------------------TYTFLQQ 81
Cdd:PTZ00290 108 WTTFVRGAatLRLNRLGvaidapSLQGVCMVVHGTLPMGAGMSASASFGVAllnaintvvtrrykgcptspgrRYSILPP 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  82 lCPDDgDLAAKALACQKAEHTFAGMPCGIMDQFISVMGKEGHALLIDCRSL--ETV-LVPLTDANLAVLITNSNVRHTLT 158
Cdd:PTZ00290 188 -MSKE-ELIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLtfESHdMTPLLGDGACFLLIDSMIKHDLL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 159 GSE---YPTRRRQCEEAAAVLGKASLRDA--TMAEL-----------------EASRSRLGEEVYQRARHVIGEIARTVQ 216
Cdd:PTZ00290 266 GGTagmYNTVRSDQEGAQKKIGKHRYRGKpfTFSDLvrnpkkytfdgdvvafmESCKPLMTPGEFERGTYNIMEQIRTLE 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 217 ------AAQAL-QDRDYKTFGRLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEAGAAER 289
Cdd:PTZ00290 346 fiklndPELPLsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDR 425

                        330       340       350
                 ....*....|....*....|....*....|...
gi 723575290 290 AQHHIKEKYSG----TATFYLTKPSGGAKVLPL 318
Cdd:PTZ00290 426 VVAHVREKFKArfgvENDVYPVVAGDGAFVVSL 458
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 2-281 9.77e-27

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 106.08  E-value: 9.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   2 VTSSAEPVEPHRVQFPAPRQGSPLSPGQPRWAN--YVKGVIQ---HYRGGPVPGFSAVIASDIPLGGGLSSSAALEVATY 76
Cdd:COG1577   28 ATVTVEPSDDDKLRIESPDLGGTLDLDPLADAAlrYIKAAIEaalEYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  77 TFLQQLC---PDDGDLAAKALACQKAEHtfaGMPCGiMDQFISVMgkeGHALLIDCRSLETVLVPLTDANLAVLitnsnv 153
Cdd:COG1577  108 RALAAFYgveLSKEELFKLALEAEKIVH---GNPSG-LDTAASTY---GGPIYYQRGDRAEPLELPKNLPLVVG------ 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 154 rhtLTGSEYPTRrrqceeaAAVLGKASLRDAtmaeleasrsrlGEEVYQRARHVIGEIARtvQAAQALQDRDYKTFGRLM 233
Cdd:COG1577  175 ---DTGVPASTK-------ELVAKVRKLKER------------NPELYEAFLEEIGDLVE--EAIEALEEGDLEALGELM 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 723575290 234 VESHNsLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTL 281
Cdd:COG1577  231 NENHG-LLRALGVSTPELDRLVEAARKA-GALGAKLTGAGGGGCVIAL 276
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 49-281 2.34e-22

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 94.28  E-value: 2.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290   49 PGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAKALACQKAEHTFAGMPCGImDQFISVMGkegHALLID 128
Cdd:TIGR00549  77 PPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSG---GPVYFE 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  129 CRSLETVLVPLTDANLavLITNSNV-RHTltgseyptrrrqceeAAAVLGKASLRDATmaeleasrsrlgEEVYQRARHV 207
Cdd:TIGR00549 153 KGEGEFTKLISLDGYF--VIADTGVsGST---------------KEAVARVRQLLERF------------PELIDSIMDA 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723575290  208 IGEIARTvqAAQALQDRDYKTFGRLMVESHnSLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTL 281
Cdd:TIGR00549 204 IGELTLE--AKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 35-285 4.24e-17

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 80.10  E-value: 4.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  35 YVKGVIQHYRG-GPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLAAKALACQKAEHTFAGMPCGImDQ 113
Cdd:PRK03926  59 YVSAAIEKMREeADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DT 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 114 FISVMGkeGHALLIDCRSLETVLVPLTDANlavlitnsnvrhtlTGSEYPTRrrqceeaaavlgkaslrdatmaELEASR 193
Cdd:PRK03926 138 YVSTMG--GFVTIPDRKKLPFPECGIVVGY--------------TGSSGSTK----------------------ELVANV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 194 SRLGE---EVYQRARHVIGEIARTvqAAQALQDRDYKTFGRLMVESHnSLRDDYEVSCPELDELVAAALEVdGVYGSRMT 270
Cdd:PRK03926 180 RKLKEeypELIEPILSSIGKISEK--GEELILSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGAKIT 255

                        250
                 ....*....|....*
gi 723575290 271 GGGFGGCTVTLLEAG 285
Cdd:PRK03926 256 GAGGGGCMVALAAPE 270
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 54-120 5.36e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 5.36e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723575290   54 VIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGdlaakALACQKAEHTFAGMPCGIMDQFISVMGK 120
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 217-299 7.37e-12

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 60.56  E-value: 7.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290  217 AAQALQDRDYKTFGRLMVESHNSL--RDDYEVSCPELDELVAAALEVDgvYGSRMTGGGFGGCTVTLLE-AGAAERAQHH 293
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG--LGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*.
gi 723575290  294 IKEKYS 299
Cdd:pfam08544  79 LREAGK 84
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 184-291 1.14e-05

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 46.38  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723575290 184 ATMAELEASRSRLGEEVYQRARHVIGeiartvQAAQALQDRDYKTFGRLMVESHNSLRdDYEVSCPELDELVAAALEvDG 263
Cdd:PTZ00298 203 GDVRKLKENQPTWFNRLLENYNACVS------EAKEALQKGNLFRVGELMNANHDLCQ-KLTVSCRELDSIVQTCRT-YG 274

                         90       100
                 ....*....|....*....|....*...
gi 723575290 264 VYGSRMTGGGFGGCTVTLleagAAERAQ 291
Cdd:PTZ00298 275 ALGAKMSGTGRGGLVVAL----AASEDQ 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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