SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
52-289
1.16e-122
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.
The actual alignment was detected with superfamily member PLN02384:
Pssm-ID: 469729 Cd Length: 264 Bit Score: 351.05 E-value: 1.16e-122
Ribose 5-phosphate isomerase [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
57-286
8.98e-108
Ribose 5-phosphate isomerase [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439890 Cd Length: 225 Bit Score: 311.97 E-value: 8.98e-108
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible ...
61-280
5.07e-103
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the conversion of phosphosugars into glycolysis intermediates, which are precursors for the synthesis of amino acids, vitamins, nucleotides, and cell wall components. In plants, RPI is part of the Calvin cycle as ribulose 5-phosphate is the carbon dioxide receptor in the first dark reaction of photosynthesis. There are two unrelated types of RPIs (A and B), which catalyze the same reaction, at least one type of RPI is present in an organism. RPI_A is more widely distributed than RPI_B in bacteria, eukaryotes, and archaea.
Pssm-ID: 238692 Cd Length: 213 Bit Score: 299.39 E-value: 5.07e-103
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of ...
61-284
5.92e-100
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of the non-oxidative branch of the pentose phosphate pathway. [Energy metabolism, Pentose phosphate pathway]
Pssm-ID: 272859 Cd Length: 218 Bit Score: 291.82 E-value: 5.92e-100
Ribose 5-phosphate isomerase A (phosphoriboisomerase A); This family consists of several ...
107-283
2.78e-88
Ribose 5-phosphate isomerase A (phosphoriboisomerase A); This family consists of several ribose 5-phosphate isomerase A or phosphoriboisomerase A (EC:5.3.1.6) from bacteria, eukaryotes and archaea.
Pssm-ID: 461804 Cd Length: 172 Bit Score: 260.38 E-value: 2.78e-88
Ribose 5-phosphate isomerase [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
57-286
8.98e-108
Ribose 5-phosphate isomerase [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439890 Cd Length: 225 Bit Score: 311.97 E-value: 8.98e-108
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible ...
61-280
5.07e-103
RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the conversion of phosphosugars into glycolysis intermediates, which are precursors for the synthesis of amino acids, vitamins, nucleotides, and cell wall components. In plants, RPI is part of the Calvin cycle as ribulose 5-phosphate is the carbon dioxide receptor in the first dark reaction of photosynthesis. There are two unrelated types of RPIs (A and B), which catalyze the same reaction, at least one type of RPI is present in an organism. RPI_A is more widely distributed than RPI_B in bacteria, eukaryotes, and archaea.
Pssm-ID: 238692 Cd Length: 213 Bit Score: 299.39 E-value: 5.07e-103
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of ...
61-284
5.92e-100
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of the non-oxidative branch of the pentose phosphate pathway. [Energy metabolism, Pentose phosphate pathway]
Pssm-ID: 272859 Cd Length: 218 Bit Score: 291.82 E-value: 5.92e-100
Ribose 5-phosphate isomerase A (phosphoriboisomerase A); This family consists of several ...
107-283
2.78e-88
Ribose 5-phosphate isomerase A (phosphoriboisomerase A); This family consists of several ribose 5-phosphate isomerase A or phosphoriboisomerase A (EC:5.3.1.6) from bacteria, eukaryotes and archaea.
Pssm-ID: 461804 Cd Length: 172 Bit Score: 260.38 E-value: 2.78e-88
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
74-114
5.48e-05
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.
Pssm-ID: 238258 Cd Length: 169 Bit Score: 42.73 E-value: 5.48e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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