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Conserved domains on  [gi|700412334|ref|XP_009960294|]
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PREDICTED: LOW QUALITY PROTEIN: galactokinase, partial [Leptosomus discolor]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-310 4.68e-126

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 364.86  E-value: 4.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTISILTT-SPEADE-------------PVNYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLS 64
Cdd:COG0153   45 AIDRGTYAAARPRDDRKVRVYSAdFDEEVEfdlddlepgeedgWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  65 SSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDASLAV 144
Cdd:COG0153  125 SSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYAL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 145 LITNSNVRHTLTGSEYPTRRQQCcEEAAAALGKASLRDATMAELEGGDGpSLGSGRSS-------GQQERTAQAAQALQD 217
Cdd:COG0153  205 VIVDTNVKHSLADSEYNERRAEC-EAAAAILGVKSLRDVTLEDLEAARA-RLGDEVLRrrarhvvTENQRVLEAVEALRA 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 218 RDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY----N 293
Cdd:COG0153  283 GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektG 362

                        330
                 ....*....|....*..
gi 700412334 294 GTATFYLTKPSGGAKVL 310
Cdd:COG0153  363 LEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-310 4.68e-126

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 364.86  E-value: 4.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTISILTT-SPEADE-------------PVNYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLS 64
Cdd:COG0153   45 AIDRGTYAAARPRDDRKVRVYSAdFDEEVEfdlddlepgeedgWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  65 SSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDASLAV 144
Cdd:COG0153  125 SSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYAL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 145 LITNSNVRHTLTGSEYPTRRQQCcEEAAAALGKASLRDATMAELEGGDGpSLGSGRSS-------GQQERTAQAAQALQD 217
Cdd:COG0153  205 VIVDTNVKHSLADSEYNERRAEC-EAAAAILGVKSLRDVTLEDLEAARA-RLGDEVLRrrarhvvTENQRVLEAVEALRA 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 218 RDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY----N 293
Cdd:COG0153  283 GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektG 362

                        330
                 ....*....|....*..
gi 700412334 294 GTATFYLTKPSGGAKVL 310
Cdd:COG0153  363 LEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 32-310 1.82e-94

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 284.51  E-value: 1.82e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  32 NYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIM 109
Cdd:PRK05101  94 NYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAENQFVGCNCGIM 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 110 DQFISVMGKEGHALLIDCRSLESVLVPLTDaSLAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGKASLRDATMAELE 189
Cdd:PRK05101 174 DQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSEYNTRRQQ-CETAARFFGVKALRDVTLEQFN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 190 GGDG--PSLGSGRSS---GQQERTAQAAQALQDRDYRMFGKLMVESHNSLRDDYEVSCPELD---ELVAAALEVDGvyGS 261
Cdd:PRK05101 252 AVAAelDPVVAKRARhviTENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDtlvEIVKAVIGDQG--GV 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 700412334 262 RMTGGGFGGCTVTLLEARAAERAQRHIQEKYNGT----ATFYLTKPSGGAKVL 310
Cdd:PRK05101 330 RMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 1-310 5.69e-88

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 268.23  E-value: 5.69e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334    1 ALQLGTVLVGSPTQDGTISILTTS----------------PEADEPVNYVKGVIQHY--RGGPVP-GFSAVIASDIPLGG 61
Cdd:TIGR00131  44 AIDFGTLCAVAVRDDKNVRIYLANadnkfaersldlpldgSEVSDWANYFKGVLHVAqeRFNSFPlGADIVCSGNVPTGS 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   62 GLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDAS 141
Cdd:TIGR00131 124 GLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLG 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  142 LAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGK---ASLRDATMAELEGGDGPS-----LGSGRSS---GQQERTAQ 210
Cdd:TIGR00131 204 IAFVIANTNVKRTLAPSNYNTRRQE-CTTAANFLAAtdkGALRDFMNEYFARYIARLtkmlpLVEERAKhvvSENLRVLK 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  211 AAQALQDRDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQE 290
Cdd:TIGR00131 283 AVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVAD 362

                         330       340
                  ....*....|....*....|....
gi 700412334  291 KYNGT----ATFYLTKPSGGAKVL 310
Cdd:TIGR00131 363 KYPKKtgleLTFYVIVSKPGAGSC 386
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 211-293 5.98e-12

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 60.56  E-value: 5.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  211 AAQALQDRDYRMFGKLMVESHNSL--RDDYEVSCPELDELVAAALEVDgvYGSRMTGGGFGGCTVTLLE-ARAAERAQRH 287
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG--LGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*.
gi 700412334  288 IQEKYN 293
Cdd:pfam08544  79 LREAGK 84
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-310 4.68e-126

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 364.86  E-value: 4.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTISILTT-SPEADE-------------PVNYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLS 64
Cdd:COG0153   45 AIDRGTYAAARPRDDRKVRVYSAdFDEEVEfdlddlepgeedgWANYVRGVAWALqeRGYKLGGFDLVIDGDVPLGAGLS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  65 SSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDASLAV 144
Cdd:COG0153  125 SSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYAL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 145 LITNSNVRHTLTGSEYPTRRQQCcEEAAAALGKASLRDATMAELEGGDGpSLGSGRSS-------GQQERTAQAAQALQD 217
Cdd:COG0153  205 VIVDTNVKHSLADSEYNERRAEC-EAAAAILGVKSLRDVTLEDLEAARA-RLGDEVLRrrarhvvTENQRVLEAVEALRA 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 218 RDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY----N 293
Cdd:COG0153  283 GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektG 362

                        330
                 ....*....|....*..
gi 700412334 294 GTATFYLTKPSGGAKVL 310
Cdd:COG0153  363 LEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 32-310 1.82e-94

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 284.51  E-value: 1.82e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  32 NYVKGVIQHY--RGGPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIM 109
Cdd:PRK05101  94 NYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAENQFVGCNCGIM 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 110 DQFISVMGKEGHALLIDCRSLESVLVPLTDaSLAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGKASLRDATMAELE 189
Cdd:PRK05101 174 DQLISALGKKDHALLIDCRSLETKAVPMPE-GVAVVIINSNVKRGLVDSEYNTRRQQ-CETAARFFGVKALRDVTLEQFN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 190 GGDG--PSLGSGRSS---GQQERTAQAAQALQDRDYRMFGKLMVESHNSLRDDYEVSCPELD---ELVAAALEVDGvyGS 261
Cdd:PRK05101 252 AVAAelDPVVAKRARhviTENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDtlvEIVKAVIGDQG--GV 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 700412334 262 RMTGGGFGGCTVTLLEARAAERAQRHIQEKYNGT----ATFYLTKPSGGAKVL 310
Cdd:PRK05101 330 RMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 1-310 5.69e-88

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 268.23  E-value: 5.69e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334    1 ALQLGTVLVGSPTQDGTISILTTS----------------PEADEPVNYVKGVIQHY--RGGPVP-GFSAVIASDIPLGG 61
Cdd:TIGR00131  44 AIDFGTLCAVAVRDDKNVRIYLANadnkfaersldlpldgSEVSDWANYFKGVLHVAqeRFNSFPlGADIVCSGNVPTGS 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   62 GLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDAS 141
Cdd:TIGR00131 124 GLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLG 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  142 LAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGK---ASLRDATMAELEGGDGPS-----LGSGRSS---GQQERTAQ 210
Cdd:TIGR00131 204 IAFVIANTNVKRTLAPSNYNTRRQE-CTTAANFLAAtdkGALRDFMNEYFARYIARLtkmlpLVEERAKhvvSENLRVLK 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  211 AAQALQDRDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQE 290
Cdd:TIGR00131 283 AVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVAD 362

                         330       340
                  ....*....|....*....|....
gi 700412334  291 KYNGT----ATFYLTKPSGGAKVL 310
Cdd:TIGR00131 363 KYPKKtgleLTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 1-310 3.17e-81

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 250.93  E-value: 3.17e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTI----------SILTTS------PEADEPVNYVKGVIQHY--RGGPVP-GFSAVIASDIPLGG 61
Cdd:PRK05322  46 AITLGTYGAARKRDDKKVrlysanfedlGIIEFDlddlsfDKEDDWANYPKGVLKFLqeAGYKIDhGFDILIYGNIPNGA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  62 GLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDAS 141
Cdd:PRK05322 126 GLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 142 LAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGK----ASLRDATMAELEG-----GDGPSLGSGRSS-GQQERTAQA 211
Cdd:PRK05322 206 YVIVIMNTNKRRELADSKYNERRAE-CEKALEELQKkldiKSLGELTEEEFDEysyliKDETLLKRARHAvTENQRTLKA 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 212 AQALQDRDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEK 291
Cdd:PRK05322 285 VKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKA 364

                        330       340
                 ....*....|....*....|...
gi 700412334 292 YNGT----ATFYLTKPSGGAKVL 310
Cdd:PRK05322 365 YEEKigyaASFYVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 1-310 3.20e-77

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 239.51  E-value: 3.20e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTI------SILTTSPEADEPVN----YVKGVI-----QHYRGGPVPGFsavIASDIPLGGGLSS 65
Cdd:PRK03817  27 AINLYTFLEIEKSEKFIFysenfnEEKTFELDKLEKLNswadYIKGVIwvlekRGYEVGGVKGK---VSSNLPIGAGLSS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  66 SAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDaSLAVL 145
Cdd:PRK03817 104 SASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFPE-DYEIL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 146 ITNSNVRHTLTGSEYPTRRQQcCEEAAAALGKASLRDATMAELEGgdGPSLGSGRSS---GQQERTAQAAQALQDRDYRM 222
Cdd:PRK03817 183 VFDTGVKRELASSEYNERRQE-CEEALKILGKKSSKEVTEEDLSK--LPPLLRKRAGyvlRENERVLKVRDALKEGDIET 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 223 FGKLMVESHNSLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY----NGTATF 298
Cdd:PRK03817 260 LGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYkkrfGIDPKY 338

                        330
                 ....*....|..
gi 700412334 299 YLTKPSGGAKVL 310
Cdd:PRK03817 339 FVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 1-283 2.17e-53

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 178.52  E-value: 2.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTISIltTSPEADEPV---------------NYVKGVIQHYR--GGPVPGFSAVIASDIPLGGGL 63
Cdd:PRK00555  29 ALPQRTVVTFTPEHTDAITA--SSDRADGSAripldttpgqvtgwaAYAAGVIWALRgaGHPVPGGAMSITSDVEIGSGL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  64 SSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLT--DAS 141
Cdd:PRK00555 107 SSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAFDpdAAG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 142 LAVLITNSNVRHTLTGSEYPTRRQQcCEEAAAALGKASLRDATMAELEG----GDGPSLGSGRSS-GQQERTAQAAQALQ 216
Cdd:PRK00555 187 VVLLLMDSRARHRHAGGEYAARRAS-CERAAADLGVSSLRAVQDRGLAAlgaiADPIDARRARHVlTENQRVLDFAAALA 265

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700412334 217 DRDYRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTLLEARAAER 283
Cdd:PRK00555 266 DSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARMTGGGFGGCVIALVPADRAED 331
PTZ00290 PTZ00290
galactokinase; Provisional
 45-312 6.01e-30

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 118.00  E-value: 6.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  45 PVPGFSAVIASDIPLGGGLSSSAALEVA----------------------TYTFLQQlCPDDgDLVAKALACQKAEHTFA 102
Cdd:PTZ00290 131 SLQGVCMVVHGTLPMGAGMSASASFGVAllnaintvvtrrykgcptspgrRYSILPP-MSKE-ELIELAKQARRIETEFC 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 103 SMPCGIMDQFISVMGKEGHALLIDCRSL--ESV-LVPLTDASLAVLITNSNVRHTLTGSE---YPTRRQQCcEEAAAALG 176
Cdd:PTZ00290 209 GVNVGIMDQFISAFAEEDKFMFLDCKSLtfESHdMTPLLGDGACFLLIDSMIKHDLLGGTagmYNTVRSDQ-EGAQKKIG 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 177 KASLRDA--TMAELE------GGDG------PSLGSGRSSGQQER-TAQAAQALQDRDYRMF----------------GK 225
Cdd:PTZ00290 288 KHRYRGKpfTFSDLVrnpkkyTFDGdvvafmESCKPLMTPGEFERgTYNIMEQIRTLEFIKLndpelplsreerfrkaGE 367

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 226 LMVESHNSLRDDYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKYNG----TATFYLT 301
Cdd:PTZ00290 368 ILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKArfgvENDVYPV 447

                        330
                 ....*....|.
gi 700412334 302 KPSGGAKVLPL 312
Cdd:PTZ00290 448 VAGDGAFVVSL 458
PLN02865 PLN02865
galactokinase
 24-310 9.77e-29

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 114.13  E-value: 9.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  24 SPEADEPVNYVKGVIQHYRGGPV---PGFSAVIASDIPL-GGGLSSSAALEVAtytFLQQLcPDDGDLVAKALAC----Q 95
Cdd:PLN02865 103 SKEESNWGDYARGAVYALQSRGHalsQGITGYISGSEGLdSSGLSSSAAVGVA---YLLAL-ENANNLTVSPEDNieldR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  96 KAEHTFASMPCGIMDQFISVMGKEGHALLIDCRSLESVLVPLTDA------SLAVLITNSNVRHTLTGSEYPTRRQQCCE 169
Cdd:PLN02865 179 LIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQqpggekPFKILLAFSGLRHALTNKPGYNLRVSECQ 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 170 EAAAALGKASLRDATMAELEGGD-----------GPSLGSGRSSGQQE--RTAQAAQALQDRDYRMFGKLMVESHNSLRD 236
Cdd:PLN02865 259 EAARFLLEASGNDELEPLLCNVEpevyeahkcklEAVLARRAEHYFSEnmRVIKGVEAWASGNLEEFGKLISASGLSSIE 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 237 DYEVSCPELDELVAAALEVDGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY-----------NGTATFYLTKPSG 305
Cdd:PLN02865 339 NYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYekaqpelasniNGDKPVLICEAGD 418


                 ....*
gi 700412334 306 GAKVL 310
Cdd:PLN02865 419 CARVL 423
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 1-275 1.79e-23

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 97.22  E-value: 1.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGTISI--------LTTSPEADEPVNYVKGVIQ---HYRGGPVPGFSAVIASDIPLGGGLSSSAAL 69
Cdd:COG1577   23 AVDRRATVTVEPSDDDKLRIespdlggtLDLDPLADAALRYIKAAIEaalEYLGLPLKGFDIEIDSEIPRKRGLGSSAAV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  70 EVATYTFLQQLC---PDDGDLVAKALACQKAEHTFASMpcgiMDQFISVMgkeGHALLIDCRSLESVLVPLTDASLAVLI 146
Cdd:COG1577  103 AVAVIRALAAFYgveLSKEELFKLALEAEKIVHGNPSG----LDTAASTY---GGPIYYQRGDRAEPLELPKNLPLVVGD 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 147 TN--SNVRHTLTG-----SEYPTRRQQCCEEAAAAlgkaslrdatmaeleggdgpslgsgrssgqqerTAQAAQALQDRD 219
Cdd:COG1577  176 TGvpASTKELVAKvrklkERNPELYEAFLEEIGDL---------------------------------VEEAIEALEEGD 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 700412334 220 YRMFGKLMVESHNsLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTL 275
Cdd:COG1577  223 LEALGELMNENHG-LLRALGVSTPELDRLVEAARKA-GALGAKLTGAGGGGCVIAL 276
PLN02521 PLN02521
galactokinase
 32-310 2.34e-22

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 96.70  E-value: 2.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  32 NYV----KGVIQHYR------GGPVpGFSAVIASDIPLGGGLSSSAALEVATYTFLqqlcpddgdLVAKALACQKAEHTF 101
Cdd:PLN02521 124 NYFicgyKGVFEFLKskgvdvGPPV-GLDVVVDGTVPTGSGLSSSAALVCSAAIAI---------MAALGLNFTKKEVAQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 102 ASMPC--------GIMDQFISVMGKEGHALLIDCRSLESVLVPLTDA-------SLAV------LITNSNVR-------- 152
Cdd:PLN02521 194 FTCKCerhigtqsGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGgtfvianSLAEsnkavtAATNYNNRvvecrlaa 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 153 ------------------HTLTGSEyptrrqQCCEEAAAALGKASLRDA----------TMAELEGGDGPSLGSGRSSGQ 204
Cdd:PLN02521 274 ivlavklgmsaeeaiskvKTLSDVE------GLCVSFAGSHGSSDPAVAvkellhegpyTAEEIEEILGESLTSIFKNSP 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 205 --------------QERTA----QAAQALQDRD-----------YRMFGKLMVESHNSLRDDYEVSCPELDELVAAALEv 255
Cdd:PLN02521 348 tslavlkaakhfklHQRAVhvysEAKRVHAFRDtvssslseeekLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRD- 426

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700412334 256 DGVYGSRMTGGGFGGCTVTLLEARAAERAQRHIQEKY-------------NGTATFYLTKPSGGAKVL 310
Cdd:PLN02521 427 NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFyksriekgvikeeDLGLYVFASKPSSGAAIL 494
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 47-275 5.67e-16

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 76.18  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   47 PGFSAVIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGDLVAKALACQKAEHTFASMPCGImDQFISVMGkegHALLID 126
Cdd:TIGR00549  77 PPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSG---GPVYFE 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  127 CRSLESVLVPLTDASLavLITNSNV-RHTltgSEYPTRRQQCCEEAAAALgkaslrDATMAELEggdgpslgsgrssgqq 205
Cdd:TIGR00549 153 KGEGEFTKLISLDGYF--VIADTGVsGST---KEAVARVRQLLERFPELI------DSIMDAIG---------------- 205

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  206 ERTAQAAQALQDRDYRMFGKLMVESHnSLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTL 275
Cdd:TIGR00549 206 ELTLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 1-275 3.46e-15

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 74.32  E-value: 3.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334   1 ALQLGTVLVGSPTQDGtISILTTSPEADEPVNYVKGVIQHYRG-GPVPGFSAVIASDIPLGGGLSSSAALEVATYTFLQQ 79
Cdd:PRK03926  28 AIDLRTYVRAEFNDDS-IYIESDYGKTGEKHPYVSAAIEKMREeADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  80 L--CPDDGDLVAKALACQKAEHTFASMPcgiMDQFISVMGkeGHALLIDCRSLesvlvPLTDASLAVLITNS-------- 149
Cdd:PRK03926 107 LlgLGLSLEEIAKLGHKVELLVQGAASP---TDTYVSTMG--GFVTIPDRKKL-----PFPECGIVVGYTGSsgstkelv 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334 150 -NVRHTLTgsEYPtrrqQCCEEAAAALGKASLRdatmaeleggdgpslgsgrssgqqertaqAAQALQDRDYRMFGKLMV 228
Cdd:PRK03926 177 aNVRKLKE--EYP----ELIEPILSSIGKISEK-----------------------------GEELILSGDYVSLGELMN 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 700412334 229 ESHnSLRDDYEVSCPELDELVAAALEVdGVYGSRMTGGGFGGCTVTL 275
Cdd:PRK03926 222 INQ-GLLDALGVSTKELSELIYAARTA-GALGAKITGAGGGGCMVAL 266
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 211-293 5.98e-12

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 60.56  E-value: 5.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700412334  211 AAQALQDRDYRMFGKLMVESHNSL--RDDYEVSCPELDELVAAALEVDgvYGSRMTGGGFGGCTVTLLE-ARAAERAQRH 287
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG--LGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*.
gi 700412334  288 IQEKYN 293
Cdd:pfam08544  79 LREAGK 84
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 52-118 6.00e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 57.17  E-value: 6.00e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700412334   52 VIASDIPLGGGLSSSAALEVATYTFLQQLCPDDGdlvakALACQKAEHTFASMPCGIMDQFISVMGK 118
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 210-286 1.77e-06

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 48.70  E-value: 1.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700412334 210 QAAQALQDRDYRMFGKLMVESHNSLRdDYEVSCPELDELVAAALEvDGVYGSRMTGGGFGGCTVTLlearAAERAQR 286
Cdd:PTZ00298 229 EAKEALQKGNLFRVGELMNANHDLCQ-KLTVSCRELDSIVQTCRT-YGALGAKMSGTGRGGLVVAL----AASEDQR 299
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-68 1.66e-03

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 39.31  E-value: 1.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 700412334   1 ALQLGTVLVGSPTQDGTISILTTSPEADE----PVNYVKGVIQHYR---GGPVPGFSAVIASDIPLGGGLSSSAA 68
Cdd:COG0083   24 ALSLYDEVEVERSDEPGLEIEIEGEGADElptdEDNLVYQAALALLeklGKEPPGLRIEIEKGIPLGRGLGSSAA 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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