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Conserved domains on  [gi|698453833|ref|XP_009701596|]
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PREDICTED: protein phosphatase 1 regulatory subunit 42 [Cariama cristata]

Protein Classification

protein phosphatase 1 regulatory subunit 42( domain architecture ID 15347297)

protein phosphatase 1 regulatory subunit 42 (PPP1R42) regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 6.03e-117

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


:

Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 337.53  E-value: 6.03e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  27 LRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMENLSSLKKLEKLYLGGNHI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 107 TVVEGLDKIEEIRELHIENQHLPLGEKLLFDPRSLRSLAKSLSVLNISNNNIDELEELAVLENLSYLRAVENQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 187 EVVLNKWTKLRRMDLTGNPICHKPKYRDRIVVQSQTLESLDGKEIKEMERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 6.03e-117

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 337.53  E-value: 6.03e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  27 LRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMENLSSLKKLEKLYLGGNHI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 107 TVVEGLDKIEEIRELHIENQHLPLGEKLLFDPRSLRSLAKSLSVLNISNNNIDELEELAVLENLSYLRAVENQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 187 EVVLNKWTKLRRMDLTGNPICHKPKYRDRIVVQSQTLESLDGKEIKEMERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-206 1.15e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  26 HLRKITHLNLSDKNIDAIGD-LSLCKSLRVLYLYDNQISQI-QNLDFASNITHLYLQNNCISRM-ENLSSLKKLEKLYLG 102
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 103 GNHITVVegldkieeirelhienqhlplgekllfdPRSLRSLaKSLSVLNISNNNIDELEELAVLENLSYLRAVENQLQH 182
Cdd:COG4886  214 GNQLTDL----------------------------PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                        170       180
                 ....*....|....*....|....
gi 698453833 183 MKDLEvvlnKWTKLRRMDLTGNPI 206
Cdd:COG4886  265 LPPLA----NLTNLKTLDLSNNQL 284
LRR_9 pfam14580
Leucine-rich repeat;
144-237 1.52e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  144 LAKSLSVLNISNNNI----DELEElaVLENLSYLRAVENQLQHMKDLEVvLNKWTKLRRMDLTGNPICHKPKYRDRIVVQ 219
Cdd:pfam14580  62 LLRRLKTLLLNNNRIcrigEGLGE--ALPNLTELILTNNNLQELGDLDP-LASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138

                          90
                  ....*....|....*...
gi 698453833  220 SQTLESLDGKEIKEMERQ 237
Cdd:pfam14580 139 VPQLRLLDFRKVKQKERQ 156
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 6.03e-117

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 337.53  E-value: 6.03e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  27 LRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMENLSSLKKLEKLYLGGNHI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 107 TVVEGLDKIEEIRELHIENQHLPLGEKLLFDPRSLRSLAKSLSVLNISNNNIDELEELAVLENLSYLRAVENQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 187 EVVLNKWTKLRRMDLTGNPICHKPKYRDRIVVQSQTLESLDGKEIKEMERQFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-206 1.15e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  26 HLRKITHLNLSDKNIDAIGD-LSLCKSLRVLYLYDNQISQI-QNLDFASNITHLYLQNNCISRM-ENLSSLKKLEKLYLG 102
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 103 GNHITVVegldkieeirelhienqhlplgekllfdPRSLRSLaKSLSVLNISNNNIDELEELAVLENLSYLRAVENQLQH 182
Cdd:COG4886  214 GNQLTDL----------------------------PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                        170       180
                 ....*....|....*....|....
gi 698453833 183 MKDLEvvlnKWTKLRRMDLTGNPI 206
Cdd:COG4886  265 LPPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-211 3.91e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  25 QHLRKITHLNLSDKNidaigDLSLCKSLRVLYLYDNQISQI-QNLDFASNITHLYLQNNCISRM-ENLSSLKKLEKLYLG 102
Cdd:COG4886   93 GDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 103 GNHITVV-EGLDKIEEIRELHIENQHLplgEKLlfdPRSLRSLaKSLSVLNISNNNIDEL-EELAVLENLSYLRAVENQL 180
Cdd:COG4886  168 NNQLTDLpEELGNLTNLKELDLSNNQI---TDL---PEPLGNL-TNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 698453833 181 QHMKDLEvvlnKWTKLRRMDLTGNPICHKPK 211
Cdd:COG4886  241 TDLPELG----NLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-170 2.64e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  27 LRKITHLNLSDKNIDAIGD-LSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMENLSSLKKLEKLYLGGNH 105
Cdd:COG4886  204 LTNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 698453833 106 ITVVEgLDKIEEIRELHIENQHLPLGEKLLFDPRSLRSLAKSLSVLNISNNNIDELEELAVLENL 170
Cdd:COG4886  284 LTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-206 3.56e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833   1 MVQLTMNLIAKSISHKNRNEEDFGQHLRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQ 80
Cdd:COG4886   25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  81 NNcisrmENLSSLKKLEKLYLGGNHITVV-EGLDKIEEIRELHIENQHLplgEKLlfdPRSLRSLaKSLSVLNISNNNID 159
Cdd:COG4886  105 GN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQL---TDL---PEPLGNL-TNLKSLDLSNNQLT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 698453833 160 EL-EELAVLENLSYLRAVENQLQhmkDLEVVLNKWTKLRRMDLTGNPI 206
Cdd:COG4886  173 DLpEELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-180 1.88e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  26 HLRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMeNLSSLKKLEKLYLGGNH 105
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLL 304

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 698453833 106 ITVVEGLDKIEEIRELHIENQHLPLGEKLLFDPRSLRSLAKSLSVLNISNNNIDELEELAVLENLSYLRAVENQL 180
Cdd:COG4886  305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 30-206 5.72e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 5.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  30 ITHLNLSDKNIDAIGDLSLCK------SLRVLYLYDNQISQIQNLDFAS------NITHLYLQNNCISR------MENLS 91
Cdd:COG5238  182 VETVYLGCNQIGDEGIEELAEaltqntTVTTLWLKRNPIGDEGAEILAEalkgnkSLTTLDLSNNQIGDegvialAEALK 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  92 SLKKLEKLYLGGNHITvVEGLDKIEEIRELHIENQHLPLGEKLLFDPrSLRSLAKSL------SVLNISNNNIDELEELA 165
Cdd:COG5238  262 NNTTVETLYLSGNQIG-AEGAIALAKALQGNTTLTSLDLSVNRIGDE-GAIALAEGLqgnktlHTLNLAYNGIGAQGAIA 339

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 698453833 166 VLENLSYLRAVE------NQL--QHMKDLEVVLNKWTKLRRMDLTGNPI 206
Cdd:COG5238  340 LAKALQENTTLHsldlsdNQIgdEGAIALAKYLEGNTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-206 6.45e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 6.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  19 NEEDFGQHLRKITH---LNLSDKNIDAIGDLSLCKSLRV------LYLYDNQ--------ISQIQNLDFASNITHLYLQN 81
Cdd:cd00116   11 KTERATELLPKLLClqvLRLEGNTLGEEAAKALASALRPqpslkeLCLSLNEtgriprglQSLLQGLTKGCGLQELDLSD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  82 NCIS-----RMENLSSLKKLEKLYLGGNHITVVEGLDKIEEIRELHIENQHLPLGEKLLFDpRSLRSLAK------SLSV 150
Cdd:cd00116   91 NALGpdgcgVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEG-ASCEALAKalranrDLKE 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 698453833 151 LNISNNNIDE------LEELAVLENLSYLRAVENQLQH--MKDLEVVLNKWTKLRRMDLTGNPI 206
Cdd:cd00116  170 LNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDegASALAETLASLKSLEVLNLGDNNL 233
LRR_9 pfam14580
Leucine-rich repeat;
144-237 1.52e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  144 LAKSLSVLNISNNNI----DELEElaVLENLSYLRAVENQLQHMKDLEVvLNKWTKLRRMDLTGNPICHKPKYRDRIVVQ 219
Cdd:pfam14580  62 LLRRLKTLLLNNNRIcrigEGLGE--ALPNLTELILTNNNLQELGDLDP-LASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138

                          90
                  ....*....|....*...
gi 698453833  220 SQTLESLDGKEIKEMERQ 237
Cdd:pfam14580 139 VPQLRLLDFRKVKQKERQ 156
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 24-226 1.62e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  24 GQHLRKITHLNLSDKNIDAIGDLSLCKSLRV------LYLYDNQISQ------IQNLDFASNITHLYLQNNCISR----- 86
Cdd:COG5238  232 LKGNKSLTTLDLSNNQIGDEGVIALAEALKNnttvetLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaia 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  87 -MENLSSLKKLEKLYLGGNHITV--VEGLDK-IEEIRELHIenqhLPLGEKLLFDpRSLRSLAK------SLSVLNISNN 156
Cdd:COG5238  312 lAEGLQGNKTLHTLNLAYNGIGAqgAIALAKaLQENTTLHS----LDLSDNQIGD-EGAIALAKylegntTLRELNLGKN 386

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 157 NIDELEELAVLENLsylravenqlqhmkdlevvlnKWTKLRRMDLTGNPICHKPkyRDRIVVQSQTLESL 226
Cdd:COG5238  387 NIGKQGAEALIDAL---------------------QTNRLHTLILDGNLIGAEA--QQRLEQLLERIKSV 433
LRR_9 pfam14580
Leucine-rich repeat;
1-107 9.22e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833    1 MVQLTMNLIAKSISHKN---RNE-----------EDFGQHLRKITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQI- 65
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNpvrEREldlrgykipiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIg 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 698453833   66 QNLD-FASNITHLYLQNNCISRM---ENLSSLKKLEKLYLGGNHIT 107
Cdd:pfam14580  81 EGLGeALPNLTELILTNNNLQELgdlDPLASLKKLTFLSLLRNPVT 126
LRR_8 pfam13855
Leucine rich repeat;
51-106 2.58e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833   51 SLRVLYLYDNQISQIQNLDFA--SNITHLYLQNNCISRMEN--LSSLKKLEKLYLGGNHI 106
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-206 2.90e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833  30 ITHLNLSDKNIDAIGDLSLCKSLRVLYLYDNQISQIQNLDFASNITHLYLQNNCISRMENLSSLKKLEKLYLGGNHITVV 109
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698453833 110 EGLDKIEEIRELHienqhlplgeklLFDPRSLRSLaKSLSVLNISNNNIDEL-EELAVLENLSYLRAVENQLqhmKDLEV 188
Cdd:COG4886   90 TDLGDLTNLTELD------------LSGNEELSNL-TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQL---TDLPE 153

                        170
                 ....*....|....*...
gi 698453833 189 VLNKWTKLRRMDLTGNPI 206
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQL 171
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 73-104 7.77e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 7.77e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 698453833   73 NITHLYLQNNCISRMENLSSLKKLEKLYLGGN 104
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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