|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-479 |
1.54e-108 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 327.64 E-value: 1.54e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319 68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319 148 DLATGKLLR-TLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSteyvlrsgafdHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGR-------------------------LLASGS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAvSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319 266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 425 LLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
108-479 |
3.03e-87 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 269.20 E-value: 3.03e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 108 CSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDP 187
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 188 QTGKPLgNPLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGS 266
Cdd:cd00200 81 ETGECV-RTLTGHTSYVSSVAFSPDG-----RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 267 QDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgafdhtgkqysspeemkkvalerynkmrgnaperlvsgsdd 346
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 347 ftmflwepavskhpktrmtghqqlvnhvyFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLL 426
Cdd:cd00200 185 -----------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 697093368 427 SGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| NLE |
pfam08154 |
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ... |
19-79 |
4.17e-12 |
|
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.
Pssm-ID: 462380 Cd Length: 66 Bit Score: 61.38 E-value: 4.17e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697093368 19 VICQLADPDGN--SLGAALYLPENAGPKELNQVVNKLLSNEER---LPYAFYISDEELVVQLGAYL 79
Cdd:pfam08154 1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEELekpVPFDFLINGEFLRTSLEEHL 66
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
107-144 |
1.57e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.17 E-value: 1.57e-10
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
107-144 |
8.89e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 53.89 E-value: 8.89e-10
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
268-437 |
6.02e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.01 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 268 DCTIKVWETSQGKLIRELKGHGHWVNSLALSTE--YVLRSGAFDHTGKQYSSPE-----EMKKVALERYNKMRGNAPERL 340
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdpTLLASGSDDGSVKLWSINQgvsigTIKTKANICCVQFPSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 341 VSGSDDFTMFLWEPAVSKHPKTRMTGHQQLVNHVYFSpDGQWIASASFDKSVKLWN------GTTGKFVAAFRGHVGPVY 414
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKN 712
|
170 180
....*....|....*....|...
gi 697093368 415 QISWSADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 713 FVGLSVSDGYIATGSETNEVFVY 735
|
|
| propeller_TolB |
TIGR02800 |
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ... |
116-180 |
1.09e-05 |
|
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]
Pssm-ID: 274305 [Multi-domain] Cd Length: 417 Bit Score: 47.65 E-value: 1.09e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368 116 TEAVLSVAFSPDGRQLA---SGSGDTTVRLWDLNTQTPLfTLQGHKNWVLSVAWSPDGKHL-VSGSKAG 180
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQRE-KVASFPGMNGAPAFSPDGSKLaVSLSKDG 256
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-479 |
1.54e-108 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 327.64 E-value: 1.54e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319 68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319 148 DLATGKLLR-TLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSteyvlrsgafdHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGR-------------------------LLASGS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAvSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319 266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 425 LLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-441 |
1.47e-97 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 299.52 E-value: 1.47e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319 190 DLATGKLLR-TLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgaFDHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVA-----------FSPDGK-------------------------LLASGS 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAVSKHPKTrMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319 308 DDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386
|
330
....*....|....*..
gi 697093368 425 LLSGSKDSTLKVWDIRT 441
Cdd:COG2319 387 LASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
108-479 |
3.03e-87 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 269.20 E-value: 3.03e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 108 CSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDP 187
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 188 QTGKPLgNPLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGS 266
Cdd:cd00200 81 ETGECV-RTLTGHTSYVSSVAFSPDG-----RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 267 QDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgafdhtgkqysspeemkkvalerynkmrgnaperlvsgsdd 346
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 347 ftmflwepavskhpktrmtghqqlvnhvyFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLL 426
Cdd:cd00200 185 -----------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 697093368 427 SGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
123-479 |
1.90e-79 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 252.91 E-value: 1.90e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 123 AFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLgNPLTGHKK 202
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 203 WITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWETSQGKL 281
Cdd:COG2319 80 AVLSVAF-----SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 282 IRELKGHGHWVNSLAlsteyvlrsgaFDHTGKqysspeemkkvalerynkmrgnapeRLVSGSDDFTMFLWEPAVSKHPK 361
Cdd:COG2319 155 LRTLTGHSGAVTSVA-----------FSPDGK-------------------------LLASGSDDGTVRLWDLATGKLLR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 362 TrMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWDIRT 441
Cdd:COG2319 199 T-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277
|
330 340 350
....*....|....*....|....*....|....*...
gi 697093368 442 KKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
107-316 |
1.17e-54 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 184.46 E-value: 1.17e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 187 PQTGKPLGNpLTGHKKWITGISWEPvhlsaPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDGVIYT-G 265
Cdd:cd00200 164 LRTGKCVAT-LTGHTGEVNSVAFSP-----DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAsG 237
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 697093368 266 SQDCTIKVWETSQGKLIRELKGHGHWVNSLALSTEY-VLRSGAFDHTGKQYS 316
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
|
|
| NLE |
pfam08154 |
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ... |
19-79 |
4.17e-12 |
|
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.
Pssm-ID: 462380 Cd Length: 66 Bit Score: 61.38 E-value: 4.17e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697093368 19 VICQLADPDGN--SLGAALYLPENAGPKELNQVVNKLLSNEER---LPYAFYISDEELVVQLGAYL 79
Cdd:pfam08154 1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEELekpVPFDFLINGEFLRTSLEEHL 66
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
107-144 |
1.57e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.17 E-value: 1.57e-10
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
107-144 |
8.89e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 53.89 E-value: 8.89e-10
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
147-186 |
1.77e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.09 E-value: 1.77e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 697093368 147 TQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
122-464 |
1.78e-09 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 60.44 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 122 VAFSPDGRQL--ASGSGDTTVRLWDL-----NTQTP--LFTLQGHknwvlSVAWSPDGKHLVS--------------GSK 178
Cdd:COG4946 110 VGWTPDGKSVlfASNRGSPPSRSNQLytvpvDGGLPerLPLPPAG-----DGSFSPDGKKLAYtrigrefrtwkryrGGT 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 179 AGELICWDPQTGKplgnpltgHKKwitgISWEPVHLSAPC----RRFVSSSKDGDARIW--DVTTRKcliclsghTLAIT 252
Cdd:COG4946 185 AGDIWIYDLGTGE--------FTR----LTDFGGNDRNPMwigdRIYFLSDRDGTFNLYsyDPDGKD--------LRQLT 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 253 C-----VKW---GGDGVIYTgsQDCTIKVWETSQGKlIRELK---------GHGHWVNSlalsTEYvLRSGAFDHTGKqy 315
Cdd:COG4946 245 HfkdfdVRFpstDGGRIVYE--QGGDLYLLDLASGE-PRKLNitlagdfpqRRPRWVDV----SGY-LTSFALSPDGK-- 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 316 sspeemkKVALErynkMRGNAperlvsgsddFTMFLWE-PAV--SKHPKTRMTghqqlvnHVYFSPDGQWIASASfDKS- 391
Cdd:COG4946 315 -------RVAFE----ARGEV----------FTVPAEKgPTRnlTNTPGVRER-------LPAWSPDGKSIAYFS-DASg 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 392 -VKLW-----NGTTGKFVAAfrGHVGPVYQISWSADSRLLLSGSKDSTLKVWDIRTKKLKQ-DLPGHADEVFAVDWSPDG 464
Cdd:COG4946 366 eYELYiapadGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKvDTDGYGDGISDLAWSPDS 443
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
399-438 |
2.57e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.70 E-value: 2.57e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 697093368 399 TGKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWD 438
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
400-438 |
1.85e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.04 E-value: 1.85e-08
10 20 30
....*....|....*....|....*....|....*....
gi 697093368 400 GKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWD 438
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
360-396 |
8.50e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 48.11 E-value: 8.50e-08
10 20 30
....*....|....*....|....*....|....*..
gi 697093368 360 PKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWN 396
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
357-396 |
8.54e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.08 E-value: 8.54e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 697093368 357 SKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWN 396
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
441-479 |
9.61e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.08 E-value: 9.61e-08
10 20 30
....*....|....*....|....*....|....*....
gi 697093368 441 TKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
149-186 |
1.42e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.73 E-value: 1.42e-07
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 149 TPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
268-437 |
6.02e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.01 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 268 DCTIKVWETSQGKLIRELKGHGHWVNSLALSTE--YVLRSGAFDHTGKQYSSPE-----EMKKVALERYNKMRGNAPERL 340
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdpTLLASGSDDGSVKLWSINQgvsigTIKTKANICCVQFPSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 341 VSGSDDFTMFLWEPAVSKHPKTRMTGHQQLVNHVYFSpDGQWIASASFDKSVKLWN------GTTGKFVAAFRGHVGPVY 414
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKN 712
|
170 180
....*....|....*....|...
gi 697093368 415 QISWSADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 713 FVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
237-275 |
8.80e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 8.80e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 697093368 237 TRKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWE 275
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
337-452 |
9.12e-07 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 51.05 E-value: 9.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 337 PERLVSGSDDFTMFLW---EPAVSKH---PKTRMTGHQQLVNHVYFSPDGQWI-ASASFDKSVKLWNGTTGKFVAAFRGH 409
Cdd:PTZ00421 88 PQKLFTASEDGTIMGWgipEEGLTQNisdPIVHLQGHTKKVGIVSFHPSAMNVlASAGADMVVNVWDVERGKAVEVIKCH 167
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 697093368 410 VGPVYQISWSADSRLLLSGSKDSTLKVWDIRTKKLKQDLPGHA 452
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
130-298 |
1.13e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 51.24 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 130 QLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSP-DGKHLVSGSKAGELICWDPQTGKPLGNPLTghKKWITGIS 208
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQ 624
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 209 WEpvhlSAPCRRFVSSSKDGDARIWDVTTRKCLIC-LSGHTLAITCVKWGGDGVIYTGSQDCTIKVWETSQG------KL 281
Cdd:PLN00181 625 FP----SESGRSLAFGSADHKVYYYDLRNPKLPLCtMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTP 700
|
170
....*....|....*..
gi 697093368 282 IRELKGHGHWVNSLALS 298
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLS 717
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
442-479 |
2.08e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.26 E-value: 2.08e-06
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 442 KKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
238-275 |
3.85e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.49 E-value: 3.85e-06
10 20 30
....*....|....*....|....*....|....*....
gi 697093368 238 RKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWE 275
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
115-274 |
4.28e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 49.31 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 115 HTEAVLSVAFSP-DGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGK-P 192
Cdd:PLN00181 574 HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlP 653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 193 LGNpLTGHKKWITGISWepvhlsAPCRRFVSSSKDGDARIWDVT------TRKCLICLSGHTLAITCVKWG-GDGVIYTG 265
Cdd:PLN00181 654 LCT-MIGHSKTVSYVRF------VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSvSDGYIATG 726
|
....*....
gi 697093368 266 SQDCTIKVW 274
Cdd:PLN00181 727 SETNEVFVY 735
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
112-239 |
7.57e-06 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 48.41 E-value: 7.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 112 IAGHTEAVLSVAFSPDGRQ-LASGSGDTTVRLWDLntqtplftlqghknwvlsvawsPDGKHLVSGSKagelicwDPQTg 190
Cdd:PTZ00420 70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEI----------------------PHNDESVKEIK-------DPQC- 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 697093368 191 kplgnPLTGHKKWITGISWEPVHLSAPCrrfvSSSKDGDARIWDVTTRK 239
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIENEK 159
|
|
| propeller_TolB |
TIGR02800 |
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ... |
116-180 |
1.09e-05 |
|
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]
Pssm-ID: 274305 [Multi-domain] Cd Length: 417 Bit Score: 47.65 E-value: 1.09e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368 116 TEAVLSVAFSPDGRQLA---SGSGDTTVRLWDLNTQTPLfTLQGHKNWVLSVAWSPDGKHL-VSGSKAG 180
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQRE-KVASFPGMNGAPAFSPDGSKLaVSLSKDG 256
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
111-198 |
1.24e-05 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 47.37 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 111 TIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDL-----------NTQ------------TPLFTLQGHKNWVLSVAWS 167
Cdd:pfam20426 119 SIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekrsrNTQtefprkdhviaeTPFHILCGHDDIITCLYVS 198
|
90 100 110
....*....|....*....|....*....|....*...
gi 697093368 168 PDGKHLVSGSKAGELICWDPQTGK-------PLGNPLT 198
Cdd:pfam20426 199 VELDIVISGSKDGTCIFHTLREGRyvrsirhPSGCPLS 236
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
359-439 |
1.37e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.77 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 359 HPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISW-SADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 524 YPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
|
..
gi 697093368 438 DI 439
Cdd:PLN00181 604 SI 605
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
114-191 |
1.52e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 47.20 E-value: 1.52e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368 114 GHTEAVLSVAFSPDGRQ-LASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGK 191
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
374-478 |
2.98e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 46.42 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 374 VYFSP-DGQWIASASFDKSVKLWN-------GTTGKFVAAFRGHVGPVYQISWSADSR-LLLSGSKDSTLKVWDIRTKKL 444
Cdd:PTZ00421 81 VAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160
|
90 100 110
....*....|....*....|....*....|....
gi 697093368 445 KQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKL 478
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
114-167 |
3.87e-05 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 42.27 E-value: 3.87e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 697093368 114 GHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWS 167
Cdd:pfam12894 36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
362-468 |
2.17e-04 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 41.58 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 362 TRMTGHQQLVNHVYFSPDGQWIA-SASFDKSVKLW----NGTTGKFVAAFRGHvgpVYQISWSADSRLLL-SGSKDSTLK 435
Cdd:COG0823 24 RRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvdaDGGEPRRLTFGGGY---NASPSWSPDGKRLAfVSRSDGRFD 100
|
90 100 110
....*....|....*....|....*....|....*
gi 697093368 436 VW--DIRTKKLKQdlpgHADEVFAVDWSPDGEKVA 468
Cdd:COG0823 101 IYvlDLDGGAPRR----LTDGPGSPSWSPDGRRIV 131
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
391-479 |
3.59e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 43.01 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 391 SVKLWNGTTGKFVAAFRGHVGPVYQISWS-ADSRLLLSGSKDSTLKVWDIR-----TKKLKQD---LPGHADEVFAVDWS 461
Cdd:PTZ00420 55 AIRLENQMRKPPVIKLKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWN 134
|
90
....*....|....*....
gi 697093368 462 PDGEKV-ASGGKDRVLKLW 479
Cdd:PTZ00420 135 PMNYYImCSSGFDSFVNIW 153
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
408-479 |
4.22e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 42.57 E-value: 4.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 408 GHVGPVYQISWSA-DSRLLLSGSKDSTLKVWDIRTKKLKQD-------LPGHADEVFAVDWSPDGEKV-ASGGKDRVLKL 478
Cdd:PTZ00421 73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVlASAGADMVVNV 152
|
.
gi 697093368 479 W 479
Cdd:PTZ00421 153 W 153
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
189-234 |
5.75e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 5.75e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 697093368 189 TGKPLGNpLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWD 234
Cdd:smart00320 1 SGELLKT-LKGHTGPVTSVAFSPDG-----KYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
154-288 |
7.69e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 41.80 E-value: 7.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 154 LQGHKNWVLSVAWSP-DGKHLVSGSKAGELICWD-PQTG--KPLGNP---LTGHKKWITGISWEPVHLSApcrrFVSSSK 226
Cdd:PTZ00421 71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGltQNISDPivhLQGHTKKVGIVSFHPSAMNV----LASAGA 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 697093368 227 DGDARIWDVTTRKCLICLSGHTLAITCVKWGGDGVIY-TGSQDCTIKVWETSQGKLIRELKGH 288
Cdd:PTZ00421 147 DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLcTTSKDKKLNIIDPRDGTIVSSVEAH 209
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
370-479 |
9.07e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.00 E-value: 9.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 370 LVNHVYFSPDGQWIASASFDKSVKLWNGTTgkFVAAFRGHVGPVYQIS---------WSADSRLLLSGSK-DSTLKVWDI 439
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHYPVVELAsrsklsgicWNSYIKSQVASSNfEGVVQVWDV 562
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 697093368 440 RTKKLKQDLPGHADEVFAVDW-SPDGEKVASGGKDRVLKLW 479
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
|
|
| WDR74 |
cd22857 |
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ... |
126-239 |
1.17e-03 |
|
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Pssm-ID: 439303 [Multi-domain] Cd Length: 325 Bit Score: 41.06 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 126 PDGRQLASGSGDTTVRLWDLNTQT-PLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLGN--PLTGHKk 202
Cdd:cd22857 190 DDHRKIVTGTGYHQVRLYDTRAQRrPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCfkGKCGGS- 268
|
90 100 110
....*....|....*....|....*....|....*..
gi 697093368 203 wITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRK 239
Cdd:cd22857 269 -IRSIARHPEL-----PLIASCGLDRYLRIWDTETRQ 299
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
113-173 |
1.39e-03 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 41.18 E-value: 1.39e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 113 AGHTEAVLSVAFSPDGRQLA----SGSGDTTVRLWDLNTQTPLFTLQGHKNWVlSVAWSPDGKHL 173
Cdd:COG4946 428 DGYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKTVQLTDGRYDDG-SPAFSPDGKYL 491
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
197-234 |
2.25e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 35.78 E-value: 2.25e-03
10 20 30
....*....|....*....|....*....|....*...
gi 697093368 197 LTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWD 234
Cdd:pfam00400 7 LEGHTGSVTSLAFSPDG-----KLLASGSDDGTVKVWD 39
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
338-396 |
3.49e-03 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 39.93 E-value: 3.49e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697093368 338 ERLVSGSDDFTMFLWE-----PAVS--KHPKTRMTGHQQLVNHVYFSPDGQWI-ASASFDKSVKLWN 396
Cdd:PTZ00420 88 EILASGSEDLTIRVWEiphndESVKeiKDPQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNIWD 154
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
122-209 |
7.57e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 35.72 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 122 VAFSPDGRQLASGSGDTTVRLWDLNTQTpLFTLQG--HKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLGNpLTG 199
Cdd:pfam12894 1 MSWCPTMDLIALATEDGELLLHRLNWQR-VWTLSPdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH-FSA 78
|
90
....*....|
gi 697093368 200 HKKWITGISW 209
Cdd:pfam12894 79 GSDLITCLGW 88
|
|
| Pgl |
COG2706 |
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism]; |
101-192 |
9.18e-03 |
|
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
Pssm-ID: 442025 [Multi-domain] Cd Length: 352 Bit Score: 38.35 E-value: 9.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 101 RIRPVTRCSATIAGHTEAVLS--VAFSPDGRQL-ASGSGDTTVRLWDLNTQTPLFTLQGHK----NWVLSVAWSPDGKHL 173
Cdd:COG2706 233 TLTLIQTVSTLPEDFTGENWAadIHISPDGRFLyVSNRGHNSIAVFAIDADGGKLTLVGHVptggKWPRDFAIDPDGRFL 312
|
90 100
....*....|....*....|..
gi 697093368 174 -VSGSKAGELICW--DPQTGKP 192
Cdd:COG2706 313 lVANQKSDNITVFriDADTGKL 334
|
|
|