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Conserved domains on  [gi|697093368|ref|XP_009600054|]
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notchless protein homolog [Nicotiana tomentosiformis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
106-479 1.54e-108

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.54e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319  148 DLATGKLLR-TLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSteyvlrsgafdHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGR-------------------------LLASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAvSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 425 LLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 19-79 4.17e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.38  E-value: 4.17e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697093368   19 VICQLADPDGN--SLGAALYLPENAGPKELNQVVNKLLSNEER---LPYAFYISDEELVVQLGAYL 79
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEELekpVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
106-479 1.54e-108

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.54e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319  148 DLATGKLLR-TLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSteyvlrsgafdHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGR-------------------------LLASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAvSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 425 LLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-479 3.03e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.20  E-value: 3.03e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 108 CSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDP 187
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 188 QTGKPLgNPLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGS 266
Cdd:cd00200   81 ETGECV-RTLTGHTSYVSSVAFSPDG-----RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 267 QDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgafdhtgkqysspeemkkvalerynkmrgnaperlvsgsdd 346
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 347 ftmflwepavskhpktrmtghqqlvnhvyFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLL 426
Cdd:cd00200  185 -----------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 697093368 427 SGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:cd00200  236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 19-79 4.17e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.38  E-value: 4.17e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697093368   19 VICQLADPDGN--SLGAALYLPENAGPKELNQVVNKLLSNEER---LPYAFYISDEELVVQLGAYL 79
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEELekpVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-144 1.57e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 1.57e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 697093368   107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-144 8.89e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 8.89e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 697093368  107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 268-437 6.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 268 DCTIKVWETSQGKLIRELKGHGHWVNSLALSTE--YVLRSGAFDHTGKQYSSPE-----EMKKVALERYNKMRGNAPERL 340
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdpTLLASGSDDGSVKLWSINQgvsigTIKTKANICCVQFPSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 341 VSGSDDFTMFLWEPAVSKHPKTRMTGHQQLVNHVYFSpDGQWIASASFDKSVKLWN------GTTGKFVAAFRGHVGPVY 414
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKN 712

                        170       180
                 ....*....|....*....|...
gi 697093368 415 QISWSADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 713 FVGLSVSDGYIATGSETNEVFVY 735
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 116-180 1.09e-05

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 47.65  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368  116 TEAVLSVAFSPDGRQLA---SGSGDTTVRLWDLNTQTPLfTLQGHKNWVLSVAWSPDGKHL-VSGSKAG 180
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQRE-KVASFPGMNGAPAFSPDGSKLaVSLSKDG 256
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
106-479 1.54e-108

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.54e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319  148 DLATGKLLR-TLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSteyvlrsgafdHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-----------PDGR-------------------------LLASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAvSKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319  266 ADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 697093368 425 LLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
106-441 1.47e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 1.47e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 106 TRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICW 185
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 186 DPQTGKPLGnPLTGHKKWITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYT 264
Cdd:COG2319  190 DLATGKLLR-TLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 265 GSQDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgaFDHTGKqysspeemkkvalerynkmrgnapeRLVSGS 344
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVA-----------FSPDGK-------------------------LLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 345 DDFTMFLWEPAVSKHPKTrMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRL 424
Cdd:COG2319  308 DDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                        330
                 ....*....|....*..
gi 697093368 425 LLSGSKDSTLKVWDIRT 441
Cdd:COG2319  387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-479 3.03e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 269.20  E-value: 3.03e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 108 CSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDP 187
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 188 QTGKPLgNPLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGS 266
Cdd:cd00200   81 ETGECV-RTLTGHTSYVSSVAFSPDG-----RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 267 QDCTIKVWETSQGKLIRELKGHGHWVNSLAlsteyvlrsgafdhtgkqysspeemkkvalerynkmrgnaperlvsgsdd 346
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 347 ftmflwepavskhpktrmtghqqlvnhvyFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLL 426
Cdd:cd00200  185 -----------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 697093368 427 SGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:cd00200  236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
123-479 1.90e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 252.91  E-value: 1.90e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 123 AFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLgNPLTGHKK 202
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 203 WITGISWepvhlSAPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWETSQGKL 281
Cdd:COG2319   80 AVLSVAF-----SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 282 IRELKGHGHWVNSLAlsteyvlrsgaFDHTGKqysspeemkkvalerynkmrgnapeRLVSGSDDFTMFLWEPAVSKHPK 361
Cdd:COG2319  155 LRTLTGHSGAVTSVA-----------FSPDGK-------------------------LLASGSDDGTVRLWDLATGKLLR 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 362 TrMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWDIRT 441
Cdd:COG2319  199 T-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 697093368 442 KKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 107-316 1.17e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.46  E-value: 1.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 187 PQTGKPLGNpLTGHKKWITGISWEPvhlsaPCRRFVSSSKDGDARIWDVTTRKCLICLSGHTLAITCVKWGGDGVIYT-G 265
Cdd:cd00200  164 LRTGKCVAT-LTGHTGEVNSVAFSP-----DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAsG 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 697093368 266 SQDCTIKVWETSQGKLIRELKGHGHWVNSLALSTEY-VLRSGAFDHTGKQYS 316
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 19-79 4.17e-12

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 61.38  E-value: 4.17e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697093368   19 VICQLADPDGN--SLGAALYLPENAGPKELNQVVNKLLSNEER---LPYAFYISDEELVVQLGAYL 79
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEELekpVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-144 1.57e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 1.57e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 697093368   107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-144 8.89e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 8.89e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 697093368  107 RCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWD 144
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-186 1.77e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.77e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 697093368   147 TQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 122-464 1.78e-09

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 60.44  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  122 VAFSPDGRQL--ASGSGDTTVRLWDL-----NTQTP--LFTLQGHknwvlSVAWSPDGKHLVS--------------GSK 178
Cdd:COG4946   110 VGWTPDGKSVlfASNRGSPPSRSNQLytvpvDGGLPerLPLPPAG-----DGSFSPDGKKLAYtrigrefrtwkryrGGT 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  179 AGELICWDPQTGKplgnpltgHKKwitgISWEPVHLSAPC----RRFVSSSKDGDARIW--DVTTRKcliclsghTLAIT 252
Cdd:COG4946   185 AGDIWIYDLGTGE--------FTR----LTDFGGNDRNPMwigdRIYFLSDRDGTFNLYsyDPDGKD--------LRQLT 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  253 C-----VKW---GGDGVIYTgsQDCTIKVWETSQGKlIRELK---------GHGHWVNSlalsTEYvLRSGAFDHTGKqy 315
Cdd:COG4946   245 HfkdfdVRFpstDGGRIVYE--QGGDLYLLDLASGE-PRKLNitlagdfpqRRPRWVDV----SGY-LTSFALSPDGK-- 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  316 sspeemkKVALErynkMRGNAperlvsgsddFTMFLWE-PAV--SKHPKTRMTghqqlvnHVYFSPDGQWIASASfDKS- 391
Cdd:COG4946   315 -------RVAFE----ARGEV----------FTVPAEKgPTRnlTNTPGVRER-------LPAWSPDGKSIAYFS-DASg 365

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  392 -VKLW-----NGTTGKFVAAfrGHVGPVYQISWSADSRLLLSGSKDSTLKVWDIRTKKLKQ-DLPGHADEVFAVDWSPDG 464
Cdd:COG4946   366 eYELYiapadGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKvDTDGYGDGISDLAWSPDS 443
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 399-438 2.57e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.57e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 697093368   399 TGKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWD 438
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
400-438 1.85e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.85e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 697093368  400 GKFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWD 438
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
360-396 8.50e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 8.50e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 697093368  360 PKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWN 396
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-396 8.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 8.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 697093368   357 SKHPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWN 396
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 441-479 9.61e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 9.61e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 697093368   441 TKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
149-186 1.42e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.42e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 697093368  149 TPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWD 186
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 268-437 6.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 268 DCTIKVWETSQGKLIRELKGHGHWVNSLALSTE--YVLRSGAFDHTGKQYSSPE-----EMKKVALERYNKMRGNAPERL 340
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdpTLLASGSDDGSVKLWSINQgvsigTIKTKANICCVQFPSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 341 VSGSDDFTMFLWEPAVSKHPKTRMTGHQQLVNHVYFSpDGQWIASASFDKSVKLWN------GTTGKFVAAFRGHVGPVY 414
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKN 712

                        170       180
                 ....*....|....*....|...
gi 697093368 415 QISWSADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 713 FVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-275 8.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 697093368   237 TRKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWE 275
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 337-452 9.12e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 9.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 337 PERLVSGSDDFTMFLW---EPAVSKH---PKTRMTGHQQLVNHVYFSPDGQWI-ASASFDKSVKLWNGTTGKFVAAFRGH 409
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWgipEEGLTQNisdPIVHLQGHTKKVGIVSFHPSAMNVlASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 697093368 410 VGPVYQISWSADSRLLLSGSKDSTLKVWDIRTKKLKQDLPGHA 452
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 130-298 1.13e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 130 QLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSP-DGKHLVSGSKAGELICWDPQTGKPLGNPLTghKKWITGIS 208
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 209 WEpvhlSAPCRRFVSSSKDGDARIWDVTTRKCLIC-LSGHTLAITCVKWGGDGVIYTGSQDCTIKVWETSQG------KL 281
Cdd:PLN00181 625 FP----SESGRSLAFGSADHKVYYYDLRNPKLPLCtMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTP 700

                        170
                 ....*....|....*..
gi 697093368 282 IRELKGHGHWVNSLALS 298
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLS 717
WD40 pfam00400
WD domain, G-beta repeat;
442-479 2.08e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 697093368  442 KKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLW 479
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
238-275 3.85e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.85e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 697093368  238 RKCLICLSGHTLAITCVKWGGDG-VIYTGSQDCTIKVWE 275
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 115-274 4.28e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 115 HTEAVLSVAFSP-DGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGK-P 192
Cdd:PLN00181 574 HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlP 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 193 LGNpLTGHKKWITGISWepvhlsAPCRRFVSSSKDGDARIWDVT------TRKCLICLSGHTLAITCVKWG-GDGVIYTG 265
Cdd:PLN00181 654 LCT-MIGHSKTVSYVRF------VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSvSDGYIATG 726


                 ....*....
gi 697093368 266 SQDCTIKVW 274
Cdd:PLN00181 727 SETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 112-239 7.57e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 7.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 112 IAGHTEAVLSVAFSPDGRQ-LASGSGDTTVRLWDLntqtplftlqghknwvlsvawsPDGKHLVSGSKagelicwDPQTg 190
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEI----------------------PHNDESVKEIK-------DPQC- 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 697093368 191 kplgnPLTGHKKWITGISWEPVHLSAPCrrfvSSSKDGDARIWDVTTRK 239
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIENEK 159
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 116-180 1.09e-05

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 47.65  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368  116 TEAVLSVAFSPDGRQLA---SGSGDTTVRLWDLNTQTPLfTLQGHKNWVLSVAWSPDGKHL-VSGSKAG 180
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQRE-KVASFPGMNGAPAFSPDGSKLaVSLSKDG 256
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 111-198 1.24e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.37  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  111 TIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDL-----------NTQ------------TPLFTLQGHKNWVLSVAWS 167
Cdd:pfam20426 119 SIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekrsrNTQtefprkdhviaeTPFHILCGHDDIITCLYVS 198

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 697093368  168 PDGKHLVSGSKAGELICWDPQTGK-------PLGNPLT 198
Cdd:pfam20426 199 VELDIVISGSKDGTCIFHTLREGRyvrsirhPSGCPLS 236
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 359-439 1.37e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 359 HPKTRMTGHQQLVNHVYFSPDGQWIASASFDKSVKLWNGTTGKFVAAFRGHVGPVYQISW-SADSRLLLSGSKDSTLKVW 437
Cdd:PLN00181 524 YPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603


                 ..
gi 697093368 438 DI 439
Cdd:PLN00181 604 SI 605
PTZ00421 PTZ00421
coronin; Provisional
 114-191 1.52e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697093368 114 GHTEAVLSVAFSPDGRQ-LASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGK 191
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
PTZ00421 PTZ00421
coronin; Provisional
 374-478 2.98e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 374 VYFSP-DGQWIASASFDKSVKLWN-------GTTGKFVAAFRGHVGPVYQISWSADSR-LLLSGSKDSTLKVWDIRTKKL 444
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                         90       100       110
                 ....*....|....*....|....*....|....
gi 697093368 445 KQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKL 478
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 114-167 3.87e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 42.27  E-value: 3.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 697093368  114 GHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPLFTLQGHKNWVLSVAWS 167
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 362-468 2.17e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 362 TRMTGHQQLVNHVYFSPDGQWIA-SASFDKSVKLW----NGTTGKFVAAFRGHvgpVYQISWSADSRLLL-SGSKDSTLK 435
Cdd:COG0823   24 RRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvdaDGGEPRRLTFGGGY---NASPSWSPDGKRLAfVSRSDGRFD 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 697093368 436 VW--DIRTKKLKQdlpgHADEVFAVDWSPDGEKVA 468
Cdd:COG0823  101 IYvlDLDGGAPRR----LTDGPGSPSWSPDGRRIV 131
PTZ00420 PTZ00420
coronin; Provisional
 391-479 3.59e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 391 SVKLWNGTTGKFVAAFRGHVGPVYQISWS-ADSRLLLSGSKDSTLKVWDIR-----TKKLKQD---LPGHADEVFAVDWS 461
Cdd:PTZ00420  55 AIRLENQMRKPPVIKLKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWN 134

                         90
                 ....*....|....*....
gi 697093368 462 PDGEKV-ASGGKDRVLKLW 479
Cdd:PTZ00420 135 PMNYYImCSSGFDSFVNIW 153
PTZ00421 PTZ00421
coronin; Provisional
 408-479 4.22e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 408 GHVGPVYQISWSA-DSRLLLSGSKDSTLKVWDIRTKKLKQD-------LPGHADEVFAVDWSPDGEKV-ASGGKDRVLKL 478
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVlASAGADMVVNV 152


                 .
gi 697093368 479 W 479
Cdd:PTZ00421 153 W 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-234 5.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 697093368   189 TGKPLGNpLTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWD 234
Cdd:smart00320   1 SGELLKT-LKGHTGPVTSVAFSPDG-----KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 154-288 7.69e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 154 LQGHKNWVLSVAWSP-DGKHLVSGSKAGELICWD-PQTG--KPLGNP---LTGHKKWITGISWEPVHLSApcrrFVSSSK 226
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGltQNISDPivhLQGHTKKVGIVSFHPSAMNV----LASAGA 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 697093368 227 DGDARIWDVTTRKCLICLSGHTLAITCVKWGGDGVIY-TGSQDCTIKVWETSQGKLIRELKGH 288
Cdd:PTZ00421 147 DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLcTTSKDKKLNIIDPRDGTIVSSVEAH 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 370-479 9.07e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 370 LVNHVYFSPDGQWIASASFDKSVKLWNGTTgkFVAAFRGHVGPVYQIS---------WSADSRLLLSGSK-DSTLKVWDI 439
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHYPVVELAsrsklsgicWNSYIKSQVASSNfEGVVQVWDV 562

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 697093368 440 RTKKLKQDLPGHADEVFAVDW-SPDGEKVASGGKDRVLKLW 479
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 126-239 1.17e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.06  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 126 PDGRQLASGSGDTTVRLWDLNTQT-PLFTLQGHKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLGN--PLTGHKk 202
Cdd:cd22857  190 DDHRKIVTGTGYHQVRLYDTRAQRrPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCfkGKCGGS- 268

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 697093368 203 wITGISWEPVHlsapcRRFVSSSKDGDARIWDVTTRK 239
Cdd:cd22857  269 -IRSIARHPEL-----PLIASCGLDRYLRIWDTETRQ 299
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 113-173 1.39e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 697093368  113 AGHTEAVLSVAFSPDGRQLA----SGSGDTTVRLWDLNTQTPLFTLQGHKNWVlSVAWSPDGKHL 173
Cdd:COG4946   428 DGYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKTVQLTDGRYDDG-SPAFSPDGKYL 491
WD40 pfam00400
WD domain, G-beta repeat;
197-234 2.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 697093368  197 LTGHKKWITGISWEPVHlsapcRRFVSSSKDGDARIWD 234
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDG-----KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 338-396 3.49e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697093368 338 ERLVSGSDDFTMFLWE-----PAVS--KHPKTRMTGHQQLVNHVYFSPDGQWI-ASASFDKSVKLWN 396
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiphndESVKeiKDPQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 122-209 7.57e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368  122 VAFSPDGRQLASGSGDTTVRLWDLNTQTpLFTLQG--HKNWVLSVAWSPDGKHLVSGSKAGELICWDPQTGKPLGNpLTG 199
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-VWTLSPdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH-FSA 78

                          90
                  ....*....|
gi 697093368  200 HKKWITGISW 209
Cdd:pfam12894  79 GSDLITCLGW 88
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
101-192 9.18e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 38.35  E-value: 9.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697093368 101 RIRPVTRCSATIAGHTEAVLS--VAFSPDGRQL-ASGSGDTTVRLWDLNTQTPLFTLQGHK----NWVLSVAWSPDGKHL 173
Cdd:COG2706  233 TLTLIQTVSTLPEDFTGENWAadIHISPDGRFLyVSNRGHNSIAVFAIDADGGKLTLVGHVptggKWPRDFAIDPDGRFL 312

                         90       100
                 ....*....|....*....|..
gi 697093368 174 -VSGSKAGELICW--DPQTGKP 192
Cdd:COG2706  313 lVANQKSDNITVFriDADTGKL 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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