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Conserved domains on  [gi|688553348|ref|XP_009299466|]
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glial cell line-derived neurotrophic factor-like [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_SF super family cl40434
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 100-195 2.34e-40

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


The actual alignment was detected with superfamily member cd19380:

Pssm-ID: 477357  Cd Length: 96  Bit Score: 132.66  E-value: 2.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 100 RACALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTGgDKNILHSSPPTTCCRPVEYDDDLSFLDDN 179
Cdd:cd19380    2 RGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTR-NKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 688553348 180 LIYHTMGRHSARKCGC 195
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
 
Name Accession Description Interval E-value
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 100-195 2.34e-40

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 132.66  E-value: 2.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 100 RACALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTGgDKNILHSSPPTTCCRPVEYDDDLSFLDDN 179
Cdd:cd19380    2 RGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTR-NKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 688553348 180 LIYHTMGRHSARKCGC 195
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
102-195 2.16e-12

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 60.80  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348  102 CALRQVQLTVSDLGLG--YRSQEELIFSYCSGVC------TNSLTNYDKILTSLtggdKNILHSSPPTTCCRPVEYdDDL 173
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCpshlnpQLSATNHAILQSLL----HSLKPANVPKPCCVPTKL-SPL 76

                          90       100
                  ....*....|....*....|....*.
gi 688553348  174 SFL----DDNLIYHTMGRHSARKCGC 195
Cdd:pfam00019  77 SVLyyddEGNVVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 100-195 2.34e-40

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 132.66  E-value: 2.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 100 RACALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTGgDKNILHSSPPTTCCRPVEYDDDLSFLDDN 179
Cdd:cd19380    2 RGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTR-NKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 688553348 180 LIYHTMGRHSARKCGC 195
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 102-195 5.56e-32

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 111.00  E-value: 5.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 102 CALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTGgdKNILHSSPPTT--CCRPVEYDDDLSFLDDN 179
Cdd:cd13750    2 CVLRELHLRVTDLGLGYASEEEVIFRYCAGSCEAARTNYDLILANLRG--WRRLRSDRKVGqpCCRPTAYDDDVSFLDDN 79

                         90
                 ....*....|....*.
gi 688553348 180 LIYHTMGRHSARKCGC 195
Cdd:cd13750   80 SRYHILRKLSAKACGC 95
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 98-196 1.04e-30

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 108.24  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348  98 KSRACALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTG------GDKNILHSSPpttCCRPVEYDD 171
Cdd:cd19383    3 RSKPCSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGkkslkkGRKDKVRARP---CCRPTAYED 79

                         90       100
                 ....*....|....*....|....*
gi 688553348 172 DLSFLDDNLIYHTMGRHSARKCGCV 196
Cdd:cd19383   80 DVSFLDNNNRYHTIQELSAKECGCV 104
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 102-196 3.93e-23

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 88.56  E-value: 3.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 102 CALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSLTGGD-----KNILHSSPPttCCRPVEYdDDLSFL 176
Cdd:cd19381    2 CRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGaippgPHERVSSQP--CCRPTRY-ENVSFM 78

                         90       100
                 ....*....|....*....|
gi 688553348 177 DDNLIYHTMGRHSARKCGCV 196
Cdd:cd19381   79 DVQNVWQTVEKLSAAECSCV 98
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 100-196 1.44e-21

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 84.44  E-value: 1.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 100 RACALRQVQLTVSDLGLGYRSQEELIFSYCSGVCTNSLTNYDKILTSL--TGGDKNILHSSPPTTCCRPVEYdDDLSFLD 177
Cdd:cd19382    1 RPCRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPRARTNHDLTLSRLlqKGDLPSLGEKIFGGPCCRPTHY-EDVAFLD 79

                         90
                 ....*....|....*....
gi 688553348 178 DNLIYHTMGRHSARKCGCV 196
Cdd:cd19382   80 DNHRWHTVEKLSAAACACV 98
TGF_beta pfam00019
Transforming growth factor beta like domain;
102-195 2.16e-12

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 60.80  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348  102 CALRQVQLTVSDLGLG--YRSQEELIFSYCSGVC------TNSLTNYDKILTSLtggdKNILHSSPPTTCCRPVEYdDDL 173
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCpshlnpQLSATNHAILQSLL----HSLKPANVPKPCCVPTKL-SPL 76

                          90       100
                  ....*....|....*....|....*.
gi 688553348  174 SFL----DDNLIYHTMGRHSARKCGC 195
Cdd:pfam00019  77 SVLyyddEGNVVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 102-195 1.52e-05

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 42.30  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553348 102 CALRQVQLTVSDLGLGYR--SQEELIFSYCSGVCTNSL------TNYDKILTSLTGGDKnilHSSPPTTCCRPVEYdDDL 173
Cdd:cd13756    1 CRRRPLYVDFSDLGWDDWiiAPKGYNANYCAGSCPFPLsshanaTNHAILQALLHSLNP---KKSVPKPCCVPTKY-SPL 76

                         90       100
                 ....*....|....*....|....*.
gi 688553348 174 SFL----DDNLIYHTMGRHSARKCGC 195
Cdd:cd13756   77 SVLyydeDGNVVLKTYPDMVVEECGC 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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