NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1827904143|ref|XP_009151707|]
View 

probable histone-arginine methyltransferase 1.4 [Brassica rapa]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
147-357 6.10e-47

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 163.28  E-value: 6.10e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 147 HYYGQLLH---QQNMLQDYVRTGTYHAAVMenRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLI 222
Cdd:COG4076     1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 223 AGNPLlAERITVIKGKIEDVELPEKADVLISEPMGTLLVNERMLETYVIARDRFLSPNGKMFPTVGRIHMAPfadeflfI 302
Cdd:COG4076    79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1827904143 303 EMANKALFWQQQNYYGVDltpLYGSAHQGYFFQPVVDAFDPRLLIAPSMFHVIDF 357
Cdd:COG4076   151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRTPLLLLLLPTAFD 202
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
147-357 6.10e-47

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 163.28  E-value: 6.10e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 147 HYYGQLLH---QQNMLQDYVRTGTYHAAVMenRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLI 222
Cdd:COG4076     1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 223 AGNPLlAERITVIKGKIEDVELPEKADVLISEPMGTLLVNERMLETYVIARDRFLSPNGKMFPTVGRIHMAPfadeflfI 302
Cdd:COG4076    79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1827904143 303 EMANKALFWQQQNYYGVDltpLYGSAHQGYFFQPVVDAFDPRLLIAPSMFHVIDF 357
Cdd:COG4076   151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRTPLLLLLLPTAFD 202
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 184-287 5.09e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 5.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 184 VVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLIAGnpLLAERITVIKGKIEDVEL--PEKADVLISEPMGTLL 260
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPvALELARKAAAA--LLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....*....
gi 1827904143 261 VN--ERMLETYViardRFLSPNGKMFPTV 287
Cdd:cd02440    80 VEdlARFLEEAR----RLLKPGGVLVLTL 104
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 184-253 6.29e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.34  E-value: 6.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827904143 184 VVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLIAGNPLlaeRITVIKGKIEDVELP-EKADVLIS 253
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPeMLERARERAAEAGL---NVEFVQGDAEDLPFPdGSFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
178-252 4.42e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 51.31  E-value: 4.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827904143 178 DFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMA-DYARKLIAGNPLlaeritvikgkIEDVELPE---KADVLI 252
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGV-----------ELNVYLPQgdlKADVIV 184
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 183-229 4.53e-04

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 40.76  E-value: 4.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1827904143 183 VVVDVGAGSGILSMFAALAGAK-HVYAVEAS-EMADYARKLIAGNPLLA 229
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLpDAYEILEENVKLNNLPN 49
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
147-357 6.10e-47

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 163.28  E-value: 6.10e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 147 HYYGQLLH---QQNMLQDYVRTGTYHAAVMenRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLI 222
Cdd:COG4076     1 DYLMQFFVprwHHPMLNDVERNDAFKAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRII 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 223 AGNPLlAERITVIKGKIEDVELPEKADVLISEPMGTLLVNERMLETYVIARDRFLSPNGKMFPTVGRIHMAPfadeflfI 302
Cdd:COG4076    79 AANGL-SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQP-------V 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1827904143 303 EMANKALFWQQQNYYGVDltpLYGSAHQGYFFQPVVDAFDPRLLIAPSMFHVIDF 357
Cdd:COG4076   151 ESPVDAEGFEDWQFDGFD---FRLFGFLLYAEPLLHLTRLVRTPLLLLLLPTAFD 202
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
169-255 1.30e-13

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 69.55  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 169 HAAVMenRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLIagnPLLAERITVIKGKIEDVELPEK 247
Cdd:COG2263    36 HLAYL--RGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPeALEIARENA---ERLGVRVDFIRADVTRIPLGGS 110


                  ....*...
gi 1827904143 248 ADVLISEP 255
Cdd:COG2263   111 VDTVVMNP 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 184-287 5.09e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 5.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 184 VVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLIAGnpLLAERITVIKGKIEDVEL--PEKADVLISEPMGTLL 260
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPvALELARKAAAA--LLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....*....
gi 1827904143 261 VN--ERMLETYViardRFLSPNGKMFPTV 287
Cdd:cd02440    80 VEdlARFLEEAR----RLLKPGGVLVLTL 104
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
178-252 5.00e-11

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 63.65  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 178 DFSGRVVVDVGAGSGILSMFAALAGAKHVY-------AVEAsemadyARKLIAGNPlLAERITVIKGkieDVELPEKADV 250
Cdd:COG2264   146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLavdidpvAVEA------ARENAELNG-VEDRIEVVLG---DLLEDGPYDL 215


                  ..
gi 1827904143 251 LI 252
Cdd:COG2264   216 VV 217
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 180-284 4.81e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.33  E-value: 4.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 180 SGRVVVDVGAGSGILSMFAALAGAkHVYAVEASE-MADYARKLIAgnpllAERITVIKGKIEDVELP-EKADVLISepMG 257
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGA-DVTGVDISPeALEIARERAA-----ELNVDFVQGDLEDLPLEdGSFDLVIC--SE 95

                          90       100
                  ....*....|....*....|....*....
gi 1827904143 258 TLlvnERMLETYVIARD--RFLSPNGKMF 284
Cdd:COG2227    96 VL---EHLPDPAALLRElaRLLKPGGLLL 121
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 180-284 1.05e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 59.00  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 180 SGRVVVDVGAGSGILS-MFAALAGAKHVYAVEASE-MADYARKLIAGNPlLAERITVIKGKIEDVE---LPEKADVLISE 254
Cdd:COG4123    37 KGGRVLDLGTGTGVIAlMLAQRSPGARITGVEIQPeAAELARRNVALNG-LEDRITVIHGDLKEFAaelPPGSFDLVVSN 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1827904143 255 P----MGTLLVNE-------RM-----LETYVIARDRFLSPNGKMF 284
Cdd:COG4123   116 PpyfkAGSGRKSPdearaiaRHedaltLEDLIRAAARLLKPGGRFA 161
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 184-253 6.29e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.34  E-value: 6.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827904143 184 VVDVGAGSGILSMFAALAGAKHVYAVEASE-MADYARKLIAGNPLlaeRITVIKGKIEDVELP-EKADVLIS 253
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPeMLERARERAAEAGL---NVEFVQGDAEDLPFPdGSFDLVVS 69
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 181-284 6.90e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.94  E-value: 6.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAKHVYAVEAS-EMADYARKLIAGNpLLAERITVIKGKIEDVELPEKADVLISEPMgTL 259
Cdd:COG2230    52 GMRVLDIGCGWGGLALYLARRYGVRVTGVTLSpEQLEYARERAAEA-GLADRVEVRLADYRDLPADGQFDAIVSIGM-FE 129

                          90       100
                  ....*....|....*....|....*.
gi 1827904143 260 LVNERMLETYvIAR-DRFLSPNGKMF 284
Cdd:COG2230   130 HVGPENYPAY-FAKvARLLKPGGRLL 154
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
181-253 5.14e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.59  E-value: 5.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827904143 181 GRVVVDVGAGSGILS-MFAALAGAKHVYAVEAS-EMADYARKLIAgnpllaeRITVIKGKIEDVELPEKADVLIS 253
Cdd:COG4106     2 PRRVLDLGCGTGRLTaLLAERFPGARVTGVDLSpEMLARARARLP-------NVRFVVADLRDLDPPEPFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
178-252 4.42e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 51.31  E-value: 4.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827904143 178 DFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMA-DYARKLIAGNPLlaeritvikgkIEDVELPE---KADVLI 252
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAvEAARENAELNGV-----------ELNVYLPQgdlKADVIV 184
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 181-253 4.53e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 4.53e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAkHVYAVEAS-EMADYARKLIAGNPLlaeRITVIKGKIEDVELPEKA-DVLIS 253
Cdd:COG2226    23 GARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARERAAEAGL---NVEFVVGDAEDLPFPDGSfDLVIS 93
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 181-252 4.70e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 51.50  E-value: 4.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMA-DYARKLIAGNPlLAERITVIKGKiedvELP-EKADVLI 252
Cdd:pfam06325 162 GESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAvRAAKENAELNG-VEARLEVYLPG----DLPkEKADVVV 230
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 179-252 1.15e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 49.77  E-value: 1.15e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827904143 179 FSGRVVVDVGAGSGILSMF--AALAGAKHVYAVEASE-MADYARKLIAgNPLLAERITVIKGKIEDVELPEKADVLI 252
Cdd:COG2519    90 FPGARVLEAGTGSGALTLAlaRAVGPEGKVYSYERREdFAEIARKNLE-RFGLPDNVELKLGDIREGIDEGDVDAVF 165
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 181-284 1.42e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 48.65  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAK-HVYAVEASEMA-DYARKLIAGNPLlaERITVIKGKI-EDVElPEKADVLISEP-- 255
Cdd:COG2813    50 GGRVLDLGCGYGVIGLALAKRNPEaRVTLVDVNARAvELARANAAANGL--ENVEVLWSDGlSGVP-DGSFDLILSNPpf 126

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1827904143 256 ----MGTLLVNERMLETyviARDRfLSPNGKMF 284
Cdd:COG2813   127 hagrAVDKEVAHALIAD---AARH-LRPGGELW 155
PRK14967 PRK14967
putative methyltransferase; Provisional
 170-255 2.75e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 48.51  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 170 AAVMENRSDFSGRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMA-DYARkliaGNPLLA-ERITVIKGKIEDVELPEK 247
Cdd:PRK14967   26 ADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAvRSAR----LNALLAgVDVDVRRGDWARAVEFRP 101


                  ....*...
gi 1827904143 248 ADVLISEP 255
Cdd:PRK14967  102 FDVVVSNP 109
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
178-246 3.67e-06

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 48.36  E-value: 3.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 178 DFSGRVVVDVGAGSGILSMFAAlAGAKHVYAVEASE-MADYARKLIAgnplLAERITVIKGKIEDVELPE 246
Cdd:PRK14896   27 DTDGDPVLEIGPGKGALTDELA-KRAKKVYAIELDPrLAEFLRDDEI----AAGNVEIIEGDALKVDLPE 91
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 178-284 1.89e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 45.27  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 178 DFSGRVVvDVGAGSGILSMFAALAGAK-HVYAVEASEMA-DYARKLIAGNplLAERITVIKGKI-EDVElPEKADVLISE 254
Cdd:pfam05175  30 DLSGKVL-DLGCGAGVLGAALAKESPDaELTMVDINARAlESARENLAAN--GLENGEVVASDVySGVE-DGKFDLIISN 105

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1827904143 255 P------MGTLLVNERMLETyviARdRFLSPNGKMF 284
Cdd:pfam05175 106 PpfhaglATTYNVAQRFIAD---AK-RHLRPGGELW 137
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 171-255 3.15e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 171 AVMENRSDFSGRVVVDVGAGSGI--LSMFAALAGAkHVYAVEASEMA-DYARKLIAGNPlLAERITVIKGKI-EDVELPE 246
Cdd:COG2890   103 LALALLPAGAPPRVLDLGTGSGAiaLALAKERPDA-RVTAVDISPDAlAVARRNAERLG-LEDRVRFLQGDLfEPLPGDG 180


                  ....*....
gi 1827904143 247 KADVLISEP 255
Cdd:COG2890   181 RFDLIVSNP 189
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 181-322 3.57e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 46.31  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAK-HVYAVEASEMadyARKLIAGNpllAER-----ITVIKGKIEDV--ELPEkAD-VL 251
Cdd:COG2242   248 GDVLWDIGAGSGSVSIEAARLAPGgRVYAIERDPE---RAALIRAN---ARRfgvpnVEVVEGEAPEAlaDLPD-PDaVF 320

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827904143 252 IsepmGTLLVNERMLETYVIARdrfLSPNgkmfptvGRIhMAPFADeflfIEMANKALFWQQQNYYGVDLT 322
Cdd:COG2242   321 I----GGSGGNLPEILEACWAR---LRPG-------GRL-VANAVT----LETLALALEALAELGYGGELV 372
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 174-263 1.26e-04

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 42.58  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 174 ENRSDFSGRVVVDVGAGSGIL--SMFAALAGAK---HVYAVEASEMA-DYARKLIAgNPLLAERITVIKGKIEDVELPEK 247
Cdd:pfam05185  57 EKKKTSKLLVILVVGAGRGPLvdRALRAAEETGtkvKIYAVEKNPNAyVTLQKRIN-FEKWGDKVTIISSDMREWQGPEK 135

                          90
                  ....*....|....*.
gi 1827904143 248 ADVLISEPMGTLLVNE 263
Cdd:pfam05185 136 ADILVSELLGSFGDNE 151
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 185-253 2.51e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 2.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1827904143 185 VDVGAGSGILSMFAALAGAkHVYAVEAS-EMADYARKLIAGNPLlaeriTVIKGKIEDVELPEKA-DVLIS 253
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISpEMLELAREKAPREGL-----TFVVGDAEDLPFPDNSfDLVLS 65
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 181-284 4.28e-04

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 41.42  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 181 GRVVVDVGAGSGILSMFAALAGAKHVYAVEASEMADYArkliagnPLLAERITVIKGKIEDVE--------LPEKADVLI 252
Cdd:pfam01728  22 GKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQLWK-------PRNDPGVTFIQGDIRDPEtldlleelLGRKVDLVL 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1827904143 253 S------------EPMGTLLVNERMLEtyvIARDrFLSPNG----KMF 284
Cdd:pfam01728  95 SdgspfisgnkvlDHLRSLDLVKAALE---VALE-LLRKGGnfvcKVF 138
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 183-229 4.53e-04

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 40.76  E-value: 4.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1827904143 183 VVVDVGAGSGILSMFAALAGAK-HVYAVEAS-EMADYARKLIAGNPLLA 229
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLpDAYEILEENVKLNNLPN 49
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 171-255 5.75e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 41.69  E-value: 5.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 171 AVMENRSDFSGRVVVDVGAGSGILsmfaALAGAKH-----VYAVEASEMA-DYARKliagN--PLLAERITVIKGKIEDV 242
Cdd:PRK09328   99 WALEALLLKEPLRVLDLGTGSGAI----ALALAKErpdaeVTAVDISPEAlAVARR----NakHGLGARVEFLQGDWFEP 170

                          90
                  ....*....|...
gi 1827904143 243 ELPEKADVLISEP 255
Cdd:PRK09328  171 LPGGRFDLIVSNP 183
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 170-252 1.90e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 40.54  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 170 AAVMENRSDFSGRVVVDVGAGSGILSMFAAlAGAKHVYAVEAS-EMADYARKLIAGNPLlaERITVIKGKIEDV----EL 244
Cdd:COG2265   223 AAALEWLDLTGGERVLDLYCGVGTFALPLA-RRAKKVIGVEIVpEAVEDARENARLNGL--KNVEFVAGDLEEVlpelLW 299


                  ....*...
gi 1827904143 245 PEKADVLI 252
Cdd:COG2265   300 GGRPDVVV 307
PRK14968 PRK14968
putative methyltransferase; Provisional
 173-237 3.03e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 3.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827904143 173 MENRSDFSGRVVVDVGAGSGILSMFAALAGAKhVYAVEASEMA-DYARKLIAGNPLLAERITVIKG 237
Cdd:PRK14968   16 AENAVDKKGDRVLEVGTGSGIVAIVAAKNGKK-VVGVDINPYAvECAKCNAKLNNIRNNGVEVIRS 80
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 184-281 3.80e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.74  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 184 VVDVGAGSGILSMFAALAGAKHVYAVEAS-EMADYARKLIAGNPLlaERITVIKGKIED-VELP-EKADVLISepMGTL- 259
Cdd:COG0500    30 VLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGL--GNVEFLVADLAElDPLPaESFDLVVA--FGVLh 105

                          90       100
                  ....*....|....*....|..
gi 1827904143 260 LVNERMLETYVIARDRFLSPNG 281
Cdd:COG0500   106 HLPPEEREALLRELARALKPGG 127
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
145-253 3.85e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.44  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827904143 145 YFHYYGQLLHQQNmlqDYVRTGTYHAAVMENRSDFSGRVVVDVGAGSGILSmfAALAG-AKHVYAVEASE-MADYARKLI 222
Cdd:COG4976    14 YADSYDAALVEDL---GYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLG--EALRPrGYRLTGVDLSEeMLAKAREKG 88

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1827904143 223 AGNPLLAERITvikgkiEDVELPEKADVLIS 253
Cdd:COG4976    89 VYDRLLVADLA------DLAEPDGRFDLIVA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH