NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1079435390|ref|XP_009114670|]
View 

putative F-box protein At3g16210 [Brassica rapa]

Protein Classification

F-box protein( domain architecture ID 17779125)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 12-50 1.34e-14

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 67.10  E-value: 1.34e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1079435390  12 RELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERF 50
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F_box_assoc_1 super family cl44343
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 107-249 2.59e-12

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


The actual alignment was detected with superfamily member TIGR01640:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 65.84  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 107 LGHCHGLFCLyFENNTFGLWNPSLRELRTIHPPYRYNWYEM----GFGYDHSSQDYKIVLVLKMQGRRSrSSQALVLSLK 182
Cdd:TIGR01640   1 VVPCDGLICF-SYGKRLVVWNPSTGQSRWLPTPKSRRSNKEsdtyFLGYDPIEKQYKVLCFSDRSGNRN-QSEHQVYTLG 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 183 SGASRMIDCLCleNFDMIHDT---ISGTLvgeiiFWQLCDDNVKVTDKLLSFDLVSETFNLcPCPSNCGK 249
Cdd:TIGR01640  79 SNSWRTIECSP--PHHPLKSRgvcINGVL-----YYLAYTLKTNPDYFIVSFDVSSERFKE-FIPLPCGN 140
 
Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 12-50 1.34e-14

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 67.10  E-value: 1.34e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1079435390  12 RELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERF 50
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 107-249 2.59e-12

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 65.84  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 107 LGHCHGLFCLyFENNTFGLWNPSLRELRTIHPPYRYNWYEM----GFGYDHSSQDYKIVLVLKMQGRRSrSSQALVLSLK 182
Cdd:TIGR01640   1 VVPCDGLICF-SYGKRLVVWNPSTGQSRWLPTPKSRRSNKEsdtyFLGYDPIEKQYKVLCFSDRSGNRN-QSEHQVYTLG 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 183 SGASRMIDCLCleNFDMIHDT---ISGTLvgeiiFWQLCDDNVKVTDKLLSFDLVSETFNLcPCPSNCGK 249
Cdd:TIGR01640  79 SNSWRTIECSP--PHHPLKSRgvcINGVL-----YYLAYTLKTNPDYFIVSFDVSSERFKE-FIPLPCGN 140
FBOX smart00256
A Receptor for Ubiquitination Targets;
14-54 3.42e-10

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 54.75  E-value: 3.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1079435390   14 LPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCRQH 54
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 13-52 1.98e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.85  E-value: 1.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCR 52
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Name Accession Description Interval E-value
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 12-50 1.34e-14

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 67.10  E-value: 1.34e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1079435390  12 RELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERF 50
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 107-249 2.59e-12

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 65.84  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 107 LGHCHGLFCLyFENNTFGLWNPSLRELRTIHPPYRYNWYEM----GFGYDHSSQDYKIVLVLKMQGRRSrSSQALVLSLK 182
Cdd:TIGR01640   1 VVPCDGLICF-SYGKRLVVWNPSTGQSRWLPTPKSRRSNKEsdtyFLGYDPIEKQYKVLCFSDRSGNRN-QSEHQVYTLG 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079435390 183 SGASRMIDCLCleNFDMIHDT---ISGTLvgeiiFWQLCDDNVKVTDKLLSFDLVSETFNLcPCPSNCGK 249
Cdd:TIGR01640  79 SNSWRTIECSP--PHHPLKSRgvcINGVL-----YYLAYTLKTNPDYFIVSFDVSSERFKE-FIPLPCGN 140
FBOX smart00256
A Receptor for Ubiquitination Targets;
14-54 3.42e-10

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 54.75  E-value: 3.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1079435390   14 LPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCRQH 54
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 13-52 1.98e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.85  E-value: 1.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCR 52
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 12-54 7.69e-07

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 45.39  E-value: 7.69e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1079435390  12 RELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCRQH 54
Cdd:cd22151     1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENA 43
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 13-46 8.64e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 45.13  E-value: 8.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFK 46
Cdd:cd09917     2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 14-44 3.83e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 3.83e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1079435390  14 LPFELVVEILTRVPVKDLMRFRCVCKSWRSL 44
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWREL 34
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 13-44 7.32e-05

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 39.68  E-value: 7.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1079435390  13 ELPFELVVEILTRVPVKDLM-RFRCVCKSWRSL 44
Cdd:cd22083     3 EIPEELLLEILTHVPATSLItNCRLVCTLWRDI 35
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 14-52 1.20e-04

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 39.09  E-value: 1.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1079435390  14 LPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCR 52
Cdd:cd22152     5 LPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFR 43
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 13-52 1.93e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 38.49  E-value: 1.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEERFCR 52
Cdd:cd22123     3 QLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 13-44 5.33e-04

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 38.42  E-value: 5.33e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1079435390  13 ELPFELVVEILTRVPVKDLMR-FRCVCKSWRSL 44
Cdd:cd22168     6 DLPEDVLLEILSLVPARDLILsCRLVCSRWRDL 38
F-box_FBXL15 cd22126
F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also ...
 14-44 9.98e-04

F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also called F-box only protein 37 (FBXO37), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Smad ubiquitination regulatory factor 1 (SMURF1), thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance. It also mediates ubiquitination of SMURF2 and WWP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438898  Cd Length: 44  Bit Score: 36.71  E-value: 9.98e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1079435390  14 LPFE--LVVEILTRVPVKDLMRFRCVCKSWRSL 44
Cdd:cd22126     4 LPWEdvLFPHILPHLSLKDLFNLRRVSKAFKSL 36
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 13-47 1.08e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 36.42  E-value: 1.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1079435390  13 ELPFELVVEILTRVPVKD-LMRFRCVCKSWRSLFKE 47
Cdd:cd22164     4 DLPDDLTASILSRLGAIDiLTNAQKVCKLWRRICKD 39
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 13-46 8.31e-03

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 33.80  E-value: 8.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFK 46
Cdd:cd22160     3 DLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 13-48 9.67e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 33.92  E-value: 9.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1079435390  13 ELPFELVVEILTRVPVKDLMRFRCVCKSWRSLFKEE 48
Cdd:cd22114     3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH