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Conserved domains on  [gi|2316585863|ref|XP_008458588|]
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protein HIRA isoform X1 [Cucumis melo]

Protein Classification

WD40 and Hira domain-containing protein( domain architecture ID 11456814)

WD40 and Hira domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 691-891 9.69e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 220.57  E-value: 9.69e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  691 GRRSMPTMMMGSAATFIDCDDcWKLLLVTRKGSLYVWDLFNRSCLLH-DSLASLIPLNPNSSTKDSGTIKVISAKLSKSG 769
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSG-SYLLAVTSVGLLYVWDIKKQKALLPpVSLAPLLDSSSRYSDKLTRAPTITSASLTSNG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  770 SPLVVLATRHAFLFDMSLMCWLRVADDCFPA-SNFSSSWNL-----GSIQSGELAALQVDIRKYLARK--------PGWS 835
Cdd:pfam07569   80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQSSAAGILSFLERKTNEELLRKgrgrllqrLAKT 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2316585863  836 RVTDDGM------QTRAHLETQMASALALKSPNEYRQWLLSYIRFLAREADESRLREVCESL 891
Cdd:pfam07569  160 LLMKEGFenfetvVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-361 5.92e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 5.92e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863    3 AEKPSWVRHEGmQIFSIDVQPGGLRFATGGGDHKVRIWNVKSvgrsledddsnQRLLATLRDHFGSVNCVRWAKHGRYVA 82
Cdd:COG2319    111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   83 SGSDDQTILVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAV 162
Cdd:COG2319    179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  163 LRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCGHFITTTHGFQKPRhs 242
Cdd:COG2319    242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVR-- 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  243 apVLERGEWSATFDFLGHNAPVIVVKFNhsmfrrnltnanemkavPVGwtnggskiggkespsyNVIAIGSQDRTITVWT 322
Cdd:COG2319    314 --LWDLATGKLLRTLTGHTGAVRSVAFS-----------------PDG----------------KTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2316585863  323 TASPRPLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:COG2319    359 LATGELLRTLTgH--TGAVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 691-891 9.69e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 220.57  E-value: 9.69e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  691 GRRSMPTMMMGSAATFIDCDDcWKLLLVTRKGSLYVWDLFNRSCLLH-DSLASLIPLNPNSSTKDSGTIKVISAKLSKSG 769
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSG-SYLLAVTSVGLLYVWDIKKQKALLPpVSLAPLLDSSSRYSDKLTRAPTITSASLTSNG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  770 SPLVVLATRHAFLFDMSLMCWLRVADDCFPA-SNFSSSWNL-----GSIQSGELAALQVDIRKYLARK--------PGWS 835
Cdd:pfam07569   80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQSSAAGILSFLERKTNEELLRKgrgrllqrLAKT 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2316585863  836 RVTDDGM------QTRAHLETQMASALALKSPNEYRQWLLSYIRFLAREADESRLREVCESL 891
Cdd:pfam07569  160 LLMKEGFenfetvVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-361 5.92e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 5.92e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863    3 AEKPSWVRHEGmQIFSIDVQPGGLRFATGGGDHKVRIWNVKSvgrsledddsnQRLLATLRDHFGSVNCVRWAKHGRYVA 82
Cdd:COG2319    111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   83 SGSDDQTILVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAV 162
Cdd:COG2319    179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  163 LRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCGHFITTTHGFQKPRhs 242
Cdd:COG2319    242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVR-- 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  243 apVLERGEWSATFDFLGHNAPVIVVKFNhsmfrrnltnanemkavPVGwtnggskiggkespsyNVIAIGSQDRTITVWT 322
Cdd:COG2319    314 --LWDLATGKLLRTLTGHTGAVRSVAFS-----------------PDG----------------KTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2316585863  323 TASPRPLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:COG2319    359 LATGELLRTLTgH--TGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-361 4.25e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.51  E-value: 4.25e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   11 HEGmQIFSIDVQPGGLRFATGGGDHKVRIWNVKsvgrsledddsNQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTI 90
Cdd:cd00200      8 HTG-GVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   91 LVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLV 170
Cdd:cd00200     76 RLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  171 KGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCG-HFITTTHGfqkprHSAPV--LE 247
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH------TGEVNSVAFSPDGeKLLSSSSD-----GTIKLwdLS 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  248 RGEWSATFDflGHNAPVIVVKFnhsmfrrnltnanemkavpvgwtnggskiggkeSPSYNVIAIGSQDRTITVWTTASPR 327
Cdd:cd00200    208 TGKCLGTLR--GHENGVNSVAF---------------------------------SPDGYLLASGSEDGTIRVWDLRTGE 252

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2316585863  328 PLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:cd00200    253 CVQTLSgH--TNSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-153 2.77e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.77e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2316585863   114 NWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWN 153
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
115-153 2.67e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.67e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2316585863  115 WKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWN 153
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 121-194 5.14e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 5.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  121 LRGHTADVVDLNWSPDDS-TLASGSLDNTVHIWNM----------SNGICtaVLRGHSSLVKGVAWDPIGSFIASQSD-D 188
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIphndesvkeiKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGfD 147


                   ....*.
gi 2316585863  189 KTVIIW 194
Cdd:PTZ00420   148 SFVNIW 153
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 691-891 9.69e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 220.57  E-value: 9.69e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  691 GRRSMPTMMMGSAATFIDCDDcWKLLLVTRKGSLYVWDLFNRSCLLH-DSLASLIPLNPNSSTKDSGTIKVISAKLSKSG 769
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSG-SYLLAVTSVGLLYVWDIKKQKALLPpVSLAPLLDSSSRYSDKLTRAPTITSASLTSNG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  770 SPLVVLATRHAFLFDMSLMCWLRVADDCFPA-SNFSSSWNL-----GSIQSGELAALQVDIRKYLARK--------PGWS 835
Cdd:pfam07569   80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQSSAAGILSFLERKTNEELLRKgrgrllqrLAKT 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2316585863  836 RVTDDGM------QTRAHLETQMASALALKSPNEYRQWLLSYIRFLAREADESRLREVCESL 891
Cdd:pfam07569  160 LLMKEGFenfetvVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-361 5.92e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 5.92e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863    3 AEKPSWVRHEGmQIFSIDVQPGGLRFATGGGDHKVRIWNVKSvgrsledddsnQRLLATLRDHFGSVNCVRWAKHGRYVA 82
Cdd:COG2319    111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   83 SGSDDQTILVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAV 162
Cdd:COG2319    179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  163 LRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCGHFITTTHGFQKPRhs 242
Cdd:COG2319    242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVR-- 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  243 apVLERGEWSATFDFLGHNAPVIVVKFNhsmfrrnltnanemkavPVGwtnggskiggkespsyNVIAIGSQDRTITVWT 322
Cdd:COG2319    314 --LWDLATGKLLRTLTGHTGAVRSVAFS-----------------PDG----------------KTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2316585863  323 TASPRPLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:COG2319    359 LATGELLRTLTgH--TGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-361 4.25e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.51  E-value: 4.25e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   11 HEGmQIFSIDVQPGGLRFATGGGDHKVRIWNVKsvgrsledddsNQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTI 90
Cdd:cd00200      8 HTG-GVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   91 LVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLV 170
Cdd:cd00200     76 RLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  171 KGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCG-HFITTTHGfqkprHSAPV--LE 247
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH------TGEVNSVAFSPDGeKLLSSSSD-----GTIKLwdLS 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  248 RGEWSATFDflGHNAPVIVVKFnhsmfrrnltnanemkavpvgwtnggskiggkeSPSYNVIAIGSQDRTITVWTTASPR 327
Cdd:cd00200    208 TGKCLGTLR--GHENGVNSVAF---------------------------------SPDGYLLASGSEDGTIRVWDLRTGE 252

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2316585863  328 PLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:cd00200    253 CVQTLSgH--TNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
15-361 6.04e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 6.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   15 QIFSIDVQPGGLRFATGGGDHKVRIWNVksvgrsledddSNQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTILVHe 94
Cdd:COG2319     80 AVLSVAFSPDGRLLASASADGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW- 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   95 kkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLVKGVA 174
Cdd:COG2319    148 ----------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  175 WDPIGSFIASQSDDKTVIIWRTSDWSLAHRTDGHwtkslgSTFFRRLGWSPCGHFITTTHGFQKPRhsapV--LERGEWS 252
Cdd:COG2319    212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGTVR----LwdLATGELL 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  253 ATFDflGHNAPVIVVKFnhsmfrrnltnanemkavpvgwtnggskiggkeSPSYNVIAIGSQDRTITVWTTASPRPLFVA 332
Cdd:COG2319    282 RTLT--GHSGGVNSVAF---------------------------------SPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                          330       340
                   ....*....|....*....|....*....
gi 2316585863  333 KHfFTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:COG2319    327 TG-HTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
10-198 3.42e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 3.42e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   10 RHEGMQIFSIDVQPGGLRFATGGGDHKVRIWNVKSvgrsledddsnQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQT 89
Cdd:COG2319    243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   90 ILVhekkpgsgttefgsgepPDVENWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSL 169
Cdd:COG2319    312 VRL-----------------WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                          170       180
                   ....*....|....*....|....*....
gi 2316585863  170 VKGVAWDPIGSFIASQSDDKTVIIWRTSD 198
Cdd:COG2319    375 VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-361 4.46e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.46e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   58 LLATLRDHFGSVNCVRWAKHGRYVASGSDDQTILVHekkpgsgttefgsgeppDVENWKVAMTLRGHTADVVDLNWSPDD 137
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------------DLETGELLRTLKGHTGPVRDVAASADG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  138 STLASGSLDNTVHIWNMSNGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDwslahrtdghwtkslgstf 217
Cdd:cd00200     64 TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET------------------- 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  218 frrlgwspcGHFITTthgfqkprhsapvlergewsatfdFLGHNAPVIVVKFnhsmfrrnltnanemkavpvgwtnggsk 297
Cdd:cd00200    125 ---------GKCLTT------------------------LRGHTDWVNSVAF---------------------------- 143

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2316585863  298 iggkeSPSYNVIAIGSQDRTITVWTTASPRPLFVAKHFfTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:cd00200    144 -----SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTI 201
WD40 COG2319
WD40 repeat [General function prediction only];
51-361 5.30e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 5.30e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   51 DDDSNQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTILVhekkpgsgttefgsgepPDVENWKVAMTLRGHTADVVD 130
Cdd:COG2319     21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLL-----------------LDAAAGALLATLLGHTAAVLS 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  131 LNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDWSLAHRtdghwt 210
Cdd:COG2319     84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT------ 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  211 kslgstffrrlgwspcghfittthgfqkprhsapvlergewsatfdFLGHNAPVIVVKFnhsmfrrnltnanemkavpvg 290
Cdd:COG2319    158 ----------------------------------------------LTGHSGAVTSVAF--------------------- 170

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2316585863  291 wtnggskiggkeSPSYNVIAIGSQDRTITVWTTASPRPLFVAK-HffTQSVVDLSWSPDGYSLFACSLDGSV 361
Cdd:COG2319    171 ------------SPDGKLLASGSDDGTVRLWDLATGKLLRTLTgH--TGAVRSVAFSPDGKLLASGSADGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
120-361 2.36e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  120 TLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIWRTSDW 199
Cdd:COG2319     31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  200 SLAHRTDGHwtkslgSTFFRRLGWSPCGHFITTTHGfqkpRHSAPV--LERGEWSATFDflGHNAPVIVVKFNHSmfRRN 277
Cdd:COG2319    111 LLLRTLTGH------TGAVRSVAFSPDGKTLASGSA----DGTVRLwdLATGKLLRTLT--GHSGAVTSVAFSPD--GKL 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  278 LTNANEMKAVPVGWTNGGSKIG---GKESPSYNV--------IAIGSQDRTITVWTTASPRPLFVAKHfFTQSVVDLSWS 346
Cdd:COG2319    177 LASGSDDGTVRLWDLATGKLLRtltGHTGAVRSVafspdgklLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFS 255

                          250
                   ....*....|....*
gi 2316585863  347 PDGYSLFACSLDGSV 361
Cdd:COG2319    256 PDGRLLASGSADGTV 270
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-153 2.77e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.77e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2316585863   114 NWKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWN 153
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
115-153 2.67e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.67e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2316585863  115 WKVAMTLRGHTADVVDLNWSPDDSTLASGSLDNTVHIWN 153
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 156-194 2.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.82e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2316585863   156 NGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIW 194
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-94 2.51e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.51e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2316585863    55 NQRLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTILVHE 94
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
157-194 4.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.32e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2316585863  157 GICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVIIW 194
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 121-194 5.14e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 5.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  121 LRGHTADVVDLNWSPDDS-TLASGSLDNTVHIWNM----------SNGICtaVLRGHSSLVKGVAWDPIGSFIASQSD-D 188
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIphndesvkeiKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGfD 147


                   ....*.
gi 2316585863  189 KTVIIW 194
Cdd:PTZ00420   148 SFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
57-92 8.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2316585863   57 RLLATLRDHFGSVNCVRWAKHGRYVASGSDDQTILV 92
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
PTZ00421 PTZ00421
coronin; Provisional
 121-193 4.49e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 4.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2316585863  121 LRGHTADVVDLNWSPD-DSTLASGSLDNTVHIWNMSNGICTAVLRGHSSLVKGVAWDPIGSFIASQSDDKTVII 193
Cdd:PTZ00421   121 LQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 34-194 9.31e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 9.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863   34 DHKVRIWNVK------SVGRSLEDDDSNQRLLATLRDHFGSVN------CVRW-AKHGRYVASGSDDQTILVHekkpgsg 100
Cdd:PLN00181   573 EHEKRVWSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKtkanicCVQFpSESGRSLAFGSADHKVYYY------- 645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316585863  101 ttefgsgeppDVENWKVAM-TLRGHTADVVDLNWSpDDSTLASGSLDNTVHIWNMS---NGICTAVLR---GHSSLVKGV 173
Cdd:PLN00181   646 ----------DLRNPKLPLcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsiSGINETPLHsfmGHTNVKNFV 714

                          170       180
                   ....*....|....*....|.
gi 2316585863  174 AWDPIGSFIASQSDDKTVIIW 194
Cdd:PLN00181   715 GLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-41 9.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 9.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2316585863     7 SWVRHEGmQIFSIDVQPGGLRFATGGGDHKVRIWN 41
Cdd:smart00320    7 TLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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