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Conserved domains on  [gi|2316535085|ref|XP_008450620|]
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probable purine permease 11 [Cucumis melo]

Protein Classification

purine permease( domain architecture ID 12180965)

purine permease is a proton-coupled transporter that mediates the uptake of nucleosides, nucleotides, and their derivatives, such as adenine and cytosine, as well as purine derivatives (hypoxanthine), phytohormones (zeatin and kinetin), and alkaloids (caffeine and nicotine)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 35-350 6.15e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


:

Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 407.82  E-value: 6.15e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  35 RIGIYTIFLVCGQSAATLLGRLYYDKGGNSKWMATLVQSAGFPILLPFLWFF----SQPTKSSSKQPNFLTFSFICFAFG 110
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSflskKRNQETTSFSSSFKRLVIIYIVLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 111 LLLIGDNLMYSYGLLYLPVSTYSLLCATQLAFSALLSFFLNAQKFTPYILNSLVLLTVSASLLAFNSESDTTTHSSKGKY 190
Cdd:pfam16913  82 LLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESKKKY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 191 VIGFLCTLGASATYSLYLCLLQVCFEKVIKRETFSIVLDMQIYPSIVASCGCVVGLFGSGEWRGLRDEMRGYEEGRVSYF 270
Cdd:pfam16913 162 VIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKSLYV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 271 MTLVWTAVTWQVSSVGLLGLIFEVSSLFSNVISTLALPVVPILAVIFFHDKMNGVKAMALVLALWGFVSYIYQNYLDESK 350
Cdd:pfam16913 242 LTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKDKKK 321
 
Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 35-350 6.15e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 407.82  E-value: 6.15e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  35 RIGIYTIFLVCGQSAATLLGRLYYDKGGNSKWMATLVQSAGFPILLPFLWFF----SQPTKSSSKQPNFLTFSFICFAFG 110
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSflskKRNQETTSFSSSFKRLVIIYIVLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 111 LLLIGDNLMYSYGLLYLPVSTYSLLCATQLAFSALLSFFLNAQKFTPYILNSLVLLTVSASLLAFNSESDTTTHSSKGKY 190
Cdd:pfam16913  82 LLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESKKKY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 191 VIGFLCTLGASATYSLYLCLLQVCFEKVIKRETFSIVLDMQIYPSIVASCGCVVGLFGSGEWRGLRDEMRGYEEGRVSYF 270
Cdd:pfam16913 162 VIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKSLYV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 271 MTLVWTAVTWQVSSVGLLGLIFEVSSLFSNVISTLALPVVPILAVIFFHDKMNGVKAMALVLALWGFVSYIYQNYLDESK 350
Cdd:pfam16913 242 LTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKDKKK 321
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 66-336 7.65e-06

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 47.14  E-value: 7.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  66 WMATLVQSAGFPILLPFLWFFSQPTKSSSKQ--PNFLTFSFICFAFGLLLigdnlmYSYGLLYLPVSTYSLLCATQLAFS 143
Cdd:COG0697    33 QLAFLRFLLAALLLLPLLLLRGRRLPPLSRRdwLLLLLRGLLGLALAFLL------FFLALQYTPAALAALLLALAPLFV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 144 ALLSFFLNAQKFTPYILNSLVLLTVSASLLAFNSESDTTThsskgkYVIGFLCTLGASATYSLYLCLLQvcfeKVIKRET 223
Cdd:COG0697   107 ALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGG------SLLGDLLALLAALSWALYTVLTR----RLSRRLD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 224 fsiVLDMQIYPSIVASCGCVVGLFGSGEWRGLRdemrgyeegrvsyfmTLVWTAVTWQVSSVGLLGLIF------EVSSL 297
Cdd:COG0697   177 ---PLTLTFWQMLVGALLLLPLALLTGLPLPLS---------------AAAWLALLYLGLFGTALAYLLwfralrRLGAS 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2316535085 298 FSNVISTLALPVVPILAVIFFHDKMNGVKAMALVLALWG 336
Cdd:COG0697   239 RAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAG 277
 
Name Accession Description Interval E-value
PUNUT pfam16913
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
 35-350 6.15e-143

Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.


Pssm-ID: 293518 [Multi-domain]  Cd Length: 321  Bit Score: 407.82  E-value: 6.15e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  35 RIGIYTIFLVCGQSAATLLGRLYYDKGGNSKWMATLVQSAGFPILLPFLWFF----SQPTKSSSKQPNFLTFSFICFAFG 110
Cdd:pfam16913   2 LVIISIFFLLIGQAISTLLGRLYFVNGGKSTWLQTLVQTAGFPLLLLPLLFSflskKRNQETTSFSSSFKRLVIIYIVLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 111 LLLIGDNLMYSYGLLYLPVSTYSLLCATQLAFSALLSFFLNAQKFTPYILNSLVLLTVSASLLAFNSESDTTTHSSKGKY 190
Cdd:pfam16913  82 LLVGADNFLYSYGLLYLPVSTFSLILATQLAFTAIFSYFINKQKFTPFIINSVVLLTISAALLALDSSSDKPSGESKKKY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 191 VIGFLCTLGASATYSLYLCLLQVCFEKVIKRETFSIVLDMQIYPSIVASCGCVVGLFGSGEWRGLRDEMRGYEEGRVSYF 270
Cdd:pfam16913 162 VIGFWCTIGASALFSLILCLVELAFEKVLKRRTFSMVLEMQIVMSLVATCVCVIGLFASGEFKDLKGEMEEFKKGKSLYV 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 271 MTLVWTAVTWQVSSVGLLGLIFEVSSLFSNVISTLALPVVPILAVIFFHDKMNGVKAMALVLALWGFVSYIYQNYLDESK 350
Cdd:pfam16913 242 LTLVGTAVSWQVYFVGAVGLVFLVSSLFSNVISTVLLPVVPVLAVIAFHDKFSGFKGVALVLAIWGFASYFYGLYKDKKK 321
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 66-336 7.65e-06

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 47.14  E-value: 7.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  66 WMATLVQSAGFPILLPFLWFFSQPTKSSSKQ--PNFLTFSFICFAFGLLLigdnlmYSYGLLYLPVSTYSLLCATQLAFS 143
Cdd:COG0697    33 QLAFLRFLLAALLLLPLLLLRGRRLPPLSRRdwLLLLLRGLLGLALAFLL------FFLALQYTPAALAALLLALAPLFV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 144 ALLSFFLNAQKFTPYILNSLVLLTVSASLLAFNSESDTTThsskgkYVIGFLCTLGASATYSLYLCLLQvcfeKVIKRET 223
Cdd:COG0697   107 ALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGG------SLLGDLLALLAALSWALYTVLTR----RLSRRLD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085 224 fsiVLDMQIYPSIVASCGCVVGLFGSGEWRGLRdemrgyeegrvsyfmTLVWTAVTWQVSSVGLLGLIF------EVSSL 297
Cdd:COG0697   177 ---PLTLTFWQMLVGALLLLPLALLTGLPLPLS---------------AAAWLALLYLGLFGTALAYLLwfralrRLGAS 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2316535085 298 FSNVISTLALPVVPILAVIFFHDKMNGVKAMALVLALWG 336
Cdd:COG0697   239 RAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAG 277
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 60-175 9.03e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.10  E-value: 9.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316535085  60 KGGNSKWMATLVQSAGFPILLPFLWFFSQPTKSSSKQ-PNFLTFSFICFAFGLLLigdnlmYSYGLLYLPVSTYSLLCAT 138
Cdd:pfam00892  26 RRISPLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSwLALLYLGVLGTFLGFLL------YFYGLKYVSASNASVITSL 99

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2316535085 139 QLAFSALLSFFLNAQKFTPYILNSLVLLTVSASLLAF 175
Cdd:pfam00892 100 SPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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