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Conserved domains on  [gi|2316573490|ref|XP_008441065|]
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cysteine proteinase inhibitor 5-like [Cucumis melo]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 15-97 7.15e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam16845:

Pssm-ID: 447698  Cd Length: 83  Bit Score: 89.02  E-value: 7.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  15 VKDPQSPRMKELAEWAVADYNKKEGTHLRFVCILECESQIVEGVNYRFILKATDEKDNEGNYEAIVWEKTWEDFKELVYF 94
Cdd:pfam16845   1 IKDVSDPHVVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGGGATKNYEAVVWEKPWEHFRSLTSF 80


                  ...
gi 2316573490  95 KQL 97
Cdd:pfam16845  81 KAL 83
 
Name Accession Description Interval E-value
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 15-97 7.15e-25

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 89.02  E-value: 7.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  15 VKDPQSPRMKELAEWAVADYNKKEGTHLRFVCILECESQIVEGVNYRFILKATDEKDNEGNYEAIVWEKTWEDFKELVYF 94
Cdd:pfam16845   1 IKDVSDPHVVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGGGATKNYEAVVWEKPWEHFRSLTSF 80


                  ...
gi 2316573490  95 KQL 97
Cdd:pfam16845  81 KAL 83
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 10-95 6.56e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 61.72  E-value: 6.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  10 GGYTPvKDPQSPRMKELAEWAVADYNKKE-GTHLRFVCILECESQIVEGVNYRFILKATD------------------EK 70
Cdd:cd00042     1 GGPSD-IPANDPEVQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGDtnckkssvpldcpdckllEE 79

                          90       100
                  ....*....|....*....|....*
gi 2316573490  71 DNEGNYEAIVWEKTWEDFKELVYFK 95
Cdd:cd00042    80 GKKKFCTAKVWEKPWENFKELLSFK 104
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 10-95 6.88e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 59.36  E-value: 6.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490   10 GGYTPVkDPQSPRMKELAEWAVADYNKKEGT--HLRFVCILECESQIVEGVNYRFILKATD---------------EKDN 72
Cdd:smart00043   4 GGPSDV-PPNDPEVQEAADFAVAEYNKKSNDkyELRVIKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpfLDQG 82

                           90       100
                   ....*....|....*....|...
gi 2316573490   73 EGNYEAIVWEKTWEDFKELVYFK 95
Cdd:smart00043  83 EKFCTAKVWEKPWENKIKLVEFK 105
 
Name Accession Description Interval E-value
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 15-97 7.15e-25

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 89.02  E-value: 7.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  15 VKDPQSPRMKELAEWAVADYNKKEGTHLRFVCILECESQIVEGVNYRFILKATDEKDNEGNYEAIVWEKTWEDFKELVYF 94
Cdd:pfam16845   1 IKDVSDPHVVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGGGATKNYEAVVWEKPWEHFRSLTSF 80


                  ...
gi 2316573490  95 KQL 97
Cdd:pfam16845  81 KAL 83
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 10-95 6.56e-14

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 61.72  E-value: 6.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  10 GGYTPvKDPQSPRMKELAEWAVADYNKKE-GTHLRFVCILECESQIVEGVNYRFILKATD------------------EK 70
Cdd:cd00042     1 GGPSD-IPANDPEVQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGDtnckkssvpldcpdckllEE 79

                          90       100
                  ....*....|....*....|....*
gi 2316573490  71 DNEGNYEAIVWEKTWEDFKELVYFK 95
Cdd:cd00042    80 GKKKFCTAKVWEKPWENFKELLSFK 104
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 10-95 6.88e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 59.36  E-value: 6.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490   10 GGYTPVkDPQSPRMKELAEWAVADYNKKEGT--HLRFVCILECESQIVEGVNYRFILKATD---------------EKDN 72
Cdd:smart00043   4 GGPSDV-PPNDPEVQEAADFAVAEYNKKSNDkyELRVIKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpfLDQG 82

                           90       100
                   ....*....|....*....|...
gi 2316573490   73 EGNYEAIVWEKTWEDFKELVYFK 95
Cdd:smart00043  83 EKFCTAKVWEKPWENKIKLVEFK 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 10-95 5.77e-11

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.88  E-value: 5.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316573490  10 GGYTPVkDPQSPRMKELAEWAVADYNKKE-GTHLRFVCILECESQIVEGVNYR--FILKATDEKDNEGNYEAIVWE-KTW 85
Cdd:pfam00031   1 GGLSPI-PDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFikVEVGETDCSKSKKLLEDCPLLdEKW 79

                          90
                  ....*....|
gi 2316573490  86 EDFKELVYFK 95
Cdd:pfam00031  80 LGLCSAQVYK 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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