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Conserved domains on  [gi|659079581|ref|XP_008440333|]
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WD40 repeat-containing protein HOS15 [Cucumis melo]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12094100)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  21468892|18925368|10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
248-561 5.19e-80

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 5.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGRTNEkskdVTTLDWNGDGT 327
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------LLRTLTGHSGA----VTSVAFSPDGK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWS-TNGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:COG2319  176 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFs 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 659079581 486 IRWSPTGPgtnnpnqqlVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLK 561
Cdd:COG2319  336 VAFSPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 8-32 1.37e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 44.62  E-value: 1.37e-06
                          10        20
                  ....*....|....*....|....*
gi 659079581    8 ELNYLVFRYLQESGFIHSAFALGYE 32
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
248-561 5.19e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 5.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGRTNEkskdVTTLDWNGDGT 327
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------LLRTLTGHSGA----VTSVAFSPDGK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWS-TNGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:COG2319  176 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFs 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 659079581 486 IRWSPTGPgtnnpnqqlVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLK 561
Cdd:COG2319  336 VAFSPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-559 1.17e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 253.03  E-value: 1.17e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGrtneKSKDVTTLDWNGDGT 327
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-------------LLRTLKG----HTGPVRDVAASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWSTN-GELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:cd00200   65 YLASGSSDKTIRLWDLEtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFs 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 659079581 486 IRWSPTGpgtnnpnqqLVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:cd00200  225 VAFSPDG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 248-398 5.44e-11

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 65.36  E-value: 5.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGS-LLASGSGDSTARIWPIADGSSrsggqsgslNVLVLKHVKGRTNEKSKDVTTLDWNG-D 325
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNDE---------SVKEIKDPQCILKGHKKKISIIDWNPmN 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 659079581 326 GTLLATGSYDGQARIWSTNGELRSTLSKHKGPIFSLKWNKKGDyLLTGSC-DKTAIVWDVKAEEWKQQFEFHSG 398
Cdd:PTZ00420 138 YYIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGN-LLSGTCvGKHMHIIDPRKQEIASSFHIHDG 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 521-559 5.69e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 5.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 659079581   521 GKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
521-559 2.27e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 2.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 659079581  521 GKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 8-32 1.37e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 44.62  E-value: 1.37e-06
                          10        20
                  ....*....|....*....|....*
gi 659079581    8 ELNYLVFRYLQESGFIHSAFALGYE 32
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 8-37 5.47e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.41  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 659079581     8 ELNYLVFRYLQESGFIHSAFALGYEAGINK 37
Cdd:smart00667   5 ELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
248-561 5.19e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.92  E-value: 5.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGRTNEkskdVTTLDWNGDGT 327
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------LLRTLTGHSGA----VTSVAFSPDGK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWS-TNGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:COG2319  176 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFs 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 659079581 486 IRWSPTGPgtnnpnqqlVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLK 561
Cdd:COG2319  336 VAFSPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-559 1.17e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 253.03  E-value: 1.17e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGrtneKSKDVTTLDWNGDGT 327
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-------------LLRTLKG----HTGPVRDVAASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWSTN-GELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:cd00200   65 YLASGSSDKTIRLWDLEtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFs 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 659079581 486 IRWSPTGpgtnnpnqqLVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:cd00200  225 VAFSPDG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
248-600 2.50e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.98  E-value: 2.50e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADgssrsggqsgslnvlvlKHVKGRTNEKSKDVTTLDWNGDGT 327
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-----------------GLLLRTLTGHTGAVRSVAFSPDGK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 328 LLATGSYDGQARIWST-NGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW- 405
Cdd:COG2319  134 TLASGSADGTVRLWDLaTGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFs 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 406 RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYT 485
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 486 IRWSPTGPgtnnpnqqlVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLKEGKI 565
Cdd:COG2319  294 VAFSPDGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 659079581 566 VKTYTG-NGGIFEVCWNKEGDKIAACFANNTVCVLD 600
Cdd:COG2319  365 LRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-602 2.00e-62

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.96  E-value: 2.00e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 347 LRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLDVDW-RNNISFATSSTDNMIYVCKI 425
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 426 GETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYTIRWSPTGpgtnnpnqqLVLA 505
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG---------TFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 506 SASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLKEGKIVKTYTG-NGGIFEVCWNKEG 584
Cdd:cd00200  152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                        250
                 ....*....|....*...
gi 659079581 585 DKIAACFANNTVCVLDFR 602
Cdd:cd00200  232 YLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
314-600 1.23e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 314 SKDVTTLDWNGDGTLLATGSYDGQARIW-STNGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQ 392
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLTLLLLdAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 393 FEFHSGPTLDVDW-RNNISFATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDK 471
Cdd:COG2319  116 LTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 472 YVYDLREHSKEIYTIRWSPTGPgtnnpnqqlVLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSL 551
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGK---------LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 659079581 552 DKSMHIWSLKEGKIVKTYTG-NGGIFEVCWNKEGDKIAACFANNTVCVLD 600
Cdd:COG2319  267 DGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
324-600 3.30e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 3.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 324 GDGTLLATGSYDGQARIWSTN-GELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWDVKAEEWKQQFEFHSGPTLD 402
Cdd:COG2319    4 ADGAALAAASADLALALLAAAlGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 403 VDWRNNIS-FATSSTDNMIYVCKIGETRPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSK 481
Cdd:COG2319   84 VAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 482 EIYTIRWSPTGpgtnnpnqQLvLASASFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLK 561
Cdd:COG2319  164 AVTSVAFSPDG--------KL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 659079581 562 EGKIVKTYTG-NGGIFEVCWNKEGDKIAACFANNTVCVLD 600
Cdd:COG2319  235 TGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-603 1.96e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.24  E-value: 1.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 430 PIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWSMKQDKYVYDLREHSKEIYTIRWSPTGP-----GTNN------- 497
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTylasgSSDKtirlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 498 ----------------------PNQQLVLASaSFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSM 555
Cdd:cd00200   81 etgecvrtltghtsyvssvafsPDGRILSSS-SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 659079581 556 HIWSLKEGKIVKTYTG-NGGIFEVCWNKEGDKIAACFANNTVCVLDFRM 603
Cdd:cd00200  160 KLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
248-345 5.21e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 5.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIWPIADGSsrsggqsgslnvlVLKHVKGRTNEkskdVTTLDWNGDGT 327
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-------------LLRTLTGHTGA----VTSVAFSPDGR 385

                         90
                 ....*....|....*...
gi 659079581 328 LLATGSYDGQARIWSTNG 345
Cdd:COG2319  386 TLASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 248-398 5.44e-11

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 65.36  E-value: 5.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 248 VTILQGHTSEVCACAWNPTGS-LLASGSGDSTARIWPIADGSSrsggqsgslNVLVLKHVKGRTNEKSKDVTTLDWNG-D 325
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNDE---------SVKEIKDPQCILKGHKKKISIIDWNPmN 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 659079581 326 GTLLATGSYDGQARIWSTNGELRSTLSKHKGPIFSLKWNKKGDyLLTGSC-DKTAIVWDVKAEEWKQQFEFHSG 398
Cdd:PTZ00420 138 YYIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGN-LLSGTCvGKHMHIIDPRKQEIASSFHIHDG 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 521-559 5.69e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 5.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 659079581   521 GKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 430-574 6.30e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 6.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 430 PIKTFAGHQGEVNCVKWDPTGS-LLASCSDDITAKIWSMKQD----KYVYD----LREHSKEIYTIRWsptgpgtnNPNQ 500
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvKEIKDpqciLKGHKKKISIIDW--------NPMN 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659079581 501 QLVLASASFDSTVKLWDVELGKLICSLNGHREpVYSVAFSPNGEYLASGSLDKSMHIWSLKEGKIVKTY-TGNGG 574
Cdd:PTZ00420 138 YYIMCSSGFDSFVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFhIHDGG 211
WD40 pfam00400
WD domain, G-beta repeat;
521-559 2.27e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 2.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 659079581  521 GKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWS 559
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 429-466 2.75e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 659079581   429 RPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWS 466
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 248-282 1.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 659079581   248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIW 282
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
429-466 1.56e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 659079581  429 RPIKTFAGHQGEVNCVKWDPTGSLLASCSDDITAKIWS 466
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 411-565 2.06e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 411 FATSSTDNMIYV--CK--IGETR----PIKTFAGhQGEVNCVKWDP-TGSLLASCSDDITAKIWSMKQDKYVYDLREHSK 481
Cdd:PLN00181 498 FATAGVNKKIKIfeCEsiIKDGRdihyPVVELAS-RSKLSGICWNSyIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEK 576

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 482 EIYTIRWSPTGPgtnnpnqqLVLASASFDSTVKLWDVELGKLICSLNGhREPVYSVAF-SPNGEYLASGSLDKSMHIWSL 560
Cdd:PLN00181 577 RVWSIDYSSADP--------TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDL 647


                 ....*
gi 659079581 561 KEGKI 565
Cdd:PLN00181 648 RNPKL 652
PTZ00421 PTZ00421
coronin; Provisional
 436-566 2.91e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 2.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 436 GHQGEVNCVKWDP-TGSLLASCSDDITAKIWSMKQD-------KYVYDLREHSKEIYTIRWSPTGPGtnnpnqqlVLASA 507
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMN--------VLASA 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 659079581 508 SFDSTVKLWDVELGKLICSLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLKEGKIV 566
Cdd:PTZ00421 145 GADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
WD40 pfam00400
WD domain, G-beta repeat;
248-282 7.93e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 7.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 659079581  248 VTILQGHTSEVCACAWNPTGSLLASGSGDSTARIW 282
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-383 1.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 659079581   344 NGELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWD 383
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
345-383 1.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 659079581  345 GELRSTLSKHKGPIFSLKWNKKGDYLLTGSCDKTAIVWD 383
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 504-602 1.05e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 504 LASASFDSTVKLWDVELGKLICSLNGHREPVYSVAF-SPNGEYLASGSLDKSMHIWSLKEGKIVKTYTGNGGIFEVCWNK 582
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100
                 ....*....|....*....|.
gi 659079581 583 E-GDKIAACFANNTVCVLDFR 602
Cdd:PLN00181 628 EsGRSLAFGSADHKVYYYDLR 648
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 8-32 1.37e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 44.62  E-value: 1.37e-06
                          10        20
                  ....*....|....*....|....*
gi 659079581    8 ELNYLVFRYLQESGFIHSAFALGYE 32
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 314-600 1.47e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 314 SKDVTTLDWNGDGTLLATGSYDGQARIWSTNGELRSTLSKH--------KGPIFSLKWNKK-GDYLLTGSCDKTAIVWDV 384
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHypvvelasRSKLSGICWNSYiKSQVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 385 KAEEWKQQFEFHSGPTLDVDWR--NNISFATSSTDNMIYVCKIGETRPIKTFAGhQGEVNCVKW-DPTGSLLASCSDDit 461
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSsaDPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSAD-- 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 462 akiwsmkQDKYVYDLRE----------HSKEIYTIRWSPTGpgtnnpnqqlVLASASFDSTVKLWDVELG------KLIC 525
Cdd:PLN00181 640 -------HKVYYYDLRNpklplctmigHSKTVSYVRFVDSS----------TLVSSSTDNTLKLWDLSMSisgineTPLH 702

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 526 SLNGHREPVYSVAFSPNGEYLASGSLDKSMHIWSLKEGKIVKTYTGNGG--------------IFEVCWNKEGDKIAACF 591
Cdd:PLN00181 703 SFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIdpvsglevddasqfISSVCWRGQSSTLVAAN 782


                 ....*....
gi 659079581 592 ANNTVCVLD 600
Cdd:PLN00181 783 STGNIKILE 791
PTZ00421 PTZ00421
coronin; Provisional
 231-486 4.75e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 4.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 231 DISTTSTSQSCeisSSDVTILQGHTSEVCACAWNPTG-SLLASGSGDSTARIWPIadgssrsggqSGSLNVLVLKHVkgr 309
Cdd:PTZ00421 104 GIPEEGLTQNI---SDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDV----------ERGKAVEVIKCH--- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 310 tnekSKDVTTLDWNGDGTLLATGSYDGQARIWST-NGELRSTLSKHKGPIFS-LKWNKKGDYLLTGSCDKT----AIVWD 383
Cdd:PTZ00421 168 ----SDQITSLEWNLDGSLLCTTSKDKKLNIIDPrDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWD 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 384 VKaeewKQQFEFHsgpTLDVDWRNNISFATSSTD-NMIYVCKIGETRpIKTFA-GHQGEVNCVKWDPTGSLLASCsddIT 461
Cdd:PTZ00421 244 TR----KMASPYS---TVDLDQSSALFIPFFDEDtNLLYIGSKGEGN-IRCFElMNERLTFCSSYSSVEPHKGLC---MM 312

                        250       260
                 ....*....|....*....|....*....
gi 659079581 462 AKiWSMKQDK----YVYDLREHSkeIYTI 486
Cdd:PTZ00421 313 PK-WSLDTRKceiaRFYALTYHS--LYTI 338
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 256-458 4.78e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 4.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 256 SEVCACAWNP-TGSLLASGSGDSTARIWPIADgssrsggqsgslNVLVLKhvkgrTNEKSKDVTTLDWN-GDGTLLATGS 333
Cdd:PLN00181 533 SKLSGICWNSyIKSQVASSNFEGVVQVWDVAR------------SQLVTE-----MKEHEKRVWSIDYSsADPTLLASGS 595

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 334 YDGQARIWSTNGELRSTLSKHKGPIFSLKW-NKKGDYLLTGSCDKTAIVWDVKAEEWKQ-QFEFHSGPTLDVDWRNNISF 411
Cdd:PLN00181 596 DDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTL 675

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 659079581 412 ATSSTDNMI-------YVCKIGETrPIKTFAGHQGEVNCVKWDPTGSLLASCSD 458
Cdd:PLN00181 676 VSSSTDNTLklwdlsmSISGINET-PLHSFMGHTNVKNFVGLSVSDGYIATGSE 728
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 471-517 1.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 659079581   471 KYVYDLREHSKEIYTIRWSPTGPgtnnpnqqlVLASASFDSTVKLWD 517
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK---------YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-342 4.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.64e-05
                           10        20
                   ....*....|....*....|....*....
gi 659079581   314 SKDVTTLDWNGDGTLLATGSYDGQARIWS 342
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
471-517 9.84e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 9.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 659079581  471 KYVYDLREHSKEIYTIRWSPTGPgtnnpnqqlVLASASFDSTVKLWD 517
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK---------LLASGSDDGTVKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 361-566 1.01e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 43.80  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581  361 LKWNKKGDYLLtgscdktaivwdVKAEEwkqqfefhsgptlDVDwRNNISFATSSTdnmIYVCKIGETrPIKTFA-GHQG 439
Cdd:pfam08662  11 LKWNKNGTYLL------------VLTDT-------------DVD-KTGKSYYGETN---LYLIGETGG-PDCVVElDKEG 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581  440 EVNCVKWDPTGSLLASCSDDITAKI--WSMKQDKyVYDLREHSKEiyTIRWSPTGpgtnnpnqQLVLaSASFDST---VK 514
Cdd:pfam08662  61 PIHDVAWSPNGKEFAVIYGYMPAKVsfFDLKGNV-IHSFGEQPRN--TIFWSPFG--------RLVL-LAGFGNLagdIE 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 659079581  515 LWDVELGKLICSLNgHREPVYsVAFSPNGEYLASGSL------DKSMHIWSLkEGKIV 566
Cdd:pfam08662 129 FWDVVNKKKIATAE-ASNATL-CEWSPDGRYFLTATTaprlrvDNGFKIWHY-NGALV 183
WD40 pfam00400
WD domain, G-beta repeat;
314-342 1.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*....
gi 659079581  314 SKDVTTLDWNGDGTLLATGSYDGQARIWS 342
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 262-364 2.43e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581  262 AWNPTGSLLASGSGD--------STARIWPIADgssrsggqsgslnvlvlkhvkgrTNEKSKdVTTLDWNGDGTLLATGS 333
Cdd:pfam12894   2 SWCPTMDLIALATEDgelllhrlNWQRVWTLSP-----------------------DKEDLE-VTSLAWRPDGKLLAVGY 57

                          90       100       110
                  ....*....|....*....|....*....|..
gi 659079581  334 YDGQARIWST-NGELRSTLSKHKGPIFSLKWN 364
Cdd:pfam12894  58 SDGTVRLLDAeNGKIVHHFSAGSDLITCLGWG 89
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 8-37 5.47e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.41  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 659079581     8 ELNYLVFRYLQESGFIHSAFALGYEAGINK 37
Cdd:smart00667   5 ELNRLILEYLLRNGYEETAETLQKESGLSL 34
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
488-599 4.45e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659079581 488 WSPTGPGTNNPNQQLVLASASFDSTVKLWDVELGKLICSLNGHREPvYSVAFSPNGEYL-ASGSLDKSMHIWSLKEGKIV 566
Cdd:COG3391   67 VADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVV 145

                         90       100       110
                 ....*....|....*....|....*....|....
gi 659079581 567 KTYTGNGGIFEVCWNKEGDKI-AACFANNTVCVL 599
Cdd:COG3391  146 ATIPVGAGPHGIAVDPDGKRLyVANSGSNTVSVI 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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