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Conserved domains on  [gi|659077924|ref|XP_008439459|]
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uncharacterized protein At4g19900 isoform X1 [Cucumis melo]

Protein Classification

Gly_transf_sug and Gb3_synth domain-containing protein( domain architecture ID 10517332)

Gly_transf_sug and Gb3_synth domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 566-695 3.71e-28

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


:

Pssm-ID: 428017  Cd Length: 130  Bit Score: 109.64  E-value: 3.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  566 AFRSHSPFIMECMKEYYSTYDDRSFRWNGAELLTRVAKRFSSEVPAEQFE------LTVQPSFAFFPIASQNITRYFVap 639
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMErvrcrgFTVLPPEAFYPIPYPNWKRFFE-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 659077924  640 asaTEKAEHeclLKKILEESVTFHFWNSLTY--SLIPESESLVSRLLQHTCIKCFDVL 695
Cdd:pfam04572  79 ---PEDLEE---TMKLTKDSYAVHLWNKLSKgePLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 437-556 4.64e-18

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


:

Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 79.68  E-value: 4.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  437 GVRHQRGLESVFLHHQNACVVIFSETIEldffkdnfvkngykvavAMPNLDELLKDTPthkfasiWF-EWKKTKFYSTHY 515
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-----------------FALDINFLKSDTP-------WFlEAYSLLPLFIAK 56

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 659077924  516 SELVRLAALYKYGGIYLDSDIVVLKPLsslhNSVGMEDQLA 556
Cdd:pfam04488  57 SDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERFL 93
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 566-695 3.71e-28

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 109.64  E-value: 3.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  566 AFRSHSPFIMECMKEYYSTYDDRSFRWNGAELLTRVAKRFSSEVPAEQFE------LTVQPSFAFFPIASQNITRYFVap 639
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMErvrcrgFTVLPPEAFYPIPYPNWKRFFE-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 659077924  640 asaTEKAEHeclLKKILEESVTFHFWNSLTY--SLIPESESLVSRLLQHTCIKCFDVL 695
Cdd:pfam04572  79 ---PEDLEE---TMKLTKDSYAVHLWNKLSKgePLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 437-556 4.64e-18

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 79.68  E-value: 4.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  437 GVRHQRGLESVFLHHQNACVVIFSETIEldffkdnfvkngykvavAMPNLDELLKDTPthkfasiWF-EWKKTKFYSTHY 515
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-----------------FALDINFLKSDTP-------WFlEAYSLLPLFIAK 56

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 659077924  516 SELVRLAALYKYGGIYLDSDIVVLKPLsslhNSVGMEDQLA 556
Cdd:pfam04488  57 SDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
485-579 1.49e-11

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 62.21  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924 485 NLDELLKDTPtHKFASiwfEWKKTKFYStHYSELVRLAALYKYGGIYLDSDIVVLKPLSSLHNS----VGMEDQLAGsSL 560
Cdd:COG3774   44 NFDDFIKEHG-PEYLE---AYYKLKKGA-ARADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEDPPPG-II 117

                         90
                 ....*....|....*....
gi 659077924 561 NGAVMAFRSHSPFIMECMK 579
Cdd:COG3774  118 SNGFIAAEPGHPFLKKALE 136
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 566-695 3.71e-28

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 109.64  E-value: 3.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  566 AFRSHSPFIMECMKEYYSTYDDRSFRWNGAELLTRVAKRFSSEVPAEQFE------LTVQPSFAFFPIASQNITRYFVap 639
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMErvrcrgFTVLPPEAFYPIPYPNWKRFFE-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 659077924  640 asaTEKAEHeclLKKILEESVTFHFWNSLTY--SLIPESESLVSRLLQHTCIKCFDVL 695
Cdd:pfam04572  79 ---PEDLEE---TMKLTKDSYAVHLWNKLSKgePLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 437-556 4.64e-18

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 79.68  E-value: 4.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  437 GVRHQRGLESVFLHHQNACVVIFSETIEldffkdnfvkngykvavAMPNLDELLKDTPthkfasiWF-EWKKTKFYSTHY 515
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-----------------FALDINFLKSDTP-------WFlEAYSLLPLFIAK 56

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 659077924  516 SELVRLAALYKYGGIYLDSDIVVLKPLsslhNSVGMEDQLA 556
Cdd:pfam04488  57 SDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
485-579 1.49e-11

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 62.21  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924 485 NLDELLKDTPtHKFASiwfEWKKTKFYStHYSELVRLAALYKYGGIYLDSDIVVLKPLSSLHNS----VGMEDQLAGsSL 560
Cdd:COG3774   44 NFDDFIKEHG-PEYLE---AYYKLKKGA-ARADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEDPPPG-II 117

                         90
                 ....*....|....*....
gi 659077924 561 NGAVMAFRSHSPFIMECMK 579
Cdd:COG3774  118 SNGFIAAEPGHPFLKKALE 136
Caps_synth pfam05704
Capsular polysaccharide synthesis protein; This family consists of several capsular ...
 501-586 5.35e-07

Capsular polysaccharide synthesis protein; This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae.


Pssm-ID: 368570  Cd Length: 278  Bit Score: 51.89  E-value: 5.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659077924  501 IWFEWKKTKFYSTHYSELVRLAALYKYGGIYLDSDIVVLKPLS---------SLHNSVGMEDQLAGSSLNGAVMAFRSHS 571
Cdd:pfam05704  99 IIEKFEKGKISRAHFSDILRLNLLAKYGGVWIDATIYCTGDLPnelldsdffTFSSSELDSNKISISRWTGFFLAAKKNN 178

                          90
                  ....*....|....*...
gi 659077924  572 PFIM---ECMKEYYSTYD 586
Cdd:pfam05704 179 PLLStlrDLLLEYWKKYN 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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