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Conserved domains on  [gi|659074697|ref|XP_008437748|]
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transcription factor bHLH67 isoform X1 [Cucumis melo]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 385)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 159-205 1.19e-28

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd11448:

Pssm-ID: 469605  Cd Length: 74  Bit Score: 106.28  E-value: 1.19e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 659074697 159 MTHIAVERNRRRQMNDHLNVIKSLIPTSYVQRGDQASIIGGAIDFVK 205
Cdd:cd11448    1 MTHIAVERNRRKQMNEHLNVLRSLMPGSYIQRGDQASIVGGAIEFVK 47
 
Name Accession Description Interval E-value
bHLH_AtFAMA_like cd11448
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar ...
 159-205 1.19e-28

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development.


Pssm-ID: 381454  Cd Length: 74  Bit Score: 106.28  E-value: 1.19e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 659074697 159 MTHIAVERNRRRQMNDHLNVIKSLIPTSYVQRGDQASIIGGAIDFVK 205
Cdd:cd11448    1 MTHIAVERNRRKQMNEHLNVLRSLMPGSYIQRGDQASIVGGAIEFVK 47
HLH pfam00010
Helix-loop-helix DNA-binding domain;
157-205 1.16e-08

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 1.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 659074697  157 QRMTHIAVERNRRRQMNDHLNVIKSLIPTS-YVQRGDQASIIGGAIDFVK 205
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLpPDKKLSKAEILRLAIEYIK 50
HLH smart00353
helix loop helix domain;
163-205 1.53e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.82  E-value: 1.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 659074697   163 AVERNRRRQMNDHLNVIKSLIPTSY-VQRGDQASIIGGAIDFVK 205
Cdd:smart00353   2 ARERRRRRKINEAFDELRSLLPTLPkNKKLSKAEILRLAIEYIK 45
 
Name Accession Description Interval E-value
bHLH_AtFAMA_like cd11448
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar ...
 159-205 1.19e-28

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development.


Pssm-ID: 381454  Cd Length: 74  Bit Score: 106.28  E-value: 1.19e-28
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 659074697 159 MTHIAVERNRRRQMNDHLNVIKSLIPTSYVQRGDQASIIGGAIDFVK 205
Cdd:cd11448    1 MTHIAVERNRRKQMNEHLNVLRSLMPGSYIQRGDQASIVGGAIEFVK 47
HLH pfam00010
Helix-loop-helix DNA-binding domain;
157-205 1.16e-08

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 1.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 659074697  157 QRMTHIAVERNRRRQMNDHLNVIKSLIPTS-YVQRGDQASIIGGAIDFVK 205
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLpPDKKLSKAEILRLAIEYIK 50
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 161-205 1.05e-06

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 45.79  E-value: 1.05e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659074697 161 HIAVERNRRRQMNDHLNVIKSLIPTSYvqRGDQASIIGGAIDFVK 205
Cdd:cd18918    1 LFATERERREKLNEKFSDLRNLIPNPT--KNDRASILSDAIKYIN 43
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 161-205 1.40e-06

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 44.86  E-value: 1.40e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659074697 161 HIAVERNRRRQMNDHLNVIKSLIPTsyVQRGDQASIIGGAIDFVK 205
Cdd:cd11393    1 HSIAERKRREKINERIRALRSLVPN--GGKTDKASILDEAIEYIK 43
HLH smart00353
helix loop helix domain;
163-205 1.53e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.82  E-value: 1.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 659074697   163 AVERNRRRQMNDHLNVIKSLIPTSY-VQRGDQASIIGGAIDFVK 205
Cdd:smart00353   2 ARERRRRRKINEAFDELRSLLPTLPkNKKLSKAEILRLAIEYIK 45
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 161-205 1.65e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 39.71  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659074697 161 HIAVERNRRRQMNDHLNVIKSLIPtsYVQRGDQASIIGGAIDFVK 205
Cdd:cd11451    6 HAMAERRRREKLNERFITLRSMVP--FVTKMDKVSILGDAIEYLK 48
bHLH_AtFIT_like cd11450
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced ...
 155-204 1.99e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced transcription factor 1 (FIT) and similar proteins; The family includes bHLH transcription factors from Arabidopsis thaliana, such as FIT and DYT1. FIT, also termed FER-like iron deficiency-induced transcription factor, or FER-like regulator of iron uptake, or AtbHLH29, or EN 43, is a bHLH transcription factor that is required for the iron deficiency response in plant. It regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. DYT1, also termed AtbHLH22, or protein dysfunctional tapetum 1, or EN 49, is a bHLH transcription factor involved in the control of tapetum development. It is required for male fertility and pollen differentiation, especially during callose deposition.


Pssm-ID: 381456 [Multi-domain]  Cd Length: 76  Bit Score: 39.43  E-value: 1.99e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 659074697 155 ESQRMTHIAVERNRRRQMNDHLNVIKSLIPTsyVQRGDQASIIGGAIDFV 204
Cdd:cd11450    1 SSPASKNLVSERNRRQKLNQRLFALRSVVPN--ITKMDKASIIKDAISYI 48
bHLH_AtAMS_like cd11443
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores ...
 165-205 3.23e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AMS, ICE1 and SCREAM2. AMS, also termed AtbHLH21, or EN 48, plays a crucial role in tapetum development and it is required for male fertility and pollen differentiation. ICE1, also termed inducer of CBF expression 1, or AtbHLH116, or EN 45, or SCREAM, acts as a transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. It binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. SCREAM2, also termed AtbHLH33, or EN 44, mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.


Pssm-ID: 381449 [Multi-domain]  Cd Length: 72  Bit Score: 38.90  E-value: 3.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 659074697 165 ERNRRRQMNDHLNVIKSLIPTsyVQRGDQASIIGGAIDFVK 205
Cdd:cd11443    7 ERRRRKKLNDRLYMLRSVVPK--ITKMDRASILGDAIDYVK 45
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
 152-205 2.74e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 36.50  E-value: 2.74e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 659074697 152 EEVESQRMTHIAVERNRRRQMNDHLNVIKSLIPTSyvQRGDQASIIGGAIDFVK 205
Cdd:cd11455    2 DKALAASKSHSEAERRRRERINSHLATLRTLLPNL--SKTDKASLLAEVVQHVK 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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