BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  36 NAPVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLL 115
Cdd:cd18388    1 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 80

                         90
                 ....*....|....*....
gi 632978769 116 YEEAKYYQLQPMLKELERW 134
Cdd:cd18388   81 YEEAKYYQLQPMVKELERW 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  36 NAPVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLL 115
Cdd:cd18388    1 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 80

                         90
                 ....*....|....*....
gi 632978769 116 YEEAKYYQLQPMLKELERW 134
Cdd:cd18388   81 YEEAKYYQLQPMVKELERW 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769    39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPivlDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDfkDFSLLYEE 118
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE---SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLEL 76

                           90
                   ....*....|....*.
gi 632978769   119 AKYYQLQPMLKELERW 134
Cdd:smart00225  77 ADYLQIPGLVELCEEF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  36 NAPVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLL 115
Cdd:cd18388    1 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 80

                         90
                 ....*....|....*....
gi 632978769 116 YEEAKYYQLQPMLKELERW 134
Cdd:cd18388   81 YEEAKYYQLQPMVKELERW 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  35 SNAPVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSL 114
Cdd:cd18387    1 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80

                         90       100
                 ....*....|....*....|....*
gi 632978769 115 LYEEAKYYQLQPMLKELERWKQDRE 139
Cdd:cd18387   81 LYEEAKYFQLQPMLLELERWKQDRE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  38 PVHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYE 117
Cdd:cd18395    2 PITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFPTKKDS-QGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLKR 80

                         90
                 ....*....|....*
gi 632978769 118 EAKYYQLQPMLKELE 132
Cdd:cd18395   81 EADFYQIQPLIEALQ 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYEE 118
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDE-DGSIFIDRDPELFRHILNFLRTGKLPLPSDFVELEELLAE 79

                 ....
gi 632978769 119 AKYY 122
Cdd:cd18316   80 AEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEP--IVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLY 116
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRqeLARDS-KGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLK 83

                         90
                 ....*....|....*
gi 632978769 117 EEAKYYQLQPMLKEL 131
Cdd:cd18367   84 REAEYFQLPELVKAL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPiVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYEE 118
Cdd:cd18375    3 VTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKDQ-DFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDYNRLARE 81

                         90
                 ....*....|....*
gi 632978769 119 AKYYQLQPMLKELER 133
Cdd:cd18375   82 AEFYGLYSLADLLSQ 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLP-EDFKDFSLLYE 117
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFSGRHSLKKDE-DGSYFIDRDGTHFRHILNYLRDGEVKIPtEDRSVLKELLE 79

                 ....*....
gi 632978769 118 EAKYYQLQP 126
Cdd:cd18376   80 EAEYYQLRG 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVL--DSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLY 116
Cdd:cd18397    5 VELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKPGELarDS-KGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQ 83

                         90
                 ....*....|....*
gi 632978769 117 EEAKYYQLQPMLKEL 131
Cdd:cd18397   84 REAEFFQLPELVKRL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVL--DSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLY 116
Cdd:cd18396    6 VELNVGGQVYVTKHSTLLSVPDSTLASMFSRRAARELprDN-RGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEKERLL 84

                         90
                 ....*....|....*
gi 632978769 117 EEAKYYQLQPMLKEL 131
Cdd:cd18396   85 REAEYFQLGDLVKLL 99

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDsrigrLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYEE 118
Cdd:cd18374    3 VKVYVGSHWYATYLKTLLKYPE-----LLSNSKKVRWITYGQTLLISGDGQMFRHILNFLRLGKLLLPSEFKEWPLLCQE 77

                         90
                 ....*....|..
gi 632978769 119 AKYYQLqPMLKE 130
Cdd:cd18374   78 VEEYQI-PALSE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKdFSLLYEE 118
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGIS-IPDLREE 79

                 ....
gi 632978769 119 AKYY 122
Cdd:cd18187   80 CDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQhYFIDRDGEIFRYILSFLRTsKLLLPEDFkDFSLLYEE 118
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGA-IFIDRDPTVFAPILNFLRT-KELDPRGI-HVSLLLHE 80

                         90
                 ....*....|....
gi 632978769 119 AKYYQLQPMLKELE 132
Cdd:cd18393   81 AQFYGITPLVRRLQ 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYpDSRIGRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYEE 118
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTKQ-DTMLRAMFSGRMEVLTDS-EGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAE 78

                 ....*..
gi 632978769 119 AKYYQLQ 125
Cdd:cd18369   79 AKYYLVQ 85

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  40 HIDVGGHMYTSSLATLTRYPDSRIGRlfngtEPIVLD-SLKQHYFIDRDGEIFRYILSFLRTSKLLLpEDFKDFSLLYEE 118
Cdd:cd18373    2 YFNVGGWIFSVPKSKLAQFPDSLLWK-----EASSLSeSENTRLFIDRDGFTFRHVHYYLQTSKLSS-SSCSELNLLYEQ 75

                         90       100
                 ....*....|....*....|..
gi 632978769 119 AKYYQLQPMLKELERWKQDREF 140
Cdd:cd18373   76 AAGLQLTSLLQALDNLKEGKHH 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  33 TKSNAPVHIDVGGHMYTSSLATLTRyPDSRIGRLFNGTEPIVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDF 112
Cdd:cd18399    3 SPSSKYVKLNVGGALYYTTMQTLTK-QDTMLKAMFSGRMEVLTDS-EGWILIDRCGKHFGTILNYLRDGAVPLPESRREI 80

                         90       100
                 ....*....|....*....|....*..
gi 632978769 113 SLLYEEAKYYQLQPMLKELERWKQDRE 139
Cdd:cd18399   81 EELLAEAKYYLVQGLVEECQAALQNKD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPI----VLDSLKQH---YFIDRDGEIFRYILSFLRTSKLLLPEDFKD 111
Cdd:cd18425    1 LNINVGGTSYQISYRVAASYPKTRIGRLATYTDRSrkldLCDDYNVQndeYFFDRDPAVFHHIYNFYRTGVLWVKDELCP 80

                         90
                 ....*....|.
gi 632978769 112 FSLLyEEAKYY 122
Cdd:cd18425   81 RNFL-EEINYW 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  41 IDVGGHMYTSSLATLTRYPDSRIGrlfnGTE-PIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDfKDFSLLYEEA 119
Cdd:cd18380    4 INVSGRRFETWKNTLEKYPDTLLG----STEkEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRH-ECISAYDDEL 78

                 ....*..
gi 632978769 120 KYYQLQP 126
Cdd:cd18380   79 AFFGILP 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  20 PVVSQGIP-SPAQLTKSNAPVHI-DVGGHMYTSSLATLTRYPDSRIGRlfnGTEPIVLDSLKQHYFIDRDGEIFRYILSF 97
Cdd:cd18419   16 PVANCPMPlAPADKNKRQDELIVlNVSGRRFQTWRTTLERYPDTLLGS---TEKEFFFNEDTKEYFFDRDPEVFRCVLNF 92

                         90       100
                 ....*....|....*....|....*....
gi 632978769  98 LRTSKLLLPEdFKDFSLLYEEAKYYQLQP 126
Cdd:cd18419   93 YRTGKLHYPR-YECISAYDEELAFYGILP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNgtEPIVLDSLKQH---YFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLL 115
Cdd:cd18389    3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQ--EDPDLDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80

                         90       100
                 ....*....|....*....|....*.
gi 632978769 116 yEEAKYYQLQPMLKELERWKQDREFR 141
Cdd:cd18389   81 -EEAEFYNIASLVRLVKERIRDNENR 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  20 PVVSQGIPSPAQLTKSNAP----VHIDVGGHMYTSSLATLTRYPDSRIGrlfNGTEPIVLDSLKQHYFIDRDGEIFRYIL 95
Cdd:cd18420   15 PIANNPLPPPPVDQERRRTddekLIINVSGRRFETWRNTLEKYPDTLLG---SNEREFFYDEETKEYFFDRDPDIFRHIL 91

                         90
                 ....*....|..
gi 632978769  96 SFLRTSKLLLPE 107
Cdd:cd18420   92 NYYRTGKLHYPK 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLyEE 118
Cdd:cd18391    3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL-EE 81

                         90
                 ....*....|.
gi 632978769 119 AKYYQLQPMLK 129
Cdd:cd18391   82 AEFYNIGPLIR 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  41 IDVGGHMYTSSLATLTRYPDSRIGRL--FNGTEPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFS 113
Cdd:cd18382    3 INVGGARYSLPWSTLDRFPLTRLSRLkaCRSEDDILrvcddYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCALS 82

                         90       100
                 ....*....|....*....|....*....
gi 632978769 114 lLYEEAKYYQLQpmLKELERWKQDREFRK 142
Cdd:cd18382   83 -FQEELAYWGIE--EAHLERCCKRRLLRR 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  41 IDVGGHMYTSSLATLTRYPDSRIGrlfNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDfKDFSLLYEEAK 120
Cdd:cd18418    4 LNVSGTRFQTWRNTLERYPDTLLG---SSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRH-ECISAYDEELA 79

                 ....*.
gi 632978769 121 YYQLQP 126
Cdd:cd18418   80 FFGIIP 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGT--EPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPED 108
Cdd:cd18378    4 VLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNthESLLelcddYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEE 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLfngTEPIV-LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFkdFSLLYE 117
Cdd:cd18416    4 VVLNVGGIRHETYKATLKKIPATRLSRL---TEALAnYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDV--CGPLFE 78

                         90       100
                 ....*....|....*....|
gi 632978769 118 EakyyqlqpmlkELERWKQD 137
Cdd:cd18416   79 E-----------ELEFWGLD 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLF--NGTEPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKD 111
Cdd:cd18384    1 IRINVGGFRRRLSASALLRFPGTRLGRLLacHSEEAILelcddYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                         90
                 ....*....|...
gi 632978769 112 FSlLYEEAKYYQL 124
Cdd:cd18384   81 FS-FSQEIEYWGI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  36 NAPVHIDVGGHMYTSSLATLTRYPDSRIGRL--FNGTEPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPED 108
Cdd:cd18413    1 NRRVVINVGGVKHEVLWRTLDRMPHTRLGKLrdSNTHEAIVelcddYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEE 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRLFNGTEpiVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFSLLYEE 118
Cdd:cd18405    3 VVINVSGLRFETQLKTLAQFPETLLGDPEKRMR--YFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFSEE 80

                         90
                 ....*....|...
gi 632978769 119 AKYYQL--QPMLK 129
Cdd:cd18405   81 VKFYELgeEALLK 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 632978769  39 VHIDVGGHMYTSSLATLTRYPDSRIGRL--FNGTEPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLL 105
Cdd:cd18421    6 VIINVGGIKYRIPWTTLEEFPLTRLGQLksCNNFDEIMdicddYDVTCNEFFFDRNPCAFRTILTFLRAGKLRL 79