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Conserved domains on  [gi|602647613|ref|XP_007430230|]
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annexin A11 isoform X2 [Python bivittatus]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 431-496 3.88e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 3.88e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  431 FFAERLHKAMKGAGTKDRTLIRIMVSRSEVDLLDIRQEYKRMYGKSLYTDIAGDTSGDYRKILLKL 496
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 200-265 7.99e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 108.33  E-value: 7.99e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  200 RDAEVLRKAMKGFGTDEQAIIECLGSRSSKQRQQIMLSFKTAYGKDLIKDLKSELSGNFEKTILAM 265
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 272-337 5.63e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 5.63e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  272 FDVHEIKEAIKGAGTDEACLIEILSSRSNKHIQEISRAYKTEFKKTLEEAIRSDTSGHFQRLLISL 337
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 356-421 1.87e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 90.61  E-value: 1.87e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  356 DVQALYAAgESRLGTDESKFNAILCTRSRTHLRAVFSEYQRMCNRDIEKSICREMSGDLESGMLAV 421
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 67-186 1.97e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.11  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   67 MASNLSGTFGGANM----PQGMYPSAPGGYPSAAPGGFGQPPQGqqpsygiyppppggnpptgmpsyPSYPGGPMPPAAQ 142
Cdd:TIGR01628 387 MGSPMGGAMGQPPYygqgPQQQFNGQPLGWPRMSMMPTPMGPGG-----------------------PLRPNGLAPMNAV 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 602647613  143 QPQP---VPYPGQQPMPSYPSGPAVNpSMPSYSGSTMPTITPGVSGN 186
Cdd:TIGR01628 444 RAPSrnaQNAAQKPPMQPVMYPPNYQ-SLPLSQDLPQPQSTASQGGQ 489
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 431-496 3.88e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 3.88e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  431 FFAERLHKAMKGAGTKDRTLIRIMVSRSEVDLLDIRQEYKRMYGKSLYTDIAGDTSGDYRKILLKL 496
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 200-265 7.99e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 108.33  E-value: 7.99e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  200 RDAEVLRKAMKGFGTDEQAIIECLGSRSSKQRQQIMLSFKTAYGKDLIKDLKSELSGNFEKTILAM 265
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 272-337 5.63e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 5.63e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  272 FDVHEIKEAIKGAGTDEACLIEILSSRSNKHIQEISRAYKTEFKKTLEEAIRSDTSGHFQRLLISL 337
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
444-496 4.19e-24

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 94.78  E-value: 4.19e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   444 GTKDRTLIRIMVSRSEVDLLDIRQEYKRMYGKSLYTDIAGDTSGDYRKILLKL 496
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
285-337 1.00e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 93.63  E-value: 1.00e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   285 GTDEACLIEILSSRSNKHIQEISRAYKTEFKKTLEEAIRSDTSGHFQRLLISL 337
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 356-421 1.87e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 90.61  E-value: 1.87e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  356 DVQALYAAgESRLGTDESKFNAILCTRSRTHLRAVFSEYQRMCNRDIEKSICREMSGDLESGMLAV 421
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
213-265 4.05e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 86.31  E-value: 4.05e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   213 GTDEQAIIECLGSRSSKQRQQIMLSFKTAYGKDLIKDLKSELSGNFEKTILAM 265
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
369-421 1.43e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 1.43e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   369 GTDESKFNAILCTRSRTHLRAVFSEYQRMCNRDIEKSICREMSGDLESGMLAV 421
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 67-186 1.97e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.11  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   67 MASNLSGTFGGANM----PQGMYPSAPGGYPSAAPGGFGQPPQGqqpsygiyppppggnpptgmpsyPSYPGGPMPPAAQ 142
Cdd:TIGR01628 387 MGSPMGGAMGQPPYygqgPQQQFNGQPLGWPRMSMMPTPMGPGG-----------------------PLRPNGLAPMNAV 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 602647613  143 QPQP---VPYPGQQPMPSYPSGPAVNpSMPSYSGSTMPTITPGVSGN 186
Cdd:TIGR01628 444 RAPSrnaQNAAQKPPMQPVMYPPNYQ-SLPLSQDLPQPQSTASQGGQ 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-170 6.63e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613    4 PGYPPASGYPPASGYPPTSGyPPAAPGSSPWGAPSYPPANPPPIGLENVgnyAGQFNPDYMAGMASNLSGTFGGANMPQG 83
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESRESL---PSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   84 MYPSAPGGYPSAAPGGFGqPPQGQQPSYGIYPPPPGGNPPTGMPSYPSYPGGPM-PPAAQQPQPVPYPGQQPMPSYPSGP 162
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPG-PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQP 2905


                  ....*...
gi 602647613  163 AVNPSMPS 170
Cdd:PHA03247 2906 ERPPQPQA 2913
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 73-170 5.40e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.69  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   73 GTFGGANMPQgMYPSAPGGYPSAAPGGfGQPPQGQQPSYGIYPPPPGGNPPTGMPSY---PSYPGGPMPPAAQQPQPVPY 149
Cdd:pfam09606 355 GNFGGLGANP-MQRGQPGMMSSPSPVP-GQQVRQVTPNQFMRQSPQPSVPSPQGPGSqppQSHPGGMIPSPALIPSPSPQ 432

                          90       100       110
                  ....*....|....*....|....*....|
gi 602647613  150 PGQQP-----MPSY-PSGPAVNP---SMPS 170
Cdd:pfam09606 433 MSQQPaqqrtIGQDsPGGSLNTPgqsAVNS 462
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 431-496 3.88e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 3.88e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  431 FFAERLHKAMKGAGTKDRTLIRIMVSRSEVDLLDIRQEYKRMYGKSLYTDIAGDTSGDYRKILLKL 496
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 200-265 7.99e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 108.33  E-value: 7.99e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  200 RDAEVLRKAMKGFGTDEQAIIECLGSRSSKQRQQIMLSFKTAYGKDLIKDLKSELSGNFEKTILAM 265
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 272-337 5.63e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 5.63e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  272 FDVHEIKEAIKGAGTDEACLIEILSSRSNKHIQEISRAYKTEFKKTLEEAIRSDTSGHFQRLLISL 337
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
444-496 4.19e-24

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 94.78  E-value: 4.19e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   444 GTKDRTLIRIMVSRSEVDLLDIRQEYKRMYGKSLYTDIAGDTSGDYRKILLKL 496
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
285-337 1.00e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 93.63  E-value: 1.00e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   285 GTDEACLIEILSSRSNKHIQEISRAYKTEFKKTLEEAIRSDTSGHFQRLLISL 337
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 356-421 1.87e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 90.61  E-value: 1.87e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 602647613  356 DVQALYAAgESRLGTDESKFNAILCTRSRTHLRAVFSEYQRMCNRDIEKSICREMSGDLESGMLAV 421
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
213-265 4.05e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 86.31  E-value: 4.05e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   213 GTDEQAIIECLGSRSSKQRQQIMLSFKTAYGKDLIKDLKSELSGNFEKTILAM 265
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
369-421 1.43e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 1.43e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 602647613   369 GTDESKFNAILCTRSRTHLRAVFSEYQRMCNRDIEKSICREMSGDLESGMLAV 421
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 67-186 1.97e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.11  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   67 MASNLSGTFGGANM----PQGMYPSAPGGYPSAAPGGFGQPPQGqqpsygiyppppggnpptgmpsyPSYPGGPMPPAAQ 142
Cdd:TIGR01628 387 MGSPMGGAMGQPPYygqgPQQQFNGQPLGWPRMSMMPTPMGPGG-----------------------PLRPNGLAPMNAV 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 602647613  143 QPQP---VPYPGQQPMPSYPSGPAVNpSMPSYSGSTMPTITPGVSGN 186
Cdd:TIGR01628 444 RAPSrnaQNAAQKPPMQPVMYPPNYQ-SLPLSQDLPQPQSTASQGGQ 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-170 6.63e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613    4 PGYPPASGYPPASGYPPTSGyPPAAPGSSPWGAPSYPPANPPPIGLENVgnyAGQFNPDYMAGMASNLSGTFGGANMPQG 83
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESRESL---PSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   84 MYPSAPGGYPSAAPGGFGqPPQGQQPSYGIYPPPPGGNPPTGMPSYPSYPGGPM-PPAAQQPQPVPYPGQQPMPSYPSGP 162
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPG-PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQP 2905


                  ....*...
gi 602647613  163 AVNPSMPS 170
Cdd:PHA03247 2906 ERPPQPQA 2913
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 73-170 5.40e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.69  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   73 GTFGGANMPQgMYPSAPGGYPSAAPGGfGQPPQGQQPSYGIYPPPPGGNPPTGMPSY---PSYPGGPMPPAAQQPQPVPY 149
Cdd:pfam09606 355 GNFGGLGANP-MQRGQPGMMSSPSPVP-GQQVRQVTPNQFMRQSPQPSVPSPQGPGSqppQSHPGGMIPSPALIPSPSPQ 432

                          90       100       110
                  ....*....|....*....|....*....|
gi 602647613  150 PGQQP-----MPSY-PSGPAVNP---SMPS 170
Cdd:pfam09606 433 MSQQPaqqrtIGQDsPGGSLNTPgqsAVNS 462
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 13-185 1.53e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   13 PPASGYPPTSGYP-PAAPGSSPWGAPSYPPANPPPIGLENVGN---YAGQFN-----PDYMAGMASNLSGTFGGANMPQG 83
Cdd:PRK10263  375 PAPEGYPQQSQYAqPAVQYNEPLQQPVQPQQPYYAPAAEQPAQqpyYAPAPEqpaqqPYYAPAPEQPVAGNAWQAEEQQS 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   84 MYPSAPGGYP-SAAPGGFGQPPQGQQPSYgIYPPPPGGNPPTGMPSYPSYPggPM--------------PPAAQQPQPVP 148
Cdd:PRK10263  455 TFAPQSTYQTeQTYQQPAAQEPLYQQPQP-VEQQPVVEPEPVVEETKPARP--PLyyfeeveekrarerEQLAAWYQPIP 531

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 602647613  149 YPGQQPMPSYPSGPAVNPSMPSYSGSTmPTITPGVSG 185
Cdd:PRK10263  532 EPVKEPEPIKSSLKAPSVAAVPPVEAA-AAVSPLASG 567
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 5-169 1.68e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 39.97  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613    5 GYPPASGYP--PASGYPPTSG--YPPAAPGSSPWGAPSYPPANPPPIGLenvgnyaGQFNPDYMAgmASNLSGTFGGANM 80
Cdd:pfam15822  61 GPAPTGMYPsiPLTGPSPGPPapFPPSGPSCPPPGGPYPAPTVPGPGPI-------GPYPTPNMP--FPELPRPYGAPTD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   81 PQGMYPSAPGGYPSAAP-----GGFGQPPQGQQPSYGIYPPPPGGNPPTGMPSYP--SYPGGPMPPAAQQPQPV---PYP 150
Cdd:pfam15822 132 PAAAAPSGPWGSMSSGPwapgmGGQYPAPNMPYPSPGPYPAVPPPQSPGAAPPVPwgTVPPGPWGPPAPYPDPTgsyPMP 211

                         170       180
                  ....*....|....*....|...
gi 602647613  151 GQQPMPSYP----SGPAVNPSMP 169
Cdd:pfam15822 212 GLYPTPNNPfqvpSGPSGAPPMP 234
SSDP pfam04503
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ...
 80-188 5.54e-03

Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.


Pssm-ID: 461334 [Multi-domain]  Cd Length: 293  Bit Score: 38.78  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   80 MPQGmyPSAPGGYPSAAPGGFGQPPQGQQPSYGIYPPPPGGNPPTGMPsyPSYPGGPMPP---AAQQPQPVPYPGQQPM- 155
Cdd:pfam04503  34 MPGG--PMPPGFFQSPPSHPSSQPSPHAQPPPHNPATMMGPHSQPFMG--PRYPGGPRPSvrmPQQGNDFNGPPGQQPMm 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 602647613  156 ------PSYPSGPAVNPSMPSYSGSTMPTITPGVSGNRG 188
Cdd:pfam04503 110 pnsmdpTRPGGHPNMGGPMQRMNPPRGPGMGPMGPQSYG 148
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 67-168 7.39e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.02  E-value: 7.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   67 MASNLSGTFGGANMPQGMYPSAPggypsAAPGGFGQPPQGQQPSYGiyPPPPGGNPPTGMPSY-PSYPGGPMPPAAQQPQ 145
Cdd:TIGR01628 409 FNGQPLGWPRMSMMPTPMGPGGP-----LRPNGLAPMNAVRAPSRN--AQNAAQKPPMQPVMYpPNYQSLPLSQDLPQPQ 481

                          90       100
                  ....*....|....*....|...
gi 602647613  146 PVPYPGQQPMPSYPSGPAVNPSM 168
Cdd:TIGR01628 482 STASQGGQNKKLAQVLASATPQM 504
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-169 7.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613    4 PGYPPASGYP--PASGYPPTSGYPPAAPGS-SPWGAPSYPPANPPPIGLeNVGNYAGQFNPDYMAGMASNLSGTFGGANM 80
Cdd:PHA03247 2763 TAGPPAPAPPaaPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAV-LAPAAALPPAASPAGPLPPPTSAQPTAPPP 2841

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602647613   81 PQGMYPS--APGGypSAAPGG--FGQPPQGQQPSYGIYPPPPGGNPPTGMPSYPSYPGGPMPPAAQQPQPVPYPGQQPMP 156
Cdd:PHA03247 2842 PPGPPPPslPLGG--SVAPGGdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919

                         170
                  ....*....|...
gi 602647613  157 SYPSGPAVNPSMP 169
Cdd:PHA03247 2920 QPQPPPPPQPQPP 2932
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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