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Conserved domains on  [gi|595791193|ref|XP_007199345|]
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aquaporin TIP1-2 [Prunus persica]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 44-270 1.25e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member pfam00230:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 223  Bit Score: 101.63  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193   44 EYFSPEMWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAF-LFLLV--TVPLSGGHMSPVFTFIAAL 120
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLaLATLVycAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  121 KGVITFARASIYILAQCIGSILGFLIIKTVMdqNAAQKYSLGGCTIKgsgstSGVGTQTALMVEFACTFVVLFVgVTVAF 200
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT--VGLQRAGLFANTLA-----PGVNAGQAFVVEIILTFQLVYC-VFATT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  201 DKRRCKELGlamvcAVVAGAMALAVFVSITVTGRvgYAGVGLSPARCLGPALLqgGRLWDGHWVFWVGPI 270
Cdd:pfam00230 153 DDRRNGSLG-----TVAPLAIGFAVFLNHLAGGP--YTGASMNPARSFGPAVV--LWKWDDHWVYWVGPF 213
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 44-270 1.25e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 101.63  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193   44 EYFSPEMWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAF-LFLLV--TVPLSGGHMSPVFTFIAAL 120
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLaLATLVycAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  121 KGVITFARASIYILAQCIGSILGFLIIKTVMdqNAAQKYSLGGCTIKgsgstSGVGTQTALMVEFACTFVVLFVgVTVAF 200
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT--VGLQRAGLFANTLA-----PGVNAGQAFVVEIILTFQLVYC-VFATT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  201 DKRRCKELGlamvcAVVAGAMALAVFVSITVTGRvgYAGVGLSPARCLGPALLqgGRLWDGHWVFWVGPI 270
Cdd:pfam00230 153 DDRRNGSLG-----TVAPLAIGFAVFLNHLAGGP--YTGASMNPARSFGPAVV--LWKWDDHWVYWVGPF 213
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 52-272 2.73e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 100.79  E-value: 2.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  52 RAAFTELVATASLLFTLTSSIISCLESGEVDPKLL-VPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALKGVITFARAS 130
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLgIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 131 IYILAQCIGSILGFLIIKTVMDQNAAQKYSLGG--CTIKGSGSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKEL 208
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595791193 209 GLAmvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQGG-RLWDGHWVFWVGPILA 272
Cdd:cd00333  161 GLA------PLAIGLLVAAIGLAGG--PITGASMNPARSLGPALFTGLaRHWHYFWVYWVGPLIG 217
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 90-271 5.62e-21

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 88.89  E-value: 5.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193   90 AVFIIAFLFLLVtvplSGGHMSPVFTFIAALKGVITFARASIYILAQCIGSILGFLIIKTVMDQNAAQKYSLGGctikgs 169
Cdd:TIGR00861  44 AVATLVYCVGGI----SGAHLNPAVTIALLLGRRFPLKRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNG------ 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  170 GSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKELGLAmvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLG 249
Cdd:TIGR00861 114 SASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFA------PLAIGLLVFLIHLSMG--PYTGTGMNPARSLG 185

                         170       180
                  ....*....|....*....|..
gi 595791193  250 PALLQGGRLWDGHWVFWVGPIL 271
Cdd:TIGR00861 186 PALFAGLAGWGNHWVYWVGPII 207
PLN00027 PLN00027
aquaporin TIP; Provisional
 43-271 3.83e-19

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 84.84  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  43 HEYFSPEMWRAAFTELVATASLLFTLTSSIIS---CLESGEVDPKLLVPIAVFIIAFLFLLVTVP--LSGGHMSPVFTFI 117
Cdd:PLN00027  12 GEASHPDALKAALAEFISTLIFVFAGEGSGMAfnkLTDNGSTTPAGLVAAALAHAFALFVAVSVGanISGGHVNPAVTFG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 118 AALKGVITFARASIYILAQCIGSILGFLIIktvmdqnaaqKYSLGGCTIKGSGSTSGVGTQTALMVEFACTFVVLFVGVT 197
Cdd:PLN00027  92 AFIGGNITLLRGILYWIAQLLGSVVACLLL----------KFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYA 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595791193 198 VAFDKRRcKELGLamvcaVVAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQGgrLWDGHWVFWVGPIL 271
Cdd:PLN00027 162 TAVDPKK-GDLGI-----IAPIAIGFIVGANILAGG--AFDGASMNPAVSFGPAVVSW--TWTNHWVYWAGPLI 225
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 50-271 2.39e-18

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 82.10  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  50 MWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALKGVITFARA 129
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 130 SIYILAQCIGSILG----FLIIKTVMDQNAAQKYSLGG-CTikgsGSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRR 204
Cdd:COG0580   82 LPYIIAQLLGAFLGaalvYLIYGGHFDATEDGGAKLGVfAT----SPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595791193 205 CKELGlamvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQ----GGRLWDGHWVFWVGPIL 271
Cdd:COG0580  158 PGGLA--------PLAIGLLVAAIGLSLG--PLTGYAINPARDLGPRLFHalgkGGSDWGYLWVPIVAPIL 218
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 44-270 1.25e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 101.63  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193   44 EYFSPEMWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAF-LFLLV--TVPLSGGHMSPVFTFIAAL 120
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLaLATLVycAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  121 KGVITFARASIYILAQCIGSILGFLIIKTVMdqNAAQKYSLGGCTIKgsgstSGVGTQTALMVEFACTFVVLFVgVTVAF 200
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT--VGLQRAGLFANTLA-----PGVNAGQAFVVEIILTFQLVYC-VFATT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  201 DKRRCKELGlamvcAVVAGAMALAVFVSITVTGRvgYAGVGLSPARCLGPALLqgGRLWDGHWVFWVGPI 270
Cdd:pfam00230 153 DDRRNGSLG-----TVAPLAIGFAVFLNHLAGGP--YTGASMNPARSFGPAVV--LWKWDDHWVYWVGPF 213
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 52-272 2.73e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 100.79  E-value: 2.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  52 RAAFTELVATASLLFTLTSSIISCLESGEVDPKLL-VPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALKGVITFARAS 130
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLgIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 131 IYILAQCIGSILGFLIIKTVMDQNAAQKYSLGG--CTIKGSGSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKEL 208
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595791193 209 GLAmvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQGG-RLWDGHWVFWVGPILA 272
Cdd:cd00333  161 GLA------PLAIGLLVAAIGLAGG--PITGASMNPARSLGPALFTGLaRHWHYFWVYWVGPLIG 217
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 90-271 5.62e-21

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 88.89  E-value: 5.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193   90 AVFIIAFLFLLVtvplSGGHMSPVFTFIAALKGVITFARASIYILAQCIGSILGFLIIKTVMDQNAAQKYSLGGctikgs 169
Cdd:TIGR00861  44 AVATLVYCVGGI----SGAHLNPAVTIALLLGRRFPLKRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNG------ 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  170 GSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKELGLAmvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLG 249
Cdd:TIGR00861 114 SASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFA------PLAIGLLVFLIHLSMG--PYTGTGMNPARSLG 185

                         170       180
                  ....*....|....*....|..
gi 595791193  250 PALLQGGRLWDGHWVFWVGPIL 271
Cdd:TIGR00861 186 PALFAGLAGWGNHWVYWVGPII 207
PLN00027 PLN00027
aquaporin TIP; Provisional
 43-271 3.83e-19

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 84.84  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  43 HEYFSPEMWRAAFTELVATASLLFTLTSSIIS---CLESGEVDPKLLVPIAVFIIAFLFLLVTVP--LSGGHMSPVFTFI 117
Cdd:PLN00027  12 GEASHPDALKAALAEFISTLIFVFAGEGSGMAfnkLTDNGSTTPAGLVAAALAHAFALFVAVSVGanISGGHVNPAVTFG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 118 AALKGVITFARASIYILAQCIGSILGFLIIktvmdqnaaqKYSLGGCTIKGSGSTSGVGTQTALMVEFACTFVVLFVGVT 197
Cdd:PLN00027  92 AFIGGNITLLRGILYWIAQLLGSVVACLLL----------KFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYA 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 595791193 198 VAFDKRRcKELGLamvcaVVAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQGgrLWDGHWVFWVGPIL 271
Cdd:PLN00027 162 TAVDPKK-GDLGI-----IAPIAIGFIVGANILAGG--AFDGASMNPAVSFGPAVVSW--TWTNHWVYWAGPLI 225
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 50-271 2.39e-18

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 82.10  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  50 MWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALKGVITFARA 129
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 130 SIYILAQCIGSILG----FLIIKTVMDQNAAQKYSLGG-CTikgsGSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRR 204
Cdd:COG0580   82 LPYIIAQLLGAFLGaalvYLIYGGHFDATEDGGAKLGVfAT----SPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595791193 205 CKELGlamvcavvAGAMALAVFVSITVTGrvGYAGVGLSPARCLGPALLQ----GGRLWDGHWVFWVGPIL 271
Cdd:COG0580  158 PGGLA--------PLAIGLLVAAIGLSLG--PLTGYAINPARDLGPRLFHalgkGGSDWGYLWVPIVAPIL 218
PLN00166 PLN00166
aquaporin TIP2; Provisional
 46-271 1.87e-17

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 79.98  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  46 FSPEMWRAAFTELVATASLLFTLTSSIIS---CLESGEVDPKLLVPIAVFIIAFLFLLVTVP--LSGGHMSPVFTFIAAL 120
Cdd:PLN00166  13 FSVASLKAYLSEFIATLLFVFAGVGSAIAfakLTSDAALDPAGLVAVAVAHAFALFVGVSIAanISGGHLNPAVTLGLAI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 121 KGVITFARASIYILAQCIGSILGFLIIktvmdqnaaqKYSLGGCTIKGSGSTSGVGTQTALMVEFACTFVVLFVGVTVAF 200
Cdd:PLN00166  93 GGNITIITGFFYWIAQCLGSIVACLLL----------VFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 595791193 201 DKRRcKELGlamvcavVAGAMALAVFVSITVTGRVGYAGVGLSPARCLGPALLQGGrlWDGHWVFWVGPIL 271
Cdd:PLN00166 163 DPKK-GSLG-------TIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGD--FSQIWIYWVGPLV 223
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 93-271 2.93e-10

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 59.92  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  93 IIAFLFLLVTVPLSGGHMSPVFTFIAALKGVITFARASIYILAQCIGSILGFLIIKTVMDQNAAQKYslggctikgsGST 172
Cdd:PLN00182  84 LIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLMFNVTPEAFF----------GTT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 173 SGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKELglamvcavvAG-AMALAVFVSITVTGRVgyAGVGLSPARCLGPA 251
Cdd:PLN00182 154 PTDSSGQALVAEIIISFLLMFVISGVATDSRAVGEL---------AGiAVGMTIILNVFVAGPI--SGASMNPARSLGPA 222

                        170       180
                 ....*....|....*....|
gi 595791193 252 LLQGgrLWDGHWVFWVGPIL 271
Cdd:PLN00182 223 IVMG--RYKGIWVYIVGPFV 240
PLN00026 PLN00026
aquaporin NIP; Provisional
 89-282 3.11e-10

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 59.88  E-value: 3.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  89 IAVFIIaflfLLVTVPLSGGHMSPVFTF-IAALKGvITFARASIYILAQCIGSILGFLIIKTVMdqnaaQKYSLGGCTIk 167
Cdd:PLN00026 113 LAVMIV----ILSTGHISGAHLNPSLTIaFAALRH-FPWKHVPAYIAAQVSASICASFALKGVF-----HPFMSGGVTV- 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 168 gsgstSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRCKELglamvcavvAG-AMALAVFVSITVTGRVgyAGVGLSPAR 246
Cdd:PLN00026 182 -----PSVSTGQAFALEFIITFNLLFVVTAVATDTRAVGEL---------AGiAVGATVMLNILVAGPS--TGGSMNPVR 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 595791193 247 CLGPALLQGGrlWDGHWVFWVGPIL----ACSVYYCVSLN 282
Cdd:PLN00026 246 TLGPAVAAGN--YRAIWIYLVAPTLgalaGAGTYTAVKLR 283
PLN00184 PLN00184
aquaporin NIP1; Provisional
 57-272 4.85e-10

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 59.26  E-value: 4.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  57 ELVATASLLFTLTSSIISCLESgevDPKLLVPiAVFIIAFLFLLVTV----PLSGGHMSPVFTFIAALKGVITFARASIY 132
Cdd:PLN00184  60 EVLGTYFLVFTGCASVVVNMQN---DNVVTLP-GIAIVWGLTIMVLIyslgHISGAHINPAVTIAFASCGRFPLKQVPAY 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 133 ILAQCIGSILGFLIIKTV--MDQNAAQkyslGGCTIKGSGSTSGVGTQtALMVEFACTFVVLFVGVTVAFDKRRCKELgl 210
Cdd:PLN00184 136 VISQVIGSTLAAATLRLLfgLDHDVCS----GKHDVFIGSSPVGSDLQ-AFVMEFIVTFYLMFIISGVATDNRAIGEL-- 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595791193 211 amvcavvAG-AMALAVFVSITVTGRVgyAGVGLSPARCLGPALLQGgrLWDGHWVFWVGPILA 272
Cdd:PLN00184 209 -------AGlAIGSTVLLNVLIAAPV--SSASMNPGRSLGPAMVYG--CYKGIWIYIVAPTLG 260
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 43-276 2.22e-09

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 57.44  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  43 HEYFSPEMWRAAFTELVATASLLFTLTSSIISCLESGEVDPKLLVPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALKG 122
Cdd:PTZ00016  42 APREYRPNVREYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 123 VITFARASIYILAQCIGSILG----FLIIKTVMDQNAAQKYSLGGCTIKGSG---STSGVGTQTALMVEFACTFVVLFvG 195
Cdd:PTZ00016 122 KFPWKKLPGYFVAQLLGAFVGaacvYGLYYGFFKDHGIPELPWETMANGFAGvfaTYPREGNFYAIFSELILTAILLL-V 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 196 VTVAFDKRRCKELGLAMVcavvagAMALAVFV-SITVTGRVGYAgvgLSPARCLGP----ALLQGGRLWDGH-WVFWV-- 267
Cdd:PTZ00016 201 ILAITDPNNCPAFNYLPV------AVGLLVFViGISFGGNTGYA---LNPARDLGPrlfsAILWGSEVFTKDnYYFWVpl 271

                        250
                 ....*....|....
gi 595791193 268 -----GPILACSVY 276
Cdd:PTZ00016 272 vapfvGAVLGMFLY 285
PRK05420 PRK05420
aquaporin Z; Provisional
 105-271 2.54e-09

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 56.51  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 105 LSGGHMSPVFTFIAALKGVITFARASIYILAQCIGSILGFLIIKTVMDQNAAQKYSLGGCTIKGSGSTS--GVGTQTALM 182
Cdd:PRK05420  57 ISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNGYGEHSpgGYSLLAALV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 183 VEFACTFVVLFV--GVTvafDKRRCKelGLAMVcaVVAGAMALAVFVSITVTGrvgyagVGLSPARCLGPALLQGGRLWD 260
Cdd:PRK05420 137 CEVVLTAFFLLVilGAT---DKRAPA--GFAPI--AIGLALTLIHLISIPVTN------TSVNPARSTGVALFVGGWALE 203

                        170
                 ....*....|.
gi 595791193 261 GHWVFWVGPIL 271
Cdd:PRK05420 204 QLWLFWVAPIV 214
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 52-271 9.24e-09

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 55.25  E-value: 9.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  52 RAAFTELVATASLLFTLTSsIISC--LESGEVDpklLVPIAVfiIAFLFLLVTV----PLSGGHMSPVFTFIAALKGVIT 125
Cdd:PLN00183  46 RMVLAEMVGTFILMFCVCG-IIAStqLSGGEVG---LLEYAA--TAGLTVVVVVfsigSISGAHVNPSVTIAFATFGHFP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 126 FARASIYILAQCIGSILGFLIIKTVMDQNAAQKyslggctikgsGSTSGVGTQTALMVEFACTFVVLFVGVTVAFDKRRC 205
Cdd:PLN00183 120 WSKVPLYITAQTVGSVLATYVGVSVYGVKADLM-----------TTKPAQGCSSAFWVEFIATFIVMFLAASLTSQPQSL 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595791193 206 KELGlamvCAVVAGAMALAVFVSITVTGRvgyagvGLSPARCLGPALLQggrlWDGH--WVFWVGPIL 271
Cdd:PLN00183 189 GHLS----GFVIGIAIGLAVLITGPVSGG------SMNPARSLGPAIVS----WDFKdiWIYITAPTI 242
PLN00167 PLN00167
aquaporin TIP5; Provisional
 44-275 1.34e-08

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 54.52  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  44 EYFSPEMWRAAFTELVATASLLFTLTSSIISC---LESGEVDPKLLVPIAvfiIAFLFLL-----VTVPLSGGHMSPVFT 115
Cdd:PLN00167  15 QSVTRNALRSYLAEFISTFFFVFAAVGSAMSSrklMPDAASDPSSLLIVA---IANAFALssavyIAANISGGHVNPAVT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 116 FIAALKGVITFARASIYILAQCIGSILGFLIIK-TVMDQNAAqkyslggcTIKGSGSTSGVGtqtALMVEFACTFVVLFV 194
Cdd:PLN00167  92 FGMAVGGHISVPTAMFYWISQMLASVMACLFLKvTTVGQHVP--------TYKIAEEMTGFG---ASVLEGVLTFGLVYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193 195 gVTVAFDKRRCKELGLA-MVCAVVAGAMALAVFvsitvtgrvGYAGVGLSPARCLGPALLQGGrlWDGHWVFWVGPILAC 273
Cdd:PLN00167 161 -VYAAGDPRRGLLGAIGpLAIGLVAGANVLAAG---------PFSGGSMNPACAFGSAVVAGS--FKNQAVYWVGPLLGG 228


                 ..
gi 595791193 274 SV 275
Cdd:PLN00167 229 AV 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 50-150 3.11e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 38.39  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595791193  50 MWRAAFTELVATASLLFTLTSSIIsclESGEVDPKLLVPIAVFIIAFLFLLVTVPLSGGHMSPVFTFIAALkgVITFARA 129
Cdd:cd00333  129 NGNAFFVEFIGTFILVLVVFATTD---DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPAL--FTGLARH 203

                         90       100
                 ....*....|....*....|....*
gi 595791193 130 S----IYILAQCIGSILGFLIIKTV 150
Cdd:cd00333  204 WhyfwVYWVGPLIGAIAGALVYDYV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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