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Conserved domains on  [gi|1063473221|ref|XP_007041092|]
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PREDICTED: glycine cleavage system H protein 2, mitochondrial [Theobroma cacao]

Protein Classification

glycine cleavage system protein H( domain architecture ID 10785558)

glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).

EC:  1.4.1.27
Gene Ontology:  GO:0019464|GO:0009249|GO:0005960
PubMed:  20375021|18941301

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 25-151 1.33e-72

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440275  Cd Length: 128  Bit Score: 213.45  E-value: 1.33e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  25 STVLNDLKYADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDgTATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063473221 104 NEELSNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEEE 151
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEEE 128
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 25-151 1.33e-72

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 213.45  E-value: 1.33e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  25 STVLNDLKYADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDgTATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063473221 104 NEELSNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEEE 151
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEEE 128
PRK01202 PRK01202
glycine cleavage system protein GcvH;
25-150 1.67e-71

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 210.79  E-value: 1.67e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  25 STVLNDLKYADSHEWVKVNGNSATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVN 104
Cdd:PRK01202    2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063473221 105 EELSNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEE 150
Cdd:PRK01202   82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIEE 127
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 31-151 1.26e-58

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 177.91  E-value: 1.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  31 LKYADSHEWVKVNGNS-ATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSN 109
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGtATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063473221 110 SPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEEE 151
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEKTLKEI 122
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 33-127 7.70e-53

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 162.32  E-value: 7.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  33 YADSHEWVKVNGNS-ATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSNSP 111
Cdd:cd06848     1 YTKDHEWVKVEGDGiATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                          90
                  ....*....|....*.
gi 1063473221 112 ALVNSSPYENGWIIKV 127
Cdd:cd06848    81 ELINSDPYGEGWLVKI 96
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 30-151 1.16e-51

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 160.77  E-value: 1.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  30 DLKYADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELS 108
Cdd:TIGR00527   5 DLRYSSEHEWVRVEGDkTATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTALE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063473221 109 NSPALVNSSPYENGWIIKVEMND-AGELKNLMGSEEYSKFCEEE 151
Cdd:TIGR00527  85 DSPELVNEDPYGDGWLIKVKLSDgESEVEGLMSAEQYEATLEHD 128
 
Name Accession Description Interval E-value
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 25-151 1.33e-72

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 213.45  E-value: 1.33e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  25 STVLNDLKYADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:COG0509     1 MEIPDDLKYTEDHEWVRVEGDgTATVGITDFAQDLLGDIVFVELPEVGTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063473221 104 NEELSNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEEE 151
Cdd:COG0509    81 NEALEDDPELVNEDPYGEGWLFKIKPSDPAELDDLLDAEAYAALLEEE 128
PRK01202 PRK01202
glycine cleavage system protein GcvH;
25-150 1.67e-71

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 210.79  E-value: 1.67e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  25 STVLNDLKYADSHEWVKVNGNSATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVN 104
Cdd:PRK01202    2 MNIPADLKYTKSHEWVRVEGDTATVGITDHAQEQLGDIVFVELPEVGDEVKAGETFGVVESVKAASDIYAPVSGEVVEVN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063473221 105 EELSNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEE 150
Cdd:PRK01202   82 EALEDSPELVNEDPYGEGWLFKIKPSDESELDDLLDAEAYEALIEE 127
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 31-151 1.26e-58

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 177.91  E-value: 1.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  31 LKYADSHEWVKVNGNS-ATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSN 109
Cdd:pfam01597   1 LYYTKEHEWVKVEGDGtATVGITDFAQAQLGDIVFVELPEVGTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063473221 110 SPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEYSKFCEEE 151
Cdd:pfam01597  81 NPGLINKDPYEDGWIAKLKPSNLEELESLMTAEQYEKTLKEI 122
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 33-127 7.70e-53

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 162.32  E-value: 7.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  33 YADSHEWVKVNGNS-ATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSNSP 111
Cdd:cd06848     1 YTKDHEWVKVEGDGiATVGITDYAQDLLGDIVFVELPEVGTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNP 80

                          90
                  ....*....|....*.
gi 1063473221 112 ALVNSSPYENGWIIKV 127
Cdd:cd06848    81 ELINSDPYGEGWLVKI 96
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 30-151 1.16e-51

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 160.77  E-value: 1.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  30 DLKYADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELS 108
Cdd:TIGR00527   5 DLRYSSEHEWVRVEGDkTATVGITKFAQDELGDIVFVELPEVGAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTALE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063473221 109 NSPALVNSSPYENGWIIKVEMND-AGELKNLMGSEEYSKFCEEE 151
Cdd:TIGR00527  85 DSPELVNEDPYGDGWLIKVKLSDgESEVEGLMSAEQYEATLEHD 128
PRK13380 PRK13380
glycine cleavage system protein H; Provisional
 30-144 2.56e-45

glycine cleavage system protein H; Provisional


Pssm-ID: 237370  Cd Length: 144  Bit Score: 145.14  E-value: 2.56e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  30 DLKY-ADSHEWVKVNGN-SATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEEL 107
Cdd:PRK13380   12 ELRYtIKNHEWLRLEGDgTVTVGITDYAQTMAGDVVFVRLKELGKKVEKGKPVATLESGKWAGPVPAPLTGEVVEVNEAL 91

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1063473221 108 SNSPALVNSSPYENGWIIKVEMNDAGELKNLMGSEEY 144
Cdd:PRK13380   92 EDSPELVNEDPYGEGWFFRFKPANPEELKQLLDGDAA 128
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 33-138 4.22e-21

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 82.57  E-value: 4.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  33 YADSHEWVK-VNGNSATIGITDHAQDHLGDVVYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSNSP 111
Cdd:PRK00624    4 YSDYHVWIEpIHSRIVRLGLTSKMQENLGNILHIDLPSVGSFCKEGEVLVILESSKSAIEVLSPVSGEVIEVNTALEDDI 83

                          90       100
                  ....*....|....*....|....*..
gi 1063473221 112 ALVNSSPYENGWIIKVEMNDAGELKNL 138
Cdd:PRK00624   84 QPINNAPESEGWFVVVQLDEDFDSENL 110
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 48-127 1.42e-17

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 72.09  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063473221  48 TIGITDHAQdHLGDVVYV-ELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEVNEELSnspalvnSSPYENGWIIK 126
Cdd:cd06663     1 TILIPDLAQ-HLGDGTVVkWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEG-------TKVEGDTPLVK 72


                  .
gi 1063473221 127 V 127
Cdd:cd06663    73 I 73
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 59-103 6.13e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 39.04  E-value: 6.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063473221  59 LGDVVYVELPE----VGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:PRK11855   10 IGEVVEVEVIEwlvkEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEI 58
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 59-103 7.92e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 38.65  E-value: 7.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063473221  59 LGDVVYVELPE----VGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:PRK11855  127 IGEITEVEVIEwlvkVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEI 175
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 69-103 1.70e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 35.43  E-value: 1.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063473221  69 EVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:COG0508    25 KEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEI 59
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 69-103 2.03e-03

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 35.07  E-value: 2.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063473221  69 EVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:cd06849    23 KEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKI 57
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 38-103 4.20e-03

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 36.36  E-value: 4.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063473221  38 EWVKVNGNSATIGITDHAQDHLGDV-------VYVELPEVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:PRK09282  501 EEVVVEPLKEIVVGGRPRASAPGAVtspmpgtVVKVKVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEI 573
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 69-103 5.67e-03

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 33.73  E-value: 5.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063473221  69 EVGATVKQGGSFGAVESVKATSDVNSPVSGKVVEV 103
Cdd:pfam00364  22 KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEI 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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