SET and MYND domain-containing protein 4 isoform X1 [Pteropus alecto]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
SET_SMYD4 | cd10536 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
412-595 | 3.96e-67 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation. : Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 221.79 E-value: 3.96e-67
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zf-MYND | pfam01753 | MYND finger; |
290-329 | 4.43e-10 | ||||
MYND finger; : Pssm-ID: 460312 Cd Length: 39 Bit Score: 55.50 E-value: 4.43e-10
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
652-718 | 6.57e-05 | ||||
Tetratricopeptide repeat; : Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 41.99 E-value: 6.57e-05
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
697-763 | 6.55e-03 | ||||
Tetratricopeptide repeat; : Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 36.21 E-value: 6.55e-03
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SET super family | cl40432 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ... |
234-263 | 8.99e-03 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site. The actual alignment was detected with superfamily member cd20071: Pssm-ID: 394802 [Multi-domain] Cd Length: 122 Bit Score: 36.97 E-value: 8.99e-03
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Name | Accession | Description | Interval | E-value | ||||
SET_SMYD4 | cd10536 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
412-595 | 3.96e-67 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation. Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 221.79 E-value: 3.96e-67
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zf-MYND | pfam01753 | MYND finger; |
290-329 | 4.43e-10 | ||||
MYND finger; Pssm-ID: 460312 Cd Length: 39 Bit Score: 55.50 E-value: 4.43e-10
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
521-567 | 1.58e-05 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 44.82 E-value: 1.58e-05
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
652-718 | 6.57e-05 | ||||
Tetratricopeptide repeat; Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 41.99 E-value: 6.57e-05
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CpoB | COG1729 | Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ... |
657-745 | 6.23e-04 | ||||
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 441335 [Multi-domain] Cd Length: 113 Bit Score: 39.97 E-value: 6.23e-04
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
521-568 | 7.28e-04 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 40.01 E-value: 7.28e-04
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SET | COG2940 | SET domain-containing protein (function unknown) [General function prediction only]; |
529-595 | 8.41e-04 | ||||
SET domain-containing protein (function unknown) [General function prediction only]; Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 40.33 E-value: 8.41e-04
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
697-763 | 6.55e-03 | ||||
Tetratricopeptide repeat; Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 36.21 E-value: 6.55e-03
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SET_SMYD | cd20071 | SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ... |
234-263 | 8.99e-03 | ||||
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 36.97 E-value: 8.99e-03
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Name | Accession | Description | Interval | E-value | ||||
SET_SMYD4 | cd10536 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
412-595 | 3.96e-67 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation. Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 221.79 E-value: 3.96e-67
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SET_SMYD | cd20071 | SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ... |
521-595 | 7.09e-23 | ||||
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 94.37 E-value: 7.09e-23
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SET_SMYD1_2_3-like | cd19167 | SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ... |
512-597 | 1.20e-20 | ||||
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. Pssm-ID: 380944 [Multi-domain] Cd Length: 205 Bit Score: 90.95 E-value: 1.20e-20
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SET_SMYD3 | cd19203 | SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ... |
512-597 | 4.42e-17 | ||||
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers. Pssm-ID: 380980 [Multi-domain] Cd Length: 210 Bit Score: 80.49 E-value: 4.42e-17
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SET_SMYD2 | cd19202 | SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ... |
520-595 | 2.43e-13 | ||||
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML). Pssm-ID: 380979 [Multi-domain] Cd Length: 206 Bit Score: 69.85 E-value: 2.43e-13
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SET_SMYD1 | cd10526 | SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ... |
520-597 | 1.93e-12 | ||||
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation. Pssm-ID: 380924 [Multi-domain] Cd Length: 210 Bit Score: 67.06 E-value: 1.93e-12
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SET_SMYD5 | cd10521 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
523-598 | 7.94e-11 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis. Pssm-ID: 380919 [Multi-domain] Cd Length: 282 Bit Score: 63.48 E-value: 7.94e-11
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zf-MYND | pfam01753 | MYND finger; |
290-329 | 4.43e-10 | ||||
MYND finger; Pssm-ID: 460312 Cd Length: 39 Bit Score: 55.50 E-value: 4.43e-10
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
521-567 | 1.58e-05 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 44.82 E-value: 1.58e-05
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SET_SETD4 | cd19177 | SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ... |
526-569 | 5.94e-05 | ||||
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed. Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 45.37 E-value: 5.94e-05
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
652-718 | 6.57e-05 | ||||
Tetratricopeptide repeat; Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 41.99 E-value: 6.57e-05
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CpoB | COG1729 | Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ... |
657-745 | 6.23e-04 | ||||
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 441335 [Multi-domain] Cd Length: 113 Bit Score: 39.97 E-value: 6.23e-04
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
521-568 | 7.28e-04 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 40.01 E-value: 7.28e-04
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SET | COG2940 | SET domain-containing protein (function unknown) [General function prediction only]; |
529-595 | 8.41e-04 | ||||
SET domain-containing protein (function unknown) [General function prediction only]; Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 40.33 E-value: 8.41e-04
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HemYx | COG3071 | Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ... |
639-718 | 3.53e-03 | ||||
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown]; Pssm-ID: 442305 [Multi-domain] Cd Length: 323 Bit Score: 40.28 E-value: 3.53e-03
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EnvC | COG4942 | Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
625-719 | 4.07e-03 | ||||
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.13 E-value: 4.07e-03
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TPR_12 | pfam13424 | Tetratricopeptide repeat; |
697-763 | 6.55e-03 | ||||
Tetratricopeptide repeat; Pssm-ID: 315987 [Multi-domain] Cd Length: 77 Bit Score: 36.21 E-value: 6.55e-03
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SET_SMYD | cd20071 | SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ... |
234-263 | 8.99e-03 | ||||
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 36.97 E-value: 8.99e-03
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Blast search parameters | ||||
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