NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|586540608|ref|XP_006925134|]
View 

SET and MYND domain-containing protein 4 isoform X1 [Pteropus alecto]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 412-595 3.96e-67

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


:

Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 221.79  E-value: 3.96e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 412 KYENNYNAVFNLLPHTENHSPEHKFLCALSVSALCRQLEAASLQilttgsksSQPKTAVAPALCQELHIWGVAMLRHMLQ 491
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYF--------LLWEASTELNGEEPESILGGLLLRHLQQ 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 492 LQCNAQAITTIQQTESKEnIITNSKQVRLATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYGPHES 571
Cdd:cd10536  116 LQCNAHAITELQTTSSGS-QVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFS 194

                        170       180
                 ....*....|....*....|....
gi 586540608 572 RMGAAERQQKLRSQYFFDCNCPAC 595
Cdd:cd10536  195 RMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
290-329 4.43e-10

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 55.50  E-value: 4.43e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 586540608  290 CHRCLKHTLATVPCDGCSYAKYCSQECMQQAWdLYHSIEC 329
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
TPR_12 pfam13424
Tetratricopeptide repeat;
652-718 6.57e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 6.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  652 QIKMAQKLLKNGKLEQAIQLLLGCRYDAESFLPAEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSL 718
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
TPR_12 pfam13424
Tetratricopeptide repeat;
697-763 6.55e-03

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 6.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  697 LAQAYAALGDWQKSAAHLQKSLHVVEVRHGPSSVEMGHELFKLAQIFFNGFAIPEALNTIQKAEKVL 763
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 234-263 8.99e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd20071:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 122  Bit Score: 36.97  E-value: 8.99e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 586540608 234 DPLKGRYLIATKDILPGELLVREDAFVSVL 263
Cdd:cd20071    6 EGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 412-595 3.96e-67

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 221.79  E-value: 3.96e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 412 KYENNYNAVFNLLPHTENHSPEHKFLCALSVSALCRQLEAASLQilttgsksSQPKTAVAPALCQELHIWGVAMLRHMLQ 491
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYF--------LLWEASTELNGEEPESILGGLLLRHLQQ 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 492 LQCNAQAITTIQQTESKEnIITNSKQVRLATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYGPHES 571
Cdd:cd10536  116 LQCNAHAITELQTTSSGS-QVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFS 194

                        170       180
                 ....*....|....*....|....
gi 586540608 572 RMGAAERQQKLRSQYFFDCNCPAC 595
Cdd:cd10536  195 RMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
290-329 4.43e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 55.50  E-value: 4.43e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 586540608  290 CHRCLKHTLATVPCDGCSYAKYCSQECMQQAWdLYHSIEC 329
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 521-567 1.58e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.82  E-value: 1.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 586540608  521 ATGIFPVVSLLNHSCSPNTSVSFI----STVATVRASVQIGKGQEILHCYG 567
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
TPR_12 pfam13424
Tetratricopeptide repeat;
652-718 6.57e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 6.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  652 QIKMAQKLLKNGKLEQAIQLLLGCRYDAESFLPAEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSL 718
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 657-745 6.23e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 657 QKLLKNGKLEQAIQLLlgcrydaESFL---PaEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSlhvveVRHGPSSVEMG 733
Cdd:COG1729    1 KALLKAGDYDEAIAAF-------KAFLkryP-NSPLAPDALYWLGEAYYALGDYDEAAEAFEKL-----LKRYPDSPKAP 67

                         90
                 ....*....|..
gi 586540608 734 HELFKLAQIFFN 745
Cdd:COG1729   68 DALLKLGLSYLE 79
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 521-568 7.28e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 7.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 586540608   521 ATGIFPVVSLLNHSCSPNTSVSFI----STVATVRASVQIGKGQEILHCYGP 568
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFVevngDDRIVIFALRDIKPGEELTIDYGS 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
529-595 8.41e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 40.33  E-value: 8.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586540608 529 SLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYG--PHESRmgaaerqqklrsqyfFDCNCPAC 595
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNC 131
TPR_12 pfam13424
Tetratricopeptide repeat;
697-763 6.55e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 6.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  697 LAQAYAALGDWQKSAAHLQKSLHVVEVRHGPSSVEMGHELFKLAQIFFNGFAIPEALNTIQKAEKVL 763
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 234-263 8.99e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.97  E-value: 8.99e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 586540608 234 DPLKGRYLIATKDILPGELLVREDAFVSVL 263
Cdd:cd20071    6 EGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 412-595 3.96e-67

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 221.79  E-value: 3.96e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 412 KYENNYNAVFNLLPHTENHSPEHKFLCALSVSALCRQLEAASLQilttgsksSQPKTAVAPALCQELHIWGVAMLRHMLQ 491
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYF--------LLWEASTELNGEEPESILGGLLLRHLQQ 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 492 LQCNAQAITTIQQTESKEnIITNSKQVRLATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYGPHES 571
Cdd:cd10536  116 LQCNAHAITELQTTSSGS-QVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFS 194

                        170       180
                 ....*....|....*....|....
gi 586540608 572 RMGAAERQQKLRSQYFFDCNCPAC 595
Cdd:cd10536  195 RMKRSERQRLLKEQYFFDCSCEAC 218
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 521-595 7.09e-23

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 94.37  E-value: 7.09e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586540608 521 ATGIFPVVSLLNHSCSPNTSVSFIST-VATVRASVQIGKGQEILHCYGPHEsrMGAAERQQKLRSQYFFDCNCPAC 595
Cdd:cd20071   49 GVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPL--LPRTERRRELLEKYGFTCSCPRC 122
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 512-597 1.20e-20

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 90.95  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 512 ITNSKQVRLATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYGPheSRMGAAERQQKLRSQYFFDCN 591
Cdd:cd19167  122 ISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYID--LLYPTEERRDQLRDQYFFLCQ 199


                 ....*.
gi 586540608 592 CPACQN 597
Cdd:cd19167  200 CADCQT 205
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 512-597 4.42e-17

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 80.49  E-value: 4.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 512 ITNSKQVRLATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYgpHESRMGAAERQQKLRSQYFFDCN 591
Cdd:cd19203  127 ICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISY--IDMLMPSEERRKQLRDQYCFECD 204


                 ....*.
gi 586540608 592 CPACQN 597
Cdd:cd19203  205 CFRCQD 210
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 520-595 2.43e-13

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 69.85  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 520 LATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCY----GPHEsrmgaaERQQKLRSQYFFDCNCPAC 595
Cdd:cd19202  131 LGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYidllYPTE------DRNDRLRDSYFFTCECQEC 204
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 520-597 1.93e-12

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 67.06  E-value: 1.93e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 586540608 520 LATGIFPVVSLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYgpHESRMGAAERQQKLRSQYFFDCNCPACQN 597
Cdd:cd10526  135 VGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSY--IDFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 523-598 7.94e-11

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 63.48  E-value: 7.94e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586540608 523 GIFPVVSLLNHSCSPNTSVSFISTVAT--VRASVQIGKGQEILHCYGPHESR-MGAAERQQKLRSQYFFDCNCPACQNE 598
Cdd:cd10521  204 GLYLLQSCCNHSCVPNAEITFPENNFTlsLKALRDIQEGEEICISYLDECQReRSRHSRQKILRENYLFICNCPKCEAQ 282
zf-MYND pfam01753
MYND finger;
290-329 4.43e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 55.50  E-value: 4.43e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 586540608  290 CHRCLKHTLATVPCDGCSYAKYCSQECMQQAWdLYHSIEC 329
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 521-567 1.58e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.82  E-value: 1.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 586540608  521 ATGIFPVVSLLNHSCSPNTSVSFI----STVATVRASVQIGKGQEILHCYG 567
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 526-569 5.94e-05

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 45.37  E-value: 5.94e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 586540608 526 PVVSLLNHSCSPNTSVSFISTVA--TVRASVQIGKGQEILHCYGPH 569
Cdd:cd19177  187 PFLDLLNHSPDVNVKAGFNKSGKcyEIRTGTDYKKGEEVFISYGPH 232
TPR_12 pfam13424
Tetratricopeptide repeat;
652-718 6.57e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 6.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  652 QIKMAQKLLKNGKLEQAIQLLLGCRYDAESFLPAEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSL 718
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 657-745 6.23e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 657 QKLLKNGKLEQAIQLLlgcrydaESFL---PaEHSVVGEIEDDLAQAYAALGDWQKSAAHLQKSlhvveVRHGPSSVEMG 733
Cdd:COG1729    1 KALLKAGDYDEAIAAF-------KAFLkryP-NSPLAPDALYWLGEAYYALGDYDEAAEAFEKL-----LKRYPDSPKAP 67

                         90
                 ....*....|..
gi 586540608 734 HELFKLAQIFFN 745
Cdd:COG1729   68 DALLKLGLSYLE 79
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 521-568 7.28e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 7.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 586540608   521 ATGIFPVVSLLNHSCSPNTSVSFI----STVATVRASVQIGKGQEILHCYGP 568
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFVevngDDRIVIFALRDIKPGEELTIDYGS 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
529-595 8.41e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 40.33  E-value: 8.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586540608 529 SLLNHSCSPNTSVSFISTVATVRASVQIGKGQEILHCYG--PHESRmgaaerqqklrsqyfFDCNCPAC 595
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNC 131
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 639-718 3.53e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 40.28  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 639 RDRLVSQLQDLQ-----QQIKMAQKLLKNGKLEQAIQLLLG--CRYD-----AESFLpaEHSVvgEIEDD------LAQA 700
Cdd:COG3071  225 DPRLVRLYGRLQggdpaKQLKRAEKWLKKHPNDPDLLLALGrlCLRNqlwgkAREYL--EAAL--ALRPSaeayaeLARL 300

                         90
                 ....*....|....*...
gi 586540608 701 YAALGDWQKSAAHLQKSL 718
Cdd:COG3071  301 LEQLGDPEEAAEHYRKAL 318
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 625-719 4.07e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540608 625 VLSCGNTSCTEAVSRDRLVSQLQDLQQQIKMAQKLLKngKLEQAIQLLLGCRYDAESFLPAEHSVVGEIEDDLAQAYAAL 704
Cdd:COG4942    8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELA--ALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL 85

                         90
                 ....*....|....*
gi 586540608 705 GDWQKSAAHLQKSLH 719
Cdd:COG4942   86 AELEKEIAELRAELE 100
TPR_12 pfam13424
Tetratricopeptide repeat;
697-763 6.55e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 6.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586540608  697 LAQAYAALGDWQKSAAHLQKSLHVVEVRHGPSSVEMGHELFKLAQIFFNGFAIPEALNTIQKAEKVL 763
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 234-263 8.99e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.97  E-value: 8.99e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 586540608 234 DPLKGRYLIATKDILPGELLVREDAFVSVL 263
Cdd:cd20071    6 EGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH