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Conserved domains on  [gi|578832648|ref|XP_006722589|]
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urea transporter 1 isoform X1 [Homo sapiens]

Protein Classification

urea transporter( domain architecture ID 10505473)

urea transporter is an integral membrane protein that facilitates the rapid and passive diffusion of urea down its concentration gradient

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
94-389 3.10e-125

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


:

Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.17  E-value: 3.10e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   94 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 173
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  174 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 253
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  254 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 333
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578832648  334 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 389
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
94-389 3.10e-125

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.17  E-value: 3.10e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   94 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 173
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  174 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 253
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  254 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 333
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578832648  334 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 389
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
90-387 2.20e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 234.38  E-value: 2.20e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  90 VLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMA 169
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648 170 VFSDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISW 249
Cdd:COG4413   83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648 250 SDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLAC 329
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578832648 330 IAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 387
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
92-385 1.71e-46

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 161.72  E-value: 1.71e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   92 QFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVF 171
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  172 SDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNiSWSD 251
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPV-AFGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  252 LSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIA 331
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578832648  332 MGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFL 385
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFL 291
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
94-389 3.10e-125

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.17  E-value: 3.10e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   94 IDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSD 173
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  174 KGdyfWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDlS 253
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  254 ALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMG 333
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578832648  334 GMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTT 389
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
90-387 2.20e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 234.38  E-value: 2.20e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  90 VLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMA 169
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648 170 VFSDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISW 249
Cdd:COG4413   83 FFFGPSPASWVLLVLGAALSA---LVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648 250 SDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLAC 329
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578832648 330 IAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 387
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
92-385 1.71e-46

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 161.72  E-value: 1.71e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   92 QFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVF 171
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  172 SDKGDYFWWLLLPVCAMSMtcpIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNiSWSD 251
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPV-AFGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  252 LSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIA 331
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578832648  332 MGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFL 385
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFL 291
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
88-218 2.22e-22

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 96.48  E-value: 2.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  88 PVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGvl 167
Cdd:COG4413  162 LTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA-- 239
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578832648 168 MAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMA 218
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLA 290
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
253-399 2.29e-20

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 90.70  E-value: 2.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648 253 SALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAM 332
Cdd:COG4413    2 PLLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLAL 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578832648 333 gGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPL 399
Cdd:COG4413   82 -GFFFGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPL 147
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
69-223 2.14e-12

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 67.34  E-value: 2.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648   69 ALGYVTGDMKELANQLK----DKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALL 144
Cdd:TIGR03441 135 AFKGLHTDAPVLPHDIEpvafGGPARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAIL 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  145 LSQDRSLIASGLYGYNATL----VGVLMAVFSDKGdyfwwLLLPVCAMSMTCpIFSSALNSMLSKWDLPVFTLPFNMALS 220
Cdd:TIGR03441 215 LGADLDSINQGLFGFNPVLtaiaLGVVFLRPSIRS-----AAYAVLGVVLTV-FVQGALDTLLTPLGLPTLTFPFVLVTW 288

                  ...
gi 578832648  221 MYL 223
Cdd:TIGR03441 289 LFL 291
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
256-387 1.75e-10

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 61.57  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832648  256 ELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGgM 335
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALP-L 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578832648  336 FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIM 387
Cdd:TIGR03441  81 FLAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTWIFLLA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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