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Conserved domains on  [gi|578830465|ref|XP_006721784|]
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CMRF35-like molecule 9 isoform X1 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-113 4.77e-20

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.99  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  19 LEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGilfSRCSGTIYAEEEGQetmKGRVSIRDSRQELSLIVTLWNLT 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                         90
                 ....*....|....*
gi 578830465  99 LQDAGEYWCGVEKRG 113
Cdd:cd05716   75 KEDAGWYWCGVGDDG 89
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-113 4.77e-20

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.99  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  19 LEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGilfSRCSGTIYAEEEGQetmKGRVSIRDSRQELSLIVTLWNLT 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                         90
                 ....*....|....*
gi 578830465  99 LQDAGEYWCGVEKRG 113
Cdd:cd05716   75 KEDAGWYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 20-109 1.56e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.25  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465   20 EGPEEISGFEGDTVSLQCTYREELRDH--RKYWCRKGGILFSRCSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNL 97
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|..
gi 578830465   98 TLQDAGEYWCGV 109
Cdd:pfam07686  81 TLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-124 1.06e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 51.74  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465    22 PEEISGFEGDTVSLQCTYREElRDHRKYWCRKGGILFSRcsgtiyaeeegqetmKGRVSIRDSRQELSLivTLWNLTLQD 101
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS-PPPEVTWYKQGGKLLAE---------------SGRFSVSRSGSTSTL--TISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 578830465   102 AGEYWCGVEKRGPDESLLISLFV 124
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-113 4.77e-20

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 83.99  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  19 LEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGilfSRCSGTIYAEEEGQetmKGRVSIRDSRQELSLIVTLWNLT 98
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS---EGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                         90
                 ....*....|....*
gi 578830465  99 LQDAGEYWCGVEKRG 113
Cdd:cd05716   75 KEDAGWYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 20-109 1.56e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.25  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465   20 EGPEEISGFEGDTVSLQCTYREELRDH--RKYWCRKGGILFSRCSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNL 97
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|..
gi 578830465   98 TLQDAGEYWCGV 109
Cdd:pfam07686  81 TLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-124 1.06e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 51.74  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465    22 PEEISGFEGDTVSLQCTYREElRDHRKYWCRKGGILFSRcsgtiyaeeegqetmKGRVSIRDSRQELSLivTLWNLTLQD 101
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS-PPPEVTWYKQGGKLLAE---------------SGRFSVSRSGSTSTL--TISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 578830465   102 AGEYWCGVEKRGPDESLLISLFV 124
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 19-120 2.12e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.28  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  19 LEGPEEISGFEGDTVSLQCTYR--EELRDHRKYWCrkggILFSRCSGTIYAEEEG-----QETMKGRVSI-RDSRQELSL 90
Cdd:cd16089    3 LEGPESITGPWKGSVNLPCTYVpeEGYTQVLVKWL----VQRDSDPVTIFLRDSSgdhiqQAKYRGRLEVsKDTPGDVSL 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 578830465  91 ivTLWNLTLQDAGEYWCGVEKRGPDESLLI 120
Cdd:cd16089   79 --QLDTLEMDDRGHYTCQVTWQTPDGNLIV 106
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 22-122 1.24e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 40.26  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465   22 PEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGILfsrcsgtiyaeEEGQETMKGRVSIRDSRqelsliVTLWNLTLQD 101
Cdd:pfam00047   3 PPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTL-----------IESLKVKHDNGRTTQSS------LLISNVTKED 65

                          90       100
                  ....*....|....*....|.
gi 578830465  102 AGEYWCGVEKRGPDESLLISL 122
Cdd:pfam00047  66 AGTYTCVVNNPGGSATLSTSL 86
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 29-118 5.44e-04

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 39.06  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  29 EGDTVSLQCTYREELRDHRKYWCRKGGilfsRCSGTIYAEEEGQETMKGRVSIRDSRqelsliVTLWNLTLQDAGEYWCG 108
Cdd:cd20946   13 ENQEVILSCKTPKKTSSPRVEWKKLQR----DVTFVVFQNNKIQGDYKGRAEILGTN------ITIKNVTRSDSGKYRCE 82

                         90
                 ....*....|
gi 578830465 109 VEKRGPDESL 118
Cdd:cd20946   83 VSARSDGQNL 92
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 24-119 1.09e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 38.27  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  24 EISGFEGDTVSLQCTYREELRDHRKYWCRK---GGILFsrcsgTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNLTLQ 100
Cdd:cd07706    8 DVSVQVGEEVTLNCRYETSWTNYYLFWYKQlpsGEMTF-----LIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLE 82

                         90
                 ....*....|....*....
gi 578830465 101 DAGEYWCGVEKRGPDESLL 119
Cdd:cd07706   83 DSAKYFCALSLPYDTDKLI 101
IgV_CD80 cd16086
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here ...
 31-114 1.65e-03

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 80). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as cluster of differentiation 152/CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 319335  Cd Length: 105  Bit Score: 37.82  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  31 DTVSLQCTYR---EELRDHRKYWCRKGGILFSRCSGTIYAEEEgqetMKGRvSIRDSRQELSLIVTlwNLTLQDAGEYWC 107
Cdd:cd16086   10 EKALLSCDYNvsvDELAQVRIYWQKDDKMVLTIISGDVKVWPE----YKNR-TLFDITNNLSIVIL--ALRLSDRGTYTC 82


                 ....*....
gi 578830465 108 GVEK--RGP 114
Cdd:cd16086   83 VVQKkeRGA 91
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 22-107 3.72e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 36.66  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578830465  22 PEEISGFEGDTVSLQCTYR--EELRDHRKYWCRKGGilFSRCSGTIYAEEEG---QETMKGRVSIRDSRQEL-SLIVTLW 95
Cdd:cd05718    6 PTEVTGFLGGSVTLPCSLTspGTTKITQVTWMKIGA--GSSQNVAVFHPQYGpsvPNPYAERVEFLAARLGLrNATLRIR 83

                         90
                 ....*....|..
gi 578830465  96 NLTLQDAGEYWC 107
Cdd:cd05718   84 NLRVEDEGNYIC 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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