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Conserved domains on  [gi|578814204|ref|XP_006716029|]
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WD repeat-containing protein 86 isoform X7 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-285 1.77e-67

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 1.77e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwDlps 153
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--D--- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 154 tpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE 233
Cdd:COG2319  258 ---------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578814204 234 HRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
Cdd:COG2319  329 HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-285 1.77e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 1.77e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwDlps 153
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--D--- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 154 tpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE 233
Cdd:COG2319  258 ---------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578814204 234 HRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
Cdd:COG2319  329 HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-292 1.38e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 195.25  E-value: 1.38e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRRWDVL 85
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  86 TGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlPStpcaeeaaaG 163
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-----PD---------G 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 164 GLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL-- 241
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVaf 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578814204 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTCRRIS 292
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-260 1.42e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578814204 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDILSGE-QLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW 260
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 2.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 578814204     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 578814204    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-285 1.77e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 1.77e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwDlps 153
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--D--- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 154 tpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE 233
Cdd:COG2319  258 ---------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578814204 234 HRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
Cdd:COG2319  329 HTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-292 1.38e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 195.25  E-value: 1.38e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRRWDVL 85
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  86 TGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlPStpcaeeaaaG 163
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-----PD---------G 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 164 GLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL-- 241
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVaf 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578814204 242 ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTCRRIS 292
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-260 3.75e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 3.75e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        250       260
                 ....*....|....*....|...
gi 578814204 240 CLELVN--RLVYSGSADRTVKCW 260
Cdd:cd00200  266 SLAWSPdgKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
4-281 4.01e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 4.01e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  82 WDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaee 159
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS------------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 160 aAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:COG2319  172 -PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 578814204 240 CLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSAL 281
Cdd:COG2319  251 SVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 COG2319
WD40 repeat [General function prediction only];
5-222 3.83e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 3.83e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSAD 76
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS------VAFspdgrllaSGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  77 CTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpst 154
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------- 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578814204 155 pcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:COG2319  341 -------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
22-281 2.64e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.14  E-value: 2.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSI 99
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 100 VNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKV 177
Cdd:COG2319   81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADR 255
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADG 226

                        250       260
                 ....*....|....*....|....*.
gi 578814204 256 TVKCWLADTGECVRTFTAHRRNVSAL 281
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSV 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-284 4.95e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 4.95e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  89 CLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLL 166
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--------------DGTYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL--V 244
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspD 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578814204 245 NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS 186
WD40 COG2319
WD40 repeat [General function prediction only];
4-182 1.99e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.99e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSA 75
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS------VAFspdgkllaSGSD 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlps 153
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP------ 382

                        170       180
                 ....*....|....*....|....*....
gi 578814204 154 tpcaeeaaAGGLLVTGSTDGTAKVWQVAS 182
Cdd:COG2319  383 --------DGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-260 1.42e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578814204 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDILSGE-QLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW 260
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 5-267 1.48e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204   5 GSALRVCADHRGGINWLSLSpdgqrlltgsedGTARLWSTADGQCCA---LLQGHESY---VTFCQLEDEAAFTCSADCT 78
Cdd:PTZ00421  32 CSNTIACNDRFIAVPWQQLG------------STAVLKHTDYGKLASnppILLGQEGPiidVAFNPFDPQKLFTASEDGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204  79 IRRWDV----LTGQC------LQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAysap 148
Cdd:PTZ00421 100 IMGWGIpeegLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLE---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578814204 149 WDLpstpcaeeaaAGGLLVTGSTDGTAKVWQ------VASGCCHQTLRGHTgAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:PTZ00421 176 WNL----------DGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-CLWAKRKDLIITLGCSKSQQRQIMLWDT 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578814204 223 --------------LSGEQLRVFREH----------RGSVICLELVN-RLVYSGSADRT--------VKCWLADTGEC 267
Cdd:PTZ00421 245 rkmaspystvdldqSSALFIPFFDEDtnllyigskgEGNIRCFELMNeRLTFCSSYSSVephkglcmMPKWSLDTRKC 322
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 2.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 578814204     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 578814204    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 1.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.51e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578814204   182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-221 4.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 578814204  183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-123 4.58e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578814204    86 TGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
87-123 2.55e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 578814204   87 GQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-260 3.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 578814204   224 SGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
225-260 7.33e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578814204  225 GEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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