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Conserved domains on  [gi|2027478507|ref|XP_006586536|]
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protein DETOXIFICATION 29, partial [Glycine max]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 49-350 2.15e-110

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 328.76  E-value: 2.15e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  49 ESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLG 128
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 129 VYMQRSWVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 209 ALVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIV-SGACGEAWSGFTFKAFHNLWGFVRLSLASAVMLCLE 287
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFfSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027478507 288 VWYFMALVLFAGYLKnAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKL 302
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 49-350 2.15e-110

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 328.76  E-value: 2.15e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  49 ESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLG 128
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 129 VYMQRSWVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 209 ALVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIV-SGACGEAWSGFTFKAFHNLWGFVRLSLASAVMLCLE 287
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFfSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027478507 288 VWYFMALVLFAGYLKnAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKL 302
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 59-350 1.03e-43

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 153.94  E-value: 1.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  59 PAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIaGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVIL 138
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 139 NATAILLSLLYIFAGHMLRAIGQT-EAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTLFS 217
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGAdGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 218 WLLILE-FG-WGLVGAAVVLNASWWFIDIAQLVYIVSG-ACGEAWSGFTFKAFHNLWGFVRLSLASAVMLCLEVWYFMAL 294
Cdd:TIGR00797 160 YILIFGkFGfLGIVGAALATVISYWLMFLLLLYYIKKAkKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2027478507 295 VLFAGYLKnaEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKE 293
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
51-349 2.65e-31

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 122.17  E-value: 2.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIaGFSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:COG0534     8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIF-FLLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAA 209
Cdd:COG0534    87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 210 LVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFKA-FHNLWGFVRLSLASAVMLCLEV 288
Cdd:COG0534   167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQQLAES 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2027478507 289 WYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:COG0534   247 LGFLVLNALVARL--GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRAR 305
MatE pfam01554
MatE; The MatE domain
 59-219 7.34e-28

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 106.50  E-value: 7.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  59 PAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVIL 138
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 139 NATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTLFS 217
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 2027478507 218 WL 219
Cdd:pfam01554 160 YL 161
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 44-350 1.17e-12

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 68.69  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  44 REFFAESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSViagFSLGITFGMG--SALETLCGQAYGA 121
Cdd:PRK01766    5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSI---WLPVILFGHGllLALTPIVAQLNGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 122 GQVHMLG-VYMQRSWVILnATAILLSLLYIFAGHMLRAIGQTEAISA--AAG--EFALWMIPQLFAYAVnypAQKFLQAQ 196
Cdd:PRK01766   82 GRRERIAhQVRQGLWLAL-FLSVLIMLVLYNAVPPILNMMNLEPEVAdiAVGylHALLWGIPAYLLYQV---LRSFIDGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 197 SRIMVMAWIAAAALVLHTLFSWLLIL-EFGW---GLVGAAVVLNASWWFIDIAQLVYIVSG---ACGEAWSGFTFKAFHN 269
Cdd:PRK01766  158 GKTKPTMVIGFLGLLINIPLNYIFIYgKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRArrfRDFRLFKGLYKPDWAV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 270 LWGFVRLSLASAVMLCLEVWYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:PRK01766  238 IKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDAR 315


                  .
gi 2027478507 350 F 350
Cdd:PRK01766  316 Q 316
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 49-350 2.15e-110

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 328.76  E-value: 2.15e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  49 ESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLG 128
Cdd:cd13132     1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 129 VYMQRSWVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13132    81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 209 ALVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIV-SGACGEAWSGFTFKAFHNLWGFVRLSLASAVMLCLE 287
Cdd:cd13132   161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFfSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027478507 288 VWYFMALVLFAGYLKnAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:cd13132   241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKL 302
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 59-350 1.03e-43

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 153.94  E-value: 1.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  59 PAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIaGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVIL 138
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 139 NATAILLSLLYIFAGHMLRAIGQT-EAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTLFS 217
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGAdGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 218 WLLILE-FG-WGLVGAAVVLNASWWFIDIAQLVYIVSG-ACGEAWSGFTFKAFHNLWGFVRLSLASAVMLCLEVWYFMAL 294
Cdd:TIGR00797 160 YILIFGkFGfLGIVGAALATVISYWLMFLLLLYYIKKAkKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2027478507 295 VLFAGYLKnaEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKE 293
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
51-349 2.65e-31

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 122.17  E-value: 2.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIaGFSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:COG0534     8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIF-FLLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAA 209
Cdd:COG0534    87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 210 LVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFKA-FHNLWGFVRLSLASAVMLCLEV 288
Cdd:COG0534   167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQQLAES 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2027478507 289 WYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:COG0534   247 LGFLVLNALVARL--GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRAR 305
MatE pfam01554
MatE; The MatE domain
 59-219 7.34e-28

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 106.50  E-value: 7.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  59 PAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVIL 138
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 139 NATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTLFS 217
Cdd:pfam01554  80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 2027478507 218 WL 219
Cdd:pfam01554 160 YL 161
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 49-349 1.77e-27

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 111.82  E-value: 1.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  49 ESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSViagFSLGITFGMG--SALETLCGQAYGAGQVHM 126
Cdd:cd13131     1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL---WFPVFTFGMGllLAVTPLVAQAHGAGDRRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 127 LGVYMQRSWVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIA 206
Cdd:cd13131    78 IRRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVIT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 207 AAALVLHTLFSWLLILE-FGW---GLVGAAVVLNASWWFIDIAQLVYIVSG------ACGEAWSGFTFKAFHNLWgfvRL 276
Cdd:cd13131   158 LLALVLNIPLNYVLIFGkFGLpalGGAGAGLATAIVYWLMFLALAFYIRRHkrfrryRLFARFWRPDWARLKELL---RL 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027478507 277 SLASAVMLCLEVWYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd13131   235 GLPIGLTIFFEVSLFAAVALLMGRL--GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADAR 305
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 51-348 6.04e-21

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 92.98  E-value: 6.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAvsvenSVIAG------FSLGITFGMGSAleTLCGQAYGAGQV 124
Cdd:cd13133     5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAA-----SGPAGvlyfaiLMLFFGLSSGVQ--VFVAQYNGAGRY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 125 HMLGVYMQRSWVILNATAILLSLLYIFAGHMLRA-IGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMA 203
Cdd:cd13133    78 SRIGRVLWQGLYFSLLLAPLLALLSALAAPLLFLlLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVM 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 204 WIAAAALVLHTLFSWLLIleFGW------GLVGAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFKAF--HNLWGFVR 275
Cdd:cd13133   158 VANLVMVVVNIVLDYALI--FGKlgfpamGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFdrELLRRILR 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027478507 276 LSLASAVMLCLEVWYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTA 348
Cdd:cd13133   236 LGLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLA 306
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 51-349 2.30e-19

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 88.34  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIA-GFSLGITFGMGSAleTLCGQAYGAGQVHMLGV 129
Cdd:cd13137     1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWlLLVLNMALGTGTV--ALVSQSYGAGDYERARR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 130 YMQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13137    79 ALGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 209 ALVLHTLFSWLLILE----FGWGLVGAAVVLNASWWFIDIAQLVYIVSGACG--EAWSGFTFKaFHNLWGFVRLSLASAV 282
Cdd:cd13137   159 VNVLNIVLDYVLIFGlwgfPGLGVAGAALATVISRVVGALLLLFLLLRGRLPikISFKGFRLD-RKIIKKLLRIGLPAGL 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2027478507 283 MLCLEVWYFMALVLFAGYLKNAEVSvdALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd13137   238 EQLLRSLGFLVLLAIVASYGTAALA--AYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEAR 302
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 57-349 4.36e-17

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 81.60  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  57 AGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVeNSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRS-W 135
Cdd:cd12082     1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGL-AFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSiV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 136 VILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTL 215
Cdd:cd12082    80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 216 FSWLLILEFG---WGLVGAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFKA-FHNLWGFVRLSLASAVMLCLEVWYF 291
Cdd:cd12082   160 LDPLLIFGLGppeLGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPdLELLRRLLRIGLPSAIQNSLLSLGL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2027478507 292 MALVLFAGYLKNAEVsVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd12082   240 LIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRAR 296
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 51-342 1.12e-12

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 68.31  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGH-VNTLALAAVSVENSVIAG-FSLGITFGMGSAleTLCGQAYGAGQVHMLG 128
Cdd:cd13143     4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMLlMALGLMIGVGGA--SLISRRLGAGDREKAN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 129 VYMQRS-WVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAA 207
Cdd:cd13143    82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 208 AALVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFK-AFHNLWGFVRLSLASAVM-LC 285
Cdd:cd13143   162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKlSLKIIKEILALGFPSFLMqLS 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2027478507 286 LEVWYFMALVLFAGYLKNAEVSvdALSICMNILGWTIMVSFGMNAAVSVRVSHELGA 342
Cdd:cd13143   242 SSVVTIVLNLTLLGYGGDIGVA--AFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGA 296
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 44-350 1.17e-12

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 68.69  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  44 REFFAESKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSViagFSLGITFGMG--SALETLCGQAYGA 121
Cdd:PRK01766    5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSI---WLPVILFGHGllLALTPIVAQLNGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 122 GQVHMLG-VYMQRSWVILnATAILLSLLYIFAGHMLRAIGQTEAISA--AAG--EFALWMIPQLFAYAVnypAQKFLQAQ 196
Cdd:PRK01766   82 GRRERIAhQVRQGLWLAL-FLSVLIMLVLYNAVPPILNMMNLEPEVAdiAVGylHALLWGIPAYLLYQV---LRSFIDGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 197 SRIMVMAWIAAAALVLHTLFSWLLIL-EFGW---GLVGAAVVLNASWWFIDIAQLVYIVSG---ACGEAWSGFTFKAFHN 269
Cdd:PRK01766  158 GKTKPTMVIGFLGLLINIPLNYIFIYgKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRArrfRDFRLFKGLYKPDWAV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 270 LWGFVRLSLASAVMLCLEVWYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:PRK01766  238 IKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDAR 315


                  .
gi 2027478507 350 F 350
Cdd:PRK01766  316 Q 316
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
51-249 5.53e-12

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 66.32  E-value: 5.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:COG0534   229 KRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALR-IESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRA 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAA 209
Cdd:COG0534   308 ARLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLR 387

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2027478507 210 LVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVY 249
Cdd:COG0534   388 LWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 50-349 2.54e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 64.45  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  50 SKKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAGFSLgITFGMGSALETLCGQAYGAGQVHMLGV 129
Cdd:cd13134     2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLIL-IFSFISTGTSILIAQYLGAKDKKKARQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 130 YMQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13134    81 IAGVALLFNLLLGLVFSLLlLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 209 ALVLHTLFSWLLILEFG----WGLVGAAVVLNASWWFIDIAQLVYIVSGacgeAWSGFTFKA-FHNLWGFVRLSLASAVM 283
Cdd:cd13134   161 MNILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRK----LKIRFRLKDlRPFPKKLLKKILKIGLP 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2027478507 284 LCLE--VWYFMALVLFAGYLKNAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd13134   237 SAGEelSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAY 304
MatE pfam01554
MatE; The MatE domain
 280-350 1.46e-09

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 56.03  E-value: 1.46e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2027478507 280 SAVMLCLEVWYFMALVLFAGYLknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAKF 350
Cdd:pfam01554   2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGV 70
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 51-349 1.52e-08

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 55.93  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGH-VNTLALAAVSVeNSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGV 129
Cdd:cd13138     3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSN-GSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 130 YMQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFA---LWMIPQLFAYAVnypAQKFLQAQSRIMVMAWI 205
Cdd:cd13138    82 AVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLricFLGIPFIFGYNA---YSAILRGLGDSKTPLYF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 206 AAAALVLHTLFSWLLILEFGWGLVGAA--------VVLNASWWFIDIAQLVYIVSgacgeaWSGFTFKaFHNLWGFVRLS 277
Cdd:cd13138   159 VIIACVLNIILDLLFIAVFHMGVAGAAlatviaqaISVLLALYYLRKKKLPFKLS------LKDFRFD-KEILKEILKIG 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2027478507 278 LASAVMlclevwyfMALVLFAGYLKNAEVS------VDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd13138   232 LPSALQ--------QSLVSISFLIINSIVNsygvvaSAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAK 301
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 51-230 2.34e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 49.04  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCqYSLGG-VTQVFSGHVNTLALAAVSVEnSVIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGV 129
Cdd:cd13134   228 KKILKIGLPSAGEELS-YNLSQtVITAFIARLGTAALAARTYA-SNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYK 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 130 YMQRSWVILNATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAA 208
Cdd:cd13134   306 RVLKSLKIGLLVSLAVALLlALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGII 385

                         170       180
                  ....*....|....*....|...
gi 2027478507 209 AL-VLHTLFSWLLILEFGWGLVG 230
Cdd:cd13134   386 SMwGISVPLAYLLGIVLGLGLLG 408
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 51-232 2.53e-06

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 48.71  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLA-LAAVSVENSVIAGFSLGITF-GMGSAleTLCGQAYGAGQVH-ML 127
Cdd:cd13136     3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGFlRMGTT--GLVAQALGAGDREeAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 128 GVYMQRSWVILNATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAA 207
Cdd:cd13136    81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160

                         170       180
                  ....*....|....*....|....*
gi 2027478507 208 AALVLHTLFSWLLILEFGWGLVGAA 232
Cdd:cd13136   161 VGNVVNIVLDPLFVFGLGWGVAGAA 185
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 71-250 3.36e-06

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 48.55  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  71 GGVTQVFSGHVNTLALAAVSVENSVIAG-----FSLG-----ITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVI-LN 139
Cdd:cd13146    20 GQLFQLLYNITDTIWISMIDPSDPALVGgiglvFPLGmiflaLGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALaLL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 140 ATAILLSLLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAALVLHTLFSWL 219
Cdd:cd13146   100 AATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPI 179

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2027478507 220 LILEFGWGLVGAAVVLNASwWFIDIAQLVYI 250
Cdd:cd13146   180 LIFVFDMGVKGAALATVLA-QAISLLYLLYV 209
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 60-250 4.58e-06

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 48.09  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  60 AIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVILN 139
Cdd:cd12082   229 AIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFR-IASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 140 ATAILLSLL-YIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWI-AAAALVLHTLFS 217
Cdd:cd12082   308 LIGAVLGLLiLLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVsLLSYWVVRLPLA 387

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2027478507 218 WLLILeFGWGLVGAAVVLNASWWFIDIAQLVYI 250
Cdd:cd12082   388 YVLAY-LGLGLYGIWLALVISLILAALVLLLFF 419
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 83-253 1.05e-05

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 47.07  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  83 TLALAAVSVENSVIaGFSLGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVILNATAILLSLL-YIFAGHMLRAIGQ 161
Cdd:cd13138   257 VVASAAYGIANKIN-SFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLvFFFAPQLLGLFTS 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 162 TEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSR-IMVMAWIAAAALVLHTLFSWLLILEFGWGLVGAAVVLNASWW 240
Cdd:cd13138   336 DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKtKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNI 415

                         170
                  ....*....|...
gi 2027478507 241 FIDIAQLVYIVSG 253
Cdd:cd13138   416 LSAIICIIYYRKG 428
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 51-349 5.68e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 44.88  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAgfsLGITFGMG--SALETLCGQAYGAGQVHMLG 128
Cdd:cd13142    11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIF---LFISLGGGltVAGTALVAQYTGAGDYDKAN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 129 VYMQRSWVILNATAILLSLLYIFAGH--MLRAIGQTEAISAAAGEFALWM---IPQLFAYAVnypAQKFLQAQSRIMVMA 203
Cdd:cd13142    88 KVAGQTFSFVIILSLILAVLGYILSRplLLLLIGAPEEVYPLALAYLRIIflgLPFMFIFFV---FNSLLRGIGDTKTPM 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 204 WIAAAALVLHTLFSWLLIleFGWGLV------GAAVVLNASWWFIDIAQLVYIVSGACGEAWSGFTFKA-FHNLWGFVRL 276
Cdd:cd13142   165 KIMFGSVLLNVILDPLLI--FGIGPFpglgvaGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPdWEWLKKIFRI 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2027478507 277 SLASAVMLCLEVWYFMALV-LFAGYlknAEVSVDALSICMNILGWTIMVSFGMNAAVSVRVSHELGASHPRTAK 349
Cdd:cd13142   243 GLPSSIEQSARALGFTVMTaLVAGF---GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAE 313
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 77-235 1.18e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 40.66  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  77 FSGHVNTLALAAVSVENSVIagFS-LGITFGMGSALETLCGQAYGAGQVHMLGVYMQRSWVILNATAILLSLLYIFAGHM 155
Cdd:cd13145    35 FAGKISTEALAALSLSFPIF--FIiIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPP 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 156 L-RAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQS------RIMVMAWIAAAALVLHTLFSWLLILEFGWGL 228
Cdd:cd13145   113 LfRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGdtksyrNFLIIGFFLNIILDPLFIFGGGGIPAMGVSG 192


                  ....*..
gi 2027478507 229 VGAAVVL 235
Cdd:cd13145   193 IALATII 199
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 51-239 2.74e-03

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 39.42  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:cd13137   226 KKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLR-IESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRY 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLS-LLYIFAGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQAQSRIMVMAWIAAAA 209
Cdd:cd13137   305 GKRALRLGVLFMGLLGlLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLIS 384

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2027478507 210 LVLHTL-FSWLLILEFGWGLVGAAVVLNASW 239
Cdd:cd13137   385 MWLVRLpLAYLLGFVLGLGLTGIWLAMFVDT 415
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 51-254 4.66e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 38.66  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSvIAGFSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:cd13133   231 RRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFS-INSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRV 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLSLLYIFAGHMLRAI---GQTEAISAAAGEFALWMIpqLFAYAVNYPAQKFLQAQS----RIMVMa 203
Cdd:cd13133   310 TRRGLKLALAYMLLLGILFLLFPELLLSIftpGADFALIAELAVPLLRFV--AAYILFDALALVFAGALRgagdTRFVM- 386

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2027478507 204 WIAAAALVLHTLFSWLLILEFGWGLVGAAVVLNASWWFIDIAQLVYIVSGA 254
Cdd:cd13133   387 LAELIVAWLYLLPPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGK 437
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 51-233 4.71e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 38.81  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507  51 KKLWYLAGPAIFTSVCQYSLGGVTQVFSGHVNTLALAAVSVENSVIAGfSLGITFGMGSALETLCGQAYGAGQVHMLGVY 130
Cdd:cd13135     1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNT-ITGFLGSISIGFTILGSQSVGAKDIKRINDY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027478507 131 MQRSWVILNATAILLSLLYIF-AGHMLRAIGQTEAISAAAGEFALWMIPQLFAYAVNYPAQKFLQA--QSRIMVMAWIAA 207
Cdd:cd13135    80 AISSIVYNSIIGVILFLLWLFgARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGigETKPIMYGGIIK 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 2027478507 208 AalVLHTLFSWLLIL-EFGW---GLVGAAV 233
Cdd:cd13135   160 N--LLNVILDYVLIFgNFGFprlGIIGAAI 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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