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Conserved domains on  [gi|571443816|ref|XP_006576323|]
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transcription factor EGL1 isoform X2 [Glycine max]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH-MYC_N pfam14215
bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a ...
 19-197 4.75e-30

bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, pfam00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).


:

Pssm-ID: 464106  Cd Length: 121  Bit Score: 114.63  E-value: 4.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   19 QLAVAVRSIQWSYGIFWSPSTTE--ERVLEWREGYYNGDiktrktvqatELEIKADKIGLqrseqlkelykfllageadh 96
Cdd:pfam14215   4 RLRSLVESSQWSYAIFWQISRSQsgRLVLGWGDGYYNGG----------EEGGKGKTRGL-------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   97 pqtkrpsvalapedlsdlewyylvcmsfvfnhnqslPGRALEIGDTVWLCNAQHADSkvFSRSLLAK-----TVVCFPYQ 171
Cdd:pfam14215  54 ------------------------------------PGKAFASGKHIWLTGADELDY--CSRSLLAKsagiqTIVCIPVP 95

                         170       180
                  ....*....|....*....|....*.
gi 571443816  172 KGVIEIGTTELVAEDPSLIQHVKACF 197
Cdd:pfam14215  96 GGVLELGSTELVPEDLELVQHIKSLF 121
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 451-511 3.12e-11

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd11451:

Pssm-ID: 469605  Cd Length: 75  Bit Score: 59.36  E-value: 3.12e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571443816 451 KKREIKN--FQVVKSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYMEVTGPEARKRSK 511
Cdd:cd11451   12 RRREKLNerFITLRSMVPF-VTKMDKVSILGDAIEYLKQLQRRVEELESRRKSSDTETRPTME 73
 
Name Accession Description Interval E-value
bHLH-MYC_N pfam14215
bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a ...
 19-197 4.75e-30

bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, pfam00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).


Pssm-ID: 464106  Cd Length: 121  Bit Score: 114.63  E-value: 4.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   19 QLAVAVRSIQWSYGIFWSPSTTE--ERVLEWREGYYNGDiktrktvqatELEIKADKIGLqrseqlkelykfllageadh 96
Cdd:pfam14215   4 RLRSLVESSQWSYAIFWQISRSQsgRLVLGWGDGYYNGG----------EEGGKGKTRGL-------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   97 pqtkrpsvalapedlsdlewyylvcmsfvfnhnqslPGRALEIGDTVWLCNAQHADSkvFSRSLLAK-----TVVCFPYQ 171
Cdd:pfam14215  54 ------------------------------------PGKAFASGKHIWLTGADELDY--CSRSLLAKsagiqTIVCIPVP 95

                         170       180
                  ....*....|....*....|....*.
gi 571443816  172 KGVIEIGTTELVAEDPSLIQHVKACF 197
Cdd:pfam14215  96 GGVLELGSTELVPEDLELVQHIKSLF 121
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 451-511 3.12e-11

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 59.36  E-value: 3.12e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571443816 451 KKREIKN--FQVVKSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYMEVTGPEARKRSK 511
Cdd:cd11451   12 RRREKLNerFITLRSMVPF-VTKMDKVSILGDAIEYLKQLQRRVEELESRRKSSDTETRPTME 73
HLH smart00353
helix loop helix domain;
451-494 4.52e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 35.66  E-value: 4.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 571443816   451 KKREIKN--FQVVKSMVPS--SISEVEKISILGDTIKYLKKLETRVEE 494
Cdd:smart00353   6 RRRRKINeaFDELRSLLPTlpKNKKLSKAEILRLAIEYIKSLQEELQK 53
 
Name Accession Description Interval E-value
bHLH-MYC_N pfam14215
bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a ...
 19-197 4.75e-30

bHLH-MYC and R2R3-MYB transcription factors N-terminal; This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, pfam00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).


Pssm-ID: 464106  Cd Length: 121  Bit Score: 114.63  E-value: 4.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   19 QLAVAVRSIQWSYGIFWSPSTTE--ERVLEWREGYYNGDiktrktvqatELEIKADKIGLqrseqlkelykfllageadh 96
Cdd:pfam14215   4 RLRSLVESSQWSYAIFWQISRSQsgRLVLGWGDGYYNGG----------EEGGKGKTRGL-------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571443816   97 pqtkrpsvalapedlsdlewyylvcmsfvfnhnqslPGRALEIGDTVWLCNAQHADSkvFSRSLLAK-----TVVCFPYQ 171
Cdd:pfam14215  54 ------------------------------------PGKAFASGKHIWLTGADELDY--CSRSLLAKsagiqTIVCIPVP 95

                         170       180
                  ....*....|....*....|....*.
gi 571443816  172 KGVIEIGTTELVAEDPSLIQHVKACF 197
Cdd:pfam14215  96 GGVLELGSTELVPEDLELVQHIKSLF 121
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 451-511 3.12e-11

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 59.36  E-value: 3.12e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571443816 451 KKREIKN--FQVVKSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYMEVTGPEARKRSK 511
Cdd:cd11451   12 RRREKLNerFITLRSMVPF-VTKMDKVSILGDAIEYLKQLQRRVEELESRRKSSDTETRPTME 73
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 449-512 1.25e-10

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 57.73  E-value: 1.25e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 571443816 449 SDKKREIKNFQVVKSMVPSSiSEVEKISILGDTIKYLKKLETRVEELESYMEVTGPEARKRSKC 512
Cdd:cd18918    7 ERREKLNEKFSDLRNLIPNP-TKNDRASILSDAIKYINELQRTVEELKSLVEKKRCGERDRKTT 69
bHLH_AtAMS_like cd11443
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores ...
 462-506 2.03e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AMS, ICE1 and SCREAM2. AMS, also termed AtbHLH21, or EN 48, plays a crucial role in tapetum development and it is required for male fertility and pollen differentiation. ICE1, also termed inducer of CBF expression 1, or AtbHLH116, or EN 45, or SCREAM, acts as a transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. It binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. SCREAM2, also termed AtbHLH33, or EN 44, mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.


Pssm-ID: 381449 [Multi-domain]  Cd Length: 72  Bit Score: 42.75  E-value: 2.03e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 571443816 462 KSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYMEVTGPEA 506
Cdd:cd11443   22 RSVVPK-ITKMDRASILGDAIDYVKELLQEINELQDELEGLPESE 65
bHLH_AtAIB_like cd11449
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE ...
 452-500 9.69e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response. MYC2, also termed protein jasmonate insensitive 1, or R-homologous Arabidopsis protein 1 (RAP-1), or AtbHLH6, or EN 38, or Z-box binding factor 1 protein, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways. MYC3, also termed protein altered tryptophan regulation 2, or AtbHLH5, or transcription factor ATR2, or EN 36, is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. MYC4, also termed AtbHLH4, or EN 37, is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses.


Pssm-ID: 381455 [Multi-domain]  Cd Length: 78  Bit Score: 38.14  E-value: 9.69e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 571443816 452 KREIKN--FQVVKSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYME 500
Cdd:cd11449   16 RREKLNqrFYALRAVVPN-VSKMDKASLLGDAISYINELKSKVQDMETEKK 65
bHLH_AtNAI1_like cd11452
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar ...
 451-505 1.31e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar proteins; NAI1, also termed AtbHLH20, or EN 27, is a bHLH transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. It is required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). It plays a role in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.


Pssm-ID: 381458 [Multi-domain]  Cd Length: 75  Bit Score: 37.83  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 571443816 451 KKRE--IKNFQVVKSMVPSsISEVEKISILGDTIKYLKKLETRVEELESYMEVTGPE 505
Cdd:cd11452   12 KRREklSQRFIALSALVPG-LKKMDKASVLGDAIKHIKQLQERVKELEEEKKEKRLM 67
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 458-496 1.46e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 37.16  E-value: 1.46e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 571443816 458 FQVVKSMVPSSiSEVEKISILGDTIKYLKKLETRVEELE 496
Cdd:cd11393   16 IRALRSLVPNG-GKTDKASILDEAIEYIKFLQEQVKVLS 53
HLH smart00353
helix loop helix domain;
451-494 4.52e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 35.66  E-value: 4.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 571443816   451 KKREIKN--FQVVKSMVPS--SISEVEKISILGDTIKYLKKLETRVEE 494
Cdd:smart00353   6 RRRRKINeaFDELRSLLPTlpKNKKLSKAEILRLAIEYIKSLQEELQK 53
bHLH_AtFAMA_like cd11448
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar ...
 460-521 5.06e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development.


Pssm-ID: 381454  Cd Length: 74  Bit Score: 36.17  E-value: 5.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571443816 460 VVKSMVPSS-ISEVEKISILGDTIKYLKKLETRVEELESymevtgpeARKRSKCPDVLEQMSD 521
Cdd:cd11448   20 VLRSLMPGSyIQRGDQASIVGGAIEFVKELEQLLQSLEA--------QKRRRTLNESSVPSST 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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