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Conserved domains on  [gi|568960649|ref|XP_006510828|]
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inhibitor of Bruton tyrosine kinase isoform X1 [Mus musculus]

Protein Classification

inhibitor of Bruton tyrosine kinase( domain architecture ID 13793999)

inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development

CATH:  1.25.40.20
Gene Ontology:  GO:0005515|GO:0030292|GO:0001933
PubMed:  17120193|27521773|17176038|11577348
SCOP:  4001139|4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 2.05e-64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 213.38  E-value: 2.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  763 KCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568960649  843 FVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGssleltdvyQKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 568960649  626 DLFEYLLQFMYTDTCDLLTHGFKPRM 651
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 2.79e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


:

Pssm-ID: 350575  Cd Length: 60  Bit Score: 108.37  E-value: 2.79e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  871 LTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 super family cl34932
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 5.40e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


The actual alignment was detected with superfamily member COG5184:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 90.04  E-value: 5.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  223 VEGLSGHncSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPAScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.61e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   47 VKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 2.05e-64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 213.38  E-value: 2.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  763 KCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568960649  843 FVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGssleltdvyQKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 568960649  626 DLFEYLLQFMYTDTCDLLTHGFKPRM 651
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 2.79e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 108.37  E-value: 2.79e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  871 LTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 5.40e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 90.04  E-value: 5.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  223 VEGLSGHncSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPAScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 561-639 3.58e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 3.58e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   561 DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:pfam00651    8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 4.44e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 4.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   761 QKKCSFLYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568960649   841 VDfvcSVLVVADQLLITRLKEICEVALTENL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-642 1.53e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 1.53e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649    565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDTCDL 642
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGKLDL 65
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.61e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   47 VKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-871 3.58e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.56  E-value: 3.58e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649    769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEavVIKESQNVDfvcSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90       100
                    ....*....|....*....|...
gi 568960649    849 VVADQLLITRLKEICEVALTENL 871
Cdd:smart00225   75 ELADYLQIPGLVELCEEFLLKLL 97
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 4.09e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 4.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568960649   247 DGCVYTFGLNMFHQLGiIPPPASCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-116 3.61e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 3.61e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568960649    45 ATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVdllVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQD 116
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 4.29e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 4.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649   59 ASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
PHA03098 PHA03098
kelch-like protein; Provisional
 765-923 5.73e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.91  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  765 SFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEAsscaALEMPIQSEILKVILDYLYTDeaVVIKESQNVDfv 844
Cdd:PHA03098    8 KFCDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLNIDYDSFNEVIKYIYTG--KINITSNNVK-- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649  845 cSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:PHA03098   80 -DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 2.05e-64

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 213.38  E-value: 2.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  763 KCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568960649  843 FVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGssleltdvyQKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 568960649  626 DLFEYLLQFMYTDTCDLLTHGFKPRM 651
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 2.79e-28

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 108.37  E-value: 2.79e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  871 LTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 5.40e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 90.04  E-value: 5.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  223 VEGLSGHncSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPAScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-854 1.24e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.45  E-value: 1.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQSEILKVILDYLYTDEAVVikesqNVDFVC 845
Cdd:cd18186     1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGELEL-----SEENVE 73


                  ....*....
gi 568960649  846 SVLVVADQL 854
Cdd:cd18186    74 ELLAAADKL 82
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-362 1.95e-18

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 88.50  E-value: 1.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  144 VYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRLV 223
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  224 EGLSghNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGiIPPPASCNVPRQIQAkylKGRTIIGVAAGRFHTVLWTRE- 302
Cdd:COG5184    95 PGLT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA---GLSGVVAIAAGGYHTCALKSDg 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960649  303 AVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLSG----VVAVAAGGDHSCALKSDGTVW 221
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-642 7.97e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 79.13  E-value: 7.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSleltdvyqkdedaAGCHLFVVEKVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKE-------------SSSSEIELDDVSPEAFEALLDYIYTGELEL 67
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 561-639 3.58e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 3.58e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   561 DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:pfam00651    8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 4.44e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.37  E-value: 4.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   761 QKKCSFLYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568960649   841 VDfvcSVLVVADQLLITRLKEICEVALTENL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 5.36e-15

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 78.09  E-value: 5.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    68 TVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG----VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  223 VeGLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPAScNVPRQIQAKylkgRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   144 V-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDR-PTPVQVGGL----SGVVAVAAGGDHScALKSD 217

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568960649  302 EAVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHhkdiAVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   218 GTVWCWGSNSsGQLGDGTTTD----RATPVQVAGLT----GVVAIAAGGSHTCALKSDGTVW 271
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 757-867 5.54e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 72.68  E-value: 5.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  757 LKLSQKkcSFLYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCaalEMPIQS---EILKVILDYLYTDeAV 833
Cdd:cd18286     9 LQLFLN--GEDSDITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLTGvshAAVSFVLLFIYGG-VL 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568960649  834 VIKESQNvdfVCSVLVVADQLLITRLKEICEVAL 867
Cdd:cd18286    82 DLPDDVN---LGELLSLADMYGLDGLKDVVAYTL 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-871 1.27e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 71.56  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  766 FLYDVTMKsVDGKEFSCHKCVLCARLEYFHSML----SRSWIEASSCAALEMP-IQSEILKVILDYLYTDEAVVikesqN 840
Cdd:cd18296    16 SFPDVCFQ-VEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIPVVTLHdVSPEVFAIVLYYIYTDDTDL-----P 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568960649  841 VDFVCSVLVVADQLLITRLKEICEVALTENL 871
Cdd:cd18296    90 PENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-642 1.53e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 1.53e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649    565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDTCDL 642
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGKLDL 65
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.61e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   47 VKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.88e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.88e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   47 VKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-871 3.58e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.56  E-value: 3.58e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649    769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEavVIKESQNVDfvcSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90       100
                    ....*....|....*....|...
gi 568960649    849 VVADQLLITRLKEICEVALTENL 871
Cdd:smart00225   75 ELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-875 8.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 66.20  E-value: 8.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCsflyDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQSEILKVILDYLYTDEAV 833
Cdd:cd18240     9 NELRLEGKLC----DVVIR-VNGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAYTRTVP 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568960649  834 VikesqNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18240    83 I-----TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 546-645 3.90e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 64.19  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  546 FFEEFGKLLretdEMDSFHDVTFQVGNRHFP--AHKYILAVRSDFFQKLFLSDGSSLEltdvyQKDEdaagchlFVVEKV 623
Cdd:cd18294     1 FAADMKSLI----NNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKES-----TQSP-------LVLSDI 64

                          90       100
                  ....*....|....*....|..
gi 568960649  624 HPDLFEYLLQFMYTDTCDLLTH 645
Cdd:cd18294    65 EPEVFRAVLEFIYTNCVTLSNH 86
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-642 4.08e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 64.24  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  547 FEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSsleltdvyQKDEDAAGCHLFVVEKVHPD 626
Cdd:cd18296     1 RVDLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFA--------ESEENNGSIPVVTLHDVSPE 72

                          90
                  ....*....|....*.
gi 568960649  627 LFEYLLQFMYTDTCDL 642
Cdd:cd18296    73 VFAIVLYYIYTDDTDL 88
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 562-637 2.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 61.59  E-value: 2.13e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  562 SFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18314     5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEV-------------TLEDVEPEIFETVLKYMYT 67
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 536-644 3.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 61.87  E-value: 3.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  536 YEIPVVSSSSffEEFGKLLRETDemdsFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFL-----SDGSSLELtdvyqKDE 610
Cdd:cd18287     1 GEIDHVHFLS--EDIGALFLNEE----YSDVTFVVEEKRFPAHRVILAARSEYFRALLYggmreSQQSEIEL-----KDT 69

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568960649  611 DAAGchlfvvekvhpdlFEYLLQFMYTDTCDLLT 644
Cdd:cd18287    70 NAEA-------------FKALLKYIYTGRLTLTD 90
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 4.09e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 4.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568960649   247 DGCVYTFGLNMFHQLGiIPPPASCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-638 5.08e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 61.11  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  547 FEEFgklLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLS---DGSSLELTdvyqkdedaagcHlfvvEKV 623
Cdd:cd18295     6 YDEF---LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwkDKREINLK------------H----PLV 66

                          90
                  ....*....|....*
gi 568960649  624 HPDLFEYLLQFMYTD 638
Cdd:cd18295    67 NPDAFRALLQYLYTG 81
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 769-871 5.89e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 60.72  E-value: 5.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQSEILKVILDYLYTDEavvIKESQNVDFVCsV 847
Cdd:cd18300    11 DVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG-L 84

                          90       100
                  ....*....|....*....|....
gi 568960649  848 LVVADQLLITRLKEICEVALTENL 871
Cdd:cd18300    85 IVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-637 6.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 60.76  E-value: 6.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  543 SSSFFEEFGKLLRETDemdsFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGChlfvvek 622
Cdd:cd18292     1 SREFLQDIAQLYNNEE----LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECA------- 69

                          90
                  ....*....|....*
gi 568960649  623 vhpDLFEYLLQFMYT 637
Cdd:cd18292    70 ---AVFEKFLRYLYT 81
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-875 6.66e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 61.34  E-value: 6.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  765 SFLYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVikesqNVDFV 844
Cdd:cd18268    21 RILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILI-----TRDNV 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568960649  845 CSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18268    95 LPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-639 7.99e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 60.81  E-value: 7.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  550 FGKLLretDEMDSFhDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFE 629
Cdd:cd18280     5 FGALL---ESEEGA-DVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEI-------------VIEDVEPPVFK 67

                          90
                  ....*....|
gi 568960649  630 YLLQFMYTDT 639
Cdd:cd18280    68 ALLHFIYKDE 77
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-116 3.61e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 3.61e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568960649    45 ATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVdllVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQD 116
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 4.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 58.63  E-value: 4.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYtDEAVVIKEsqnvDFVCSVL 848
Cdd:cd18265    25 DVVLL-VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE----DNVESVL 98

                          90       100
                  ....*....|....*....|....*..
gi 568960649  849 VVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18265    99 EASDLLQVSKLREACVRFLEGQLHPCN 125
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-876 5.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 58.32  E-value: 5.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAvvikesQNVDFVC-SV 847
Cdd:cd18345    20 DVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKA------PNLDKMAdDL 92

                          90       100
                  ....*....|....*....|....*....
gi 568960649  848 LVVADQLLITRLKEICEVALTENLTLKNA 876
Cdd:cd18345    93 LAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 732-875 6.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 58.32  E-value: 6.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  732 LSSRLEGVRLENEkinviakktgnklklsqkkcsfLYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAAL 811
Cdd:cd18236    11 LQNGLENLRLENS----------------------LTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKII 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960649  812 EMPIQSEILKVILDYLYTDEAVVIKesQNVDfvcSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18236    68 IKGVDAETMQILLDYTYTSKVLITK--QNVQ---RVLEAASLFQFLRMVDACASFLTEALHPEN 126
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 232-354 8.46e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 61.92  E-value: 8.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  232 SQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGiIPPPASCNVPRQIQAkylkGRTIIGVAAGRFHTVLWTRE-AVYTLGLN 310
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLG-DGTTTDRSTPVRVPG----LSNVVAVAAGGDHTCALKADgTVWCWGNN 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568960649  311 G-GQLGhlldpNGEK-CVTTPRQVSALHH-KDIAV----SLVAASDGATVC 354
Cdd:COG5184    76 SyGQLG-----DGTTtDRTTPVKVPGLTGvVAVAAgyyhSCALKSDGTVWC 121
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 57.53  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEaVVIKESQnvdfVCSVL 848
Cdd:cd18252    23 DITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQ-ICITERN----VQSLL 97

                          90       100
                  ....*....|....*....|....*..
gi 568960649  849 VVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18252    98 EAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-864 1.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 56.87  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  776 DGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALE-MPIQSEILKVILDYLYTDEAvvikeSQNVDFVCSVLVVADQL 854
Cdd:cd18294    24 ERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlSDIEPEVFRAVLEFIYTNCV-----TLSNHTVIEVLAAAVEY 98

                          90
                  ....*....|
gi 568960649  855 LITRLKEICE 864
Cdd:cd18294    99 GLDELRKLCE 108
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-673 1.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 56.56  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDvyqkdedaagchlfvvekVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18303    18 YSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSD------------------ISYEVVLALLRWLYTDELDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568960649  643 ------------LTHGFKPRMIVKRkaedCEGSPDSHLHTVNC 673
Cdd:cd18303    80 tlddefllelmkAAKRFQLTDLVER----CERALMSSVNVDNC 118
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 749-875 2.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 56.55  E-value: 2.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  749 IAKKTGNKLKLSQ-KKCSFLydvtmksVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYL 827
Cdd:cd18343     8 LAEDLGNLWENSRfTDCSLF-------VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568960649  828 YTDEAvvikesQNVDFVC-SVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18343    81 YTGKA------PNLDKMAdNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-863 2.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 56.19  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLSRSW-IEASSCAALE-MPIQSEILKVILDYLYTDEavvIKESQnvDFVCSVLVVAD 852
Cdd:cd18245    21 VGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNIQDIVQAAD 95

                          90
                  ....*....|.
gi 568960649  853 QLLITRLKEIC 863
Cdd:cd18245    96 LLLMTDLKDLC 106
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 3.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 56.38  E-value: 3.19e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTdvyqkdedaagchlFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18224    28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVART--------------YVVDFITPANFEKVLSFIYT 86
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 562-673 4.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 55.87  E-value: 4.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  562 SFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlSDGSSLELTDVYQkdedaagchlfvVEKVHPDLFEYLLQFMYTDTCD 641
Cdd:cd18256    19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQ------------IHGVEPDIFHILLDFIYTGVVE 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568960649  642 LLTHGFKPRMIvkrkAED----------CEGSPDSHLHTVNC 673
Cdd:cd18256    86 VTVSNVQELLV----AADmlqltevveiCCEFLKGQLHPSNC 123
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-263 4.99e-09

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 59.61  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsgvyVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   219 TVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVK 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568960649  223 VEGLSghNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGI 263
Cdd:COG5184   295 VPGLS--GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGD 333
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-875 6.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 55.63  E-value: 6.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLYDVTM--KSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMPIQS-------EILKVILDYLYTDE 831
Cdd:cd18241    17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRKWSsepgpdpDTVEAVIQYMYTGR 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568960649  832 AVVIKESqnvdfVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18241    96 IRVSTGN-----VHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 6.42e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 55.34  E-value: 6.42e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFfqklflsdgssleLTDVYQKDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18306    18 FCDVILQVGGHEIPAHRAVLACASPY-------------LFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 7.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 55.35  E-value: 7.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIkesQNVDFVCSVLVVADQL 854
Cdd:cd18344    30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKY 106

                          90       100
                  ....*....|....*....|..
gi 568960649  855 LITRLKEICEVALTENLTLKNA 876
Cdd:cd18344   107 GLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 1.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 54.80  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVikESQNVDfvcS 846
Cdd:cd18237    21 LCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV--NSNNVQ---S 94

                          90       100
                  ....*....|....*....|....*....
gi 568960649  847 VLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18237    95 LLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 54.20  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQSEILKVILDYLYTDEAVVIKESQNVDFvcSV 847
Cdd:cd18297    14 DVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDDAL--EL 89

                          90       100
                  ....*....|....*....|....*...
gi 568960649  848 LVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18297    90 LRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 54.07  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKEsqnvdFVCSVL 848
Cdd:cd18279    20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-----MADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 568960649  849 VVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18279    94 AAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-876 2.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 54.00  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKEsqN 840
Cdd:cd18250    16 RAERKFF-DVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQD--N 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568960649  841 VDfvcSVLVVADQLLITRLKEICEVALTENLTLKNA 876
Cdd:cd18250    92 VE---ALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-863 2.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 53.56  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCsflyDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVV 834
Cdd:cd18256    12 NKLRGQHEFC----DVQLQ-VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                          90       100
                  ....*....|....*....|....*....
gi 568960649  835 ikesqNVDFVCSVLVVADQLLITRLKEIC 863
Cdd:cd18256    87 -----TVSNVQELLVAADMLQLTEVVEIC 110
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-123 5.33e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 5.33e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649    57 HLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHgVSLYMQDkEGLSPL 123
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTAL 65
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-853 5.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 52.62  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQSEILKVILDYLYTDEAVVIKESQnvDFVCSV 847
Cdd:cd18287    24 DVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEAFKALLKYIYTGRLTLTDLKE--DVLLDV 99


                  ....*.
gi 568960649  848 LVVADQ 853
Cdd:cd18287   100 LGLAHQ 105
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-875 7.00e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 52.09  E-value: 7.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQSEILKVILDYLYTDEAVVIKesqnvDFVC 845
Cdd:cd18352    13 LSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITN-----DIAK 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 568960649  846 SVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18352    86 DLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 759-876 7.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 52.68  E-value: 7.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  759 LSQKKCSF----LYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEaVV 834
Cdd:cd18274    10 LQQLKAMYdegqLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSR-VT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568960649  835 IKESQnvdfVCSVLVVADQLLITRLKEICEVALTENLTLKNA 876
Cdd:cd18274    89 LTEAN----VQALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-673 8.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 51.91  E-value: 8.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  549 EFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-----GSSLELTDVyqkDEDAagchlfvvekv 623
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaeskQDSITIKDI---DEEA----------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  624 hpdlFEYLLQFMYTDTCDLLTHGFKPRMI------VKRKAEDCEGSPDSHLHTVNC 673
Cdd:cd18238    67 ----VELLVDFAYTGKLTLTVDNVQSLLYaasllqVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-871 1.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 51.76  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKEsqNVDFvcsVL 848
Cdd:cd18253    20 DVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE--NVQY---LF 93

                          90       100
                  ....*....|....*....|...
gi 568960649  849 VVADQLLITRLKEICEVALTENL 871
Cdd:cd18253    94 ETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-863 1.92e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 50.74  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEassCAALEMPIQS---EILKVILDYLYTdeAVVIKESQNVDf 843
Cdd:cd18247    19 LCDVTLK-VGDQKFSAHRIVLAATIPYFHAMFTHDMVE---SKQDEITMQGiepSALEALINFAYS--GRIAIDTSNVQ- 91

                          90       100
                  ....*....|....*....|
gi 568960649  844 vcSVLVVADQLLITRLKEIC 863
Cdd:cd18247    92 --SLLVGASFLQLQSVKDAC 109
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-650 2.24e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 51.99  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLretdEMDSFHDVTFQVG--NRHFPAHKYILAVRSDFF------------QKLFLSDGSSLELTDVyQKDEDAA 613
Cdd:cd18308    12 DDFGRLL----ESRQFCDVEFIVGeeEERIPAHIAFVAARSKWLrnkilqarerqkQKAEQEVEDEGSEADS-SSASKND 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568960649  614 GCHLFV-VEKVHPDLFEYLLQFMYTDTCDLLTHGFKPR 650
Cdd:cd18308    87 SPMLEVrLPEADPEAFELILSFIYTDKIDPTRKGQDPG 124
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-870 2.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 50.74  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKSVdGKEFSCHKCVLCaRLEYFHSMLSRSWIEA-SSCAALEMP---IQSEILKVILDYLYTDEaVVIKESQnvdfV 844
Cdd:cd18305    17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDE-IEIKPSR----V 89

                          90       100
                  ....*....|....*....|....*.
gi 568960649  845 CSVLVVADQLLITRLKEICEVALTEN 870
Cdd:cd18305    90 VSILAAATLLQLDGLIQQCSEVMKET 115
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 3.34e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 3.34e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649   47 VKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   181 ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 3.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 50.49  E-value: 3.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAvvikesQNVDFVC-SVLVVADQ 853
Cdd:cd18342    29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMAdDLLAAADK 102

                          90       100
                  ....*....|....*....|...
gi 568960649  854 LLITRLKEICEVALTENLTLKNA 876
Cdd:cd18342   103 YALERLKVMCEDALCSNLSVENA 125
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 764-880 4.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 50.59  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  764 CSFLYDVTMKSV-------DGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEavVIK 836
Cdd:cd18273    23 ARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568960649  837 ESQNVDfvcSVLVVADQLLITRLKEICEVALTENLTLKNAAMLL 880
Cdd:cd18273   101 SEANVQ---RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-867 4.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 50.02  E-value: 4.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASS-CAALEmPIQSEILKVILDYLYTDE-------AVVIKESQN 840
Cdd:cd18280    16 DVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIE-DVEPPVFKALLHFIYKDElpddvepAGSDSSSLD 93

                          90       100
                  ....*....|....*....|....*..
gi 568960649  841 VDFVCSVLVVADQLLITRLKEICEVAL 867
Cdd:cd18280    94 TTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-875 4.82e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 50.13  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  752 KTGNKLKLSQKKCsflyDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDE 831
Cdd:cd18242    10 NTMNSLRKSNTLC----DVTLR-VEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTET 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568960649  832 AVVikesqNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18242    85 VHV-----TVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 4.98e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 49.56  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  768 YDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScaaLEMPIQS---EILKVILDYLYTDEaVVIKESQNVDfv 844
Cdd:cd18298    13 SDLKFR-VDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK---NVIEIDQysyPVYYAFLRYLYTDQ-VDLPPEDAIG-- 85

                          90       100
                  ....*....|....*....|
gi 568960649  845 csVLVVADQLLITRLKEICE 864
Cdd:cd18298    86 --LLDLANSYCEERLKKLCE 103
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 6.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 49.59  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKV---ILDYLYTDEAVVikesqNVDF 843
Cdd:cd18292    17 LSDIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekFLRYLYTGQISV-----NLET 90

                          90       100
                  ....*....|....*....|.
gi 568960649  844 VCSVLVVADQLLITRLKEICE 864
Cdd:cd18292    91 ALPLLMLADKYNVTDLKQLCV 111
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 7.77e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.41  E-value: 7.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdvyqKDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMF--------------ADEGEVGQSIYMLEGMVAETFGALLEFIYT 83
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 8.75e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 49.46  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFEYLLQ 633
Cdd:cd18341    18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEV-------------VLDNVDPNIMDMILK 84


                  ....*....
gi 568960649  634 FMYTDTCDL 642
Cdd:cd18341    85 YLYSAEIDL 93
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 8.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 49.31  E-value: 8.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASscaalempiQSEI---------LKVILDYLYTDEAVVike 837
Cdd:cd18255    18 LLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRESS---------QDEIelkgvsakgLKHILDFAYTSELTL--- 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568960649  838 sqNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18255    85 --DLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 9.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 48.55  E-value: 9.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  565 DVTFQVGN----RHFPAHKYILAVRSDFFQKLFLSDgssleLTDvyQKDEdaagchlFVVEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18282     9 DVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFYGG-----LAE--NKNE-------IEIPDVEPAAFLNLLRYLYCDEI 74


                  ..
gi 568960649  641 DL 642
Cdd:cd18282    75 DL 76
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 1.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.06  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLretdEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDL 627
Cdd:cd18279     7 EDLGNLW----ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-------------VDPEV 69

                          90
                  ....*....|
gi 568960649  628 FEYLLQFMYT 637
Cdd:cd18279    70 FKEMMRFIYT 79
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 765-863 1.07e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 48.78  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  765 SFLYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQSEILKVILDYLYTDEAvvikESQnVDF 843
Cdd:cd18295    17 GSYSDVTF-NVHGESFPAHRCILSARSPYFAEMFETKWKD-KREINLKHPlVNPDAFRALLQYLYTGRL----EIH-VDD 89

                          90       100
                  ....*....|....*....|....
gi 568960649  844 VCSVLVVADQ----LLITRLKEIC 863
Cdd:cd18295    90 VEDCKRLAKQcrleELIEELEAKC 113
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 48.84  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgsslelTDVYQKDedaagchLFVVEKVHPDLFEYLLQ 633
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF---------QDFTQEP-------LVEIEGVSNMAFRHLIE 72


                  ....
gi 568960649  634 FMYT 637
Cdd:cd18221    73 FTYT 76
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-871 1.35e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 48.31  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVdfvcS 846
Cdd:cd18360    10 LADVVFK-IQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASILQAM----A 84

                          90       100
                  ....*....|....*....|....*
gi 568960649  847 VLVVADQLLITRLKEICEVALTENL 871
Cdd:cd18360    85 LLICAEMYQVSRLQHICELYIITQL 109
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-637 1.56e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 47.98  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLREtdemDSFHDVTFQVGNRH-FPAHKYILAVRSDFFQKLFLSdgssleLTDVyQKDEDaagchlfvvekVHPD 626
Cdd:cd18299     1 EDLRNLLHS----PSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLM------MTVV-TLDSD-----------ITPE 58

                          90
                  ....*....|.
gi 568960649  627 LFEYLLQFMYT 637
Cdd:cd18299    59 AFRRVLEFLYT 69
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 48.59  E-value: 1.73e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-------------ELQGLTASTMEILLDFVYTET 84
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 2.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 48.41  E-value: 2.72e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGchlfvvekvhpdlFEYLLQFMYTDTCDL 642
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATG-------------FSHVLQFMYYGTIEL 96
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-876 3.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 47.64  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCsflyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVV 834
Cdd:cd18306    10 NALRKNRQFC----DVIL-QVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568960649  835 ikesqNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKNA 876
Cdd:cd18306    85 -----PADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 3.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 47.70  E-value: 3.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlSDGssleltdVYQKDEDAAGCHlfvvEKVHPDLFEYLLQFMYT 637
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMF-SNG-------LRESLDSTVNFH----DSLHPEVLELLLDFAYS 84
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 3.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 46.98  E-value: 3.27e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKD-------------VDPDALWTLVQYCYTGRLEL 67
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 757-871 3.28e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 48.45  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  757 LKLSQKKCSFLyDVTMKSvDGKEFSCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQSEILKVILDYLYTDEAVVI 835
Cdd:cd18267    31 LNLLRQQRLFT-DVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESqDSEVNFHDSIHPEVLELLLDYAYSSRVIIN 108

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568960649  836 KESQNvdfvcSVLVVADQLLITRLKEICEVALTENL 871
Cdd:cd18267   109 EENAE-----SLLEAGDMLEFQDIRDACAEFLEKNL 139
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 565-637 3.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 46.39  E-value: 3.33e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSlELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALLKETPPD-EHPVIILPD-------------VPYSELKALLDFIYT 61
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 3.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 47.90  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASScAALEM-PIQSEILKVILDYLYTDEAVVIKEsqNVDfvc 845
Cdd:cd18259    32 LSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESIS-ARVEIkDVDPAVMESLIDFAYTGKLTINQG--NVE--- 104

                          90       100       110
                  ....*....|....*....|....*....|
gi 568960649  846 SVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18259   105 ALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
143-192 3.61e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.20  E-value: 3.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568960649   143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFsrSGVYVKQVVLCKFHSVFL 192
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGL--SGNKVVQVACGGDHTVAL 50
Ank_4 pfam13637
Ankyrin repeats (many copies);
57-102 4.15e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 4.15e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568960649    57 HLASSCGKKGVLDWLIEKGVDLLVKDkESGWTALHRSVFYGHIDCV 102
Cdd:pfam13637    6 HAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVL 50
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 4.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 47.15  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLretdEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-----GSSLELTDVYQkdedaagchlfvvek 622
Cdd:cd18345     7 DDLGLLF----ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEmeerkQNRVEITDVDH--------------- 67

                          90
                  ....*....|....*
gi 568960649  623 vhpDLFEYLLQFMYT 637
Cdd:cd18345    68 ---EVMREMLRFIYT 79
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-125 4.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 4.82e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568960649    71 LIEKGVDLLVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 5.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 46.51  E-value: 5.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  565 DVTFQVG----NRHFPAHKYILAVRSDFFQKLFLSDGSsleltdvyqkdEDAAGCHlfvVEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18349    10 DVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLA-----------EVKSEIH---IPDVEPAAFLILLKYMYSDEI 75


                  ..
gi 568960649  641 DL 642
Cdd:cd18349    76 DL 77
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-875 6.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 46.93  E-value: 6.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCSFLyDVTMKSVDgKEFSCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQSEILKVILDYLYTDEAV 833
Cdd:cd18254    11 THLNTLRKQCMFT-DVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSRII 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568960649  834 VIKESQNvdfvcSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18254    89 INEENAE-----SLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 125
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-863 7.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 46.65  E-value: 7.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  762 KKCSFLYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKEsqNV 841
Cdd:cd18235    16 RKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEE--NV 92

                          90       100
                  ....*....|....*....|..
gi 568960649  842 DfvcSVLVVADQLLITRLKEIC 863
Cdd:cd18235    93 Q---VLLPAANLLQLTDVRDAC 111
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-875 1.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 46.33  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  766 FLYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLsRSWIEASSCAALEMPIQSEI-LKVILDYLYTDEAvvikeSQNVDFV 844
Cdd:cd18264    27 FLCDVVLE-AEGNEFPAHRSLLACSSDYFRALF-KDYTQESKARVIHLPVVSAAgLQRVLDFIYTSWL-----SLSLDTL 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568960649  845 CSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18264   100 EDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 761-863 1.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 44.64  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSflyDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEaVVIKESQN 840
Cdd:cd18314     3 DSEFS---DVVLC-VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQ-VTLSEENV 77

                          90       100
                  ....*....|....*....|...
gi 568960649  841 VDfvcsVLVVADQLLITRLKEIC 863
Cdd:cd18314    78 LD----LLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 1.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 45.86  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFEYLLQ 633
Cdd:cd18269    18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEV-------------VLEDVDPDVMGMILK 84


                  ....*....
gi 568960649  634 FMYTDTCDL 642
Cdd:cd18269    85 YLYTSEIDL 93
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 1.77e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 45.13  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDvyqkdedaagchlfvVEKVHPDLFEYLLQ 633
Cdd:cd18217     9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLD---------------QSQVSADGFQKLLE 73


                  ....*....
gi 568960649  634 FMYTDTCDL 642
Cdd:cd18217    74 FIYTGNLNL 82
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 553-637 1.82e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 46.15  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  553 LLRETDemDSFHDVTFQV-GNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDV-YQKDEdaagchLFVVEKVHPDLFEY 630
Cdd:cd18310    10 LLDSPD--LFYSDAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRE------LIPGGIVGYDAFML 81


                  ....*..
gi 568960649  631 LLQFMYT 637
Cdd:cd18310    82 VLSYLYS 88
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-863 1.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 45.45  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  750 AKKTGNKLKlSQkkcSFLYDVTMKSVDgKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYT 829
Cdd:cd18338     8 AFKVMNELR-SQ---NLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYT 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568960649  830 DEAVVIKESQNVdfvcsVLVVADQLLITRLKEIC 863
Cdd:cd18338    83 AEIQVTEENVQV-----LLPAAGLLQLQDVKKTC 111
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 871-923 3.06e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 44.14  E-value: 3.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568960649  871 LTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKEL 53
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 3.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 44.61  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLretdEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDL 627
Cdd:cd18343    10 EDLGNLW----ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND-------------VDPEV 72

                          90
                  ....*....|
gi 568960649  628 FEYLLQFMYT 637
Cdd:cd18343    73 FKEMMRFIYT 82
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 3.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 44.59  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVikesqNVDFVCS 846
Cdd:cd18238    15 LCDVTLK-VGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL-----TVDNVQS 88

                          90
                  ....*....|....*...
gi 568960649  847 VLVVADQLLITRLKEICE 864
Cdd:cd18238    89 LLYAASLLQVEEVAKACC 106
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 562-644 4.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 44.19  E-value: 4.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  562 SFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlSDGSSLELTDVYQKDEdaagchlfvvekVHPDLFEYLLQFMYTDTCD 641
Cdd:cd18297    11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSML-SSGSTEAQTPVIEIPD------------IRYDIFQLMMQYLYTGGVE 77


                  ...
gi 568960649  642 LLT 644
Cdd:cd18297    78 SLD 80
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 4.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 44.24  E-value: 4.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKsVDGKEFSCHKCVLCARleyfhsmlSRSWIEASSCAALEMP---IQSEILKVILDYLYTDEavvIKESQNVDFVC 845
Cdd:cd18303    20 DITIK-LADKSIPAHKFVLAAR--------SEKWSNENLASTNELDlsdISYEVVLALLRWLYTDE---LDLTLDDEFLL 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 568960649  846 SVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18303    88 ELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-639 5.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 44.08  E-value: 5.50e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlSDGSSLELTDVyqkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18228    19 FCDVTIRVQDKIFRAHKVVLAACSDFFRSKL-VGQASPRLVLV-----SPAGKCVLDLHHVTVTGFAPLLEYAYTST 89
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 6.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 44.44  E-value: 6.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-----GSSLELTDvyqkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18259    32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvesiSARVEIKD------------------VDPAVMESLIDFAYT 93
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 6.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 43.63  E-value: 6.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLYDVTMKSvDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP-IQSEILKVILDYLYTDEAVVIKESQ 839
Cdd:cd18293     9 QQNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQgLKAHTLLKLVDFLYTSELEVSSEEA 87

                          90       100
                  ....*....|....*....|....
gi 568960649  840 NvdfvcSVLVVADQLLITRLKEIC 863
Cdd:cd18293    88 Q-----DVLAAARRLQISELESLC 106
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-843 6.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 42.54  E-value: 6.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLsrswIEASSC--AALEMP-IQSEILKVILDYLYTDEaVVIKESQNVDF 843
Cdd:cd18315     1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALL----KETPPDehPVIILPdVPYSELKALLDFIYTGE-VNVSQEQLESL 74
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 6.72e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 43.81  E-value: 6.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP---IQSEILKVILDYLYTDEAVVikESQNVDfvcSVLVVA 851
Cdd:cd18258    24 VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTmsnINADVLELLLEFVYTGSLII--DSANAK---TLLEAA 98

                          90       100
                  ....*....|....*....|....
gi 568960649  852 DQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18258    99 NKFQFHTFCKVCVSFLEKQLTASN 122
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-640 6.72e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 44.12  E-value: 6.72e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSslELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDTC 640
Cdd:cd18213    23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSS--ECIKIQPTD-------------IQPDIFSYLLHIMYTGKG 83
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 6.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 44.02  E-value: 6.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-----GSSLELTDVYqkdedaagchlfvvekvhPDLFEYLLQFMYTDT 639
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNmteskSSEVELKDAE------------------PDIIELLVEFAYTAR 84


                  ...
gi 568960649  640 CDL 642
Cdd:cd18237    85 ISV 87
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-864 6.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 43.80  E-value: 6.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEM-PIQSEILKVILDYLYTDEAVVIKESqnvdfVCSV 847
Cdd:cd18207    29 DVLLR-VGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTSRIVVRLES-----FPEL 102

                          90
                  ....*....|....*..
gi 568960649  848 LVVADQLLITRLKEICE 864
Cdd:cd18207   103 MTAAKFLLMRSVIDICQ 119
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-841 1.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 43.10  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  752 KTGNKLKLSQKKCsflyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQSEILKVILDYLYTDE 831
Cdd:cd18204     7 KTLNEQRLEGEFC----DIAI-VVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF-LRSDIFEEVLNYMYTAK 80

                          90
                  ....*....|
gi 568960649  832 AVVIKESQNV 841
Cdd:cd18204    81 ISVKKEDVNL 90
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 752-869 1.33e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 43.03  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  752 KTGNKLKLSQKKCSFlYDVTMKSVDGKeFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDE 831
Cdd:cd18358     6 RKANRIKECLSKGTF-SDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568960649  832 avvIKESQNVDFVcSVLVVADQLLITRLkeiceVALTE 869
Cdd:cd18358    84 ---LSPTADLDPL-ELIALANRFCLPHL-----VALTE 112
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 42.67  E-value: 1.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdVYQKDEdaagCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18193    23 DCTVAIGDVYFKAHKSVLASFSNYFKMLF-----------VHQTSE----CVRLKPTDIQPDIFSYLLHLMYT 80
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 1.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 43.44  E-value: 1.46e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsDGSSLELTDVYQKDEDAagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18267    40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMF--SGGLKESQDSEVNFHDS----------IHPEVLELLLDYAYS 102
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 1.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 42.90  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQSEILKVILDYLYTDEAVVikESQNVDfvcSVLVVADQ 853
Cdd:cd18340    34 IKEKEFPCHRLVLAACSPYFRAMF-LSDLEESKKREIVLEdVDPDVMGKILHYIYTSEIEI--TEQNVQ---DIFAAANM 107

                          90       100
                  ....*....|....*....|..
gi 568960649  854 LLITRLKEICEVALTENLTLKN 875
Cdd:cd18340   108 FQIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-639 1.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 42.55  E-value: 1.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSslELTDVYQKDedaagchlfvveKVHPDLFEYLLQFMYTDT 639
Cdd:cd18209    18 LCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKEN--ESQSVFQLD------------FCEPDAFENVLNYIYSSS 80
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 42.62  E-value: 1.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSdGSSLELTDVYQKDedaagchlFVVekvhPDLFEYLLQFMYTDT 639
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEID--------FVS----AEALTALLDFAYTAT 88
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 42.72  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEmpiqseiLKVILDYLYTDEAVVikesqNVDFVCSVL 848
Cdd:cd18243    34 DVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANVTL-----SLDTVEEVL 100

                          90       100
                  ....*....|....*....|....*..
gi 568960649  849 VVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18243   101 SVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 552-642 1.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 42.33  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  552 KLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdVYQKDEDAAGCHLFVVEKVHPDLFEYL 631
Cdd:cd18245     3 RALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKL-----------NYNPPKDDGSTYKIELEGISVEVMEEI 71

                          90
                  ....*....|.
gi 568960649  632 LQFMYTDTCDL 642
Cdd:cd18245    72 LDYIYTGQIKL 82
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 2.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 42.64  E-value: 2.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGssleltdvyqkdEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18207    27 FCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQE------------GDGGTPRELEMHTISSKVFGDILDFAYT 89
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-871 2.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 42.37  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCSFLYDVTMKSVDgKEFSCHKCVLCARLEYFHSMLSRSWIEassCAALEMPIQS---EILKVILDYLYTDE 831
Cdd:cd18248    13 NELRLSQQLCDVTLKVKYQDPK-EEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIEGvhpCVMSRLIEFAYTAS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568960649  832 AVVIKESqnvdfVCSVLVVADQLLITRLKEICEVALTENL 871
Cdd:cd18248    89 ISVGEKC-----VLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-863 2.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 41.71  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  774 SVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQ---SEILKVILDYLYTDEaVVIKEsQNVDfvcSVLVV 850
Cdd:cd18307     7 SVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylsPETVEQLLDYFYTGK-IVISE-KNVE---DLLKG 81

                          90
                  ....*....|...
gi 568960649  851 ADQLLITRLKEIC 863
Cdd:cd18307    82 AKYFNIPRLKDHC 94
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
233-260 2.41e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 39.33  E-value: 2.41e-04
                           10        20
                   ....*....|....*....|....*...
gi 568960649   233 QVAAAKDHTVVLTDDGCVYTFGLNMFHQ 260
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 2.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 42.37  E-value: 2.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  565 DVTFQVGNRH----FPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18248    23 DVTLKVKYQDpkeeFMAHKVVLASSSPYFKAMFTSGLRECGMEVV-------------PIEGVHPCVMSRLIEFAYT 86
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 2.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 41.76  E-value: 2.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQ-KLFLSDGSSLELTDVyqkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18200    18 FCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNCLVLPSV-----------------IEAAAFENLLQLIYS 76
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 561-642 2.79e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 41.86  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  561 DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsDGSSLEltdvyqkdEDAAGCHLfvvEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18286    15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAML--SGSWAE--------SNSSEITL---TGVSHAAVSFVLLFIYGGVL 81


                  ..
gi 568960649  641 DL 642
Cdd:cd18286    82 DL 83
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 769-864 3.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 41.42  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMKSVDGKEFSCHKCVLCARLEYFHSMlsrSWIEASSCAALEMP--IQSEILKVILDYLYTDEAVVIKESqnvdfVCS 846
Cdd:cd18311    16 DLTLQFRDNEQLKVHRLVLSACTDYFNVL---EQTCEIVDDTLIMPneLQADAVVPVINFMYTGQLEFEEKS-----YGK 87

                          90
                  ....*....|....*...
gi 568960649  847 VLVVADQLLITRLKEICE 864
Cdd:cd18311    88 LLRTAKELNMTVLLKLLE 105
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 542-637 3.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 41.88  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  542 SSSSF--FEEF---GKLLretdemdsfhDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDgssleLTDVYQKDedaagch 616
Cdd:cd18247     3 PSSGFpvMEEIrrqGKLC----------DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHD-----MVESKQDE------- 60

                          90       100
                  ....*....|....*....|.
gi 568960649  617 lFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18247    61 -ITMQGIEPSALEALINFAYS 80
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 553-637 3.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 42.06  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  553 LLRETDEM---DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedaagchlfVVEKVHPDLFE 629
Cdd:cd18250     8 LLRGLSELraeRKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRV-------------VLHGVSAEILG 74


                  ....*...
gi 568960649  630 YLLQFMYT 637
Cdd:cd18250    75 LLLDFSYT 82
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-864 3.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 41.47  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  774 SVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESqnvdfVCSVLVVADQ 853
Cdd:cd18353    26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPED-----AIGLLDLATS 100

                          90
                  ....*....|.
gi 568960649  854 LLITRLKEICE 864
Cdd:cd18353   101 YCENRLKKLCQ 111
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 4.29e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 4.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649   59 ASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 5.58e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 41.71  E-value: 5.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSdgssleltdvYQKDEDAAGCHLFVVEKVHpdlFEYLLQFMYT 637
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKD----------YTQESKARVIHLPVVSAAG---LQRVLDFIYT 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-123 6.71e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.40  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   43 NAATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSP 122
Cdd:COG0666    45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123


                  .
gi 568960649  123 L 123
Cdd:COG0666   124 L 124
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-831 7.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 40.94  E-value: 7.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  767 LYDVTMKSvDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDE 831
Cdd:cd18276    21 LTDVVLVA-EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSD 84
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 7.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 41.03  E-value: 7.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVV-IKESQNvdfvcsV 847
Cdd:cd18272    34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLrVEELQE------T 106

                          90       100
                  ....*....|....*....|....*...
gi 568960649  848 LVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18272   107 YEVADMYQLTALFEECSRFLARTVQVRN 134
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 8.28e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 40.88  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  565 DVTFQVGN----RHFPAHKYILAVRSDFFQKLF---LSDGSS-LELTDVyqkdEDAAgchlfvvekvhpdlFEYLLQFMY 636
Cdd:cd18281    24 DVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFnggMATTSAeIELPDV----EPAA--------------FLALLRFLY 85


                  ....*.
gi 568960649  637 TDTCDL 642
Cdd:cd18281    86 SDEVQI 91
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-834 9.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.17  E-value: 9.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960649  761 QKKCSFLyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSwiEASSCAALEMpIQSEILKVILDYLYTDEAVV 834
Cdd:cd18226    17 QKQSSFC-DLVI-TVEGKEFSAHKVVVAVGSSYFHACLSKN--PNTDAVTLDH-VSYSVFQHLLEFLYTSEFFV 85
Ank_4 pfam13637
Ankyrin repeats (many copies);
86-124 9.53e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 9.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568960649    86 GWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLD 124
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 40.23  E-value: 1.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSsleltdvyqkdedAAGCHLFVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKKLFTSGAV-------------VDQQNVYEIDFVSPEALTALLEFAYTAT 88
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 1.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 40.59  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDgssleLTDVYQKDedaagchlFVVEKVHPDLFEYLLQ 633
Cdd:cd18340    18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSD-----LEESKKRE--------IVLEDVDPDVMGKILH 84


                  ....
gi 568960649  634 FMYT 637
Cdd:cd18340    85 YIYT 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-123 1.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.12  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   17 HALDVLSVVTKGSESQIKSFLARYCynAATVKDAFGRNAGHLASSCG--KKGVLDWLIEKGVDLLVKDK----------- 83
Cdd:PHA03100  108 TPLLYAISKKSNSYSIVEYLLDNGA--NVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvpi 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568960649   84 ----ESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03100  186 nikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 872-923 1.29e-03

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.03  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568960649  872 TLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLEL 52
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 777-831 1.32e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 39.24  E-value: 1.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  777 GKEFSCHKCVLCARLEYFHSMLSRSW-IEASSCAALEM-PIQSEILKVILDYLYTDE 831
Cdd:cd18283    11 GTCFPVHRAILSARCPFFRDLLSSSPgYGAEIPVDLPTaGIDVPMFSALLRYLYTGE 67
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 559-660 1.38e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 40.37  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  559 EMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGCHLFVVEKVHPDLF--EYLLQFMY 636
Cdd:cd18270    22 EQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAinDSTVEQLY 101

                          90       100
                  ....*....|....*....|....*...
gi 568960649  637 TDTCDL----LTHGFKPRMIVKRKAEDC 660
Cdd:cd18270   102 ETACFLqvedVLQRCREYLIKKINAENC 129
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-829 1.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 39.47  E-value: 1.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568960649  767 LYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYT 829
Cdd:cd18215    19 LTDVVL-VVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 67-157 1.74e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   67 VLDWLIEKGVDLLVKDKeSGWTALHR--SVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDLLMKDRPTHV------VFKD 138
Cdd:PHA03095   99 VIKLLIKAGADVNAKDK-VGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVellrllIDAG 177

                          90
                  ....*....|....*....
gi 568960649  139 TDPTEVytwgDNTNFTLGH 157
Cdd:PHA03095  178 ADVYAV----DDRFRSLLH 192
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 1.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 39.53  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLYDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRsWIEAS---SCAALEMpIQSEILKVILDYLYTDEAVVIKE 837
Cdd:cd18330    12 QRKRDFFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIH-YIQDSgrhSTASLDI-VTSEAFSIILDFLYSGKLDLCSE 88

                          90       100
                  ....*....|....*....|....*..
gi 568960649  838 SqnvdfVCSVLVVADQLLITRLKEICE 864
Cdd:cd18330    89 N-----VIEVMSAASYLQMTDVVNFCK 110
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 745-875 1.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 39.96  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  745 KINVIAKKTGNKLK---LSQKKCSflyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQSEILK 821
Cdd:cd18351     2 KLTEIKRKQTSRLDphfLNNKEMS---DVTF-LVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISY-VKYHIFQ 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  822 VILDYLYT--DEAVVIKESQnvdfVCSVLVVADQLLITRLKEICEVALTENLTLKN 875
Cdd:cd18351    77 LVMQYLYCggTESLLIKNNE----IMELLSAAKFFQLEALQRHCEIICAKSINTEN 128
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 575-638 1.93e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.85  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  575 FPAHKYILAVRSDFFQKLFLSdgssleltdvyqkdEDAAGCHLFV---VEKVHPDLFEYLLQFMYTD 638
Cdd:cd18283    14 FPVHRAILSARCPFFRDLLSS--------------SPGYGAEIPVdlpTAGIDVPMFSALLRYLYTG 66
BACK_RCBTB1_2 cd18498
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, ...
 871-923 2.03e-03

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.


Pssm-ID: 350573  Cd Length: 64  Bit Score: 38.03  E-value: 2.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568960649  871 LTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd18498     1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDF 53
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 779-831 2.12e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 40.02  E-value: 2.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960649  779 EFSCHKCVLCARLEYFHSMLSRSWIEASSCAAL--------EMPIQSEILKVILDYLYTDE 831
Cdd:cd18284    29 ELRCHKAILSARSPFFRNLLQRRIRTGEDRTLStptrivldESIIPRRYARVLLHAMYTDS 89
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 552-637 2.18e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 38.87  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  552 KLLREtdEMdsFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLEltdvyqKDEdaagchLFVVEKVHPDLFEYL 631
Cdd:cd18285     8 RLLRE--EL--HTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGKLSSLE------DQE------PINIENLEASEFKTF 71


                  ....*.
gi 568960649  632 LQFMYT 637
Cdd:cd18285    72 LRQVYT 77
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-641 2.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 39.23  E-value: 2.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELtdvyqkdedaagcHLFVVEKVHPDLFEYLLQFMYTDTCD 641
Cdd:cd18240    19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK-------------KVYKIPGVSPEMMELIIEYAYTRTVP 82
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 561-642 2.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 39.45  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  561 DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdvyqkdEDAAGCHLFVVE---KVHPDLFEYLLQFMYT 637
Cdd:cd18331    22 DILTDVVIVVSREQFRAHKTVLMACSGLFYSIF----------------TDQLKCNLSVINldpEINPEGFNILLDFMYT 85


                  ....*
gi 568960649  638 DTCDL 642
Cdd:cd18331    86 SRLNL 90
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-879 2.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 39.82  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  775 VDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKEsqNVDFvcsVLVVADQL 854
Cdd:cd18271    31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD--NVEM---FFQMSSFL 105

                          90       100
                  ....*....|....*....|....*
gi 568960649  855 LITRLKEICEVALTENLTLKNAAML 879
Cdd:cd18271   106 QVSLLSKACSDFLIKSIDLTNCLQL 130
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 563-595 2.26e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.68  E-value: 2.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLS 595
Cdd:cd18309    20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRS 52
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-841 2.51e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 39.00  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLYDVTMKSVDGKeFSCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQSEILKVILDYLYTDEaVVIKESQ 839
Cdd:cd18223    12 QRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISS-HVLELPdLKAEVFAEILNFIYSSK-VVVKRQE 88


                  ..
gi 568960649  840 NV 841
Cdd:cd18223    89 TV 90
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-872 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 39.56  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  761 QKKCSFLYDVTMKSVDGKeFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEaVVIKESQN 840
Cdd:cd18261    22 QRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQ-ILLEPGVI 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568960649  841 VDfvcsVLVVADQLLITRLKEICEVALTENLT 872
Cdd:cd18261   100 QD----VLAAGSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-864 2.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 39.06  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  755 NKLKLSQKKCsflyDVTMkSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP--IQSEILKViLDYLYTDEA 832
Cdd:cd18202    11 NQQRLNNQFC----DVTL-LIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSgfCKSSFLPL-LEFAYTSEL 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568960649  833 VvikesqnVDFvCS---VLVVADQLLITRLKEICE 864
Cdd:cd18202    85 T-------FDF-CSmaeVAMLARHLFMNEVLEICE 111
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 538-639 2.91e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 39.06  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  538 IPVVSSSSffeEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVyqkdedAAGCHL 617
Cdd:cd18327     3 IPFPEHSS---ELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA------GGGQDV 73

                          90       100
                  ....*....|....*....|..
gi 568960649  618 FVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18327    74 CELDFVGPEALGALLEFAYTAT 95
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-636 3.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 39.04  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQkdedaagchlfvvEKVHPDLFEYLLQ 633
Cdd:cd18323    14 LREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINN-------------EIVTAPAFSLLLE 80


                  ...
gi 568960649  634 FMY 636
Cdd:cd18323    81 FMY 83
BACK_AtBPM-like cd14736
BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The ...
 869-918 3.19e-03

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350516  Cd Length: 62  Bit Score: 37.32  E-value: 3.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568960649  869 ENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSED 918
Cdd:cd14736     2 EGVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKES 51
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 3.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 39.26  E-value: 3.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSleltdvyQKDEDAAgchlfvVEKVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVRE-------AKQEEIK------MEGVDPDALKALVHYAYTGVLEL 85
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 3.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 39.05  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  548 EEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-GSSLELtdvyqkdedaagchLFVVEKVHPD 626
Cdd:cd18253     3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDhRESREM--------------LVEINGILAE 68

                          90
                  ....*....|.
gi 568960649  627 LFEYLLQFMYT 637
Cdd:cd18253    69 AMDCFLQYVYT 79
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-637 3.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 38.86  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  550 FGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdvyqKDEDAAGCHLFVVEKVHPDLFE 629
Cdd:cd18204     5 FLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF--------------KKLEVDSSSVIEIDFLRSDIFE 70


                  ....*...
gi 568960649  630 YLLQFMYT 637
Cdd:cd18204    71 EVLNYMYT 78
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 552-637 3.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 38.59  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  552 KLLRETD---EMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlSDGSSLELtdvyqkdedaagchlfVVEKVHPDLF 628
Cdd:cd18232     4 KVLQALNkqrEEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY-GDGTSGSV----------------VLPESFAEVF 66


                  ....*....
gi 568960649  629 EYLLQFMYT 637
Cdd:cd18232    67 GLLLDFFYT 75
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 4.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 38.37  E-value: 4.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssLELTDVYQKD-EDAAGchlfvvekvhpdlFEYLLQFMYT 637
Cdd:cd18206    24 DCTFVVDGVDFKAHKAVLAACSEYFRMLF------VDQKDVVHLDiSNAAG-------------LGQVLEFMYT 78
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-644 4.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 38.78  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdgssleltdVYQKDEDAAGChlFVVEKVHPDLFEYLLQFMYTD---- 638
Cdd:cd18344    23 FTDCCLLVAGHEFRAHKAILAARSPVFRAMF-----------EHEMEERLKNP--IEIHDLDPQVFKEMMGFIYTGkaph 89

                          90
                  ....*....|..
gi 568960649  639 ------TCDLLT 644
Cdd:cd18344    90 lhshsmACDVLA 101
Ank_5 pfam13857
Ankyrin repeats (many copies);
37-91 4.18e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 4.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568960649    37 LARYCYNAATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKEsGWTALH 91
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE-GLTALD 54
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 561-640 4.24e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 38.50  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  561 DSFHDVTFQ-VGNRHFPAHKYILAVRSDFFQKLFL------SDGSSLELtdvyqkdedaagchlfvveKVHPDLFEYLLQ 633
Cdd:cd18302     3 SDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSsswieaSSCSALTM-------------------PIPSDILEIILD 63


                  ....*..
gi 568960649  634 FMYTDTC 640
Cdd:cd18302    64 YLYTDEA 70
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 86-117 4.79e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 4.79e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568960649    86 GWTALHRSV-FYGHIDCVWSLLKHGVSLYMQDK 117
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-647 4.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 38.27  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLflsdgssLELTDVYQKDEDAagchlfvvekVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18225    23 FCDCTIFIGTFHFRAHKLVLAASSLLFKSL-------LDSTDTISIDASV----------VSPEEFALLLEMVYTGKLPP 85


                  ....*
gi 568960649  643 LTHGF 647
Cdd:cd18225    86 GKHNF 90
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 563-640 5.26e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 37.99  E-value: 5.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDedaagchlfvvekVHPDLFEYLLQFMYTDTC 640
Cdd:cd18300     9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPG-------------VSKETFLALLEYLYTDQA 73
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 775-832 5.27e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 37.26  E-value: 5.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649  775 VDGKEFSCHKCVLCARLEYFhSMLSRSWIEASSCAALEMP-IQSEILKVILDYLYTDEA 832
Cdd:cd01165     5 VEGEKFHVNKELLAQSSEYF-RALFRGGFRESGQAEINLRdISPEDFRALLEFLYGGKR 62
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-836 5.33e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 37.89  E-value: 5.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLSrswiEASSCAALEMpIQSEILKVILDYLYTDEAVVIK 836
Cdd:cd18219    23 DVTV-IVEDRKFRAHKNILSASSTYFHQLFS----VAGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 5.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 38.49  E-value: 5.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYqkdedaagchlfvVEKVHPDLFEYLLQFMYTDTCDL 642
Cdd:cd18335    21 DVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIK-------------MEGIDPNALWDLVQFAYTGCLEL 85
PHA03098 PHA03098
kelch-like protein; Provisional
 765-923 5.73e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.91  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  765 SFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEAsscaALEMPIQSEILKVILDYLYTDeaVVIKESQNVDfv 844
Cdd:PHA03098    8 KFCDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLNIDYDSFNEVIKYIYTG--KINITSNNVK-- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568960649  845 cSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:PHA03098   80 -DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 5.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 37.45  E-value: 5.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  565 DVTFQVGNRHFPAHKYILAVRSDFFQKlflsdgsslelTDVYQKDEDaagchlFVV---EKVHPDLFEYLLQFMYT 637
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLS-----------RVVGQTDGD------LVItlpEEVTVKGFEPLLQFAYT 61
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 555-604 6.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 37.70  E-value: 6.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568960649  555 RETDEmdsFHDVTFQVGNRHFPAHKYILAVRSDFFQKL----FLSDGSSLELTD 604
Cdd:cd18312     4 RDTGE---PSDITVRVGNTTFHLHKFPLCSKSGYFKRLasssSESDPSEIELND 54
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-637 6.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 37.89  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  551 GKLLRETDEMDS---FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTdvyqkdedaagchlfvveKVHPDL 627
Cdd:cd18219     6 GSLLKSLNEQRGhglFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELN------------------FIRADI 67

                          90
                  ....*....|
gi 568960649  628 FEYLLQFMYT 637
Cdd:cd18219    68 FAEILNYIYS 77
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 566-642 6.67e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 36.88  E-value: 6.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568960649  566 VTFQVGNRHFPAHKYILAVRSDFFQKLFLSdgssleltdvYQKDEDAAGCHLFVVEkvhPDLFEYLLQFMYTDTCDL 642
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRG----------GFRESGQAEINLRDIS---PEDFRALLEFLYGGKRDL 64
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-863 6.91e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 38.26  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  765 SFLYDVTMKsVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVikesqNVDFV 844
Cdd:cd18251    21 GILFDVVLV-VEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELEL-----SLDNV 94

                          90
                  ....*....|....*....
gi 568960649  845 CSVLVVADQLLITRLKEIC 863
Cdd:cd18251    95 QETLTAACQLQIPEVIGFC 113
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-123 6.92e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649   25 VTKGSESQIKSFLArycYNA-ATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKeSGWTALHRSVFYGHIDCVW 103
Cdd:PHA02874  132 IKKGDLESIKMLFE---YGAdVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN-NGESPLHNAAEYGDYACIK 207

                          90       100
                  ....*....|....*....|
gi 568960649  104 SLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA02874  208 LLIDHGNHIMNKCKNGFTPL 227
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 6.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 38.26  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQkLFLSDgsSLELTDVYQKDEDAagchlfvvekVHPDLFEYLLQ 633
Cdd:cd18194    14 LREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRD--RLDKRDLVRLNSDI----------VTAPAFGLLLD 80


                  ....*....
gi 568960649  634 FMYTDTCDL 642
Cdd:cd18194    81 FMYEGRLAL 89
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-637 7.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 37.95  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  551 GKLLRETDEM---DSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGCHLFVVEKVHPDL 627
Cdd:cd18195     3 GALLLQLNEQrlrGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPERVLELPGVKAGV 82

                          90
                  ....*....|
gi 568960649  628 FEYLLQFMYT 637
Cdd:cd18195    83 FSDVLNFIYS 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
90-123 7.81e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 7.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568960649    90 LHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL 34
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-636 7.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 37.83  E-value: 7.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960649  563 FHDVTFQVGNRHFPAHKYILAVRSDFFQKLFlsdGSSLEltdvyqkdedaaGCHLFVVE--KVHPDLFEYLLQFMY 636
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMF---GGHLK------------ESRQAVVEiqKVSAAAMEVLLDYMY 83
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-649 8.41e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 37.53  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  554 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSsleltdvyqkdedAAGCHLFVVEKVHPDLFEYLLQ 633
Cdd:cd18332    10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVG-------------EGVSVLTLPSGLEARGFQLLLD 76

                          90
                  ....*....|....*.
gi 568960649  634 FMYTdTCDLLTHGFKP 649
Cdd:cd18332    77 FMYT-SRLPLTPRTVP 91
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-876 8.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 37.90  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960649  769 DVTMkSVDGKEFSCHKCVLCARLEYFHSMLS-RSWIEASSCAALEMP-IQSEILKVILDYLYTDEAvvikESQNVDF--V 844
Cdd:cd18350    26 DVTF-LVEGKLFYAHKVLLVTASNRFKSLLTnKSEQESQGSKTIEISdIKYHIFQMLMQYLYYGGT----ESMEIPIadV 100

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568960649  845 CSVLVVADQLLITRLKEICEVALTENLTLKNA 876
Cdd:cd18350   101 LELLSAASLFQLDALQRHCEILCSQTINLENA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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