KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568943186     6 PISFKDLAVRFSEEEWRLLQEGQREFYRDVMRENYETLVSVG 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42

KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568943186   403 GPMTLASRASSSPLEALEACLKGIPPGGSSPLQsLAISWSRSPQ 446
Cdd:pfam15287    1 GPMAQGASPGSSPLQGLINCLKEILVPGPQHPQ-PATSLSPPPQ 43

104 kDa microneme/rhoptry antigen; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943186  742 STGRAEEKPH-PPRREDGAERTRQPGPvtnaegkgAAAGHPSPAPQLEEKPE-PKGTEDSRDLEPGHRPPSAaaRTQGKL 819
Cdd:PTZ00449  537 SKESDEPKEGgKPGETKEGEVGKKPGP--------AKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRP--RSAQRP 606

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568943186  820 LSGDPPESPSKSPLPTTVLSKWSPTSLQPPCPCGRSLQQE 859
Cdd:PTZ00449  607 TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPE 646

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568943186     6 PISFKDLAVRFSEEEWRLLQEGQREFYRDVMRENYETLVSVG 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568943186    7 ISFKDLAVRFSEEEWRLLQEGQREFYRDVMRENYETLVS 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39

KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568943186   403 GPMTLASRASSSPLEALEACLKGIPPGGSSPLQsLAISWSRSPQ 446
Cdd:pfam15287    1 GPMAQGASPGSSPLQGLINCLKEILVPGPQHPQ-PATSLSPPPQ 43

104 kDa microneme/rhoptry antigen; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943186  742 STGRAEEKPH-PPRREDGAERTRQPGPvtnaegkgAAAGHPSPAPQLEEKPE-PKGTEDSRDLEPGHRPPSAaaRTQGKL 819
Cdd:PTZ00449  537 SKESDEPKEGgKPGETKEGEVGKKPGP--------AKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRP--RSAQRP 606

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568943186  820 LSGDPPESPSKSPLPTTVLSKWSPTSLQPPCPCGRSLQQE 859
Cdd:PTZ00449  607 TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPE 646

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568943186     6 PISFKDLAVRFSEEEWRLLQEGQREFYRDVMRENYETLVSVG 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568943186    7 ISFKDLAVRFSEEEWRLLQEGQREFYRDVMRENYETLVS 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39

KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568943186   403 GPMTLASRASSSPLEALEACLKGIPPGGSSPLQsLAISWSRSPQ 446
Cdd:pfam15287    1 GPMAQGASPGSSPLQGLINCLKEILVPGPQHPQ-PATSLSPPPQ 43

104 kDa microneme/rhoptry antigen; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943186  742 STGRAEEKPH-PPRREDGAERTRQPGPvtnaegkgAAAGHPSPAPQLEEKPE-PKGTEDSRDLEPGHRPPSAaaRTQGKL 819
Cdd:PTZ00449  537 SKESDEPKEGgKPGETKEGEVGKKPGP--------AKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRP--RSAQRP 606

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568943186  820 LSGDPPESPSKSPLPTTVLSKWSPTSLQPPCPCGRSLQQE 859
Cdd:PTZ00449  607 TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPE 646