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Conserved domains on  [gi|564395462|ref|XP_006255523|]
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exocyst complex component 3-like protein isoform X1 [Rattus norvegicus]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 193-726 1.16e-133

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 1.16e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  193 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 248
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  249 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 326
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  327 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 406
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  407 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 485
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  486 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 552
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  553 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 631
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  632 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 708
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 564395462  709 AGPPPSPSTG--RRALFSLV 726
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 193-726 1.16e-133

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 1.16e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  193 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 248
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  249 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 326
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  327 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 406
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  407 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 485
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  486 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 552
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  553 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 631
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  632 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 708
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 564395462  709 AGPPPSPSTG--RRALFSLV 726
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
290-703 8.35e-08

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 55.72  E-value: 8.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 290 ELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQLLSgPELGAADTFALLHWAlhvymgKEMMGNLELGPEADVSQL 369
Cdd:COG5173  292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 370 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEW-SREQEPTTDPSGFYHSPMPAIVLQILAENIQVtslISDSL 448
Cdd:COG5173  365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFyARNEEPSRDSDGKLVLPGTVSLFQMITQQLEP---IAFTN 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 449 HRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRG------EAVAPH-YVPYLLAAFNHQ-------SALRSSVSVLLPDGE 514
Cdd:COG5173  442 RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKqfksnpESSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTFELITSEY 521

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 515 TSGVLAPVEAALD---DVERRICRLVLEVLQAELQPLFAALPSRRWLLSselldSVYEQTLHFCKDFWRVRKPAVQ---- 587
Cdd:COG5173  522 ENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGG-----SVTKVIVDTLQDYLSDYQNTMSeylf 596

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 588 -LLLTETERTVVLHYLRALMQGRlVCRGADERSQAaerLQHDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLHDPT 664
Cdd:COG5173  597 vTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRNDDL 672

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 564395462 665 LLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 703
Cdd:COG5173  673 FI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 193-726 1.16e-133

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 1.16e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  193 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 248
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  249 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 326
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  327 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 406
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  407 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 485
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  486 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 552
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  553 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 631
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462  632 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 708
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 564395462  709 AGPPPSPSTG--RRALFSLV 726
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
290-703 8.35e-08

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 55.72  E-value: 8.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 290 ELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQLLSgPELGAADTFALLHWAlhvymgKEMMGNLELGPEADVSQL 369
Cdd:COG5173  292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 370 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEW-SREQEPTTDPSGFYHSPMPAIVLQILAENIQVtslISDSL 448
Cdd:COG5173  365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFyARNEEPSRDSDGKLVLPGTVSLFQMITQQLEP---IAFTN 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 449 HRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRG------EAVAPH-YVPYLLAAFNHQ-------SALRSSVSVLLPDGE 514
Cdd:COG5173  442 RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKqfksnpESSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTFELITSEY 521

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 515 TSGVLAPVEAALD---DVERRICRLVLEVLQAELQPLFAALPSRRWLLSselldSVYEQTLHFCKDFWRVRKPAVQ---- 587
Cdd:COG5173  522 ENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGG-----SVTKVIVDTLQDYLSDYQNTMSeylf 596

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395462 588 -LLLTETERTVVLHYLRALMQGRlVCRGADERSQAaerLQHDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLHDPT 664
Cdd:COG5173  597 vTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRNDDL 672

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 564395462 665 LLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 703
Cdd:COG5173  673 FI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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