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Conserved domains on  [gi|545706118|ref|XP_005705377|]
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acylglycerol lipase [Galdieria sulphuraria]

Protein Classification

alpha/beta hydrolase( domain architecture ID 12114401)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917|19508187|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 14-271 2.24e-57

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


:

Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 183.95  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   14 QPKACVFLIHGL--HSNTFceylepdpsQNSARRLyqnsipqllNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADT 91
Cdd:pfam12146   2 EPRAVVVLVHGLgeHSGRY---------AHLADAL---------AAQGFAVYAYDHRGHGRSDGK-RGHVPSFDDYVDDL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   92 YQYMEwITKEKYPvlkEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASnqfGVMGRILRPLSGIVSTWYPT 171
Cdd:pfam12146  63 DTFVD-KIREEHP---GLPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKP---YLAPPILKLLAKLLGKLFPR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  172 LPVLRLPKNEKF---PELQKSWDNDELnYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFD 248
Cdd:pfam12146 136 LRVPNNLLPDSLsrdPEVVAAYAADPL-VHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYE 214

                         250       260
                  ....*....|....*....|...
gi 545706118  249 KVASSDKKVVLLEGRWHILHHEP 271
Cdd:pfam12146 215 RAGSTDKTLKLYPGLYHELLNEP 237
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 14-271 2.24e-57

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 183.95  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   14 QPKACVFLIHGL--HSNTFceylepdpsQNSARRLyqnsipqllNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADT 91
Cdd:pfam12146   2 EPRAVVVLVHGLgeHSGRY---------AHLADAL---------AAQGFAVYAYDHRGHGRSDGK-RGHVPSFDDYVDDL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   92 YQYMEwITKEKYPvlkEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASnqfGVMGRILRPLSGIVSTWYPT 171
Cdd:pfam12146  63 DTFVD-KIREEHP---GLPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKP---YLAPPILKLLAKLLGKLFPR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  172 LPVLRLPKNEKF---PELQKSWDNDELnYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFD 248
Cdd:pfam12146 136 LRVPNNLLPDSLsrdPEVVAAYAADPL-VHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYE 214

                         250       260
                  ....*....|....*....|...
gi 545706118  249 KVASSDKKVVLLEGRWHILHHEP 271
Cdd:pfam12146 215 RAGSTDKTLKLYPGLYHELLNEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-286 1.29e-35

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 127.43  E-value: 1.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  14 QPKACVFLIHGLHSNtfceylepdpsqnsARRLYqnSIPQLLNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADTYQ 93
Cdd:COG2267   26 SPRGTVVLVHGLGEH--------------SGRYA--ELAEALAAAGYAVLAFDLRGHGRSDGP-RGHVDSFDDYVDDLRA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  94 YMEWITKEKypvlkEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVsqasnqfgvmgrILRPLSGIVSTWYPTLp 173
Cdd:COG2267   89 ALDALRARP-----GLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAY------------RADPLLGPSARWLRAL- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 174 vlrlpknekfpelqkswdndelnyhgklrarvgeqfmktydELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFDKvASS 253
Cdd:COG2267  151 -----------------------------------------RLAEALARIDVPVLVLHGGADRVVPPEAARRLAAR-LSP 188

                        250       260       270
                 ....*....|....*....|....*....|...
gi 545706118 254 DKKVVLLEGRWHILHHEPGKESVRQQFLQWMEE 286
Cdd:COG2267  189 DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 11-288 9.57e-32

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 119.88  E-value: 9.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  11 STIQPKACVFLIHGLhsntfceylepdpsQNSARRLYQNSiPQLLNGHGFVVFAHDHQGHGKSQGkCKGYFNSMDTLVAD 90
Cdd:PLN02298  54 SSSPPRALIFMVHGY--------------GNDISWTFQST-AIFLAQMGFACFALDLEGHGRSEG-LRAYVPNVDLVVED 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  91 TYQYMEWITKEkyPVLKEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASNQfgvmgRILRPLSGI---VST 167
Cdd:PLN02298 118 CLSFFNSVKQR--EEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKI-----RPPWPIPQIltfVAR 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 168 WYPTLPVLR----LPKNEKFPELQKSWDNDELNYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGM 243
Cdd:PLN02298 191 FLPTLAIVPtadlLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPDVS 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 545706118 244 QSFFDKVASSDKKVVLLEGRWH-ILHHEPGK--ESVRQQFLQWMEERC 288
Cdd:PLN02298 271 RALYEEAKSEDKTIKIYDGMMHsLLFGEPDEniEIVRRDILSWLNERC 318
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 19-285 4.66e-21

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 91.00  E-value: 4.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   19 VFLIHGLHSNTFCEYLEPD---PSQNSA-------RRLYQNSIPQLLNGHGFVVFAHDHQGHGKSQG--KCKGYFNSMDT 86
Cdd:TIGR01607  24 IVLIHGLKSHLRLQFLKINakiVNNDRAvlidtdnYYIYKDSWIENFNKNGYSVYGLDLQGHGESDGlqNLRGHINCFDD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   87 LVADTYQYMEWITKEkypVLKEK-------------------PLFLIGCSMGSLVSI----LLGLKYESL---------- 133
Cdd:TIGR01607 104 LVYDVIQYMNRINDS---IILENetksddesydivntkenrlPMYIIGLSMGGNIALrlleLLGKSNENNdklnikgcis 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  134 LRGAVLISPAVSQASNQFGvmgRILRPLSGIVSTWYPTLpvlRLPKN---EKFPELQKSWDNDELNYHGKLRARVGEQFM 210
Cdd:TIGR01607 181 LSGMISIKSVGSDDSFKFK---YFYLPVMNFMSRVFPTF---RISKKiryEKSPYVNDIIKFDKFRYDGGITFNLASELI 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545706118  211 KTYDELSEKATLF--SVPFIMYYGSEDTLVDPKGMQSFFDKVASSDKKVVLLEGRWHILHHEPGKESVRQQFLQWME 285
Cdd:TIGR01607 255 KATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIEPGNEEVLKKIIEWIS 331
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 14-271 2.24e-57

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 183.95  E-value: 2.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   14 QPKACVFLIHGL--HSNTFceylepdpsQNSARRLyqnsipqllNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADT 91
Cdd:pfam12146   2 EPRAVVVLVHGLgeHSGRY---------AHLADAL---------AAQGFAVYAYDHRGHGRSDGK-RGHVPSFDDYVDDL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   92 YQYMEwITKEKYPvlkEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASnqfGVMGRILRPLSGIVSTWYPT 171
Cdd:pfam12146  63 DTFVD-KIREEHP---GLPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKP---YLAPPILKLLAKLLGKLFPR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  172 LPVLRLPKNEKF---PELQKSWDNDELnYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFD 248
Cdd:pfam12146 136 LRVPNNLLPDSLsrdPEVVAAYAADPL-VHGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYE 214

                         250       260
                  ....*....|....*....|...
gi 545706118  249 KVASSDKKVVLLEGRWHILHHEP 271
Cdd:pfam12146 215 RAGSTDKTLKLYPGLYHELLNEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-286 1.29e-35

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 127.43  E-value: 1.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  14 QPKACVFLIHGLHSNtfceylepdpsqnsARRLYqnSIPQLLNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADTYQ 93
Cdd:COG2267   26 SPRGTVVLVHGLGEH--------------SGRYA--ELAEALAAAGYAVLAFDLRGHGRSDGP-RGHVDSFDDYVDDLRA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  94 YMEWITKEKypvlkEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVsqasnqfgvmgrILRPLSGIVSTWYPTLp 173
Cdd:COG2267   89 ALDALRARP-----GLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAY------------RADPLLGPSARWLRAL- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 174 vlrlpknekfpelqkswdndelnyhgklrarvgeqfmktydELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFDKvASS 253
Cdd:COG2267  151 -----------------------------------------RLAEALARIDVPVLVLHGGADRVVPPEAARRLAAR-LSP 188

                        250       260       270
                 ....*....|....*....|....*....|...
gi 545706118 254 DKKVVLLEGRWHILHHEPGKESVRQQFLQWMEE 286
Cdd:COG2267  189 DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 11-288 9.57e-32

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 119.88  E-value: 9.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  11 STIQPKACVFLIHGLhsntfceylepdpsQNSARRLYQNSiPQLLNGHGFVVFAHDHQGHGKSQGkCKGYFNSMDTLVAD 90
Cdd:PLN02298  54 SSSPPRALIFMVHGY--------------GNDISWTFQST-AIFLAQMGFACFALDLEGHGRSEG-LRAYVPNVDLVVED 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  91 TYQYMEWITKEkyPVLKEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASNQfgvmgRILRPLSGI---VST 167
Cdd:PLN02298 118 CLSFFNSVKQR--EEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKI-----RPPWPIPQIltfVAR 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 168 WYPTLPVLR----LPKNEKFPELQKSWDNDELNYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGM 243
Cdd:PLN02298 191 FLPTLAIVPtadlLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPDVS 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 545706118 244 QSFFDKVASSDKKVVLLEGRWH-ILHHEPGK--ESVRQQFLQWMEERC 288
Cdd:PLN02298 271 RALYEEAKSEDKTIKIYDGMMHsLLFGEPDEniEIVRRDILSWLNERC 318
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
15-286 8.26e-26

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 102.33  E-value: 8.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  15 PKACVfLIHGLHSntfceylepdpSQNSARRLyqnsiPQLLNGHGFVVFAHDHQGHGKSQgkckgyfnsmDTLVADTYQy 94
Cdd:COG1647   15 RKGVL-LLHGFTG-----------SPAEMRPL-----AEALAKAGYTVYAPRLPGHGTSP----------EDLLKTTWE- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  95 mEWI--TKEKYPVLKE--KPLFLIGCSMGSLVSILLGLKYESLlRGAVLISPAVSqasnqfgvMGRILRPLSGIVSTWYP 170
Cdd:COG1647   67 -DWLedVEEAYEILKAgyDKVIVIGLSMGGLLALLLAARYPDV-AGLVLLSPALK--------IDDPSAPLLPLLKYLAR 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 171 TLPvlRLPKNEKFPELQKSWdndelnYHgKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFDKV 250
Cdd:COG1647  137 SLR--GIGSDIEDPEVAEYA------YD-RTPLRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERL 207

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 545706118 251 ASSDKKVVLLEGRWHILHHEPGKESVRQQFLQWMEE 286
Cdd:COG1647  208 GSPDKELVWLEDSGHVITLDKDREEVAEEILDFLER 243
PHA02857 PHA02857
monoglyceride lipase; Provisional
 15-287 4.70e-24

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 98.42  E-value: 4.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  15 PKACVFLIHGlhsntfceylepdPSQNSARrlYQNsIPQLLNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVADTYQY 94
Cdd:PHA02857  24 PKALVFISHG-------------AGEHSGR--YEE-LAENISSLGILVFSHDHIGHGRSNGE-KMMIDDFGVYVRDVVQH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  95 MEwITKEKYPVLkekPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASNQFgvMGRILRPLSGIVstwYPTLPV 174
Cdd:PHA02857  87 VV-TIKSTYPGV---PVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVNAEAVPR--LNLLAAKLMGIF---YPNKIV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 175 LRLPKNEKFPELQK--SWDNDELNYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVDPKGMQsFFDKVAS 252
Cdd:PHA02857 158 GKLCPESVSRDMDEvyKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAY-YFMQHAN 236

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 545706118 253 SDKKVVLLEGRWHILHHEPG--KESVRQQFLQWMEER 287
Cdd:PHA02857 237 CNREIKIYEGAKHHLHKETDevKKSVMKEIETWIFNR 273
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 14-288 2.74e-23

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 97.52  E-value: 2.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  14 QPKACVFLIHGlHSNTFCEYLEpdpsqNSARRLyqnsipqllNGHGFVVFAHDHQGHGKSQGkCKGYFNSMDTLVADTyq 93
Cdd:PLN02385  85 RPKAAVCFCHG-YGDTCTFFFE-----GIARKI---------ASSGYGVFAMDYPGFGLSEG-LHGYIPSFDDLVDDV-- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  94 yMEWITKEK-YPVLKEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPavsqasnqfgvMGRILRPLSgivstwyPTL 172
Cdd:PLN02385 147 -IEHYSKIKgNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAP-----------MCKIADDVV-------PPP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 173 PVLR--------LPKNEKFP-----EL-------QKSWDNDELNYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYG 232
Cdd:PLN02385 208 LVLQilillanlLPKAKLVPqkdlaELafrdlkkRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHG 287

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 233 SEDTLVDPKGMQSFFDKVASSDKKVVLLEGRWH-ILHHEPGkESVRQQF---LQWMEERC 288
Cdd:PLN02385 288 EADKVTDPSVSKFLYEKASSSDKKLKLYEDAYHsILEGEPD-EMIFQVLddiISWLDSHS 346
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 16-287 2.86e-23

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 98.04  E-value: 2.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  16 KACVFLIHGL--HSNTFCEYLEpdpsqnsarrlyqnsipqLLNGHGFVVFAHDHQGHGKSQGkCKGYFNSMDTLVADTYQ 93
Cdd:PLN02652 136 RGILIIIHGLneHSGRYLHFAK------------------QLTSCGFGVYAMDWIGHGGSDG-LHGYVPSLDYVVEDTEA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  94 YMEWITKEKYPVlkekPLFLIGCSMGSLVSILLGL--KYESLLRGAVLISPAVSqasnqfgvmgriLRPLSGIVSTWYPT 171
Cdd:PLN02652 197 FLEKIRSENPGV----PCFLFGHSTGGAVVLKAASypSIEDKLEGIVLTSPALR------------VKPAHPIVGAVAPI 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 172 LPVLrLPKNE------------KFPELQKSWDNDELNYHGKLRARVGEQFMKTYDELSEKATLFSVPFIMYYGSEDTLVD 239
Cdd:PLN02652 261 FSLV-APRFQfkgankrgipvsRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGTADRVTD 339

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 545706118 240 PKGMQSFFDKVASSDKKVVLLEGRWHILHHEPGKESVRQQFLQWMEER 287
Cdd:PLN02652 340 PLASQDLYNEAASRHKDIKLYDGFLHDLLFEPEREEVGRDIIDWMEKR 387
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 19-285 4.66e-21

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 91.00  E-value: 4.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   19 VFLIHGLHSNTFCEYLEPD---PSQNSA-------RRLYQNSIPQLLNGHGFVVFAHDHQGHGKSQG--KCKGYFNSMDT 86
Cdd:TIGR01607  24 IVLIHGLKSHLRLQFLKINakiVNNDRAvlidtdnYYIYKDSWIENFNKNGYSVYGLDLQGHGESDGlqNLRGHINCFDD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   87 LVADTYQYMEWITKEkypVLKEK-------------------PLFLIGCSMGSLVSI----LLGLKYESL---------- 133
Cdd:TIGR01607 104 LVYDVIQYMNRINDS---IILENetksddesydivntkenrlPMYIIGLSMGGNIALrlleLLGKSNENNdklnikgcis 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  134 LRGAVLISPAVSQASNQFGvmgRILRPLSGIVSTWYPTLpvlRLPKN---EKFPELQKSWDNDELNYHGKLRARVGEQFM 210
Cdd:TIGR01607 181 LSGMISIKSVGSDDSFKFK---YFYLPVMNFMSRVFPTF---RISKKiryEKSPYVNDIIKFDKFRYDGGITFNLASELI 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545706118  211 KTYDELSEKATLF--SVPFIMYYGSEDTLVDPKGMQSFFDKVASSDKKVVLLEGRWHILHHEPGKESVRQQFLQWME 285
Cdd:TIGR01607 255 KATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIEPGNEEVLKKIIEWIS 331
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 19-270 1.02e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 63.10  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  19 VFLIHGLHSNtfceylepdpsqnsaRRLYQNSIPQLlnGHGFVVFAHDHQGHGKSQGKCKGYfnSMDTLVADTYQYMEWi 98
Cdd:COG0596   26 VVLLHGLPGS---------------SYEWRPLIPAL--AAGYRVIAPDLRGHGRSDKPAGGY--TLDDLADDLAALLDA- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  99 tkekypvLKEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASNQFGVMGRILRPLSGIVSTWYPTLPVLRLP 178
Cdd:COG0596   86 -------LGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRRPGLAPEALAALLRALARTDLRERLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 179 KnekfpelqkswdndelnyhgklrarvgeqfmktydelsekatlFSVPFIMYYGSEDTLVDPKGMQSFFDKVAssDKKVV 258
Cdd:COG0596  159 R-------------------------------------------ITVPTLVIWGEKDPIVPPALARRLAELLP--NAELV 193

                        250
                 ....*....|..
gi 545706118 259 LLEGRWHILHHE 270
Cdd:COG0596  194 VLPGAGHFPPLE 205
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 50-270 1.88e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 59.83  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   50 SIPQLLNGHGFVVFAHDHQGHGKSQ-GKCKGYFnSMDTLVADtyqyMEWItKEKYPVlkeKPLFLIGCSMGSLVSILLGL 128
Cdd:pfam00561  18 KLAPALARDGFRVIALDLRGFGKSSrPKAQDDY-RTDDLAED----LEYI-LEALGL---EKVNLVGHSMGGLIALAYAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  129 KYESLLRGAVLISP----------AVSQASNQFGVMGRI--------LRPLSGIVSTWYPT--LPVLRLP-KNEKFPelQ 187
Cdd:pfam00561  89 KYPDRVKALVLLGAldppheldeaDRFILALFPGFFDGFvadfapnpLGRLVAKLLALLLLrlRLLKALPlLNKRFP--S 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  188 KSWDNDELNYHGKLRARVGEqfmkTYDELSEKATLFSVPFIMYYGSEDTLVDPKgMQSFFDKVASSDKKVVLLEGRwHIL 267
Cdd:pfam00561 167 GDYALAKSLVTGALLFIETW----STELRAKFLGRLDEPTLIIWGDQDPLVPPQ-ALEKLAQLFPNARLVVIPDAG-HFA 240


                  ...
gi 545706118  268 HHE 270
Cdd:pfam00561 241 FLE 243
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
14-286 3.31e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 53.10  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  14 QPKACVFLIHGLHSNTFCEYlepdpsqnsarrlyqNSIPQLLNGHGFVVFAHDHQGHGKSQGKcKGYFNSMDTLVAdtyq 93
Cdd:COG1506   21 KKYPVVVYVHGGPGSRDDSF---------------LPLAQALASRGYAVLAPDYRGYGESAGD-WGGDEVDDVLAA---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  94 yMEWITKEKYpvLKEKPLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAVSQASnqfgvmgriLRPLSGIVSTWYPTLP 173
Cdd:COG1506   81 -IDYLAARPY--VDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRS---------YYGTTREYTERLMGGP 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 174 vlrlpknekfpelqksWDNDELnyhgklrarvgeqfmktYDELS--EKATLFSVPFIMYYGSEDTLVDPKGMQSFFD--K 249
Cdd:COG1506  149 ----------------WEDPEA-----------------YAARSplAYADKLKTPLLLIHGEADDRVPPEQAERLYEalK 195

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 545706118 250 VASSDKKVVLLEGRWHiLHHEPGKESVRQQFLQWMEE 286
Cdd:COG1506  196 KAGKPVELLVYPGEGH-GFSGAGAPDYLERILDFLDR 231
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 53-286 9.78e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 51.84  E-value: 9.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  53 QLLNGHGFVVFAHDHQGHGKSQGKCKGYFNsmdtlvADTYQYMEWITK-EKYPVLKEKPLFLIGCSMGSLVSILLGLKYE 131
Cdd:COG1073   58 QRLAELGFNVLAFDYRGYGESEGEPREEGS------PERRDARAAVDYlRTLPGVDPERIGLLGISLGGGYALNAAATDP 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118 132 SlLRGAVLISPAVS--QASNQfgvmgrILRPLSGIVSTWYPTLPVLRLpknekfpelqkswdndelnyhgklrarvgEQF 209
Cdd:COG1073  132 R-VKAVILDSPFTSleDLAAQ------RAKEARGAYLPGVPYLPNVRL-----------------------------ASL 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545706118 210 MKTYDELSEKATLFSVPFIMYYGSEDTLVdPKGM-QSFFDKvASSDKKVVLLEGRWHILHHEPGKESVRQQFLQWMEE 286
Cdd:COG1073  176 LNDEFDPLAKIEKISRPLLFIHGEKDEAV-PFYMsEDLYEA-AAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKK 251
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
2-144 4.17e-06

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 47.45  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   2 LDFLQGKDAStiqpKACVFLIHGLhsntfceylepdpsQNSARRLYQNSIPQLLNGHGFVVFAHDHQGHGKSQGKCKGYF 81
Cdd:COG0429   51 LDWSDPPAPS----KPLVVLLHGL--------------EGSSDSHYARGLARALYARGWDVVRLNFRGCGGEPNLLPRLY 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545706118  82 NSMDTlvADTYQYMEWItKEKYPvlkEKPLFLIGCSMG-SLVsillgLKY-------ESLLRGAVLISPAV 144
Cdd:COG0429  113 HSGDT--EDLVWVLAHL-RARYP---YAPLYAVGFSLGgNLL-----LKYlgeqgddAPPLKAAVAVSPPL 172
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
93-144 3.67e-04

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 41.12  E-value: 3.67e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 545706118  93 QYMEWITKE-------KYPVLKEKpLFLIGCSMGSLVSILLGLKYESLLRGAVLISPAV 144
Cdd:COG2819  108 AFLRFLEEElkpyidkRYRTDPER-TGLIGHSLGGLFSLYALLKYPDLFGRYIAISPSL 165
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 55-271 8.63e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 39.76  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118   55 LNGHGFVVFAHDHQGHGKSQGKCKGYFNSMDtlVADTYQYmewitkekypVLKEKPLFLIGCSMGSLVSILLGlkyESLL 134
Cdd:pfam12697  17 LLAAGVAVLAPDLPGHGSSSPPPLDLADLAD--LAALLDE----------LGAARPVVLVGHSLGGAVALAAA---AAAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  135 RGAVLISPAVSQASNQFGVMGRILRPlsgivstwyptLPVLRLPKNEKFPELQKSWDNDELNYHGKLRARVGEQFMKTYD 214
Cdd:pfam12697  82 VVGVLVAPLAAPPGLLAALLALLARL-----------GAALAAPAWLAAESLARGFLDDLPADAEWAAALARLAALLAAL 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 545706118  215 ELSEKATLFSVPFIMYYGSEDTLVDPKGMQSFFDKVAssDKKVVLLEGRWHILHHEP 271
Cdd:pfam12697 151 ALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAALA--GARLVVLPGAGHLPLDDP 205
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
55-138 1.03e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 39.56  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545706118  55 LNGHGFVVFA---HDHQGHGKSQGKCKGYFNSMD--TLVADTYQYMEWITKEkyPVLKEKPLFLIGCSMGSLVSILLGLK 129
Cdd:COG0412   52 LAAAGYVVLApdlYGRGGPGDDPDEARALMGALDpeLLAADLRAALDWLKAQ--PEVDAGRVGVVGFCFGGGLALLAAAR 129


                 ....*....
gi 545706118 130 YESlLRGAV 138
Cdd:COG0412  130 GPD-LAAAV 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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