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Conserved domains on  [gi|528483013|ref|XP_005166146|]
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beta-1,4 N-acetylgalactosaminyltransferase 1 [Danio rerio]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 281-404 3.60e-14

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 70.50  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013  281 TIATKTFLRYDKLQNLIDSI-RQYYPTVTIVIADDSEHPKTV--------SGPYIEHYIMPFGKGWFAGRNLAVSQVTTK 351
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528483013  352 YVLWVDDDFIFSANtKLEKLVDVLEKTTLDLVGGAVREATGYTATYRQTISIE 404
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRIT 132
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 281-404 3.60e-14

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 70.50  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013  281 TIATKTFLRYDKLQNLIDSI-RQYYPTVTIVIADDSEHPKTV--------SGPYIEHYIMPFGKGWFAGRNLAVSQVTTK 351
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528483013  352 YVLWVDDDFIFSANtKLEKLVDVLEKTTLDLVGGAVREATGYTATYRQTISIE 404
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRIT 132
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
280-385 1.25e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 58.08  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 280 VTIATKTFLRYDKLQNLIDSI-RQYYPTVTIVIADDS------EHPKTVSGPYIEHYIMPFGKGWFAGRNLAVSQVTTKY 352
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLlAQTYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528483013 353 VLWVDDDFIFSANTkLEKLVDV----LEKTTLDLVGG 385
Cdd:COG1216   85 LLFLDDDTVVEPDW-LERLLAAacllIRREVFEEVGG 120
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 293-386 3.91e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 49.81  E-value: 3.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 293 LQNLIDSI-RQYYPTVTIVIADDSEHPKTV--------SGPYIEHYIMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFIFS 363
Cdd:cd00761   12 LERCLESLlAQTYPNFEVIVVDDGSTDGTLeileeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLLL 91

                         90       100
                 ....*....|....*....|....
gi 528483013 364 ANtKLEKLVDVLEK-TTLDLVGGA 386
Cdd:cd00761   92 PD-WLERLVAELLAdPEADAVGGP 114
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 280-377 1.72e-04

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 43.06  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013  280 VTIATKTFLRYDKLQNLIDSIRQYYPTVTIVIADDSE---------HPKTVSGPYIEHYIMPFGKGWFAGRNL-AVSQVT 349
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDekfnennlkVFKNYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 528483013  350 TKYVLWVDDD--FIFSAntkLEKLVDVLEK 377
Cdd:TIGR04440  82 TPYVVICADDdfIIPSG---LTECLSFLEA 108
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 281-404 3.60e-14

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 70.50  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013  281 TIATKTFLRYDKLQNLIDSI-RQYYPTVTIVIADDSEHPKTV--------SGPYIEHYIMPFGKGWFAGRNLAVSQVTTK 351
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528483013  352 YVLWVDDDFIFSANtKLEKLVDVLEKTTLDLVGGAVREATGYTATYRQTISIE 404
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRIT 132
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
280-385 1.25e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 58.08  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 280 VTIATKTFLRYDKLQNLIDSI-RQYYPTVTIVIADDS------EHPKTVSGPYIEHYIMPFGKGWFAGRNLAVSQVTTKY 352
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLlAQTYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528483013 353 VLWVDDDFIFSANTkLEKLVDV----LEKTTLDLVGG 385
Cdd:COG1216   85 LLFLDDDTVVEPDW-LERLLAAacllIRREVFEEVGG 120
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 293-456 4.90e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 56.25  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 293 LQNLIDSIR-QYYPTVTIVIADDSEHPKTVS--------GPYIEHYIMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFIFS 363
Cdd:COG0463   17 LEEALESLLaQTYPDFEIIVVDDGSTDGTAEilrelaakDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 364 ANtKLEKLVDVLEKTTLDLVGGAVREATGYTATYRQTISIeageedgdcLHMRRGFHHiiqgfphcvITDGVINFFLART 443
Cdd:COG0463   97 PE-KLEELVAALEEGPADLVYGSRLIREGESDLRRLGSRL---------FNLVRLLTN---------LPDSTSGFRLFRR 157

                        170
                 ....*....|...
gi 528483013 444 DKVQQVGFDPRLA 456
Cdd:COG0463  158 EVLEELGFDEGFL 170
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 293-386 3.91e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 49.81  E-value: 3.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 293 LQNLIDSI-RQYYPTVTIVIADDSEHPKTV--------SGPYIEHYIMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFIFS 363
Cdd:cd00761   12 LERCLESLlAQTYPNFEVIVVDDGSTDGTLeileeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLLL 91

                         90       100
                 ....*....|....*....|....
gi 528483013 364 ANtKLEKLVDVLEK-TTLDLVGGA 386
Cdd:cd00761   92 PD-WLERLVAELLAdPEADAVGGP 114
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 293-388 1.24e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 47.43  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 293 LQNLIDSI-RQYYPT--VTIVIADDSEHPKTV--------SGPYIEHYIMPF--GKGWfaGRNLAVSQVTTKYVLWVDDD 359
Cdd:COG1215   44 IEETLRSLlAQDYPKekLEVIVVDDGSTDETAeiarelaaEYPRVRVIERPEngGKAA--ALNAGLKAARGDIVVFLDAD 121

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528483013 360 FIFSANTkLEKLVDVLEKTTLDLVG--GAVR 388
Cdd:COG1215  122 TVLDPDW-LRRLVAAFADPGVGASGanLAFR 151
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 280-377 1.72e-04

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 43.06  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013  280 VTIATKTFLRYDKLQNLIDSIRQYYPTVTIVIADDSE---------HPKTVSGPYIEHYIMPFGKGWFAGRNL-AVSQVT 349
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDekfnennlkVFKNYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 528483013  350 TKYVLWVDDD--FIFSAntkLEKLVDVLEK 377
Cdd:TIGR04440  82 TPYVVICADDdfIIPSG---LTECLSFLEA 108
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 289-377 9.05e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 37.15  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528483013 289 RYDKLQNLIDSI-RQYYPTVTIVIADDSEHPKTVS-----GPYIEHYIMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFIF 362
Cdd:cd04186    8 SLEYLKACLDSLlAQTYPDFEVIVVDNASTDGSVEllrelFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVV 87

                         90
                 ....*....|....*
gi 528483013 363 SANTkLEKLVDVLEK 377
Cdd:cd04186   88 EPGA-LLELLDAAEQ 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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