sclerostin [Echinops telfairi]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||
| GHB_like super family | cl21545 | Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ... |
29-117 | 4.26e-44 | |||
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer. The actual alignment was detected with superfamily member pfam05463: Pssm-ID: 473907 Cd Length: 198 Bit Score: 142.36 E-value: 4.26e-44
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| Name | Accession | Description | Interval | E-value | |||
| Sclerostin | pfam05463 | Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ... |
29-117 | 4.26e-44 | |||
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients. Pssm-ID: 398883 Cd Length: 198 Bit Score: 142.36 E-value: 4.26e-44
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| Name | Accession | Description | Interval | E-value | |||
| Sclerostin | pfam05463 | Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ... |
29-117 | 4.26e-44 | |||
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients. Pssm-ID: 398883 Cd Length: 198 Bit Score: 142.36 E-value: 4.26e-44
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| DAN | pfam03045 | DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the ... |
54-119 | 1.87e-13 | |||
DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonize different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo. Pssm-ID: 460786 Cd Length: 108 Bit Score: 61.53 E-value: 1.87e-13
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