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Conserved domains on  [gi|460393470|ref|XP_004242332|]
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DAR GTPase 3, chloroplastic isoform X1 [Solanum lycopersicum]

Protein Classification

YlqF/YawG family GTPase( domain architecture ID 11497227)

YlqF/YawG family GTPase such as bacterial ribosome biogenesis GTPase YlqF, an essential protein that is required for a late step of 50S ribosomal subunit assembly

CATH:  3.40.50.300
Gene Ontology:  GO:0005525|GO:0003924
PubMed:  11916378
SCOP:  4004041|4007669

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 95-366 2.56e-101

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


:

Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 300.58  E-value: 2.56e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470   95 QWYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMISTADRNAWATYYANQGIKVV 174
Cdd:TIGR03596   2 QWFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKGIKAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  175 FSNGQLGMGALKLGRLAKALAGTVNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRF 254
Cdd:TIGR03596  82 AVNAKKGAGVKKIIKAAKKLLKEKNEKLKAKGLKNRPIRAMIVGIPNVGKSTLINRLAGKKVAKVGNRPGVTKGQQWIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  255 GKDLELLDSPGIIPMRISDQTAAIKLAICDDIGERSYDAADVAAILVQMLSGLptvGNKVLCDRYKIEADGRSGKIFVQK 334
Cdd:TIGR03596 162 SDNLELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYLLEH---YPELLKERYKLDELPEDPVELLEA 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 460393470  335 LAVQ--LFNA----DNNQAAFRILQDFRKGKFGWIALE 366
Cdd:TIGR03596 239 IAKKrgCLLKggelDLDRAAEILLNDFRKGKLGRISLE 276
 
Name Accession Description Interval E-value
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 95-366 2.56e-101

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 300.58  E-value: 2.56e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470   95 QWYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMISTADRNAWATYYANQGIKVV 174
Cdd:TIGR03596   2 QWFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKGIKAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  175 FSNGQLGMGALKLGRLAKALAGTVNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRF 254
Cdd:TIGR03596  82 AVNAKKGAGVKKIIKAAKKLLKEKNEKLKAKGLKNRPIRAMIVGIPNVGKSTLINRLAGKKVAKVGNRPGVTKGQQWIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  255 GKDLELLDSPGIIPMRISDQTAAIKLAICDDIGERSYDAADVAAILVQMLSGLptvGNKVLCDRYKIEADGRSGKIFVQK 334
Cdd:TIGR03596 162 SDNLELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYLLEH---YPELLKERYKLDELPEDPVELLEA 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 460393470  335 LAVQ--LFNA----DNNQAAFRILQDFRKGKFGWIALE 366
Cdd:TIGR03596 239 IAKKrgCLLKggelDLDRAAEILLNDFRKGKLGRISLE 276
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
94-370 2.55e-81

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 249.64  E-value: 2.55e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  94 VQWYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMistADRN---AWATYYANQG 170
Cdd:COG1161    3 IQWFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADL---ADPSvtkQWLKYFEKQG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 171 IKVVFSNGQLGMGALKLGRLAKALAgtvnikrKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELK 250
Cdd:COG1161   80 VDALAISAKKGKGIKELIEAIRELA-------PEKGIKRRPIRVMIVGIPNVGKSTLINRLAGKKVAKTGNKPGVTKGQQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 251 WVRFGKDLELLDSPGIIPMRISDQTAAIKLAICDDIGERSYDAADVAAILVQMLSGL-PtvgnKVLCDRYKIEADGRSGK 329
Cdd:COG1161  153 WIKLDDGLELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYLARRyP----ELLKERYKLDELPRTKL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 460393470 330 IFVQKLAVQL------FNADNNQAAFRILQDFRKGKFGWIALERPPK 370
Cdd:COG1161  229 ELLEAIGRKRgcllsgGEVDLEKAAEILLTDFRSGKLGRITLETPEE 275
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 96-266 1.94e-79

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 240.89  E-value: 1.94e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  96 WYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMISTADRNAWATYYANQGIKVVF 175
Cdd:cd01856    1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 176 SNGQLGMGALKLGRLAKALAGTvNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFG 255
Cdd:cd01856   81 VNAKNGKGVKKLLKKAKKLLKE-NEKLKAKGLLPRPLRAMVVGIPNVGKSTLINRLRGKKVAKVGNKPGVTRGQQWIRIG 159

                        170
                 ....*....|.
gi 460393470 256 KDLELLDSPGI 266
Cdd:cd01856  160 PNIELLDTPGI 170
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 213-268 1.23e-16

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 74.96  E-value: 1.23e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 460393470  213 RAGVVGYPNVGKSSLVNRLLKRRmCAAAPRPGVTRELKWVRF---GKDLELLDSPGIIP 268
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAK-AIVSDYPGTTRDPNEGRLelkGKQIILVDTPGLIE 58
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 217-281 3.37e-10

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 61.22  E-value: 3.37e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460393470 217 VGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR-----ELKWvrFGKDLELLDSPGI------IPMRISDQT-AAIKLA 281
Cdd:PRK00093   7 VGRPNVGKSTLFNRLTGKRDAIVADTPGVTRdriygEAEW--LGREFILIDTGGIepdddgFEKQIREQAeLAIEEA 81
 
Name Accession Description Interval E-value
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 95-366 2.56e-101

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 300.58  E-value: 2.56e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470   95 QWYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMISTADRNAWATYYANQGIKVV 174
Cdd:TIGR03596   2 QWFPGHMAKARREIKENLKLVDVVIEVLDARIPLSSRNPMIDEIRGNKPRLIVLNKADLADPAVTKQWLKYFEEKGIKAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  175 FSNGQLGMGALKLGRLAKALAGTVNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRF 254
Cdd:TIGR03596  82 AVNAKKGAGVKKIIKAAKKLLKEKNEKLKAKGLKNRPIRAMIVGIPNVGKSTLINRLAGKKVAKVGNRPGVTKGQQWIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  255 GKDLELLDSPGIIPMRISDQTAAIKLAICDDIGERSYDAADVAAILVQMLSGLptvGNKVLCDRYKIEADGRSGKIFVQK 334
Cdd:TIGR03596 162 SDNLELLDTPGILWPKFEDQEVGLKLAATGAIKDEALDLEDVALFLLEYLLEH---YPELLKERYKLDELPEDPVELLEA 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 460393470  335 LAVQ--LFNA----DNNQAAFRILQDFRKGKFGWIALE 366
Cdd:TIGR03596 239 IAKKrgCLLKggelDLDRAAEILLNDFRKGKLGRISLE 276
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
94-370 2.55e-81

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 249.64  E-value: 2.55e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  94 VQWYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMistADRN---AWATYYANQG 170
Cdd:COG1161    3 IQWFPGHMAKARRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVGNKPRLLVLNKADL---ADPSvtkQWLKYFEKQG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 171 IKVVFSNGQLGMGALKLGRLAKALAgtvnikrKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELK 250
Cdd:COG1161   80 VDALAISAKKGKGIKELIEAIRELA-------PEKGIKRRPIRVMIVGIPNVGKSTLINRLAGKKVAKTGNKPGVTKGQQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 251 WVRFGKDLELLDSPGIIPMRISDQTAAIKLAICDDIGERSYDAADVAAILVQMLSGL-PtvgnKVLCDRYKIEADGRSGK 329
Cdd:COG1161  153 WIKLDDGLELLDTPGILWPKFEDPEVGYKLAATGAIKDEVLDLEEVALFLLGYLARRyP----ELLKERYKLDELPRTKL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 460393470 330 IFVQKLAVQL------FNADNNQAAFRILQDFRKGKFGWIALERPPK 370
Cdd:COG1161  229 ELLEAIGRKRgcllsgGEVDLEKAAEILLTDFRSGKLGRITLETPEE 275
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 96-266 1.94e-79

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 240.89  E-value: 1.94e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  96 WYPGHIAKTEKELKEQLKLMDVVIEVRDARIPMSTSHPQMDSWLGNRKRILVLNREDMISTADRNAWATYYANQGIKVVF 175
Cdd:cd01856    1 WFPGHMAKALRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGNKPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 176 SNGQLGMGALKLGRLAKALAGTvNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFG 255
Cdd:cd01856   81 VNAKNGKGVKKLLKKAKKLLKE-NEKLKAKGLLPRPLRAMVVGIPNVGKSTLINRLRGKKVAKVGNKPGVTRGQQWIRIG 159

                        170
                 ....*....|.
gi 460393470 256 KDLELLDSPGI 266
Cdd:cd01856  160 PNIELLDTPGI 170
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 116-266 1.28e-32

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 119.41  E-value: 1.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 116 DVVIEVRDARIPMSTSHPQMD--SWLGNRKRILVLNREDMISTADRNAWATYYAN-QGIKVVFSNGQLGMGALKLGRLAK 192
Cdd:cd01849    1 DVVVEVVDARDPLSSRNPDIEvlINEKNKKLIMVLNKADLVPKEVLRKWVAELSElYGTKTFFISATNGQGILKLKAEIT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 460393470 193 alagtvniKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFGKDLELLDSPGI 266
Cdd:cd01849   81 --------KQKLKLKYKKGIRVGVVGLPNVGKSSFINALLNKFKLKVGSIPGTTKLQQDVKLDKEIYLYDTPGI 146
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 116-266 2.78e-31

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 116.52  E-value: 2.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 116 DVVIEVRDARIPMSTSHPQMDSW---LGNRKR-ILVLNREDMISTADRNAWATYYAN-------------------QGIK 172
Cdd:cd04178    1 DVILEVLDARDPLGCRCPQVERAvlvLGPNKKlVLVLNKIDLVPKENVEKWLKYLRNefptvafkastqqqkknlsRKSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 173 VVFSNGQLGMGALKLG-----RLAKALAGTVNIKRkakgllprPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR 247
Cdd:cd04178   81 KVKASDDLLSSSACLGadallKLLKNYARNKGIKT--------SITVGVVGYPNVGKSSVINSLKRSRACNVGATPGVTK 152

                        170
                 ....*....|....*....
gi 460393470 248 ELKWVRFGKDLELLDSPGI 266
Cdd:cd04178  153 SMQEVHLDKHVKLLDSPGV 171
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 112-266 5.28e-30

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 112.80  E-value: 5.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 112 LKLMDVVIEVRDARIPMSTSHPQMDSWL--GNRKRILVLNREDMISTADRNAWATYYANQGIKVVFSNGQLGMGALKLGR 189
Cdd:cd01859    9 IKEADVVLEVVDARDPELTRSRKLERMAleLGKKLIIVLNKADLVPREVLEKWKEVFESEGLPVVYVSARERLGTRILRR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 190 LAKALAGTVnikrkakgllpRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAP---RPGVTRELKWVRFGKDLELLDSPGI 266
Cdd:cd01859   89 TIKELAIDG-----------KPVIVGVVGYPKVGKSSIINALKGRHSASTSPipgSPGYTKGIQLVRIDSKIYLIDTPGV 157
NGP_1 cd01858
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; ...
 116-266 4.33e-21

A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; Autoantigen NGP-1 (Nucleolar G-protein gene 1) has been shown to localize in the nucleolus and nucleolar organizers in all cell types analyzed, which is indicative of a function in ribosomal assembly. NGP-1 and its homologs show a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with NKXD motif) are relocated to the N terminus.


Pssm-ID: 206751 [Multi-domain]  Cd Length: 157  Bit Score: 88.51  E-value: 4.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 116 DVVIEVRDARIPMSTSHPQMDSWLGNRKR----ILVLNREDMISTADRNAWATYYANQGIKVVFS---NGQLGMGALklg 188
Cdd:cd01858   10 DVIIQVLDARDPMGTRCKHVEKYLRKEKPhkhlIFVLNKCDLVPTWVTKRWVKVLSKEYPTLAFHasiTNPFGKGAL--- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 189 rlakalagtVNIKRKAKGLLP--RPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFGKDLELLDSPGI 266
Cdd:cd01858   87 ---------INLLRQFAKLHSdkKQISVGFIGYPNVGKSSVINTLRSKKVCKVAPIPGETKVWQYITLMKRIYLIDCPGV 157
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 116-267 1.58e-19

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 83.82  E-value: 1.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 116 DVVIEVRDARIPMSTSHPQMDSWL----GNRKRILVLNREDMISTADRNAWATYYANQGIKVVFSngqlgmgalklgrlA 191
Cdd:cd01857   13 DVVVQIVDARNPLFFRCPDLEKYVkevdPSKENVLLLNKADLVTEEQRKAWARYFKKEGIVVLFF--------------S 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 460393470 192 KALAGTVnikrkakgllprpvraGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFGKDLELLDSPGII 267
Cdd:cd01857   79 ALNEATI----------------GLVGYPNVGKSSLINALVGSKKVSVSSTPGKTKHFQTIFLEPGITLCDCPGLV 138
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 213-268 1.23e-16

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 74.96  E-value: 1.23e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 460393470  213 RAGVVGYPNVGKSSLVNRLLKRRmCAAAPRPGVTRELKWVRF---GKDLELLDSPGIIP 268
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAK-AIVSDYPGTTRDPNEGRLelkGKQIILVDTPGLIE 58
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 217-281 1.85e-11

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 61.68  E-value: 1.85e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460393470 217 VGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR-----ELKWvrFGKDLELLDSPGIIPM------RISDQT-AAIKLA 281
Cdd:cd01894    3 VGRPNVGKSTLFNRLTGRRDAIVSDTPGVTRdrkygEAEW--GGREFILIDTGGIEPDdegiskEIREQAeIAIEEA 77
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
216-281 4.30e-11

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 63.89  E-value: 4.30e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR-----ELKWvrFGKDLELLDSPGI-------IPMRISDQT-AAIKLA 281
Cdd:COG1160    7 IVGRPNVGKSTLFNRLTGRRDAIVDDTPGVTRdriygEAEW--GGREFTLIDTGGIepddddgLEAEIREQAeLAIEEA 83
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 217-281 3.37e-10

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 61.22  E-value: 3.37e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 460393470 217 VGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR-----ELKWvrFGKDLELLDSPGI------IPMRISDQT-AAIKLA 281
Cdd:PRK00093   7 VGRPNVGKSTLFNRLTGKRDAIVADTPGVTRdriygEAEW--LGREFILIDTGGIepdddgFEKQIREQAeLAIEEA 81
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 215-319 5.08e-10

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 57.85  E-value: 5.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 215 GVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRE-----LKWVRFGKDLELLDSPGIIPMRISDQTAAIKLAI--CD--- 284
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDpdvyvKELDKGKVKLVLVDTPGLDEFGGLGREELARLLLrgADlil 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 460393470 285 ---DIGERSYDAADVAAILVQMLS-GLPT--VGNKvlCDRY 319
Cdd:cd00882   81 lvvDSTDRESEEDAKLLILRRLRKeGIPIilVGNK--IDLL 119
PRK03003 PRK03003
GTP-binding protein Der; Reviewed
 204-324 6.17e-10

GTP-binding protein Der; Reviewed


Pssm-ID: 179525 [Multi-domain]  Cd Length: 472  Bit Score: 60.37  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 204 AKGLLPRPVRAgVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR-----ELKWVrfGKDLELLDSPGIIP------MRIS 272
Cdd:PRK03003  32 AAEGGPLPVVA-VVGRPNVGKSTLVNRILGRREAVVEDVPGVTRdrvsyDAEWN--GRRFTVVDTGGWEPdakglqASVA 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 460393470 273 DQ------TA-AIKLAICDDIGERSYDAAdVAAILVQmlSGLPT--VGNKVlcDRYKIEAD 324
Cdd:PRK03003 109 EQaevamrTAdAVLFVVDATVGATATDEA-VARVLRR--SGKPVilAANKV--DDERGEAD 164
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 215-319 8.72e-10

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 56.87  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 215 GVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRElkWVRF------GKDLELLDSPGII------PMRIS------DQTA 276
Cdd:cd00880    1 AIFGRPNVGKSSLLNALLGQNVGIVSPIPGTTRD--PVRKewellpLGPVVLIDTPGLDeegglgRERVEearqvaDRAD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 460393470 277 AIKLAICDDIGERSYDAadvaaiLVQML--SGLPTVG--NKvlCDRY 319
Cdd:cd00880   79 LVLLVVDSDLTPVEEEA------KLGLLreRGKPVLLvlNK--IDLV 117
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 211-266 2.57e-09

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 55.90  E-value: 2.57e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 460393470 211 PVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR---ELKWVRFGKDLELLDSPGI 266
Cdd:cd01895    2 PIKIAIIGRPNVGKSSLLNALLGEERVIVSDIAGTTRdsiDVPFEYDGQKYTLIDTAGI 60
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 105-266 3.34e-09

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 58.14  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 105 EKELKEQLKLM----DVVIEVRDARIPMSTSHPQMDSWLgnRKR----ILVLNREDmiSTADRNAWATYYAnQGIKVVF- 175
Cdd:PRK00093  67 EKQIREQAELAieeaDVILFVVDGRAGLTPADEEIAKIL--RKSnkpvILVVNKVD--GPDEEADAYEFYS-LGLGEPYp 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 176 ---SNGQlGMGALkLGRLAKALAgtvniKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR---EL 249
Cdd:PRK00093 142 isaEHGR-GIGDL-LDAILEELP-----EEEEEDEEDEPIKIAIIGRPNVGKSSLINALLGEERVIVSDIAGTTRdsiDT 214

                        170
                 ....*....|....*..
gi 460393470 250 KWVRFGKDLELLDSPGI 266
Cdd:PRK00093 215 PFERDGQKYTLIDTAGI 231
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
209-266 1.14e-08

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 56.19  E-value: 1.14e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 460393470 209 PRPVRAGVVGYPNVGKSSLVNRLL-KRRMcAAAPRPGVTR---ELKWVRFGKDLELLDSPGI 266
Cdd:COG1160  173 DDPIKIAIVGRPNVGKSSLINALLgEERV-IVSDIAGTTRdsiDTPFERDGKKYTLIDTAGI 233
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 191-266 4.67e-08

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 52.65  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 191 AKALAGTVNIKRKAKGLLPRPVRAGVVGYPNVGKSSLVNRLLKRRMCAA-----------APRPGVTRELKWVRFGKDLE 259
Cdd:cd01855  105 AKKGWGVEELIEEIKKLAKYRGDVYVVGATNVGKSTLINALLKSNGGKVqaqalvqrltvSPIPGTTLGLIKIPLGEGKK 184


                 ....*..
gi 460393470 260 LLDSPGI 266
Cdd:cd01855  185 LYDTPGI 191
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 216-265 2.51e-07

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 52.49  E-value: 2.51e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRE-----LKWVrfGKDLELLDSPG 265
Cdd:PRK09518 280 IVGRPNVGKSTLVNRILGRREAVVEDTPGVTRDrvsydAEWA--GTDFKLVDTGG 332
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 217-308 9.08e-07

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 48.26  E-value: 9.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 217 VGYPNVGKSSLVNRLLKRRmcaAA---PRPGVTRElkWVRFGKDLElldspGiIPMRISDqTAAIKLAicDD----IG-E 288
Cdd:cd04164    9 AGKPNVGKSSLLNALAGRD---RAivsDIAGTTRD--VIEEEIDLG-----G-IPVRLID-TAGLRET--EDeiekIGiE 74

                         90       100
                 ....*....|....*....|...
gi 460393470 289 RSYDA---ADVAAILVQMLSGLP 308
Cdd:cd04164   75 RAREAieeADLVLLVVDASEGLD 97
YeeP COG3596
Predicted GTPase [General function prediction only];
210-266 1.91e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 48.99  E-value: 1.91e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 460393470 210 RPVRAGVVGYPNVGKSSLVNRLLKRRMCA-AAPRPgVTRELKWVRFGKD----LELLDSPGI 266
Cdd:COG3596   38 PPPVIALVGKTGAGKSSLINALFGAEVAEvGVGRP-CTREIQRYRLESDglpgLVLLDTPGL 98
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 217-265 2.39e-06

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 47.12  E-value: 2.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 460393470 217 VGYPNVGKSSLVNRLLKRRMCA-AAPRPGVTRELKWVRFGKDLELLDSPG 265
Cdd:cd01876    5 AGRSNVGKSSLINALTNRKKLArTSKTPGRTQLINFFNVGDKFRLVDLPG 54
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 126-232 6.83e-06

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 46.00  E-value: 6.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  126 IPMSTSHPQMDSWLGNR----------KRILVLNREDMISTADR-NAWATYYANQGIKVVFSNGQLGMGalkLGRLAKAL 194
Cdd:pfam03193  28 IVFSLKEPDFNLNLLDRflvlaeasgiEPVIVLNKIDLLDEEEElEELLKIYRAIGYPVLFVSAKTGEG---IEALKELL 104

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 460393470  195 AGTVNIkrkakgllprpvragVVGYPNVGKSSLVNRLL 232
Cdd:pfam03193 105 KGKTTV---------------LAGQSGVGKSTLLNALL 127
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 212-266 1.73e-05

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 44.36  E-value: 1.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 460393470  212 VRAGVVGYPNVGKSSLVNRLlkrrmCAAAPR----PGVTRELKWVRF---GKDLELLDSPGI 266
Cdd:pfam02421   1 ITIALVGNPNVGKTTLFNAL-----TGANQHvgnwPGVTVEKKEGKFkykGYEIEIVDLPGI 57
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 216-266 1.84e-05

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 44.37  E-value: 1.84e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 460393470 216 VVGYPNVGKSSLVNRLlkrrmCAAAPR----PGVTRELKWVRF---GKDLELLDSPGI 266
Cdd:cd01879    2 LVGNPNVGKTTLFNAL-----TGARQKvgnwPGVTVEKKEGEFklgGKEIEIVDLPGT 54
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
 213-267 4.13e-05

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 44.46  E-value: 4.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 460393470 213 RAGVVGYPNVGKSSLVNRLLKRRMCAAA-------PRPGVtRELKwvrfGKDLELLDSPGII 267
Cdd:cd01896    2 RVALVGFPSVGKSTLLSKLTNTKSEVAAyefttltCVPGV-MEYK----GAKIQLLDLPGII 58
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 211-296 4.79e-05

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 43.13  E-value: 4.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  211 PVRAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRELKWVRFGKD-----LELLDSPGII---PMRISDQTAAIKLAI 282
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSITEYYPGTTRNYVTTVIEEDgktykFNLLDTAGQEdydAIRRLYYPQVERSLR 80

                          90
                  ....*....|....
gi 460393470  283 CDDIGERSYDAADV 296
Cdd:TIGR00231  81 VFDIVILVLDVEEI 94
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
 218-266 7.00e-05

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 44.73  E-value: 7.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 460393470  218 GYPNVGKSSLVNRLLKRRMcAAAPRPGVTRELKWVRF---GKDLELLDSPGI 266
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQ-TVGNWPGVTVEKKEGKLgfqGEDIEIVDLPGI 51
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 213-247 7.93e-05

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 42.83  E-value: 7.93e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 460393470 213 RAG---VVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR 247
Cdd:cd04163    2 KSGfvaIIGRPNVGKSTLLNALVGQKISIVSPKPQTTR 39
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
145-232 7.96e-05

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 44.08  E-value: 7.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 145 ILVLNREDMISTADR---NAWATYYANQGIKVVF--SNGQLGMGALKlgrlaKALAGTVNIkrkakgllprpvragVVGY 219
Cdd:PRK12288 154 LIVLNKIDLLDDEGRafvNEQLDIYRNIGYRVLMvsSHTGEGLEELE-----AALTGRISI---------------FVGQ 213

                         90
                 ....*....|...
gi 460393470 220 PNVGKSSLVNRLL 232
Cdd:PRK12288 214 SGVGKSSLINALL 226
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 145-232 1.18e-04

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 42.77  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 145 ILVLNREDMISTADRNAWATYYANQGIKVVFSNGQLGMGalkLGRLAKALAGTVNikrkakgllprpVRAGVVGypnVGK 224
Cdd:cd01854   37 VIVLNKADLVDDEELEELLEIYEKLGYPVLAVSAKTGEG---LDELRELLKGKTS------------VLVGQSG---VGK 98


                 ....*...
gi 460393470 225 SSLVNRLL 232
Cdd:cd01854   99 STLLNALL 106
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 215-268 1.27e-04

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 42.00  E-value: 1.27e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 460393470 215 GVVGYPNVGKSSLVNrLLKRRMCAAAPRPGVTRELKWVRF----GKDLELLDSPGIIP 268
Cdd:cd01881    1 GLVGLPNVGKSTLLS-ALTSAKVEIASYPFTTLEPNVGVFefgdGVDIQIIDLPGLLD 57
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
 217-297 2.07e-04

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 42.85  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470  217 VGYPNVGKSSLVNRLLKRrmcAAA---PRPGVTRelkwvrfgkDL--ELLDSPGiIPMRISDqTAAIKLAicDD----IG 287
Cdd:pfam12631 100 VGKPNVGKSSLLNALLGE---ERAivtDIPGTTR---------DVieETINIGG-IPLRLID-TAGIRET--DDevekIG 163

                          90
                  ....*....|.
gi 460393470  288 -ERSYDAADVA 297
Cdd:pfam12631 164 iERAREAIEEA 174
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 216-266 2.98e-04

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 41.01  E-value: 2.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMcAAAPRPGVTREL-------KWVRFgkdlELLDSPGI 266
Cdd:cd01897    5 IAGYPNVGKSSLVNKLTRAKP-EVAPYPFTTKSLfvghfdyKYLRW----QVIDTPGI 57
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 217-304 3.23e-04

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 42.36  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 217 VGYPNVGKSSLVNRLLKRrmcAAA---PRPGVTRelkwvrfgkDL--ELLDSPGiIPMRISDqTAAIKLAicDD----IG 287
Cdd:COG0486  219 VGRPNVGKSSLLNALLGE---ERAivtDIAGTTR---------DVieERINIGG-IPVRLID-TAGLRET--EDevekIG 282

                         90
                 ....*....|....*...
gi 460393470 288 -ERSYDAADVAAILVQML 304
Cdd:COG0486  283 iERAREAIEEADLVLLLL 300
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 217-265 3.45e-04

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 40.92  E-value: 3.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 460393470  217 VGYPNVGKSSLVNRLLKRRMCA-AAPRPGVTRELKWVRFGKDLELLDSPG 265
Cdd:TIGR03598  24 AGRSNVGKSSLINALTNRKKLArTSKTPGRTQLINFFEVNDGFRLVDLPG 73
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
186-296 3.47e-04

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 42.41  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 186 KLGRLAKALAGTVNIKRKAKGLlprpvRAGV----VGYPNVGKSSLVNRLLKRRmcaAA---PRPGVTRELkwvrfgkdL 258
Cdd:PRK05291 191 KLEELIAELEALLASARQGEIL-----REGLkvviAGRPNVGKSSLLNALLGEE---RAivtDIAGTTRDV--------I 254

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 460393470 259 E---LLDSpgiIPMRISDqTAAIKLAicDD----IG-ERSYDA---ADV 296
Cdd:PRK05291 255 EehiNLDG---IPLRLID-TAGIRET--DDevekIGiERSREAieeADL 297
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
210-266 3.53e-04

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 42.41  E-value: 3.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 460393470 210 RPVRAGVVGYPNVGKSSLVNRL--LKRRMcaaAPRPGVTRELKWVRF---GKDLELLDSPGI 266
Cdd:COG0370    2 KMITIALVGNPNVGKTTLFNALtgSRQKV---GNWPGVTVEKKEGKFklkGKEIELVDLPGT 60
era TIGR00436
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other ...
 213-247 4.08e-04

GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other bacteria. It plays a role in ribosome biogenesis. Few bacteria lack this protein. [Protein synthesis, Other]


Pssm-ID: 129528 [Multi-domain]  Cd Length: 270  Bit Score: 41.61  E-value: 4.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 460393470  213 RAGVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR 247
Cdd:TIGR00436   2 FVAILGRPNVGKSTLLNQLHGQKISITSPKAQTTR 36
Era COG1159
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
213-247 5.65e-04

GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440773 [Multi-domain]  Cd Length: 290  Bit Score: 41.13  E-value: 5.65e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 460393470 213 RAG---VVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR 247
Cdd:COG1159    2 RSGfvaIVGRPNVGKSTLLNALVGQKVSIVSPKPQTTR 39
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
 216-266 8.53e-04

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 39.84  E-value: 8.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMCAAAPRPgVTRELKWVRFG--KDLELLDSPGI 266
Cdd:cd09912    5 VVGEFSAGKSTLLNALLGEEVLPTGVTP-TTAVITVLRYGllKGVVLVDTPGL 56
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
216-268 9.96e-04

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 40.94  E-value: 9.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMCAAA-------PRPGVTrELKWVRFgkdlELLDSPGIIP 268
Cdd:COG1163   68 LVGFPSVGKSTLLNKLTNAKSEVGAyefttldVVPGML-EYKGAKI----QILDVPGLIE 122
PRK04213 PRK04213
GTP-binding protein EngB;
216-301 1.02e-03

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 39.90  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMcAAAPRPGVTR---ELKWvrfgKDLELLDSPGI-----IPMRISDQtaaIKlaicDDIG 287
Cdd:PRK04213  14 FVGRSNVGKSTLVRELTGKKV-RVGKRPGVTRkpnHYDW----GDFILTDLPGFgfmsgVPKEVQEK---IK----DEIV 81

                         90
                 ....*....|....*.
gi 460393470 288 ERSYDAAD--VAAILV 301
Cdd:PRK04213  82 RYIEDNADriLAAVLV 97
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
216-319 1.44e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 39.19  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460393470 216 VVGYPNVGKSSLVNRLLKRRMCAAAPRP--GVTR---ELKWVRFGKDLELLDSPGIIPMRISDQTAAIKLAICD------ 284
Cdd:COG1100    8 VVGTGGVGKTSLVNRLVGDIFSLEKYLStnGVTIdkkELKLDGLDVDLVIWDTPGQDEFRETRQFYARQLTGASlylfvv 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 460393470 285 --DIGERSYDAADVAAILVQMLSGLPT--VGNKvlCDRY 319
Cdd:COG1100   88 dgTREETLQSLYELLESLRRLGKKSPIilVLNK--IDLY 124
era PRK00089
GTPase Era; Reviewed
 213-247 1.83e-03

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 39.65  E-value: 1.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 460393470 213 RAG---VVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTR 247
Cdd:PRK00089   4 KSGfvaIVGRPNVGKSTLLNALVGQKISIVSPKPQTTR 41
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 208-265 2.34e-03

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 38.51  E-value: 2.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 460393470 208 LPRPVRAGV--VGYPNVGKSSLVNRLLKRRMCA-AAPRPGVTRELKWVRFGKDLELLDSPG 265
Cdd:COG0218   18 LPPDDLPEIafAGRSNVGKSSLINALTNRKKLArTSKTPGKTQLINFFLINDKFYLVDLPG 78
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
216-231 3.21e-03

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 39.05  E-value: 3.21e-03
                         10
                 ....*....|....*.
gi 460393470 216 VVGYPNVGKSSLVNRL 231
Cdd:COG1084  165 VAGYPNVGKSSLVSKV 180
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 202-233 3.52e-03

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 39.16  E-value: 3.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 460393470 202 RKAKGLLPRPV---RAGVVGYPNVGKSSLVNRLLK 233
Cdd:PTZ00258   9 EEKKVLLGRPGnnlKMGIVGLPNVGKSTTFNALCK 43
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 215-277 4.57e-03

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 36.93  E-value: 4.57e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 460393470 215 GVVGYPNVGKSSLVNRLLKRRMCAAAPRPGVTRE---LKWVRFGKDLELLDSPGIIPMRISDQTAA 277
Cdd:cd11383    1 GLMGKTGAGKSSLCNALFGTEVAAVGDRRPTTRAaqaYVWQTGGDGLVLLDLPGVGERGRRDREYE 66
PRK03003 PRK03003
GTP-binding protein Der; Reviewed
 211-231 5.75e-03

GTP-binding protein Der; Reviewed


Pssm-ID: 179525 [Multi-domain]  Cd Length: 472  Bit Score: 38.41  E-value: 5.75e-03
                         10        20
                 ....*....|....*....|.
gi 460393470 211 PVRAGVVGYPNVGKSSLVNRL 231
Cdd:PRK03003 211 PRRVALVGKPNVGKSSLLNKL 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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