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Conserved domains on  [gi|460369101|ref|XP_004230402|]
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TMV resistance protein N-like [Solanum lycopersicum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 8-1007 2.63e-132

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 432.38  E-value: 2.63e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    8 TSSSFVYPSIYHAFLSFRGEDTRKTFTDTLYAALVGAGWRTFKDdNEIERGENIKTELENAIRNSRSSIIILSKNYATST 87
Cdd:PLN03210    3 SSSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKD-NEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   88 WCLDELVKILEHKRTKGHAILPVFYHVDPSEVRDQTKSFAEAFS-TYERQIEaesDEGKRewmdkvqkWRAALGEVADLG 166
Cdd:PLN03210   82 WCLNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEkTCQNKTE---DEKIQ--------WKQALTDVANIL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  167 GVLVNNQEDrkESEFIEEILQLIEDKLNRTISSVAPYLVGISSRVKNIVSWLQDGSHDDNLIAICGMSGIGKTTVAKYVF 246
Cdd:PLN03210  151 GYHSQNWPN--EAKMIEEIANDVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  247 TTNFRRFEGSSFL--------------ANIQDISQQndglIRLQKQLLYDLTGKKS-KIQDtdegIIKIRDAICFKRVLV 311
Cdd:PLN03210  229 SRLSRQFQSSVFIdrafisksmeiyssANPDDYNMK----LHLQRAFLSEILDKKDiKIYH----LGAMEERLKHRKVLI 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  312 ILDDIDQIEQIHAIIGMKNWFCPGSKIIITTKNSCLLKVEEIQKVHKVREMGNDESLELFSWHSFGEDHPADDYMELSKR 391
Cdd:PLN03210  301 FIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASE 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  392 VVKHCGGLPLALQVLGSSLCGRSIDVWKSALDKLEAIPASQVIKKLKFGYDSLKDDHDKNLFLDIACFFTRKDKDYVIAV 471
Cdd:PLN03210  381 VALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLL 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  472 LDESYIYTRVGIQNLTDRFLLTIEGNKLIMHQMIRDMGREIVRQESSkKPGRRTRLWHYKDSFNVLREDMGSETIEGLFF 551
Cdd:PLN03210  461 LANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSN-EPGEREFLVDAKDICDVLEDNTGTKKVLGITL 539

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  552 DMNmvkedqsfmgssssgrkwlltevksyrfgfsrhtsnfsskTLNELELGTNLFTVMNKLRLLQInYT----------- 620
Cdd:PLN03210  540 DID----------------------------------------EIDELHIHENAFKGMRNLLFLKF-YTkkwdqkkevrw 578

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  621 HLNGAYKDFPKNLRWLYWRGFPLKCVPNDFPLESLSVLDMRNSCLERLWEGRRVLPLVKILNLSHSHSLFRTPDFSGLPM 700
Cdd:PLN03210  579 HLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATN 658

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  701 LEKLVLKECVNLIEVHESIGTLEaRLIFLNIKNCKRLKKLPREIcKLKVLKTFIISGCSNLVELPRDLWRMQSLEVflaN 780
Cdd:PLN03210  659 LETLKLSDCSSLVELPSSIQYLN-KLEDLDMSRCENLEILPTGI-NLKSLYRLNLSGCSRLKSFPDISTNISWLDL---D 733

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  781 EIPMCQLPSK-RKQNSIWHALIQSWLPK--PRKVLDLPWVS-LPKSLVNLSLSGcNLSDVAFPRDFSNLMLLQNLDLS-- 854
Cdd:PLN03210  734 ETAIEEFPSNlRLENLDELILCEMKSEKlwERVQPLTPLMTmLSPSLTRLFLSD-IPSLVELPSSIQNLHKLEHLEIEnc 812

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  855 KNpISCLPDCVrTLSRLNSLELGSCTMLKLLIDLP-RIHNLRLGHcTSLERVTYLSEVCRAVVY-HLNGCKALTDMEGNF 932
Cdd:PLN03210  813 IN-LETLPTGI-NLESLESLDLSGCSRLRTFPDIStNISDLNLSR-TGIEEVPWWIEKFSNLSFlDMNGCNNLQRVSLNI 889

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  933 -KLEAMGGIEIEK-KSLELSMWDSVGSSEVKlynNSTNTESRGP--VKVLF--------------ERGMISIYLPGSKVP 994
Cdd:PLN03210  890 sKLKHLETVDFSDcGALTEASWNGSPSEVAM---ATDNIHSKLPstVCINFincfnldqeallqqQSIFKQLILSGEEVP 966

                        1050
                  ....*....|...
gi 460369101  995 NWFCYKSAGATLS 1007
Cdd:PLN03210  967 SYFTHRTTGASLT 979
C-JID super family cl45530
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 988-1068 5.17e-04

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


The actual alignment was detected with superfamily member pfam20160:

Pssm-ID: 466313  Cd Length: 108  Bit Score: 40.89  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   988 LPGSKVPNWFCYKSAGATLSFAVP-SPPDLKIQGITVCSV--YTIDWKVWIAGIEFYLIIHNE--QKNVKLIYSPTCYGL 1062
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPeNWYNDNFLGFAVCAVgsLIPSLHNFLGYIHFFLIPLVSlwDTSKANGKTPNDYGR 80


                   ....*.
gi 460369101  1063 PEAQNE 1068
Cdd:pfam20160   81 IEASFE 86
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 8-1007 2.63e-132

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 432.38  E-value: 2.63e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    8 TSSSFVYPSIYHAFLSFRGEDTRKTFTDTLYAALVGAGWRTFKDdNEIERGENIKTELENAIRNSRSSIIILSKNYATST 87
Cdd:PLN03210    3 SSSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKD-NEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   88 WCLDELVKILEHKRTKGHAILPVFYHVDPSEVRDQTKSFAEAFS-TYERQIEaesDEGKRewmdkvqkWRAALGEVADLG 166
Cdd:PLN03210   82 WCLNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEkTCQNKTE---DEKIQ--------WKQALTDVANIL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  167 GVLVNNQEDrkESEFIEEILQLIEDKLNRTISSVAPYLVGISSRVKNIVSWLQDGSHDDNLIAICGMSGIGKTTVAKYVF 246
Cdd:PLN03210  151 GYHSQNWPN--EAKMIEEIANDVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  247 TTNFRRFEGSSFL--------------ANIQDISQQndglIRLQKQLLYDLTGKKS-KIQDtdegIIKIRDAICFKRVLV 311
Cdd:PLN03210  229 SRLSRQFQSSVFIdrafisksmeiyssANPDDYNMK----LHLQRAFLSEILDKKDiKIYH----LGAMEERLKHRKVLI 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  312 ILDDIDQIEQIHAIIGMKNWFCPGSKIIITTKNSCLLKVEEIQKVHKVREMGNDESLELFSWHSFGEDHPADDYMELSKR 391
Cdd:PLN03210  301 FIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASE 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  392 VVKHCGGLPLALQVLGSSLCGRSIDVWKSALDKLEAIPASQVIKKLKFGYDSLKDDHDKNLFLDIACFFTRKDKDYVIAV 471
Cdd:PLN03210  381 VALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLL 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  472 LDESYIYTRVGIQNLTDRFLLTIEGNKLIMHQMIRDMGREIVRQESSkKPGRRTRLWHYKDSFNVLREDMGSETIEGLFF 551
Cdd:PLN03210  461 LANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSN-EPGEREFLVDAKDICDVLEDNTGTKKVLGITL 539

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  552 DMNmvkedqsfmgssssgrkwlltevksyrfgfsrhtsnfsskTLNELELGTNLFTVMNKLRLLQInYT----------- 620
Cdd:PLN03210  540 DID----------------------------------------EIDELHIHENAFKGMRNLLFLKF-YTkkwdqkkevrw 578

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  621 HLNGAYKDFPKNLRWLYWRGFPLKCVPNDFPLESLSVLDMRNSCLERLWEGRRVLPLVKILNLSHSHSLFRTPDFSGLPM 700
Cdd:PLN03210  579 HLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATN 658

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  701 LEKLVLKECVNLIEVHESIGTLEaRLIFLNIKNCKRLKKLPREIcKLKVLKTFIISGCSNLVELPRDLWRMQSLEVflaN 780
Cdd:PLN03210  659 LETLKLSDCSSLVELPSSIQYLN-KLEDLDMSRCENLEILPTGI-NLKSLYRLNLSGCSRLKSFPDISTNISWLDL---D 733

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  781 EIPMCQLPSK-RKQNSIWHALIQSWLPK--PRKVLDLPWVS-LPKSLVNLSLSGcNLSDVAFPRDFSNLMLLQNLDLS-- 854
Cdd:PLN03210  734 ETAIEEFPSNlRLENLDELILCEMKSEKlwERVQPLTPLMTmLSPSLTRLFLSD-IPSLVELPSSIQNLHKLEHLEIEnc 812

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  855 KNpISCLPDCVrTLSRLNSLELGSCTMLKLLIDLP-RIHNLRLGHcTSLERVTYLSEVCRAVVY-HLNGCKALTDMEGNF 932
Cdd:PLN03210  813 IN-LETLPTGI-NLESLESLDLSGCSRLRTFPDIStNISDLNLSR-TGIEEVPWWIEKFSNLSFlDMNGCNNLQRVSLNI 889

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  933 -KLEAMGGIEIEK-KSLELSMWDSVGSSEVKlynNSTNTESRGP--VKVLF--------------ERGMISIYLPGSKVP 994
Cdd:PLN03210  890 sKLKHLETVDFSDcGALTEASWNGSPSEVAM---ATDNIHSKLPstVCINFincfnldqeallqqQSIFKQLILSGEEVP 966

                        1050
                  ....*....|...
gi 460369101  995 NWFCYKSAGATLS 1007
Cdd:PLN03210  967 SYFTHRTTGASLT 979
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 18-194 9.19e-50

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 173.70  E-value: 9.19e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    18 YHAFLSFRGEDTRKTFTDTLYAALVGAGWRTFKDDNEIERGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKIL 97
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    98 EHKRTKGHAILPVFYHVDPSEVRDQTKSFAEAFSTYERQIEAEsdegkrewmdKVQKWRAALGEVADLGGVLvnNQEDrk 177
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEE----------KVLKWRGALNEVANIWHSK--SVSD-- 146

                          170
                   ....*....|....*..
gi 460369101   178 ESEFIEEILQLIEDKLN 194
Cdd:pfam01582  147 ESKFWKKIAYDISNKLN 163
TIR smart00255
Toll - interleukin 1 - resistance;
18-150 1.01e-28

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 112.42  E-value: 1.01e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101     18 YHAFLSFRG-EDTRKTFTDTLYAALVGAGWRTFKDDNEIerGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKI 96
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 460369101     97 LEHK-RTKGHAILPVFYHVDPSEVRDQTKSFAEAFstYERQIEAESDEGKREWMD 150
Cdd:smart00255   80 LENAlEEGGLRVIPIFYEVIPSDVRKQPGKFRKVF--KKNYLKWPEDEKEQFWKK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-969 5.12e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 5.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  561 SFMGSSSSGRKWLLTEVKSYRFGFSRHTSNFSSKTLNELELGTNLFTVMNKLRLLQINYTHLNGAYKDFPKNLRWLYwrg 640
Cdd:COG4886    26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  641 fpLKCVPNDFPLESLSVLDMRNSCLERLWEGRRVLPLVKILNLSHS--HSLfrTPDFSGLPMLEKLVLKECvNLIEVHES 718
Cdd:COG4886   103 --LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNqlTDL--PEPLGNLTNLKSLDLSNN-QLTDLPEE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  719 IGTLEaRLIFLNIKNCKrLKKLPREICKLKVLKTFIISGCsNLVELPRDLWRMQSLEVFlaneipmcqlpskrkqnSIWH 798
Cdd:COG4886   178 LGNLT-NLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETL-----------------DLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  799 ALIQswlpkprkvlDLPWVSLPKSLVNLSLSGCNLSDVAFPRDFSNlmlLQNLDLSKNPISCLpdCVRTLsrLNSLELGS 878
Cdd:COG4886   238 NQLT----------DLPELGNLTNLEELDLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDL--KLKEL--ELLLGLNS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  879 CTMLKLLIDLPRIHNLRLGHCTSLERVTYLSEVCRAVVYHLNGCKALTDMEGNFKLEAMGGIEIEKKSLELSMWDSVGSS 958
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380

                         410
                  ....*....|.
gi 460369101  959 EVKLYNNSTNT 969
Cdd:COG4886   381 TLALLLLTLLL 391
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 818-875 2.61e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 2.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 460369101  818 SLPKSLVNLSLSGCNLSDVAfprDFSNLMLLQNLDLSKNPISCLPDCVRTLSRLNSLE 875
Cdd:cd21340   117 ALSNSLRVLNISGNNIDSLE---PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLR 171
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 988-1068 5.17e-04

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 40.89  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   988 LPGSKVPNWFCYKSAGATLSFAVP-SPPDLKIQGITVCSV--YTIDWKVWIAGIEFYLIIHNE--QKNVKLIYSPTCYGL 1062
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPeNWYNDNFLGFAVCAVgsLIPSLHNFLGYIHFFLIPLVSlwDTSKANGKTPNDYGR 80


                   ....*.
gi 460369101  1063 PEAQNE 1068
Cdd:pfam20160   81 IEASFE 86
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 8-1007 2.63e-132

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 432.38  E-value: 2.63e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    8 TSSSFVYPSIYHAFLSFRGEDTRKTFTDTLYAALVGAGWRTFKDdNEIERGENIKTELENAIRNSRSSIIILSKNYATST 87
Cdd:PLN03210    3 SSSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKD-NEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   88 WCLDELVKILEHKRTKGHAILPVFYHVDPSEVRDQTKSFAEAFS-TYERQIEaesDEGKRewmdkvqkWRAALGEVADLG 166
Cdd:PLN03210   82 WCLNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEkTCQNKTE---DEKIQ--------WKQALTDVANIL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  167 GVLVNNQEDrkESEFIEEILQLIEDKLNRTISSVAPYLVGISSRVKNIVSWLQDGSHDDNLIAICGMSGIGKTTVAKYVF 246
Cdd:PLN03210  151 GYHSQNWPN--EAKMIEEIANDVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  247 TTNFRRFEGSSFL--------------ANIQDISQQndglIRLQKQLLYDLTGKKS-KIQDtdegIIKIRDAICFKRVLV 311
Cdd:PLN03210  229 SRLSRQFQSSVFIdrafisksmeiyssANPDDYNMK----LHLQRAFLSEILDKKDiKIYH----LGAMEERLKHRKVLI 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  312 ILDDIDQIEQIHAIIGMKNWFCPGSKIIITTKNSCLLKVEEIQKVHKVREMGNDESLELFSWHSFGEDHPADDYMELSKR 391
Cdd:PLN03210  301 FIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASE 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  392 VVKHCGGLPLALQVLGSSLCGRSIDVWKSALDKLEAIPASQVIKKLKFGYDSLKDDHDKNLFLDIACFFTRKDKDYVIAV 471
Cdd:PLN03210  381 VALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLL 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  472 LDESYIYTRVGIQNLTDRFLLTIEGNKLIMHQMIRDMGREIVRQESSkKPGRRTRLWHYKDSFNVLREDMGSETIEGLFF 551
Cdd:PLN03210  461 LANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSN-EPGEREFLVDAKDICDVLEDNTGTKKVLGITL 539

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  552 DMNmvkedqsfmgssssgrkwlltevksyrfgfsrhtsnfsskTLNELELGTNLFTVMNKLRLLQInYT----------- 620
Cdd:PLN03210  540 DID----------------------------------------EIDELHIHENAFKGMRNLLFLKF-YTkkwdqkkevrw 578

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  621 HLNGAYKDFPKNLRWLYWRGFPLKCVPNDFPLESLSVLDMRNSCLERLWEGRRVLPLVKILNLSHSHSLFRTPDFSGLPM 700
Cdd:PLN03210  579 HLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATN 658

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  701 LEKLVLKECVNLIEVHESIGTLEaRLIFLNIKNCKRLKKLPREIcKLKVLKTFIISGCSNLVELPRDLWRMQSLEVflaN 780
Cdd:PLN03210  659 LETLKLSDCSSLVELPSSIQYLN-KLEDLDMSRCENLEILPTGI-NLKSLYRLNLSGCSRLKSFPDISTNISWLDL---D 733

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  781 EIPMCQLPSK-RKQNSIWHALIQSWLPK--PRKVLDLPWVS-LPKSLVNLSLSGcNLSDVAFPRDFSNLMLLQNLDLS-- 854
Cdd:PLN03210  734 ETAIEEFPSNlRLENLDELILCEMKSEKlwERVQPLTPLMTmLSPSLTRLFLSD-IPSLVELPSSIQNLHKLEHLEIEnc 812

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  855 KNpISCLPDCVrTLSRLNSLELGSCTMLKLLIDLP-RIHNLRLGHcTSLERVTYLSEVCRAVVY-HLNGCKALTDMEGNF 932
Cdd:PLN03210  813 IN-LETLPTGI-NLESLESLDLSGCSRLRTFPDIStNISDLNLSR-TGIEEVPWWIEKFSNLSFlDMNGCNNLQRVSLNI 889

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  933 -KLEAMGGIEIEK-KSLELSMWDSVGSSEVKlynNSTNTESRGP--VKVLF--------------ERGMISIYLPGSKVP 994
Cdd:PLN03210  890 sKLKHLETVDFSDcGALTEASWNGSPSEVAM---ATDNIHSKLPstVCINFincfnldqeallqqQSIFKQLILSGEEVP 966

                        1050
                  ....*....|...
gi 460369101  995 NWFCYKSAGATLS 1007
Cdd:PLN03210  967 SYFTHRTTGASLT 979
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 18-194 9.19e-50

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 173.70  E-value: 9.19e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    18 YHAFLSFRGEDTRKTFTDTLYAALVGAGWRTFKDDNEIERGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKIL 97
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    98 EHKRTKGHAILPVFYHVDPSEVRDQTKSFAEAFSTYERQIEAEsdegkrewmdKVQKWRAALGEVADLGGVLvnNQEDrk 177
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEE----------KVLKWRGALNEVANIWHSK--SVSD-- 146

                          170
                   ....*....|....*..
gi 460369101   178 ESEFIEEILQLIEDKLN 194
Cdd:pfam01582  147 ESKFWKKIAYDISNKLN 163
TIR smart00255
Toll - interleukin 1 - resistance;
18-150 1.01e-28

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 112.42  E-value: 1.01e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101     18 YHAFLSFRG-EDTRKTFTDTLYAALVGAGWRTFKDDNEIerGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKI 96
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 460369101     97 LEHK-RTKGHAILPVFYHVDPSEVRDQTKSFAEAFstYERQIEAESDEGKREWMD 150
Cdd:smart00255   80 LENAlEEGGLRVIPIFYEVIPSDVRKQPGKFRKVF--KKNYLKWPEDEKEQFWKK 132
NB-ARC pfam00931
NB-ARC domain;
228-443 1.64e-18

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 86.28  E-value: 1.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   228 IAICGMSGIGKTTVAKYVFT---TNFRRFEGSSFLAniqdISQQnDGLIRLQKQLLYDLTGKKSKIQDTDEGII--KIRD 302
Cdd:pfam00931   21 VGIHGMGGVGKTTLAAQIFNdfdEVEGHFDSVAWVV----VSKT-FTISTLQQTILQNLGLSEDDWDNKEEGELarKIRR 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   303 AICFKRVLVILDDIDQIEQIHAIIGMKNWFCPGSKIIITTKNSCLLK-VEEIQKVHKVREMGNDESLELFSWHSF-GEDH 380
Cdd:pfam00931   96 ALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGrVGGPSDPHEVELLEPDEAWELFENKVFpKTLG 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   381 PADDYMELSKRVVKHCGGLPLALQVLGSSL-CGRSIDVWKSALDKLEAIPASQ------VIKKLKFGYDS 443
Cdd:pfam00931  176 ECELLEDVAKEIVEKCRGLPLALKVLGGLLsCKKTVEEWKHVYDVLQSELKSNsyslnsVRSILQLSYEN 245
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 21-116 2.82e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 75.81  E-value: 2.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101    21 FLSFRGEDtrKTFTDTLYAALVGAGWRTFKDDNEIERGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKILEhK 100
Cdd:pfam13676    2 FISYAGED--RAWAEWLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA-D 78

                           90
                   ....*....|....*.
gi 460369101   101 RTKGHAILPVFYHVDP 116
Cdd:pfam13676   79 PEGRKRLIPVRLECDL 94
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-969 5.12e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 5.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  561 SFMGSSSSGRKWLLTEVKSYRFGFSRHTSNFSSKTLNELELGTNLFTVMNKLRLLQINYTHLNGAYKDFPKNLRWLYwrg 640
Cdd:COG4886    26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  641 fpLKCVPNDFPLESLSVLDMRNSCLERLWEGRRVLPLVKILNLSHS--HSLfrTPDFSGLPMLEKLVLKECvNLIEVHES 718
Cdd:COG4886   103 --LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNqlTDL--PEPLGNLTNLKSLDLSNN-QLTDLPEE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  719 IGTLEaRLIFLNIKNCKrLKKLPREICKLKVLKTFIISGCsNLVELPRDLWRMQSLEVFlaneipmcqlpskrkqnSIWH 798
Cdd:COG4886   178 LGNLT-NLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETL-----------------DLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  799 ALIQswlpkprkvlDLPWVSLPKSLVNLSLSGCNLSDVAFPRDFSNlmlLQNLDLSKNPISCLpdCVRTLsrLNSLELGS 878
Cdd:COG4886   238 NQLT----------DLPELGNLTNLEELDLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDL--KLKEL--ELLLGLNS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  879 CTMLKLLIDLPRIHNLRLGHCTSLERVTYLSEVCRAVVYHLNGCKALTDMEGNFKLEAMGGIEIEKKSLELSMWDSVGSS 958
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380

                         410
                  ....*....|.
gi 460369101  959 EVKLYNNSTNT 969
Cdd:COG4886   381 TLALLLLTLLL 391
PLN03194 PLN03194
putative disease resistance protein; Provisional
 21-182 1.42e-11

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 64.46  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   21 FLSFRGEDTRKTFTDTLYAALVGAGWRTFKDDNEIERGENIKTELENAIRNSRSSIIILSKNYATSTWCLDELVKILEHK 100
Cdd:PLN03194   30 FINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCLHELALIMESK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  101 RTkghaILPVFYHVDPSEVRdqtksfaeafstyerqieaESDEGKREwMDKVQKWRAALGEVADLGGvLVNNQEDRKESE 180
Cdd:PLN03194  110 KR----VIPIFCDVKPSQLR-------------------VVDNGTCP-DEEIRRFNWALEEAKYTVG-LTFDSLKGNWSE 164


                  ..
gi 460369101  181 FI 182
Cdd:PLN03194  165 VV 166
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
18-130 7.07e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 57.82  E-value: 7.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   18 YHAFLSFRGEDtrKTFTDTLYAALVGAGWRTFKDDNEIER--GENIKTELENAIRN-SRSSIIILSKNYATSTWCLDELV 94
Cdd:COG4916     1 YDVALSFAGED--REFVERVAEALKARGIKVFYDENEEAElwGKDLDEYLQDIYRSeSRFVVVFLSKDYVEKKWTGLERR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 460369101   95 KILEH-KRTKGHAILPVFY-HVDPSEVR------DQTKSFAEAF 130
Cdd:COG4916    79 AALARaMQRKKEYILPIRLdDTEIPGILatigyiDLRNRTPEEI 122
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 818-875 2.61e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 2.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 460369101  818 SLPKSLVNLSLSGCNLSDVAfprDFSNLMLLQNLDLSKNPISCLPDCVRTLSRLNSLE 875
Cdd:cd21340   117 ALSNSLRVLNISGNNIDSLE---PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLR 171
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 988-1068 5.17e-04

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 40.89  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   988 LPGSKVPNWFCYKSAGATLSFAVP-SPPDLKIQGITVCSV--YTIDWKVWIAGIEFYLIIHNE--QKNVKLIYSPTCYGL 1062
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPeNWYNDNFLGFAVCAVgsLIPSLHNFLGYIHFFLIPLVSlwDTSKANGKTPNDYGR 80


                   ....*.
gi 460369101  1063 PEAQNE 1068
Cdd:pfam20160   81 IEASFE 86
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
105-342 6.30e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 44.03  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  105 HAILPVFYHVDPSEVRDQTKSFAEAFSTYERQIEAESDEGKREWMDKVQKWRAALGEVADLGGVLVNNQEDRKESEFIEE 184
Cdd:COG5635    60 ALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  185 ILQLIEDKLNRTISSVAPYLVGISSRVKNIVSWLQDGSHDDNLIAICGMSGIGKTTVAKYVFTTNFRRFEGSS----FLA 260
Cdd:COG5635   140 LLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEdpipILI 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  261 NIQDISQQNDglirLQKQLLYDLTGKKSKIQDTdegiikIRDAICFKRVLVILDDIDQIEQIHAIIGMKNWF------CP 334
Cdd:COG5635   220 ELRDLAEEAS----LEDLLAEALEKRGGEPEDA------LERLLRNGRLLLLLDGLDEVPDEADRDEVLNQLrrflerYP 289


                  ....*...
gi 460369101  335 GSKIIITT 342
Cdd:COG5635   290 KARVIITS 297
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 675-878 8.94e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  675 LPLVKILNLSHSHSLFRTPD------------------FSG------LPMLEKLVLKECVNLIEVHESIGTLeARLIFLN 730
Cdd:PLN00113   92 LPYIQTINLSNNQLSGPIPDdifttssslrylnlsnnnFTGsiprgsIPNLETLDLSNNMLSGEIPNDIGSF-SSLKVLD 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  731 IKNCKRLKKLPREICKLKVLKTFIISGCSNLVELPRDLWRMQSLEVF------LANEIP--MCQLPSKRKQNSIWHALIQ 802
Cdd:PLN00113  171 LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIylgynnLSGEIPyeIGGLTSLNHLDLVYNNLTG 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101  803 SWLPKPRKVLDLPWV---------SLPKSLVNLS-LSGCNLSDVAFPRDFSNLML-LQNLDL----SKNPISCLPDCVRT 867
Cdd:PLN00113  251 PIPSSLGNLKNLQYLflyqnklsgPIPPSIFSLQkLISLDLSDNSLSGEIPELVIqLQNLEIlhlfSNNFTGKIPVALTS 330

                         250
                  ....*....|.
gi 460369101  868 LSRLNSLELGS 878
Cdd:PLN00113  331 LPRLQVLQLWS 341
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 227-375 1.30e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 40.75  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   227 LIAICGMSGIGKTTVAK----------------YVFTTNFRRFEGSSFLANIQDIsqqndgLIRLQKQLLYDLTGKKSKI 290
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQklallwaqgklpqgfdFVFFLPCRELSRSGNARSLADL------LFSQWPEPAAPVSEVWAVI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460369101   291 QDTdegiikirdaicFKRVLVILDDIDQIEQI--------HAIIGMKNWF----CPGSKIIITTKNSCLLK----VEEIQ 354
Cdd:pfam05729   76 LEL------------PERLLLILDGLDELVSDlgqldgpcPVLTLLSSLLrkklLPGASLLLTVRPDALRDlrrgLEEPR 143

                          170       180
                   ....*....|....*....|..
gi 460369101   355 KVHkVREMGNDESLELFS-WHS 375
Cdd:pfam05729  144 YLE-VRGFSESDRKQYVRkYFS 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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