|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
35-471 |
2.39e-174 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 498.64 E-value: 2.39e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 35 EAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLLG 114
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 115 LTLQRTIILLLISSLPISFLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAIL 194
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 195 AILFHIPINYFFVCVFEWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSDCLKEWKSLLGLAIPSCISVCLE 274
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 275 WWWYEIMILLSGfMLNPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLG--IS 352
Cdd:cd13132 241 WWAFEILVLLAG-LLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGvvVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 353 ALLFAFkiRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAIWLSF 432
Cdd:cd13132 320 ILLLVL--RDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAF 397
|
410 420 430
....*....|....*....|....*....|....*....
gi 778699759 433 YGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNWEEQAER 471
Cdd:cd13132 398 VLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
37-458 |
5.14e-56 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 193.44 E-value: 5.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLT 116
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 117 LQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILA 195
Cdd:COG0534 87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 196 ILFHIPINYFFVCVFEWGIRGVALGAVWTN-FNFVGSLVVFVLFSGVYKKTWPGMSSDcLKEWKSLLGLAIPSCISVCLE 274
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQaVSALLLLYYLFRKRSLLRLRLRDLRPD-RKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 275 WwwyeIMILLSGFMLNPQST--VASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLGIS 352
Cdd:COG0534 246 S----LGFLVLNALVARLGTaaVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 353 ALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAIWLSF 432
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF 401
|
410 420
....*....|....*....|....*.
gi 778699759 433 YgGWDFKGLWIGLLAAQASCAMTMLM 458
Cdd:COG0534 402 L-GLGLTGVWLALPIGEVLRALLLLL 426
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
45-386 |
1.25e-43 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 157.79 E-value: 1.25e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 45 PMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAiGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTIILL 124
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 125 LISSLPISFLWFNMKKILLFCGQ-DVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHIPIN 203
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 204 YFFV-CVF-EWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSDCLKEWKSLLGLAIPSCISVCLEWWWYEIM 281
Cdd:TIGR00797 160 YILIfGKFgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 282 ILLSGfmLNPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLGISALLFAFKIR 361
Cdd:TIGR00797 240 ALLVA--RLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 778699759 362 KVWATMFTEDIQIIELTSLILPIIG 386
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
33-463 |
1.37e-32 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 129.93 E-value: 1.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 33 LSEAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGgsLAIGfANI--TGYSLLSGLAMGMEPICGQAFGAKRF 110
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAA--VAIG-TSIwlPVILFGHGLLLALTPIVAQLNGAGRR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 111 KLLGLTLQRTIILLLISSLPISF-LWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLT 189
Cdd:PRK01766 85 ERIAHQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 190 YCAILAILFHIPINYFFVcvfeWGIRGV-ALGAV----------WTNF-------NFVGSLVVFVLFSGVYKKTWpgmss 251
Cdd:PRK01766 165 VIGFLGLLINIPLNYIFI----YGKFGFpELGGVgcgvataivyWVMFlamliyiKRARRFRDFRLFKGLYKPDW----- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 252 dclKEWKSLLGLAIPSCISVCLEWWWYE-IMILLSGFMLNpqsTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGAN 330
Cdd:PRK01766 236 ---AVIKRLLKLGLPIGLAIFFEVSLFAvVTLLVSPLGTV---TVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 331 HPNKAKLAAIVGLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKL 410
Cdd:PRK01766 310 RTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRV 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 778699759 411 GANINLGCFYMVGMPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRT 463
Cdd:PRK01766 390 IFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
45-205 |
1.24e-31 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 119.59 E-value: 1.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 45 PMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTIILL 124
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 125 LISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHIPIN 203
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 778699759 204 YF 205
Cdd:pfam01554 160 YL 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
35-471 |
2.39e-174 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 498.64 E-value: 2.39e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 35 EAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLLG 114
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 115 LTLQRTIILLLISSLPISFLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAIL 194
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 195 AILFHIPINYFFVCVFEWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSDCLKEWKSLLGLAIPSCISVCLE 274
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 275 WWWYEIMILLSGfMLNPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLG--IS 352
Cdd:cd13132 241 WWAFEILVLLAG-LLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGvvVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 353 ALLFAFkiRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAIWLSF 432
Cdd:cd13132 320 ILLLVL--RDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAF 397
|
410 420 430
....*....|....*....|....*....|....*....
gi 778699759 433 YGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNWEEQAER 471
Cdd:cd13132 398 VLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
37-458 |
5.14e-56 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 193.44 E-value: 5.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLT 116
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 117 LQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILA 195
Cdd:COG0534 87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 196 ILFHIPINYFFVCVFEWGIRGVALGAVWTN-FNFVGSLVVFVLFSGVYKKTWPGMSSDcLKEWKSLLGLAIPSCISVCLE 274
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQaVSALLLLYYLFRKRSLLRLRLRDLRPD-RKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 275 WwwyeIMILLSGFMLNPQST--VASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLGIS 352
Cdd:COG0534 246 S----LGFLVLNALVARLGTaaVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 353 ALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAIWLSF 432
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF 401
|
410 420
....*....|....*....|....*.
gi 778699759 433 YgGWDFKGLWIGLLAAQASCAMTMLM 458
Cdd:COG0534 402 L-GLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
35-462 |
1.46e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 171.14 E-value: 1.46e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 35 EAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFaNITGYSLLSGLAMGMEPICGQAFGAKRFKLLG 114
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL-WFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 115 LTLQRTIILLLISSLPISFLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAIL 194
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 195 AILFHIPINYFFVC----VFEWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYK--KTWPGMSSDCLKEWKSLLGLAIPSC 268
Cdd:cd13131 160 ALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRryRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 269 ISVCLEWWWYEIMILLSGfMLNPQsTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISF- 347
Cdd:cd13131 240 LTIFFEVSLFAAVALLMG-RLGTT-VLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVg 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 348 FLGISALLFAFkIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVA 427
Cdd:cd13131 318 FAALTALLLLL-FPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLG 396
|
410 420 430
....*....|....*....|....*....|....*
gi 778699759 428 IWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTR 462
Cdd:cd13131 397 YLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRR 431
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
45-386 |
1.25e-43 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 157.79 E-value: 1.25e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 45 PMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAiGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTIILL 124
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 125 LISSLPISFLWFNMKKILLFCGQ-DVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHIPIN 203
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 204 YFFV-CVF-EWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSDCLKEWKSLLGLAIPSCISVCLEWWWYEIM 281
Cdd:TIGR00797 160 YILIfGKFgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 282 ILLSGfmLNPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLGISALLFAFKIR 361
Cdd:TIGR00797 240 ALLVA--RLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 778699759 362 KVWATMFTEDIQIIELTSLILPIIG 386
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
37-465 |
2.03e-35 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 137.64 E-value: 2.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLT 116
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 117 LQRTIILLLISSLPISFLWFNMKK-ILLFCGQDVDIANEAHSYILcslPDLVALSFLHPLRIY---LRSQ-SINLPLtYC 191
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEpLLRLLGADPEVIALALTYLR---IVLLGIPFFFLSLVGnaaLRGAgDTKTPM-YI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 192 AILAILFHIPINYFFV----CVFEWGIRGVALGAVWTNFnFVGSLVVFVLFSG--VYKKTWPGMSSDcLKEWKSLLGLAI 265
Cdd:cd13137 156 MIIVNVLNIVLDYVLIfglwGFPGLGVAGAALATVISRV-VGALLLLFLLLRGrlPIKISFKGFRLD-RKIIKKLLRIGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 266 PSCISVCLewwWYEIMILLSGFMLNPQSTV-ASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLC 344
Cdd:cd13137 234 PAGLEQLL---RSLGFLVLLAIVASYGTAAlAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 345 ISF-FLGISALLFAFkIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVG 423
Cdd:cd13137 311 LGVlFMGLLGLLLFI-FAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVR 389
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 778699759 424 MPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNW 465
Cdd:cd13137 390 LPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
33-463 |
1.37e-32 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 129.93 E-value: 1.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 33 LSEAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGgsLAIGfANI--TGYSLLSGLAMGMEPICGQAFGAKRF 110
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAA--VAIG-TSIwlPVILFGHGLLLALTPIVAQLNGAGRR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 111 KLLGLTLQRTIILLLISSLPISF-LWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLT 189
Cdd:PRK01766 85 ERIAHQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 190 YCAILAILFHIPINYFFVcvfeWGIRGV-ALGAV----------WTNF-------NFVGSLVVFVLFSGVYKKTWpgmss 251
Cdd:PRK01766 165 VIGFLGLLINIPLNYIFI----YGKFGFpELGGVgcgvataivyWVMFlamliyiKRARRFRDFRLFKGLYKPDW----- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 252 dclKEWKSLLGLAIPSCISVCLEWWWYE-IMILLSGFMLNpqsTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGAN 330
Cdd:PRK01766 236 ---AVIKRLLKLGLPIGLAIFFEVSLFAvVTLLVSPLGTV---TVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 331 HPNKAKLAAIVGLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKL 410
Cdd:PRK01766 310 RTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRV 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 778699759 411 GANINLGCFYMVGMPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRT 463
Cdd:PRK01766 390 IFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
45-205 |
1.24e-31 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 119.59 E-value: 1.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 45 PMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTIILL 124
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 125 LISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHIPIN 203
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 778699759 204 YF 205
Cdd:pfam01554 160 YL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
43-460 |
5.88e-29 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 118.97 E-value: 5.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 43 AFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTII 122
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 123 LLLISSLPIS-FLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHIP 201
Cdd:cd12082 80 LAILLGLLLAaLLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 202 INYFFV---CVFEWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSDCLKEWKSLLGLAIPSCISVCLEWWWY 278
Cdd:cd12082 160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 279 EIMILLSGfMLNPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCISFFLGISALLFAF 358
Cdd:cd12082 240 LIIVAIVA-AFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 359 KIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAiWLSFYGGWDF 438
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA-YVLAYLGLGL 397
|
410 420
....*....|....*....|..
gi 778699759 439 KGLWIGLLAAQASCAMTMLMVL 460
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-447 |
1.85e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 114.91 E-value: 1.85e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAggslAIGFAN---ITGYSLLSGLAMGMEPICGQAFGAKRFKLL 113
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVA----AVGVANqilFLLILIFSFISTGTSILIAQYLGAKDKKKA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 114 GLTLQRTIILLLISSLPIS-FLWFNMKKILLFCGQDVDIANEAHSYIL----CSLPDLVALSFLHPLRIYLRSQSInlpl 188
Cdd:cd13134 79 RQIAGVALLFNLLLGLVFSlLLLFFGAELLRLMGLPPELLALGSTYLRivggSLFLQALSLTLSAILRSHGRTKIP---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 189 TYCAILAILFHIPINYFFVCVF----EWGIRGVALGAVWTNFnfVGSLVVFVLfsgVYKKTWPGMSSDCL-----KEWKS 259
Cdd:cd13134 155 MYVSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRA--VGLVLLFIL---LFRKLKIRFRLKDLrpfpkKLLKK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 260 LLGLAIPSCISVCLewWWYEIMILLSGF-MLNPQStVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLA 338
Cdd:cd13134 230 ILKIGLPSAGEELS--YNLSQTVITAFIaRLGTAA-LAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 339 AI----VGLCISFFLGISALLFAFKIrkvwATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANI 414
Cdd:cd13134 307 VLkslkIGLLVSLAVALLLALFREPI----LGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLI 382
|
410 420 430
....*....|....*....|....*....|...
gi 778699759 415 NLGCFYMVGMPVAIWLSFYGGWDFKGLWIGLLA 447
Cdd:cd13134 383 GIISMWGISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
37-466 |
1.58e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 111.78 E-value: 1.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGG-LSLAggslAIGFAN-----ITgySLLSGLAMGMEPICGQAFGAKRF 110
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGvAALA----AVSNGSpiiflLT--AIGMGLSMGGTILISQYIGAKDE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 111 KLLGLTLQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYI---LCSLPDLVALSFLHPLriyLRSQ--SI 184
Cdd:cd13138 77 EKAKKAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLricFLGIPFIFGYNAYSAI---LRGLgdSK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 185 nLPLtYCAILAILFHIPINYFFVCVFEWGIRGVALGAVWTN-FNFVGSLVVFVLFSGVYKKTWPGMSSDcLKEWKSLLGL 263
Cdd:cd13138 154 -TPL-YFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQaISVLLALYYLRKKKLPFKLSLKDFRFD-KEILKEILKI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 264 AIPSCISvclewwwyEIMILLSGFMLNPQ------STVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKL 337
Cdd:cd13138 231 GLPSALQ--------QSLVSISFLIINSIvnsygvVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKK 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 338 AAIVGLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLG 417
Cdd:cd13138 303 GLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISIL 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 778699759 418 CFYMVGMPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNWE 466
Cdd:cd13138 383 RLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
266-429 |
6.27e-26 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 103.80 E-value: 6.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 266 PSCISVCLEWWWYEIMILLSGFMlnPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLCI 345
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 346 SFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCfYMVGMP 425
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
....
gi 778699759 426 VAIW 429
Cdd:pfam01554 158 LNYL 161
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-447 |
1.86e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 102.99 E-value: 1.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMIlVGFLMYSrsMISM---LFLGRLGGLSLAGGSLAiGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLL 113
Cdd:cd13133 5 REILKIALPLV-LSMLSQT--VMGFtdrAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 114 GLTLQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSY----ILCSLPDLVALSFlhplRIYLRSQSINLPL 188
Cdd:cd13133 81 GRVLWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYfrirILGAPFSLLGAAL----RAFFSGIGRTRVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 189 TYCAILAILFHIPINYFFV----CVFEWGIRGVALGAVWTNFnfVGSLV-VFVLFSGVYKKTWPGMSSD--CLKEWKSLL 261
Cdd:cd13133 157 MVANLVMVVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEA--VSLLFfLLLLFRRKNRRRFGLRRAWrfDRELLRRIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 262 GLAIPSCISVCLEWWWYEIMILLSGfMLNPQStVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIV 341
Cdd:cd13133 235 RLGLPSGLQFFLDVGAFTVFFLLIG-RLGTTE-LAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 342 GLCISFFLGISALLFAFKIRKVWATMFTEDI---QIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGC 418
Cdd:cd13133 313 GLKLALAYMLLLGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIV 392
|
410 420
....*....|....*....|....*....
gi 778699759 419 FYMVGMPVAiWLSFYGGWDFKGLWIGLLA 447
Cdd:cd13133 393 AWLYLLPPA-YLLVVLGAGLAGAWTVETV 420
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
43-460 |
6.69e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 97.97 E-value: 6.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 43 AFPMILVGFLMYSRSMISMLFLGRL-GGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTI 121
Cdd:cd13143 10 ALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLL-MALGLMIGVGGASLISRRLGAGDREKANRIFSTAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 122 ILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCAILAILFHI 200
Cdd:cd13143 89 LLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 201 PINYFFVCVFEWGIRGVALGAVWTNFnfVGSLVVFVLF---SGVYKKTWPGMSSDcLKEWKSLLGLAIPSCISvclewww 277
Cdd:cd13143 169 ILDPLFIFVLGLGIAGAALATVIAQL--ISLLLLLLYFfrgKSLLKLSLLRFKLS-LKIIKEILALGFPSFLM------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 278 yEIMILLSGFMLNPQ-------STVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKA----KLAAIVGLCIS 346
Cdd:cd13143 239 -QLSSSVVTIVLNLTllgyggdIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVkqalKLALIVALIYG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 347 FFLGISALLFAFKIrkvwATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPV 426
Cdd:cd13143 318 LVLFLILLLFPEQI----VSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPL 393
|
410 420 430
....*....|....*....|....*....|....
gi 778699759 427 AIWLSFYggWDFKGLWIGLLAAQASCAMTMLMVL 460
Cdd:cd13143 394 LLILPRL--FGLDGIWLAFPLAEILTLLLALILL 425
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-465 |
2.46e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 84.55 E-value: 2.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 36 AKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAigFANI-TGYSLLSGLAMGMEPICGQAFGAKRFKLLG 114
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSIS--WPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 115 LTLQRTIILLLISSLPISFLWFNMKK--ILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRS--QSInLPLTY 190
Cdd:cd13142 88 KVAGQTFSFVIILSLILAVLGYILSRplLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGigDTK-TPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 191 CAILAILFHI--PINYF-FVCVFEWGIRGVALGAVWTNFnFVGSLVVFVLFSGVY--KKTWPGMSSDclKEW-KSLLGLA 264
Cdd:cd13142 167 MFGSVLLNVIldPLLIFgIGPFPGLGVAGAALATVISRG-IAAVIGLYLLFKGRVglKISLRDLKPD--WEWlKKIFRIG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 265 IPSCISVCLEWWWYEIMI-LLSGFmlnPQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGL 343
Cdd:cd13142 244 LPSSIEQSARALGFTVMTaLVAGF---GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 344 CISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVG 423
Cdd:cd13142 321 LLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIR 400
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 778699759 424 MPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNW 465
Cdd:cd13142 401 IPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-442 |
2.72e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 81.03 E-value: 2.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 36 AKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAG-GslAIGFANITGYSLLSGLAMGMEPICGQAFGAKRFKLLG 114
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAvG--TAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 115 LTLQRTIIL-LLISSLPISFLWFNMKKILLFCG-QDVDIANEAHSYILCSLPDLVAlSFLHPL--RIYLRSQSINLPLtY 190
Cdd:cd13140 82 KYARNALQLnLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIF-SFLNPVftGIFNALGDSKTPF-I 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 191 CAILAILFHIPINYFFVCVF----EWGIRGVALGAVwtnfnfVGSLVVFVLF------SGVYKKTWPGMSSDCLKEWKSL 260
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFgpfpALGVAGAALATV------LAQAIVFLLFlyalkkKKGLFLKIRILKRPDRKYIKEI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 261 LGLAIPSCISVCLewwwYEI--MIL---LSGFMLNPqstVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKA 335
Cdd:cd13140 234 LKLGLPVALQSIL----FALisMILariIASFGPVA---IAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 336 KLAAIVGLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANIN 415
Cdd:cd13140 307 RKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIIS 386
|
410 420
....*....|....*....|....*..
gi 778699759 416 LGcFYMVGMPVAIWLSFYgGWDFKGLW 442
Cdd:cd13140 387 IV-FNGLRIPLALLLSPT-GLGLNGIW 411
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-465 |
1.62e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 72.64 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAggslAIGFANIT---GYSLLSGLAMGMEPICGQAFGAKRFKLL 113
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIA----TVGLTESVltiVYSIAIGLSMAATALVARRIGEKDPEGA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 114 GLTLQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSY---ILCSLPdLVALSFL------------HPLRI 177
Cdd:cd13139 90 GFAAVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYtriMFGGNG-FIMLLFLingifrgagdaaIAMRS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 178 YLRSQSINLPLTYCAILAILFhIPinyffvcvfEWGIRGVALGAVWTnfNFVGSLV-VFVLFSG---------VYKKTWP 247
Cdd:cd13139 169 LWLANGLNIILDPLFIFGLGP-IP---------AMGVTGAAIATTIG--RSIGVLYqLYHLFKGkgriqirrrHLKLDWA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 248 GMSSDCLKEWKSLLGLAIPSCIsvclewwWYEIMILLSGFmlnpQSTVASMGILIQTTALIYIFPS-SLSFGVSTRVGNE 326
Cdd:cd13139 237 IIKKIIKIAVGGILQFLIASSS-------WIFLVRIIAEF----GSTALAGYTIAIRIIMFALLPAwGLSNAAATLVGQN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 327 LGANHPNKAKLAA-IVGLCISFFLGISALLFAFKIRKVwATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRG- 404
Cdd:cd13139 306 LGAGQPDRAEKSVwRAGKYNMVFLGIVSLVFFLFAEPL-VSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGa 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 778699759 405 --TARPKLganINLGCFYMVGMPVAIWLSFYGGWDFKGLWIGLLAAQASCAMTMLMVLTRTNW 465
Cdd:cd13139 385 gdTKTPTL---INLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
237-456 |
4.32e-10 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 62.07 E-value: 4.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 237 LFSGVYKKTWPGMssdclkewKSLLGLAIPSCISVCLEWWWYEIMILLSGFMLNPQstVASMGILIQTTALIYIFPSSLS 316
Cdd:PRK00187 223 LRKGLSRPSRAAL--------RELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQ--LAAHQIALQIVSVAFMVPVGLS 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 317 FGVSTRVGNELGANHPNKAKLAAIVGLCisfFLGISALLFA--FKIRKVWATMFTEDI------QIIELTSLILPIIGLC 388
Cdd:PRK00187 293 YAVTMRVGQHYGAGRLLEARRAGRVGIG---FGAVVMLLFAglFWLLPEAIIGLFLDRndpafaEIVQLAVSLLAVAAWF 369
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 389 ELGNCPQTTSCGVLRGTARPKLGANINLGCFYMVGMPVAIWLSFYGGWDFKGLWIGLLA--AQASCAMTM 456
Cdd:PRK00187 370 ELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALglACAAVALTL 439
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
28-242 |
6.01e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 61.31 E-value: 6.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 28 RFSHVLSEAKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGA 107
Cdd:COG0534 220 DLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGA 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 108 KRFKLLGLTLQRTIILLLISSLPIS-FLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINL 186
Cdd:COG0534 299 GDYDRARRAARLALLLALGIGLLLAlLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTR 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 778699759 187 PLTYCAILA-ILFHIPINYFFVcVFEWGIRGVALGavwtnfnFVGSLVVFVLFSGVY 242
Cdd:COG0534 379 FPMIISLLRlWLVRLPLAYLLA-FLGLGLTGVWLA-------LPIGEVLRALLLLLR 427
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-447 |
1.12e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 60.38 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAggslAIGFANITGYSLLSGL---AMGMEPICGQAFGAKRFKLL 113
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYS----AVGNVTTPFNTITGFLgsiSIGFTILGSQSVGAKDIKRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 114 GLTLQRTIILLLISSLPISFLW-FNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCA 192
Cdd:cd13135 77 NDYAISSIVYNSIIGVILFLLWlFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 193 ILAILFHIPINYFFV---CVF-EWGIRGVALGAVWTNFNFVGSLVVFVLfsgVYKKTWPGMSSDCLKEWK-SLLGLAIPS 267
Cdd:cd13135 157 IIKNLLNVILDYVLIfgnFGFpRLGIIGAAIATTIANVLNLIILVYLCR---KIKKLTFKLSNTKVLKANiRPYKFTIKL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 268 CISVCLEWWWYEIMILLSGFMLNPQSTVAsMGI--LIQTTALIYIFP-SSLSFGVSTRVGNELGANHPNKAKLAAIVGLC 344
Cdd:cd13135 234 GLPLGGEEFLWNIGNLAVIRILNRIGELA-LGIytLVFGIENIVLMPmYGYSSAALTLVGESIGKKDLKEALRIGNICLG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 345 ISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINL-GCFYMVG 423
Cdd:cd13135 313 LGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIiGTIIVVS 392
|
410 420
....*....|....*....|....
gi 778699759 424 mpVAIWLSFYGGWDFKGLWIGLLA 447
Cdd:cd13135 393 --VALLLIFVFKLGLAGVYITLFI 414
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
37-447 |
2.18e-09 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 59.50 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLS-LAGGSLAIGFANITgYSLLSGLAMGMEPICGQAFGAKRFKLLGL 115
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 116 TLQRTIIL-LLISSLPISFLWFNMKKILLFCGQDVDIANEAHSY----ILCSLPDLVALSFLHPLRIYLRSQsinLPLtY 190
Cdd:cd13136 82 LLVRALLLaLAIGLLLILLQSPLLALALLLLGASAAVAALARQYlrirILGAPAVLLNYVATGWFRGLQDTR---TPL-I 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 191 CAILAILFHIPINYFFVCVFEWGIRGVALGAV---WTnfnfvGSLVVFVLFSGVYKKTWPGMSSDCL--KEWKSLLGLAI 265
Cdd:cd13136 158 LQIVGNVVNIVLDPLFVFGLGWGVAGAALATViaqYL-----GALLGLWLLRRRVRLLGKSLSRRLPskAALKRLFKLNR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 266 PSCI-SVCLewwwyeIMILLSGFMLNPQSTVASMG---ILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIV 341
Cdd:cd13136 233 DIFIrTLAL------LAAFLFFTALAARLGDVILAanqILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 342 GLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGANINLGCFym 421
Cdd:cd13136 307 LLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSL-- 384
|
410 420
....*....|....*....|....*.
gi 778699759 422 VGMPVAIWLsFYGGWDFKGLWIGLLA 447
Cdd:cd13136 385 AVFLPLLFL-LVPLWGNHGLWLALIL 409
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-449 |
4.07e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 55.77 E-value: 4.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 36 AKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAggslAIGFANITGY---SLLSGLAMGMEPICGQAFGAKRFKL 112
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLflnSLTIGLGIGASAVISRAIGAGDRNK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 113 LGLTLQRTIILLLISSLPISFL-WFNMKKILLFCGQDVDIANEAHSY-------------------ILCSLPDLVAlsfl 172
Cdd:cd13149 84 AKRLATDSLILSLLLSVIVSLLgLFTIPPLFSLLGASGEILPLIVEYmaiwylglvflvlpmvgnaIIRATGDTKR---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 173 hPLRIYLRSQSINLPLTYCAILAIlFHIPInyffvcvfeWGIRGVALGAVWTNFNFVGSLVVFVLFSGVYKKTWPGMSSD 252
Cdd:cd13149 160 -PSLVMLGAALVNVILDPILIFGF-GPIPG---------MGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 253 CLKEWKSLLGLAIPSCISVClewwwyeIMILLSGFMLNPQST-----VASMGILIQTTALIYIFPSSLSFGVSTRVGNEL 327
Cdd:cd13149 229 LFRSWKDILSIGIPAALSNI-------LTPLSAAFITALVATygpaaVAAFGVATRIESFAFIIVMALSSALGPFVGQNW 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 328 GANHPNKAKLAAIVGLCISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTAR 407
Cdd:cd13149 302 GAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGK 381
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 778699759 408 PKLGANINLGCFYMVGMPVAIWLSFYGGwdFKGLWIGLLAAQ 449
Cdd:cd13149 382 PLYSLGLNLIRVFLLYIPLAYVGSHLLG--FAGVFIGALAGN 421
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
49-459 |
4.65e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 49.13 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 49 VGFL---MYSrsMISMLFLGRLGGLSLAGGSLA--IGFANItgySLLSGLAMGMEPICGQAFGAKRFKLLGLTLQRTIIL 123
Cdd:cd13145 20 VGFFfntMFN--VVDTFFAGKISTEALAALSLSfpIFFIII---AIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 124 LLISSLPISFLWFNMKKILL-FCGQDVDIANEAHSY---ILCSLPDLVALSFLHPLriyLRSQSINLPLTYCAILAILFH 199
Cdd:cd13145 95 GIILAILLTVIGLFAAPPLFrLLGAEGDYLDLALEYmdvIFAGSIFFLLNFGLNGI---LNAQGDTKSYRNFLIIGFFLN 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 200 IPINYFFV----CVFEWGIRGVALGAVWTNFnfvgsLVVFVLFSGVYK-KTWPGMSSDCLKE----WKSLLGLAIPSCIS 270
Cdd:cd13145 172 IILDPLFIfgggGIPAMGVSGIALATIISQF-----IGMFYLLYKVRKsGIISGCRLRDFIPrldvYKEILKQGFPASLN 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 271 VclewwwyeIMILLSGFMLN------PQSTVASMGILIQTTALIYIFPSSLSFGVSTRVGNELGANHPNKAKLAAIVGLC 344
Cdd:cd13145 247 M--------MTIGLGIFVITyfvgqfGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 345 ISFFLGISALLFAFKIRKVWATMFTEDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTARPKLGanINLGCFYMVGM 424
Cdd:cd13145 319 YGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFA--LWIGLYRQLVG 396
|
410 420 430
....*....|....*....|....*....|....*..
gi 778699759 425 PVAI-WL-SFYGGWDFKGLWIGLLAAQASCAMTMLMV 459
Cdd:cd13145 397 PALVfWLlVNVLGLGVTGIWWGIFTIVWSAAIIALLY 433
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
37-447 |
1.59e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 47.54 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 37 KSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAggslAIGFAN---ITGYSLLSGLAMGMEPICGQAFGAKRFKLL 113
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALA----AIGFVFplfMIIIGLGNGLGAGASSAISRRIGAKDKEGA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 114 GLTLQRTIILLLISSLPISFLWF-NMKKILLFCGqDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYCA 192
Cdd:cd13147 85 DNAAVHSILLGLIISIILTIVLLpFLEPILVLMG-AGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 193 ILAILFHIPINYFFVCVFEWGIRGVALGAVWTNFnFVGSLVVFVLFSG--VYKKTWPGMSSDCLKEWKSLLGLAIPSCIS 270
Cdd:cd13147 164 VAGSILNIILDPIFIYTLGLGIAGAAWATVISML-ISSLVLLYWFFVKkdTYVSLSLKNFKFDKKIVKDILKVGIPASLE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 271 VCLewwWYEIMILLSGFMLNPQSTvasMGILIQTTAL-IYIFPSSLSFGVSTRV----GNELGANHPNKAKLA----AIV 341
Cdd:cd13147 243 QLI---MSVLMIILNLILVIVAGT---DGVAVYTAGWrIVSFAIIPLIGIATAVtsvtGAAYGARNYEKLKTAynysIKL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 342 GLCISFFLGISALLFAFKIrkvwATMFT---EDIQIIELTSLILPIIGLCELGNCPQTTSCGVLRGTAR--PKLGANINL 416
Cdd:cd13147 317 GLIIELIIAILIFIFAPQI----AYLFTyseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKglTSLIITILR 392
|
410 420 430
....*....|....*....|....*....|.
gi 778699759 417 GCFYMVGMpvAIWLSFYGGWDFKGLWIGLLA 447
Cdd:cd13147 393 ELIFQVLF--AYLFAIVLGLGLFGVWWGIVL 421
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-244 |
1.49e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 44.42 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 36 AKSIADIAFPMILVGFLMYSRSMISMLFLGRLGGLSLAGGSLAI---GFANITGYsllsGLAMGMEPICGQAFGAKRFKL 112
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLrieSLAFMPGF----GFSMAASTLVGQNLGAGDPDE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 778699759 113 LGLTLQRTIILLLISSLPIS-FLWFNMKKILLFCGQDVDIANEAHSYILCSLPDLVALSFLHPLRIYLRSQSINLPLTYC 191
Cdd:cd13137 301 ARRYGKRALRLGVLFMGLLGlLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLII 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 778699759 192 AILAI-LFHIPINYFFVCVFEWGIRGVALGavwtnfNFVGSLVVFVLFSGVYKK 244
Cdd:cd13137 381 NLISMwLVRLPLAYLLGFVLGLGLTGIWLA------MFVDTIVRAILLLYRFRK 428
|
|
| |
