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Conserved domains on  [gi|410913821|ref|XP_003970387|]
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NADH-ubiquinone oxidoreductase subunit 8-like isoform X2 [Takifugu rubripes]

Protein Classification

NuoI/complex I 23 kDa subunit family protein( domain architecture ID 11481829)

NuoI/complex I 23 kDa subunit family protein such as bacterial NADH-quinone oxidoreductase subunit I (NuoI), which is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064|33957129|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
50-209 1.52e-91

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.21  E-value: 1.52e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  50 ITDRAATTLLWtELFRGLAMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEA 129
Cdd:PRK05888   1 IKQYLKSMLLK-ELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 130 ETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEKLLNNGDQWEVEISENIKADYLYR 209
Cdd:PRK05888  80 AEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
50-209 1.52e-91

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.21  E-value: 1.52e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  50 ITDRAATTLLWtELFRGLAMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEA 129
Cdd:PRK05888   1 IKQYLKSMLLK-ELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 130 ETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEKLLNNGDQWEVEISENIKADYLYR 209
Cdd:PRK05888  80 AEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 66-187 8.16e-63

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 190.70  E-value: 8.16e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821   66 GLAMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAETRADGSRRTTRYDID 145
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 410913821  146 MTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEKL 187
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 107-179 1.10e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 86.72  E-value: 1.10e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtradgsRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPnFEFSTETHEE 179
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDG------EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 107-165 5.87e-17

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 73.59  E-value: 5.87e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADgsrrttrydIDMTKCIYCGFCQEACPVDAIV 165
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLEDELEIV---------IDKEKCIGCGICAEVCPVNAIK 126
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 110-163 3.32e-13

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 61.77  E-value: 3.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 410913821  110 CIACKLCEAICPAQAITIEAETRADGsrrTTRYDIDMTKCIYCGFCQEACPVDA 163
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKG---TKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 74-164 1.61e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 44.08  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  74 LFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAETRADGSrrttrydidmtKCIYCG 153
Cdd:NF038196 151 GPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGKPVWGH-----------NCTHCL 219

                         90
                 ....*....|.
gi 410913821 154 FCQEACPVDAI 164
Cdd:NF038196 220 ACIHRCPKEAI 230
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
50-209 1.52e-91

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.21  E-value: 1.52e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  50 ITDRAATTLLWtELFRGLAMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEA 129
Cdd:PRK05888   1 IKQYLKSMLLK-ELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 130 ETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEKLLNNGDQWEVEISENIKADYLYR 209
Cdd:PRK05888  80 AEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 66-187 8.16e-63

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 190.70  E-value: 8.16e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821   66 GLAMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAETRADGSRRTTRYDID 145
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 410913821  146 MTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEKL 187
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 107-179 1.10e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 86.72  E-value: 1.10e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtradgsRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPnFEFSTETHEE 179
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDG------EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
ndhI CHL00014
NADH dehydrogenase subunit I
 65-184 3.49e-19

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 80.57  E-value: 3.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  65 RGLAMTLSYLFREPATINYPFEKGPLSPRFRGehalrRYPNGEERCIACKLCEAICPAQAITIEAETRAD-GSRRTTRYD 143
Cdd:CHL00014  21 QGFMITLSHANRLPVTIQYPYEKLITSERFRG-----RIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDiRKKRLLNYS 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 410913821 144 IDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNK 184
Cdd:CHL00014  96 IDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQ 136
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 78-185 9.35e-18

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 76.99  E-value: 9.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  78 PATINYPFEKGPLSPRFRG--EHALrrypngeERCIACKLCEAICPAQAITIEAETRADgsrrTTRYDIDMTKCIYCGFC 155
Cdd:PRK12387  13 TATSSYPLEPIAVDKNFRGkpEYNP-------QQCIGCAACVNACPSNALTVETDLATG----ELAWEFNLGRCIFCGRC 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 410913821 156 QEACPVDAIVQGPNFEFSTETHEELLYNKE 185
Cdd:PRK12387  82 EEVCPTAAIKLSQEFELAVWKKEDLLQQSE 111
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 107-165 5.87e-17

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 73.59  E-value: 5.87e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADgsrrttrydIDMTKCIYCGFCQEACPVDAIV 165
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLEDELEIV---------IDKEKCIGCGICAEVCPVNAIK 126
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 107-186 9.48e-16

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 70.50  E-value: 9.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 107 EERCIACKLCEAICPAQAITIEaetraDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYNKEK 186
Cdd:cd10549    5 PEKCIGCGICVKACPTDAIELG-----PNGAIARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEEK 79
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 79-184 1.53e-15

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 71.32  E-value: 1.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  79 ATINYPFEKGPLSPRFRGEHALrrypnGEERCIACKLCEAICPAQAITIEaeTRADGSRRTtrYDIDMTKCIYCGFCQEA 158
Cdd:PRK08222  14 ATVKYPFAPLEVSPGFRGKPDL-----MPSQCIACGACTCACPANALTIQ--TDDQQNSRT--WQLYLGRCIYCGRCEEV 84

                         90       100
                 ....*....|....*....|....*.
gi 410913821 159 CPVDAIVQGPNFEFsTETHEELLYNK 184
Cdd:PRK08222  85 CPTRAIQLTNNFEL-TVTNKADLYTR 109
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 107-164 6.41e-15

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 66.61  E-value: 6.41e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtradgsrrttRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG2221   14 EEKCIGCGLCVAVCPTGAISLDDG----------KLVIDEEKCIGCGACIRVCPTGAI 61
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
98-164 1.02e-14

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 66.29  E-value: 1.02e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 410913821  98 HALRRYPNGEERCIACKLCEAICPAQAITIEAEtradgsrrttRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG2768    1 HSLGKPYVDEEKCIGCGACVKVCPVGAISIEDG----------KAVIDPEKCIGCGACIEVCPVGAI 57
PRK13984 PRK13984
putative oxidoreductase; Provisional
 73-159 2.25e-14

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 70.95  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  73 YLFREPATINYPFEKGPLSPRFRGEHAlrrypNGEERCIACKLCEAICPAQAIT---IEAETRADGSrRTTRYDIDMTKC 149
Cdd:PRK13984  15 FLFRKPVTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITmveVPDLPQEYGK-KPQRPVIDYGRC 88

                         90
                 ....*....|
gi 410913821 150 IYCGFCQEAC 159
Cdd:PRK13984  89 SFCALCVDIC 98
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 107-164 2.62e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 63.96  E-value: 2.62e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10549   39 EDKCVFCGACVEVCPTGAIELTPE-GKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAI 95
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 107-165 2.76e-13

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 62.37  E-value: 2.76e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydIDMTKCIYCGFCQEACPVDAIV 165
Cdd:COG4231   21 EDKCTGCGACVKVCPADAIEEGDGKAV----------IDPDLCIGCGSCVQVCPVDAIK 69
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 110-163 3.32e-13

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 61.77  E-value: 3.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 410913821  110 CIACKLCEAICPAQAITIEAETRADGsrrTTRYDIDMTKCIYCGFCQEACPVDA 163
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKG---TKTVVIDPERCVGCGACVAVCPTGA 51
NapF COG1145
Ferredoxin [Energy production and conversion];
107-164 5.00e-13

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 65.90  E-value: 5.00e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAdgsrrttrYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG1145  181 AEKCIGCGLCVKVCPTGAIRLKDGKPQ--------IVVDPDKCIGCGACVKVCPVGAI 230
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 67-175 1.03e-12

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 62.16  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  67 LAMTLSYLFREPATINYP-FEKGPLSPRFRGEHALRRypngeERCIACKLCEAICPAQAITIEAETRadgsrrttRYDID 145
Cdd:PRK08348   5 LPTVLRNLFKKPATNLFPaTEPVPVPEDFRGKILYDV-----DKCVGCRMCVTVCPAGVFVYLPEIR--------KVALW 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 410913821 146 MTKCIYCGFCQEACPVDAIVQGPNFEFSTE 175
Cdd:PRK08348  72 TGRCVFCGQCVDVCPTGALQMSDDFLLASY 101
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 107-165 1.93e-12

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 60.45  E-value: 1.93e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtradgsrrtTRYDIDMTKCIYCGFCQEACPVDAIV 165
Cdd:COG1144   29 EDKCIGCGLCWIVCPDGAIRVDDG---------KYYGIDYDYCKGCGICAEVCPVKAIE 78
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 107-164 3.73e-12

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 59.36  E-value: 3.73e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAEtradgsrrtTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG1149   10 EEKCIGCGLCVEVCPEGAIKLDDG---------GAPVVDPDLCTGCGACVGVCPTGAI 58
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 107-164 1.17e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 57.80  E-value: 1.17e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRadgsrRTTRYDIDmtKCIYCGFCQEACPVDAI 164
Cdd:COG1146    7 TDKCIGCGACVEVCPVDVLELDEEGK-----KALVINPE--ECIGCGACELVCPVGAI 57
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
107-181 3.02e-10

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 58.72  E-value: 3.02e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAdgsrrttryDIDMTKCIYCGFCQEACPVDAIVQgPNFefsteTHEELL 181
Cdd:COG1148  495 PEKCTGCGRCVEVCPYGAISIDEKGVA---------EVNPALCKGCGTCAAACPSGAISL-KGF-----TDDQIL 554
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
110-165 7.29e-10

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 57.25  E-value: 7.29e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 110 CIACKLCEAICPAQAITIEaetradgsrrTTRYDIDMTKCIYCGFCQEACPVDAIV 165
Cdd:PRK07118 215 CIGCGKCVKACPAGAITME----------NNLAVIDQEKCTSCGKCVEKCPTKAIR 260
Fer4_9 pfam13187
4Fe-4S dicluster domain;
109-164 1.97e-09

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 51.79  E-value: 1.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821  109 RCIACKLCEAICPAQAITIeaetraDGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVP------DLVGQTIRGDIAGLACIGCGACVDACPRGAI 50
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
107-165 2.01e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 56.19  E-value: 2.01e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEaetraDGSRRttrydIDMTKCIYCGFCQEACPVDAIV 165
Cdd:COG4624   90 KEKCKNCYPCVRACPVKAIKVD-----DGKAE-----IDEEKCISCGQCVAVCPFGAIT 138
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 101-165 8.70e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 51.81  E-value: 8.70e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 101 RRYPNGEERCIACKLCE-----AICPAQAITIEAETRAdgsrrttrYDIDMTKCIYCGFCQEACPVDAIV 165
Cdd:cd10550   37 RFEPEGLDVPVVCRQCEdapcvEACPVGAISRDEETGA--------VVVDEDKCIGCGMCVEACPFGAIR 98
FeFe_hydrog_B1 TIGR04105
[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.
 108-165 2.52e-08

[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.


Pssm-ID: 274983 [Multi-domain]  Cd Length: 462  Bit Score: 52.98  E-value: 2.52e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821  108 ERCIACKLC----------------EAICPAQAITIEAETRADgsrrttrydIDMTKCIYCGFCQEACPVDAIV 165
Cdd:TIGR04105 142 EKCIECGKCkkacpynaiveierpcEKACPVGAISSDEDGRAV---------IDYDKCISCGACMVACPFGAIS 206
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 98-165 2.93e-08

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 51.49  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  98 HALRRYPNG-----EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYCGF---------CQEACPVDA 163
Cdd:COG0437   75 GATYKREDGivlvdYDKCIGCRYCVAACPYGAPRFNPETGV------------VEKCTFCADrldegllpaCVEACPTGA 142


                 ..
gi 410913821 164 IV 165
Cdd:COG0437  143 LV 144
PRK13795 PRK13795
hypothetical protein; Provisional
 109-161 3.29e-08

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 52.69  E-value: 3.29e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 410913821 109 RCIACKLCEAICPAQAITIEAETRadgsrrttRYDIDMTKCIYCGFCQEACPV 161
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKR--------KISVDEEKCIHCGKCTEVCPV 626
PRK06273 PRK06273
ferredoxin; Provisional
 107-200 5.63e-08

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 50.48  E-value: 5.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 107 EERCIACKLCEAICPAQAIT---IEAETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEELLYN 183
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEmipVEPVKITEGYVKTKIPKIDYEKCVYCLYCHDFCPVFALFNEISPIHPRDVGEDIEVD 127

                         90
                 ....*....|....*..
gi 410913821 184 KEKLLNNgdqwEVEISE 200
Cdd:PRK06273 128 VSKLLEK----PVEISE 140
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 109-164 5.83e-08

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 51.92  E-value: 5.83e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 109 RCIACKLCEAICPAQAItIEAETRADGSR----RTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:PRK14028 248 KCIMCRKCWLYCPDDAI-IEAWREAEGPRgrkfRMKMIDFDYQYCKGCGVCAEVCPTGAI 306
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 107-164 1.60e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 48.80  E-value: 1.60e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADGSRRTTRYDIdMTKCIYCGF------CQEACPVDAI 164
Cdd:cd10554   84 EERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAV-AVKCDLCAGreggpaCVEACPTKAL 146
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
107-166 2.35e-07

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 48.11  E-value: 2.35e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADGSrrttrydidmTKCIYCGF------CQEACPVDAIVQ 166
Cdd:COG1142   80 EEKCIGCGLCVLACPFGAITMVGEKSRAVA----------VKCDLCGGreggpaCVEACPTGALRL 135
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
110-164 3.64e-07

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 47.73  E-value: 3.64e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410913821 110 CIACKL--CEAICPAQAITieaetradgsRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG1142   52 CRHCEDapCAEVCPVGAIT----------RDDGAVVVDEEKCIGCGLCVLACPFGAI 98
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 108-173 4.06e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 48.30  E-value: 4.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 108 ERCIACKLCEAICPAQAITI---EAETRADGSRRTTRYdidMTKCIYC------G---FCQEACPVDAIVQG----PNFE 171
Cdd:cd10551   83 DKCIGCRYCMAACPYGARYFnpeEPHEFGEVPVRPKGV---VEKCTFCyhrldeGllpACVEACPTGARIFGdlddPNSE 159


                 ..
gi 410913821 172 FS 173
Cdd:cd10551  160 VS 161
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 110-168 4.27e-07

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 49.49  E-value: 4.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 110 CIACKLCEAICPAQAITIEAETRadgsrrttRYDIDMTKCIYCGFCQEACPVDAIVQGP 168
Cdd:PRK12771 512 CFECDNCYGACPQDAIIKLGPGR--------RYHFDYDKCTGCHICADVCPCGAIEMGP 562
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 97-165 4.31e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 47.38  E-value: 4.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  97 EHALRRYPNG-----EERCIACKLCEAICPAQAITIEAETRadgsrrttrydiDMTKCIYCGF---------CQEACPVD 162
Cdd:cd04410   64 TGAIYKDEDGivlidEDKCIGCGSCVEACPYGAIVFDPEPG------------KAVKCDLCGDrldeglepaCVKACPTG 131


                 ...
gi 410913821 163 AIV 165
Cdd:cd04410  132 ALT 134
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
107-164 5.25e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 48.91  E-value: 5.25e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQaITIeaetrADGSrrttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG0348  209 RGDCIDCGLCVKVCPMG-IDI-----RKGE-------INQSECINCGRCIDACPKDAI 253
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 107-165 9.74e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 46.86  E-value: 9.74e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIA------CKLCEAICPAQAITIEAEtraDGSRRTTrydIDMTKCIYCGFCQEACPVD---AIV 165
Cdd:cd16373   90 KDRCLAwqggtdCGVCVEACPTEAIAIVLE---DDVLRPV---VDEDKCVGCGLCEYVCPVEppkAIV 151
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 111-164 1.43e-06

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 46.08  E-value: 1.43e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 410913821 111 IACKLCEAICPAQAITIEAETRADGSRRttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10564   86 VECRSCQDACPTQAIRFRPRLGGIALPE-----LDADACTGCGACVSVCPVGAI 134
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
109-164 1.57e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 47.71  E-value: 1.57e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 109 RCIACKLCEAICPAQAITIEAETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG4624   53 RCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAI 108
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 107-164 2.39e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 45.26  E-value: 2.39e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYCG---FCQEACPVDAI 164
Cdd:cd10550   79 EDKCIGCGMCVEACPFGAIRVDPETGK------------AIKCDLCGgdpACVKVCPTGAL 127
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 107-160 3.20e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 43.01  E-value: 3.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 410913821  107 EERCIACKLCEAICPAQAITIEAETRADGSRRTtryDIDMTKCIYCGFCQEACP 160
Cdd:pfam13237   6 PDKCIGCGRCTAACPAGLTRVGAIVERLEGEAV---RIGVWKCIGCGACVEACP 56
NapF COG1145
Ferredoxin [Energy production and conversion];
106-169 5.17e-06

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 45.87  E-value: 5.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821 106 GEERCIACKLCEAICPAQAITIEAETRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVQGPN 169
Cdd:COG1145  141 EAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDG 204
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 116-164 5.44e-06

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 44.94  E-value: 5.44e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 410913821 116 CEAICPAQAITIeaetRADGSRRttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG0437   68 CVKVCPTGATYK----REDGIVL-----VDYDKCIGCRYCVAACPYGAP 107
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 142-164 6.09e-06

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 41.46  E-value: 6.09e-06
                          10        20
                  ....*....|....*....|...
gi 410913821  142 YDIDMTKCIYCGFCQEACPVDAI 164
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAI 23
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
110-160 9.09e-06

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 42.09  E-value: 9.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410913821  110 CIACKLCEAICPAQAIT---IEAETRADGSRRTTRYD---------IDMTKCIYCGFCQEACP 160
Cdd:pfam13484   1 CGSCGKCIDACPTGAIVgpeGVLDARRCISYLTIEKKglipdelrcLLGNRCYGCDICQDVCP 63
PRK09898 PRK09898
ferredoxin-like protein;
107-164 1.08e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 44.44  E-value: 1.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADgsrrttrydidmTKCIYCGFCQEACPVDAI 164
Cdd:PRK09898 153 HKRCIGCSACTTACPWMMATVNTESKKS------------SKCVLCGECANACPTGAL 198
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 109-164 1.35e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 43.40  E-value: 1.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 109 RCIACKLCEAICPAQAITIeaETRADGSR--RTTRYDIDMTKCIYCG-FCQEACPVDAI 164
Cdd:cd16373   15 LCIRCGLCVEACPTGVIQP--AGLEDGLEggRTPYLDPREGPCDLCCdACVEVCPTGAL 71
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 108-169 1.56e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 43.15  E-value: 1.56e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821 108 ERCIACK--LCEAICPAQAITIeaetRADGsrrttRYDIDMTKCIYCGFCQEACPVDAIVQGPN 169
Cdd:cd04410   48 VSCMHCEdpPCVKACPTGAIYK----DEDG-----IVLIDEDKCIGCGSCVEACPYGAIVFDPE 102
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 74-164 1.61e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 44.08  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  74 LFREPATINYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAETRADGSrrttrydidmtKCIYCG 153
Cdd:NF038196 151 GPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGKPVWGH-----------NCTHCL 219

                         90
                 ....*....|.
gi 410913821 154 FCQEACPVDAI 164
Cdd:NF038196 220 ACIHRCPKEAI 230
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
107-164 1.81e-05

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 42.24  E-value: 1.81e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIeaetRADGSrrttrYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:PRK09623  50 ESKCVKCYICWKFCPEPAIYI----KEDGY-----VAIDYDYCKGCGICANECPTKAI 98
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 107-168 2.36e-05

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 42.86  E-value: 2.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410913821  107 EERCIACKLCEAICPAQAITieaetradGSRRTTRYDIdMTKCIYCGFCQEACPVDAIVQGP 168
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAIV--------GAAKAMHTVI-ADECTGCDLCVEPCPTDCIEMIP 164
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
108-170 2.54e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 42.34  E-value: 2.54e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 108 ERCIACKLCEAICPAQAITIEAETRADGSRRTTRYDIDM-TKCIYC--GFCQEACPVDAIVQGPNF 170
Cdd:COG1142   10 EKCIGCRTCEAACAVAHEGEEGEPFLPRIRVVRKAGVSApVQCRHCedAPCAEVCPVGAITRDDGA 75
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 107-164 2.89e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 43.44  E-value: 2.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPAQAITIEAetraDGSRRttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG2878  136 EYGCIGCGDCIKACPFDAIVGAA----KGMHT-----VDEDKCTGCGLCVEACPVDCI 184
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 107-164 3.92e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.58  E-value: 3.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADGSRRTTRYdidmtKCIYCG------FCQEACPVDAI 164
Cdd:PRK12769  84 QQKCIGCKSCVVACPFGTMQIVLTPVAAGKVKATAH-----KCDLCAgrengpACVENCPADAL 142
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 107-168 4.51e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 41.61  E-value: 4.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 107 EERCIACKLCEAICPaQAITIEAETRADGSRRTTRYDIDM----TKCIYCGF--CQEACPVDAIVQGP 168
Cdd:cd04410    5 LDRCIGCGTCEVACK-QEHGLRPGPDWSRIKVIEGGGLERaflpVSCMHCEDppCVKACPTGAIYKDE 71
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 110-164 4.85e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 41.49  E-value: 4.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410913821 110 CIACKL--CEAICPAQAItieaETRADGSRRTTRydidmTKCIYCGFCQEACPVDAI 164
Cdd:cd16370   53 CRACEDppCAEACPTGAL----EPRKGGGVVLDK-----EKCIGCGNCVKACIVGAI 100
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 116-164 5.33e-05

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 42.13  E-value: 5.33e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 410913821 116 CEAICPAQAITIeaetRADGsrrttRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10551   61 CVKVCPTGATYK----REDG-----IVLVDYDKCIGCRYCMAACPYGAR 100
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 138-169 5.73e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 40.03  E-value: 5.73e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 410913821 138 RTT--RYDIDMTKCIYCGFCQEACPVDAIVQGPN 169
Cdd:COG4231   11 RTTamRYVIDEDKCTGCGACVKVCPADAIEEGDG 44
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 99-164 7.05e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 41.10  E-value: 7.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821  99 ALRRYPNG-----EERCIACKLCEAICPAQAITIEAETRadgsrrttrYDIdmtKCIYCGFCQEACPVDAI 164
Cdd:cd16370   69 ALEPRKGGgvvldKEKCIGCGNCVKACIVGAIFWDEETN---------KPI---ICIHCGYCARYCPHDVL 127
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 116-165 7.35e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.01  E-value: 7.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 410913821 116 CEAICPAQAITIeaetRADGsrrTTRYDIDmtKCIYCGFCQEACPVDAIV 165
Cdd:cd16371   62 CVKVCPTGAITK----REDG---IVVVDQD--KCIGCGYCVWACPYGAPQ 102
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 107-135 7.55e-05

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 39.69  E-value: 7.55e-05
                         10        20
                 ....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADG 135
Cdd:COG1146   39 PEECIGCGACELVCPVGAITVEDDEPEEQ 67
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 107-165 8.75e-05

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 40.40  E-value: 8.75e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETradgsrrttrYDI-DMTKCIYCGFCQEACPVDAIV 165
Cdd:PRK09624  50 RDKCVRCYLCYIYCPEPAIYLDEEG----------YPVfDYDYCKGCGICANECPTKAIE 99
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 110-166 9.66e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 40.78  E-value: 9.66e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 110 CIACKLCEAICPAQAITieaetradgsrRTTR--YDIDMTKCIYCGFCQEACPVDAIVQ 166
Cdd:cd16372   49 CNQCGECIDVCPTGAIT-----------RDANgvVMINKKLCVGCLMCVGFCPEGAMFK 96
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 124-164 9.80e-05

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.65  E-value: 9.80e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 410913821 124 AITIEAETRAD--GSRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG1144    5 AITEPGGTAAYktGGWRVERPVVDEDKCIGCGLCWIVCPDGAI 47
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 144-165 1.01e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 39.33  E-value: 1.01e-04
                         10        20
                 ....*....|....*....|..
gi 410913821 144 IDMTKCIYCGFCQEACPVDAIV 165
Cdd:COG1149    8 IDEEKCIGCGLCVEVCPEGAIK 29
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
107-162 1.16e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 42.24  E-value: 1.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAIC---PAQAITIEAetraDGSRRttrYDIDMTKCIYCGFCQEACPVD 162
Cdd:PRK08318 341 QDKCIGCGRCYIACedtSHQAIEWDE----DGTRT---PEVIEEECVGCNLCAHVCPVE 392
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 99-164 1.27e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 40.40  E-value: 1.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821  99 ALRRYPNG-----EERCIACKLCEAICPAQAITIEAETradgsrrttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd16372   63 AITRDANGvvminKKLCVGCLMCVGFCPEGAMFKHEDY------------PEPFKCIACGICVKACPTGAL 121
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
107-166 1.52e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.46  E-value: 1.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICPAQAIT-IEAETRADGSRRTTRYDIDMTK-----CIYCGFCQEACPVDAIVQ 166
Cdd:PRK07118 167 EDKCTGCGACVKACPRNVIElIPKSARVFVACNSKDKGKAVKKvcevgCIGCGKCVKACPAGAITM 232
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 144-170 1.65e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 40.55  E-value: 1.65e-04
                          10        20
                  ....*....|....*....|....*..
gi 410913821  144 IDMTKCIYCGFCQEACPVDAIVQGPNF 170
Cdd:TIGR01944 110 IDEDNCIGCTKCIQACPVDAIVGAAKA 136
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 109-164 1.87e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.95  E-value: 1.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821 109 RCIACK--LCEAICPAQAITIEAetraDGSRRttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd16374   42 RCRHCEdaPCMEVCPTGAIYRDE----DGAVL-----VDPDKCIGCGMCAMACPFGVP 90
PRK06991 PRK06991
electron transport complex subunit RsxB;
95-168 1.95e-04

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 41.32  E-value: 1.95e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 410913821  95 RGEHALRRYPNGEERCIAcKLCEAI-CPAqaITIEAETRADGSRRTTRydIDMTKCIYCGFCQEACPVDAIVQGP 168
Cdd:PRK06991  37 AGEANYNRCPPGGAEGIA-RLAALLgKPV--IPLDPANGVERPRAVAV--IDEQLCIGCTLCMQACPVDAIVGAP 106
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 144-179 2.09e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 38.15  E-value: 2.09e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 410913821 144 IDMTKCIYCGFCQEACPVDAIVQGPNFEFSTETHEE 179
Cdd:COG1146    5 IDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPE 40
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-169 2.25e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 39.48  E-value: 2.25e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410913821 108 ERCIACKLCEAIC---------PAQA-ITIeaetradgSRRTTRYDIDMTKCIYCG--FCQEACPVDAIVQGPN 169
Cdd:cd10550    6 EKCTGCRTCELACslkhegvfnPSLSrIRV--------VRFEPEGLDVPVVCRQCEdaPCVEACPVGAISRDEE 71
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 107-128 2.56e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.17  E-value: 2.56e-04
                         10        20
                 ....*....|....*....|..
gi 410913821 107 EERCIACKLCEAICPAQAITIE 128
Cdd:COG1149   40 PDLCTGCGACVGVCPTGAITLE 61
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 99-175 2.90e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.57  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  99 ALRRYPNG-----EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYCG---------FCQEACPVDAI 164
Cdd:cd16374   59 AIYRDEDGavlvdPDKCIGCGMCAMACPFGVPRFDPSLKV------------AVKCDLCIdrrregklpACVEACPTGAL 126

                         90
                 ....*....|.
gi 410913821 165 VQGPNFEFSTE 175
Cdd:cd16374  127 KFGDIEELLKE 137
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 108-164 4.42e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.15  E-value: 4.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410913821 108 ERCIACKLCEAICPAQAITIeaetradGSRRTTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10564   13 DLCTRCGDCVEACPEGIIVR-------GDGGFPELDFSRGECTFCGACAEACPEGAL 62
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 107-169 4.65e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.86  E-value: 4.65e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICpaqAITIEAETRADGSR-RTTRYD--IDMTKCIYCGFCQEACPVDAIVQGPN 169
Cdd:cd16372    7 PEKCIGCLQCEEAC---SKTFFKEEDREKSCiRITETEggYAINVCNQCGECIDVCPTGAITRDAN 69
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-168 4.89e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 39.29  E-value: 4.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821 108 ERCIACKLCEAICPaqaitiEAETRaDGSRRTTRYDID--------MTKCIYC--GFCQEACPVDAIVQGP 168
Cdd:cd16369    9 SRCIGCRACVAACR------ECGTH-RGKSMIHVDYIDrgestqtaPTVCMHCedPTCAEVCPADAIKVTE 72
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 107-133 7.99e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 36.94  E-value: 7.99e-04
                         10        20
                 ....*....|....*....|....*..
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRA 133
Cdd:COG4231   50 PDLCIGCGSCVQVCPVDAIKLEKRVPE 76
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 143-169 8.28e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.15  E-value: 8.28e-04
                         10        20
                 ....*....|....*....|....*..
gi 410913821 143 DIDMTKCIYCGFCQEACPVDAIVQGPN 169
Cdd:cd10549    2 KYDPEKCIGCGICVKACPTDAIELGPN 28
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 108-170 9.56e-04

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 38.01  E-value: 9.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410913821 108 ERCIACKLCEAICPA----QAITIEAETRADGSRR-TTRYDIDMTKCIYC-----GFCQEACPVDAIVQGPNF 170
Cdd:cd10554    7 DKCIGCRTCEVACAAahsgKGIFEAGTDGLPFLPRlRVVKTGEVTAPVQCrqcedAPCANVCPVGAISQEDGV 79
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 107-171 1.01e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 38.82  E-value: 1.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETrADGSRRTTRYDIDMTKCIYC-GFCQEACPVDAIVQGPNFE 171
Cdd:COG2878  166 EDKCTGCGLCVEACPVDCIEMVPVS-PTVVVSSWDKGKAVRKVVGCiGLCCKKCCPAAAITVNNLA 230
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 107-126 1.07e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 35.30  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|
gi 410913821  107 EERCIACKLCEAICPAQAIT 126
Cdd:pfam00037   5 EEKCIGCGACVEVCPVGAIT 24
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
107-142 1.14e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 36.63  E-value: 1.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRADGSRRTTRY 142
Cdd:COG2768   39 PEKCIGCGACIEVCPVGAIKIEWEEDEEFQEKMAEY 74
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 139-164 1.16e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.18  E-value: 1.16e-03
                         10        20
                 ....*....|....*....|....*.
gi 410913821 139 TTRYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:COG2221    7 TWPPKIDEEKCIGCGLCVAVCPTGAI 32
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 109-162 1.16e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 36.13  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410913821  109 RCIACKLCEAICPA---------QAITIEAETRADGSRRTTRYDIDMTKCIYCGFCQEACPVD 162
Cdd:pfam13183   1 RCIRCGACLAACPVylvtggrfpGDPRGGAAALLGRLEALEGLAEGLWLCTLCGACTEVCPVG 63
NapF COG1145
Ferredoxin [Energy production and conversion];
107-130 1.24e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 38.94  E-value: 1.24e-03
                         10        20
                 ....*....|....*....|....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAE 130
Cdd:COG1145  212 PDKCIGCGACVKVCPVGAISLEPK 235
PRK09898 PRK09898
ferredoxin-like protein;
108-160 1.41e-03

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 38.28  E-value: 1.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 410913821 108 ERCIACK--LCEAICPAQAITIEAETRAdgsrrttrYDIDMTKCIYCGFCQEACP 160
Cdd:PRK09898 121 DTCRQCKepQCMNVCPIGAITWQQKEGC--------ITVDHKRCIGCSACTTACP 167
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 99-165 1.49e-03

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 37.62  E-value: 1.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 410913821  99 ALRRYP-NG-----EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYCGF-----CQEACPVDAIV 165
Cdd:cd10563   73 AMHKDPeTGivihdEEKCVGCWMCVMVCPYGAIRPDKERKV------------ALKCDLCPDretpaCVEACPTGALV 138
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 99-167 1.56e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 37.76  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  99 ALRRYPNG-----EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYC------GF---CQEACPVDAI 164
Cdd:cd16366   86 AIIRTETGtvvvdPETCIGCGYCVNACPFDIPRFDEETGR------------VAKCTLCydrisnGLqpaCVKTCPTGAL 153


                 ...
gi 410913821 165 VQG 167
Cdd:cd16366  154 TFG 156
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 107-128 1.65e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 36.99  E-value: 1.65e-03
                         10        20
                 ....*....|....*....|..
gi 410913821 107 EERCIACKLCEAICPAQAITIE 128
Cdd:cd10549  107 KEKCIGCGICAEVCPVNAIKLV 128
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 144-165 1.72e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 38.00  E-value: 1.72e-03
                         10        20
                 ....*....|....*....|..
gi 410913821 144 IDMTKCIYCGFCQEACPVDAIV 165
Cdd:PRK05113 111 IDEDNCIGCTKCIQACPVDAIV 132
RDH TIGR02486
reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S ...
 110-160 1.84e-03

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.


Pssm-ID: 274158  Cd Length: 314  Bit Score: 38.18  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821  110 CIACKLCEAICPAQAITIEAETRADGSRRTTRYD----------IDMTKCI----------YCGFCQEACP 160
Cdd:TIGR02486 207 CETCGKCADECPSGAISKGGEPTWDPEDSNGDPPgennpglkwqYDGWRCLlfrcynegggGCGVCQAVCP 277
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 88-160 2.35e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 38.06  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  88 GPLSPRFRGEHALRRYPNGEER------CIACKLCEAICPAQAIT-------------IEAETRADGSRRTTRYDIDMTK 148
Cdd:PRK06259 107 KSLRNYLQRKNEKITYPEDIEDikklrgCIECLSCVSTCPARKVSdypgptfmrqlarFAFDPRDEGDREKEAFDEGLYN 186

                         90
                 ....*....|..
gi 410913821 149 CIYCGFCQEACP 160
Cdd:PRK06259 187 CTTCGKCVEVCP 198
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 116-164 2.47e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 37.28  E-value: 2.47e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 410913821 116 CEAICPAQAITIEAetraDGSrrttrYDIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10562   78 CVKVCPTGALYKTE----NGA-----VVVDEDKCIGCGYCVAACPFDVP 117
PRK06991 PRK06991
electron transport complex subunit RsxB;
107-164 2.77e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 37.85  E-value: 2.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410913821 107 EERCIACKLCEAICPAQAI--------TIEAETradgsrrttrydidmtkCIYCGFCQEACPVDAI 164
Cdd:PRK06991  84 EQLCIGCTLCMQACPVDAIvgapkqmhTVLADL-----------------CTGCDLCVPPCPVDCI 132
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 111-164 2.78e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 36.85  E-value: 2.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 111 IACKLCE-----AICPAQAITieaetRADGSRRttrydIDMTKCIYCGFCQEACPVDAI 164
Cdd:cd10554   54 VQCRQCEdapcaNVCPVGAIS-----QEDGVVQ-----VDEERCIGCKLCVLACPFGAI 102
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 107-164 3.18e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 35.85  E-value: 3.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAD-GSRRTTRYDidmTKCIYCGFCQEACPVDAI 164
Cdd:PRK09626  15 ESRCKACDICVSVCPAGVLAMRIDPHAVlGKMIKVVHP---ESCIGCRECELHCPDFAI 70
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 149-169 3.96e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 37.28  E-value: 3.96e-03
                         10        20
                 ....*....|....*....|.
gi 410913821 149 CIYCGFCQEACPVDAIVQGPN 169
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGAAK 159
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 94-169 5.33e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 35.75  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  94 FRGEHALRRypnGEERCIACKLCEAICpaqaitieaETRADGS----RRTTRYD-IDM-TKCIYC--GFCQEACPVDAIV 165
Cdd:cd16367    8 IQGTNLLVI---DLDRCIRCDNCEKAC---------ADTHDGHsrldRNGLRFGnLLVpTACRHCvdPVCMIGCPTGAIH 75


                 ....
gi 410913821 166 QGPN 169
Cdd:cd16367   76 RDDG 79
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 107-128 5.73e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 34.26  E-value: 5.73e-03
                         10        20
                 ....*....|....*....|..
gi 410913821 107 EERCIACKLCEAICPAQAITIE 128
Cdd:COG2221   43 EEKCIGCGACIRVCPTGAIKGE 64
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 108-160 6.10e-03

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 35.49  E-value: 6.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 410913821 108 ERCIACKLCEAICPAQAITieaetradgSRRTTRYDIDMTKCIYCGFCQEACP 160
Cdd:PRK09625  59 EICINCFNCWVYCPDAAIL---------SRDKKLKGVDYSHCKGCGVCVEVCP 102
PRK09326 PRK09326
F420H2 dehydrogenase subunit F; Provisional
 110-161 6.15e-03

F420H2 dehydrogenase subunit F; Provisional


Pssm-ID: 181779 [Multi-domain]  Cd Length: 341  Bit Score: 36.74  E-value: 6.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 410913821 110 CIACKLCEAICPAQAITIE--AETRADGSRRTTRYDIDMTKCIYCGFCQEACPV 161
Cdd:PRK09326  14 CTACGACEAVCPIGAITVDkkAEIRDPNDLELYEKGAAPNVCEGCLTCSRICPV 67
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 107-168 6.35e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 36.13  E-value: 6.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410913821 107 EERCIACKLCEAICPAQAITIEAETRAdgsrrttrydidMTKCIYC------GF---CQEACPVDAIVQGP 168
Cdd:cd10562   99 EDKCIGCGYCVAACPFDVPRYDETTNK------------ITKCTLCfdrienGMqpaCVKTCPTGALTFGD 157
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 95-176 7.12e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 36.40  E-value: 7.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410913821  95 RG-EHA---------LRRYPNGE--ERCIACKLCEAICPAQAITIEaetraDGSRRTTrydiDMTKCIYCGFCQEACPVD 162
Cdd:PRK00783 144 RGkEHAkwqpgsacgYKYYPRIEvsEDCDECEKCVEACPRGVLELK-----EGKLVVT----DLLNCSLCKLCERACPGK 214

                         90
                 ....*....|....*..
gi 410913821 163 AIVQG--PN-FEFSTET 176
Cdd:PRK00783 215 AIRVSddENkFIFTVES 231
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 110-160 7.34e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 35.83  E-value: 7.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 410913821 110 CIACKL--CEAICPAQAITIEaetrADGSRRTTrydiDMTKCIYCGFCQEACP 160
Cdd:cd16369   51 CMHCEDptCAEVCPADAIKVT----EDGVVQSA----LKPRCIGCSNCVNACP 95
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 107-160 9.22e-03

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 36.34  E-value: 9.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 410913821 107 EERCIACKLCEAICPAQAITieAETRADGSR------RTTRYDID------MTKCIY-CGFCQEACP 160
Cdd:COG1600  183 EDHCGSCTRCLDACPTGAIV--APYVLDARRcisyltIELKGPIPeelrpkMGNRIYgCDDCQDVCP 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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